The Experts below are selected from a list of 72 Experts worldwide ranked by ideXlab platform
Wentzell, Meaghan L. - One of the best experts on this subject based on the ideXlab platform.
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Hypertrophic Osteodystrophy preceding canine juvenile cellulitis in an Australian shepherd puppy
Canadian Veterinary Medical Association, 2026Co-Authors: Wentzell, Meaghan L.Abstract:A 10-week-old intact female Australian shepherd dog was presented sternally recumbent, mildly pyrexic, and painful on long bone palpation of both forelimbs. Based on radiographs she was diagnosed with Hypertrophic Osteodystrophy. Analgesia was provided with intravenous, oral, and topical medications. Approximately 2 wk later she was presented for facial swelling, regional dermatitis, and lymphadenopathy. Canine juvenile cellulitis was diagnosed and successfully treated
J M Angles - One of the best experts on this subject based on the ideXlab platform.
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Hypertrophic Osteodystrophy in the weimaraner dog lack of association between dqa1 alleles of the canine mhc and Hypertrophic Osteodystrophy
Veterinary Journal, 2006Co-Authors: Patrick T Crumlish, T Sweeney, B R Jones, J M AnglesAbstract:Abstract Hypertrophic Osteodystrophy (HOD) is a canine bone disease that affects mainly large breed dogs, including the Weimaraner, and studies have shown a link between recent vaccination with a modified live virus and the onset of HOD in this breed. In humans, it has been suggested that human leukocyte antigen (HLA) alleles can influence antibody response to vaccination. The aim of this study was to investigate whether there is an association between the development of HOD in Weimaraners and MHC alleles at the DLA-DQA1 locus in a group of 33 unrelated dogs. The DQA1 allele and genotype frequencies were determined by sequence-based typing. Although clinical signs developed within six weeks of vaccination in all 12 dogs for which information was available, no association was found between DQA1 alleles and HOD in this population of Weimaraner dogs. A role for other immune-response genes in the pathogenesis of HOD should not however be ruled out. Whereas recent vaccination may be a trigger for the disease, it was concluded that there is no specific vaccine that is most responsible for the expression of the disease.
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Hypertrophic Osteodystrophy in six weimaraner puppies associated with systemic signs
Veterinary Record, 1999Co-Authors: V Abeles, J M Angles, Shimon Harrus, Itzhak Aizenberg, G Shalev, Y Peres, Itamar ArochAbstract:Six weimaraner puppies, five of which were genetically related, showed systemic signs associated with Hypertrophic Osteodystrophy, including fever and involvement of the gastrointestinal, respiratory or nervous systems, in addition to the metaphyseal lesions. In five of the dogs the clinical signs developed less than 10 days after they had been vaccinated with a modified live virus vaccine. Radiographic findings suggested that both the hindlimbs and forelimbs were equally involved in the disease process. Abnormal haematological findings included leucocytosis with neutrophilia and monocytosis, and there was a consistent increase in the activity of alkaline phosphatase. Serum protein electrophoretic studies of three of the dogs revealed hypogammaglobulinaemia and abetaglobulinaemia in two of them. Conservative treatment with rest and non-steroidal anti-inflammatory drugs had little effect, and treatment with corticosteroids appeared to give the best results.
Miller C - One of the best experts on this subject based on the ideXlab platform.
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Hypertrophic Osteodystrophy in a Great Dane puppy.
2001Co-Authors: Miller CAbstract:An intact male, Great Dane puppy was evaluated for weakness, lethargy, reluctance to move, and inability to stand. Hypertrophic Osteodystrophy was diagnosed based on clinical and radiographic findings. Clinical signs, radiographic lesions, gross pathology, histopathology, etiology, and treatment of the disease are discussed
Benander Benjamin - One of the best experts on this subject based on the ideXlab platform.
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Severe Hypertrophic Osteodystrophy in a Great Dane puppy
2004Co-Authors: Benander BenjaminAbstract:Senior seminar (D.V.M.) -- Cornell University, 2004. Includes bibliographical references (leaf 11).A four month old, intact male Great Dane puppy was examined for progressive lameness, recumbency, fever, anorexia, lethargy, and respiratory distress. Hypertrophic Osteodystrophy was diagnosed based on radiographic findings and clinical signs. An interstitial pattern of unknown etiology was noted on thoracic radiographs, and low grade Disseminated Intravascular Coagulation was presumed based on prolonged coagulation times. Clinical signs, diagnostic testing, pathology, etiology and treatment of HOD are discussed, as well as acute management of systemic inflammatory conditions.Alejandro Aguirre, Carrie Goldkam
Shimon Harrus - One of the best experts on this subject based on the ideXlab platform.
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development of Hypertrophic Osteodystrophy and antibody response in a litter of vaccinated weimaraner puppies
Journal of Small Animal Practice, 2002Co-Authors: Shimon Harrus, Trevor Waner, Itzhak Aizenberg, N Safra, A Mosenco, M Radoshitsky, Hylton BarkAbstract:Two different vaccination protocols were compared with regard to the development of Hypertrophic Osteodystrophy (HOD) (also termed metaphyseal osteopathy) and effectiveness of immunisation in a litter of 10 Weimaraner puppies. Five puppies (group 1) were vaccinated with a modified live canine parvovirus vaccine (CPV) and then two weeks later with a trivalent vaccine containing modified live canine distemper virus and adenovirus type 2 combined with a Leptospira bacterin (DHL). The CPV and DHL vaccine protocols were administered a further two times, at two-week intervals. Group 2 was vaccinated with three consecutive multivalent vaccines containing modified live canine distemper virus, canine parvovirus, parainfluenza and adenovirus type 2 combined with a Leptospira bacterin, at four-week intervals. All puppies were first vaccinated at the age of eight weeks. Three dogs in group 1 developed HOD, while all five dogs in group 2 developed HOD during the study period. Dogs in group 2 had more episodes of HOD than those in group 1. Dogs in group 1 developed higher antibody titres to canine distemper virus and parvovirus compared with those in group 2. Only two out of the 10 dogs developed protective antibody titres to parvovirus. The results of this study suggest that the two different vaccination protocols affected the pattern of appearance of HOD and immunization in this litter of Weimaraner puppies. The results obtained and the previously reported data suggest that a larger controlled study is needed to further elucidate the effect of different vaccination protocols on HOD and immunisation in Weimaraner puppies.
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Hypertrophic Osteodystrophy in six weimaraner puppies associated with systemic signs
Veterinary Record, 1999Co-Authors: V Abeles, J M Angles, Shimon Harrus, Itzhak Aizenberg, G Shalev, Y Peres, Itamar ArochAbstract:Six weimaraner puppies, five of which were genetically related, showed systemic signs associated with Hypertrophic Osteodystrophy, including fever and involvement of the gastrointestinal, respiratory or nervous systems, in addition to the metaphyseal lesions. In five of the dogs the clinical signs developed less than 10 days after they had been vaccinated with a modified live virus vaccine. Radiographic findings suggested that both the hindlimbs and forelimbs were equally involved in the disease process. Abnormal haematological findings included leucocytosis with neutrophilia and monocytosis, and there was a consistent increase in the activity of alkaline phosphatase. Serum protein electrophoretic studies of three of the dogs revealed hypogammaglobulinaemia and abetaglobulinaemia in two of them. Conservative treatment with rest and non-steroidal anti-inflammatory drugs had little effect, and treatment with corticosteroids appeared to give the best results.