The Experts below are selected from a list of 34266 Experts worldwide ranked by ideXlab platform
Natalia S. Rost - One of the best experts on this subject based on the ideXlab platform.
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normal appearing white matter microstructural injury is associated with white matter Hyperintensity burden in acute ischemic stroke
International Journal of Stroke, 2021Co-Authors: Mark R Etherton, Annekatrin Giese, Natalia S. RostAbstract:BackgroundWhite matter Hyperintensity of presumed vascular origin is a risk factor for poor stroke outcomes. In patients with acute ischemic stroke, however, the in vivo mechanisms of white matter ...
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prospectively collected cardiovascular biomarkers and white matter Hyperintensity volume in ischemic stroke patients
Journal of Stroke & Cerebrovascular Diseases, 2020Co-Authors: Pamela M. Rist, Nancy R. Cook, Julie E. Buring, Kathryn M. Rexrode, Natalia S. RostAbstract:Abstract Background: Few prospective cohort studies collect detailed information on stroke characteristics among individuals who experience ischemic stroke, including white matter Hyperintensity volume, and thus cannot explore how prospectively collected biomarkers prior to the stroke influence white matter Hyperintensity volume. We explored the association between a large panel of prospectively collected lipid and inflammatory biomarkers and white matter Hyperintensity volume among participants in the Women's Health Study with incident ischemic stroke. Methods: Among Women's Health Study participants with first ischemic stroke who had baseline serum biomarkers and available magnetic resonance imaging, we measured white matter Hyperintensity volume using a validated semi-automated method. Linear regression was used to explore the associations between biomarkers and log-transformed white matter Hyperintensity volume. Results: After multivariate adjustment, a 1% increment in HbA1c% was associated with an increase in white matter Hyperintensity volume (P value = .05). Evidence of a nonlinear association between high density lipoprotein cholesterol levels and ApoA1 levels with white matter Hyperintensity volume was noted (P values for nonlinearity = .01 and .001, respectively). No other biomarkers were significantly associated with white matter Hyperintensity volume. Conclusions: Chronic hyperglycemia as evidenced by HbA1c levels measured years prior to stroke is associated with white matter Hyperintensity volume at the time of stroke. Additional research is needed to explain why low levels of high density lipoprotein cholesterol levels and ApoA1 may be associated with similar white matter Hyperintensity volume as high levels.
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Prospectively Collected Cardiovascular Biomarkers and White Matter Hyperintensity Volume in Ischemic Stroke Patients
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020Co-Authors: Pamela M. Rist, Nancy R. Cook, Julie E. Buring, Kathryn M. Rexrode, Natalia S. RostAbstract:Few prospective cohort studies collect detailed information on stroke characteristics among individuals who experience ischemic stroke, including white matter Hyperintensity volume, and thus cannot explore how prospectively collected biomarkers prior to the stroke influence white matter Hyperintensity volume. We explored the association between a large panel of prospectively collected lipid and inflammatory biomarkers and white matter Hyperintensity volume among participants in the Women's Health Study with incident ischemic stroke. Among Women's Health Study participants with first ischemic stroke who had baseline serum biomarkers and available magnetic resonance imaging, we measured white matter Hyperintensity volume using a validated semi-automated method. Linear regression was used to explore the associations between biomarkers and log-transformed white matter Hyperintensity volume. After multivariate adjustment, a 1% increment in HbA1c% was associated with an increase in white matter Hyperintensity volume (P value = .05). Evidence of a nonlinear association between high density lipoprotein cholesterol levels and ApoA1 levels with white matter Hyperintensity volume was noted (P values for nonlinearity = .01 and .001, respectively). No other biomarkers were significantly associated with white matter Hyperintensity volume. Chronic hyperglycemia as evidenced by HbA1c levels measured years prior to stroke is associated with white matter Hyperintensity volume at the time of stroke. Additional research is needed to explain why low levels of high density lipoprotein cholesterol levels and ApoA1 may be associated with similar white matter Hyperintensity volume as high levels. Copyright © 2020 Elsevier Inc. All rights reserved.
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carotid artery stiffness accurately predicts white matter Hyperintensity volume 20 years later a secondary analysis of the atherosclerosis risk in the community study
American Journal of Neuroradiology, 2019Co-Authors: A De Havenon, Kaho Wong, A Elkhetali, Joseph S Mcnally, Jennifer J Majersik, Natalia S. RostAbstract:BACKGROUND AND PURPOSE: Arterial stiffness is a biomarker of cerebrovascular disease and dementia risk. Studies have shown an association between carotid artery stiffness and increased white matter Hyperintensity volume and, as a result, reduced total brain volume on MR imaging, but none have had prolonged follow-up to fully evaluate the slow change seen in white matter Hyperintensity volume and total brain volume with time. Our objective was to determine whether common carotid artery stiffness on sonography accurately predicts white matter Hyperintensity volume and total brain volume on MR imaging more than 20 years later. MATERIALS AND METHODS: We performed a secondary analysis of the Atherosclerosis Risk in the Community study to compare 5 measurements of carotid artery stiffness, including strain, distensibility, compliance, Stiffness index, and pressure-strain elastic modulus, with the white matter Hyperintensity volume and total brain volume on a follow-up MR imaging using linear regression. RESULTS: We included 1402 patients enrolled in the Atherosclerosis Risk in the Community study. There was a significant relationship between increasing carotid artery stiffness and both higher white matter Hyperintensity volume and lower total brain volume on MR imaging, measured at a mean of 21.5 years later. In multivariable linear regression models, the carotid strain, distensibility, Stiffness index, and pressure-strain elastic modulus were associated with white matter Hyperintensity volume. Only compliance was associated with total brain volume in the multivariate models. CONCLUSIONS: Sonography measurements of carotid artery stiffness are predictive of white matter Hyperintensity volume and total brain volume on MR imaging more than 20 years later. The association is more robust for white matter Hyperintensity volume than total brain volume. These findings support the role of arterial stiffness as a method for identifying patients at risk of developing white matter Hyperintensity volume and as a potential mechanism leading to small-artery disease of the brain.
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abstract 141 systolic blood pressure and white matter Hyperintensity progression in accord mind
Stroke, 2018Co-Authors: Adam De Havenon, Jennifer J Majersik, David L Tirschwell, Scott J Mcnally, Natalia S. RostAbstract:Introduction: Small vessel disease can be detected on MRI as white matter Hyperintensity (WMH), but its pathophysiology remains elusive. We sought to examine the effect of elevated systolic blood p...
Kaori Togashi - One of the best experts on this subject based on the ideXlab platform.
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hyperintense dentate nucleus on unenhanced t1 weighted mr images is associated with a history of brain irradiation
Radiology, 2011Co-Authors: Seiko Kasahara, Takeshi Sawada, Mitsunori Kanagaki, Tomohisa Okada, Nobuyuki Mori, Toshiaki Taoka, Yukio Miki, Akira Yamamoto, Kaori TogashiAbstract:Hyperintensity of the dentate nucleus may be seen on T1-weighted MR images and in some cases may be associated with a history of brain irradiation.
Toshiaki Taoka - One of the best experts on this subject based on the ideXlab platform.
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the use of susceptibility weighted imaging as an indicator of retrograde leptomeningeal venous drainage and venous congestion with dural arteriovenous fistula diagnosis and follow up after treatment
Neurosurgery, 2013Co-Authors: Ichiro Nakagawa, Toshiaki Taoka, Takeshi Wada, Hiroyuki Nakagawa, Masahiko Sakamoto, Kimihiko Kichikawa, Yasuo Hironaka, Yasushi Motoyama, Youngsu Park, Hiroyuki NakaseAbstract:BACKGROUND Retrograde leptomeningeal venous drainage (RLVD) in dural arteriovenous fistulas (DAVFs) is associated with intracerebral hemorrhage and nonhemorrhagic neurological deficits or death. Angiographic evidence of RLVD is a definite indication for treatment, but less invasive methods of identifying RLVD are required. OBJECTIVE To evaluate the efficacy of susceptibility-weighted magnetic resonance imaging (SWI) in detecting RLVD in DAVFs. METHODS We retrospectively identified 17 DAVF patients who had angiographic evidence of RLVD and received treatment. Conventional angiography and SWI were assessed at pretreatment and posttreatment time points. The presence of RLVD on SWI was defined as cortical venous Hyperintensity, and the presence of venous congestion on SWI venograms was defined as increased caliber of cortical or medullary veins. RESULTS Cortical venous Hyperintensity was identified in pretreatment SWI of 15 patients. Cortical venous Hyperintensity was absent in early posttreatment SWI, consistent with the absence of RLVD in posttreatment angiography, in all but one of these patients. In 2 patients, cortical venous Hyperintensity was identified during follow-up, indicating the recurrence of RLVD. Cortical venous Hyperintensity was not identified in the pretreatment SWI of 2 patients despite angiographic evidence of RLVD. Venous congestion was identified in pretreatment SWI venograms of 11 patients and had an appearance similar to that identified from angiography. Venous congestive signs improved over the follow-up period. CONCLUSION The presence of SWI Hyperintensity within the venous structure could be a useful indicator of RLVD in DAVF patients. Thus, SWI offers a noninvasive alternative to angiography for the identification of RLVD in pretreated and posttreated DAVF patients.
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hyperintense dentate nucleus on unenhanced t1 weighted mr images is associated with a history of brain irradiation
Radiology, 2011Co-Authors: Seiko Kasahara, Takeshi Sawada, Mitsunori Kanagaki, Tomohisa Okada, Nobuyuki Mori, Toshiaki Taoka, Yukio Miki, Akira Yamamoto, Kaori TogashiAbstract:Hyperintensity of the dentate nucleus may be seen on T1-weighted MR images and in some cases may be associated with a history of brain irradiation.
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sulcal Hyperintensity on fluid attenuated inversion recovery mr images in patients without apparent cerebrospinal fluid abnormality
American Journal of Roentgenology, 2001Co-Authors: Toshiaki Taoka, William T C Yuh, Matthew L White, Jerome P Quets, Joan E Maley, Toshihiro UedaAbstract:OBJECTIVE. Failure to suppress cerebrospinal fluid (CSF) signal intensity (sulcal Hyperintensity) on fluid-attenuated inversion recovery (FLAIR) images has been reported in patients with abnormal CSF, such as those with meningitis and subarachnoid hemorrhage. Our study investigates the clinical history and MR findings associated with sulcal Hyperintensity on FLAIR images in patients without apparent CSF abnormality.SUBJECTS AND METHODS. Three hundred consecutive MR imaging examinations were prospectively screened for patients with sulcal Hyperintensity on FLAIR images. Nine patients with clinical, CT, or laboratory evidence suggesting abnormal CSF were excluded. The distribution of sulcal Hyperintensity on FLAIR images and associated abnormal enhancement were evaluated. The presence of the “dirty CSF” sign (mild increase in CSF signal on unenhanced T1-weighted images or mild decrease on T2-weighted images) in the corresponding hyperintense sulcus was also assessed.RESULTS. Twenty-six (8.9%) of the 291 pat...
Shigeru Furui - One of the best experts on this subject based on the ideXlab platform.
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high signal intensity in dentate nucleus on unenhanced t1 weighted mr images association with linear versus macrocyclic gadolinium chelate administration
Radiology, 2015Co-Authors: Tomonori Kanda, Marie Osawa, Keiko Toyoda, Junichi Kotoku, Koji Takeshita, Takahiro Haruyama, Shigeru FuruiAbstract:Hyperintensity in the dentate nucleus on unenhanced T1-weighted MR images may vary with the chelate type of previously administered gadolinium-based contrast agents, but further studies with a longitudinal design and larger cohorts are necessary.
Charles Decarli - One of the best experts on this subject based on the ideXlab platform.
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white matter Hyperintensity penumbra
Stroke, 2011Co-Authors: Pauline Maillard, Evan Fletcher, Danielle J Harvey, Owen Carmichael, Bruce R Reed, Dan M Mungas, Charles DecarliAbstract:Background and Purpose—White matter hyperintensities (WMHs) are associated with progressive age-related cognitive decline and cardiovascular risk factors, but their biological relevance as indicators of generalized white matter injury is unclear. Diffusion tensor imaging provides more sensitive indications of subtle white matter disruption and can therefore clarify whether WMHs represent foci of generalized white matter damage that extends over a broader neighborhood. Methods—Two hundred eight participants from the University of California, Davis Alzheimer's Disease Center received a comprehensive clinical evaluation and brain MRI including fluid-attenuated inversion recovery and diffusion tensor imaging sequences. Voxelwise maps of WMHs were produced from fluid-attenuated inversion recovery using a standardized WMH detection protocol. Fractional anisotropy maps were calculated from diffusion tensor imaging. All WMH and fractional anisotropy maps were coregistered to a standardized space. For each normal-...
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chronic kidney disease is associated with white matter Hyperintensity volume the northern manhattan study nomas
Stroke, 2007Co-Authors: Minesh Khatri, Clinton B Wright, Thomas L Nickolas, Mitsuhiro Yoshita, Myunghee C Paik, Grace Kranwinkel, Ralph L Sacco, Charles DecarliAbstract:Background and Purpose—White matter hyperintensities have been associated with increased risk of stroke, cognitive decline, and dementia. Chronic kidney disease is a risk factor for vascular disease and has been associated with inflammation and endothelial dysfunction, which have been implicated in the pathogenesis of white matter hyperintensities. Few studies have explored the relationship between chronic kidney disease and white matter hyperintensities. Methods—The Northern Manhattan Study is a prospective, community-based cohort of which a subset of stroke-free participants underwent MRIs. MRIs were analyzed quantitatively for white matter hyperintensities volume, which was log-transformed to yield a normal distribution (log-white matter Hyperintensity volume). Kidney function was modeled using serum creatinine, the Cockcroft-Gault formula for creatinine clearance, and the Modification of Diet in Renal Disease formula for estimated glomerular filtration rate. Creatinine clearance and estimated glomerular filtration rate were trichotomized to 15 to 60 mL/min, 60 to 90 mL/min, and 90 mL/min (reference). Linear regression was used to measure the association between kidney function and log-white matter Hyperintensity volume adjusting for age, gender, race–ethnicity, education, cardiac disease, diabetes, homocysteine, and hypertension. Results—Baseline data were available on 615 subjects (mean age 70 years, 60% women, 18% whites, 21% blacks, 62% Hispanics). In multivariate analysis, creatinine clearance 15 to 60 mL/min was associated with increased log-white matter Hyperintensity volume ( 0.322; 95% CI, 0.095 to 0.550) as was estimated glomerular filtration rate 15 to 60 mL/min ( 0.322; 95% CI, 0.080 to 0.564). Serum creatinine, per 1-mg/dL increase, was also positively associated with log-white matter Hyperintensity volume ( 1.479; 95% CI, 1.067 to 2.050). Conclusions—The association between moderate–severe chronic kidney disease and white matter Hyperintensity volume highlights the growing importance of kidney disease as a possible determinant of cerebrovascular disease and/or as a marker of microangiopathy. (Stroke. 2007;38:3121-3126.)
