The Experts below are selected from a list of 231 Experts worldwide ranked by ideXlab platform

Veronique Gouverneur - One of the best experts on this subject based on the ideXlab platform.

  • Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [ 64 Cu]-ATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO Tumor Hypoxia Accumulation
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Philip D, Veronique Gouverneur
    Abstract:

    Background: Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO in a preclinical model of tumor hypoxia. Methodology/Principal Findings: The effect of carrier gas and anaesthetic was studied in 6 groups of CaNT-bearing CBA mice using [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 or [ 18 F]-FMISO. Mice were anaesthetised with isoflurane in air, isoflurane in pure oxygen, with ketamine/xylazine or Hypnorm/hypnovel whilst breathing air, or in the awake state whilst breathing air or pure oxygen. PET or SPECT imaging was performed after which the mice were killed for organ/tumor tracer quantitation. Tumor hypoxia was confirmed. Arterial blood gas analysis was performed for the different anaesthetic regimes. The results demonstrate marked influences on tumor uptake of both carrier gas and anaesthetic, and show differences between [ 99m Tc]-HL91, [ 18 F]-FMISO and [ 64 Cu]-CuATSM. [ 99m Tc]-HL91 tumor uptake was only altered significantly by administration of 100 % oxygen. The latter was not the case for [ 18 F]-FMISO and [ 64 Cu]-CuATSM. Tumor-to-muscle ratio (TMR) for both compounds was reduced significantly when either oxygen or anaesthetics (isoflurane in air, ketamine/xylazine or Hypnorm/ hypnovel) were introduced. For [ 18 F]-FMISO no further decrease was measured when both isoflurane and oxygen were administered, [ 64 Cu]-CuATSM did show an additional significant decrease in TMR. When using the same anaestheti

  • Overall mean tumor uptake for [99mTc]-HL91 as a function of time by dynamic planar SPECT imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

  • Schematic representation of the anaesthesia regimes used.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    *Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine;∥Awake breathing oxygen;¶Awake breathing room air.

  • Arterial pO2, pCO2 and sO2 levels at 90 min post anaesthesia induction for different anaesthesia regimes (n = 5/group).
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    Results are expressed as average ± standard deviation.*Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine.

  • Overall mean heart and tumor uptake for [18F]-FMISO as a function of time by kinetic PET imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    (A) Heart and (B) Tumour uptake. HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

Veerle Kersemans - One of the best experts on this subject based on the ideXlab platform.

  • Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [ 64 Cu]-ATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO Tumor Hypoxia Accumulation
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Philip D, Veronique Gouverneur
    Abstract:

    Background: Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO in a preclinical model of tumor hypoxia. Methodology/Principal Findings: The effect of carrier gas and anaesthetic was studied in 6 groups of CaNT-bearing CBA mice using [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 or [ 18 F]-FMISO. Mice were anaesthetised with isoflurane in air, isoflurane in pure oxygen, with ketamine/xylazine or Hypnorm/hypnovel whilst breathing air, or in the awake state whilst breathing air or pure oxygen. PET or SPECT imaging was performed after which the mice were killed for organ/tumor tracer quantitation. Tumor hypoxia was confirmed. Arterial blood gas analysis was performed for the different anaesthetic regimes. The results demonstrate marked influences on tumor uptake of both carrier gas and anaesthetic, and show differences between [ 99m Tc]-HL91, [ 18 F]-FMISO and [ 64 Cu]-CuATSM. [ 99m Tc]-HL91 tumor uptake was only altered significantly by administration of 100 % oxygen. The latter was not the case for [ 18 F]-FMISO and [ 64 Cu]-CuATSM. Tumor-to-muscle ratio (TMR) for both compounds was reduced significantly when either oxygen or anaesthetics (isoflurane in air, ketamine/xylazine or Hypnorm/ hypnovel) were introduced. For [ 18 F]-FMISO no further decrease was measured when both isoflurane and oxygen were administered, [ 64 Cu]-CuATSM did show an additional significant decrease in TMR. When using the same anaestheti

  • Overall mean tumor uptake for [99mTc]-HL91 as a function of time by dynamic planar SPECT imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

  • Schematic representation of the anaesthesia regimes used.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    *Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine;∥Awake breathing oxygen;¶Awake breathing room air.

  • Arterial pO2, pCO2 and sO2 levels at 90 min post anaesthesia induction for different anaesthesia regimes (n = 5/group).
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    Results are expressed as average ± standard deviation.*Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine.

  • Overall mean heart and tumor uptake for [18F]-FMISO as a function of time by kinetic PET imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    (A) Heart and (B) Tumour uptake. HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

Sally A. Hill - One of the best experts on this subject based on the ideXlab platform.

  • Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [ 64 Cu]-ATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO Tumor Hypoxia Accumulation
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Philip D, Veronique Gouverneur
    Abstract:

    Background: Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO in a preclinical model of tumor hypoxia. Methodology/Principal Findings: The effect of carrier gas and anaesthetic was studied in 6 groups of CaNT-bearing CBA mice using [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 or [ 18 F]-FMISO. Mice were anaesthetised with isoflurane in air, isoflurane in pure oxygen, with ketamine/xylazine or Hypnorm/hypnovel whilst breathing air, or in the awake state whilst breathing air or pure oxygen. PET or SPECT imaging was performed after which the mice were killed for organ/tumor tracer quantitation. Tumor hypoxia was confirmed. Arterial blood gas analysis was performed for the different anaesthetic regimes. The results demonstrate marked influences on tumor uptake of both carrier gas and anaesthetic, and show differences between [ 99m Tc]-HL91, [ 18 F]-FMISO and [ 64 Cu]-CuATSM. [ 99m Tc]-HL91 tumor uptake was only altered significantly by administration of 100 % oxygen. The latter was not the case for [ 18 F]-FMISO and [ 64 Cu]-CuATSM. Tumor-to-muscle ratio (TMR) for both compounds was reduced significantly when either oxygen or anaesthetics (isoflurane in air, ketamine/xylazine or Hypnorm/ hypnovel) were introduced. For [ 18 F]-FMISO no further decrease was measured when both isoflurane and oxygen were administered, [ 64 Cu]-CuATSM did show an additional significant decrease in TMR. When using the same anaestheti

  • Overall mean tumor uptake for [99mTc]-HL91 as a function of time by dynamic planar SPECT imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

  • Schematic representation of the anaesthesia regimes used.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    *Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine;∥Awake breathing oxygen;¶Awake breathing room air.

  • Arterial pO2, pCO2 and sO2 levels at 90 min post anaesthesia induction for different anaesthesia regimes (n = 5/group).
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    Results are expressed as average ± standard deviation.*Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine.

  • Overall mean heart and tumor uptake for [18F]-FMISO as a function of time by kinetic PET imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    (A) Heart and (B) Tumour uptake. HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

Nadia Falzone - One of the best experts on this subject based on the ideXlab platform.

  • Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [ 64 Cu]-ATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO Tumor Hypoxia Accumulation
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Philip D, Veronique Gouverneur
    Abstract:

    Background: Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO in a preclinical model of tumor hypoxia. Methodology/Principal Findings: The effect of carrier gas and anaesthetic was studied in 6 groups of CaNT-bearing CBA mice using [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 or [ 18 F]-FMISO. Mice were anaesthetised with isoflurane in air, isoflurane in pure oxygen, with ketamine/xylazine or Hypnorm/hypnovel whilst breathing air, or in the awake state whilst breathing air or pure oxygen. PET or SPECT imaging was performed after which the mice were killed for organ/tumor tracer quantitation. Tumor hypoxia was confirmed. Arterial blood gas analysis was performed for the different anaesthetic regimes. The results demonstrate marked influences on tumor uptake of both carrier gas and anaesthetic, and show differences between [ 99m Tc]-HL91, [ 18 F]-FMISO and [ 64 Cu]-CuATSM. [ 99m Tc]-HL91 tumor uptake was only altered significantly by administration of 100 % oxygen. The latter was not the case for [ 18 F]-FMISO and [ 64 Cu]-CuATSM. Tumor-to-muscle ratio (TMR) for both compounds was reduced significantly when either oxygen or anaesthetics (isoflurane in air, ketamine/xylazine or Hypnorm/ hypnovel) were introduced. For [ 18 F]-FMISO no further decrease was measured when both isoflurane and oxygen were administered, [ 64 Cu]-CuATSM did show an additional significant decrease in TMR. When using the same anaestheti

  • Overall mean tumor uptake for [99mTc]-HL91 as a function of time by dynamic planar SPECT imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

  • Schematic representation of the anaesthesia regimes used.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    *Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine;∥Awake breathing oxygen;¶Awake breathing room air.

  • Arterial pO2, pCO2 and sO2 levels at 90 min post anaesthesia induction for different anaesthesia regimes (n = 5/group).
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    Results are expressed as average ± standard deviation.*Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine.

  • Overall mean heart and tumor uptake for [18F]-FMISO as a function of time by kinetic PET imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    (A) Heart and (B) Tumour uptake. HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

Bart Cornelissen - One of the best experts on this subject based on the ideXlab platform.

  • Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [ 64 Cu]-ATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO Tumor Hypoxia Accumulation
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Philip D, Veronique Gouverneur
    Abstract:

    Background: Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 and [ 18 F]-FMISO in a preclinical model of tumor hypoxia. Methodology/Principal Findings: The effect of carrier gas and anaesthetic was studied in 6 groups of CaNT-bearing CBA mice using [ 64 Cu]-CuATSM, [ 99m Tc]-HL91 or [ 18 F]-FMISO. Mice were anaesthetised with isoflurane in air, isoflurane in pure oxygen, with ketamine/xylazine or Hypnorm/hypnovel whilst breathing air, or in the awake state whilst breathing air or pure oxygen. PET or SPECT imaging was performed after which the mice were killed for organ/tumor tracer quantitation. Tumor hypoxia was confirmed. Arterial blood gas analysis was performed for the different anaesthetic regimes. The results demonstrate marked influences on tumor uptake of both carrier gas and anaesthetic, and show differences between [ 99m Tc]-HL91, [ 18 F]-FMISO and [ 64 Cu]-CuATSM. [ 99m Tc]-HL91 tumor uptake was only altered significantly by administration of 100 % oxygen. The latter was not the case for [ 18 F]-FMISO and [ 64 Cu]-CuATSM. Tumor-to-muscle ratio (TMR) for both compounds was reduced significantly when either oxygen or anaesthetics (isoflurane in air, ketamine/xylazine or Hypnorm/ hypnovel) were introduced. For [ 18 F]-FMISO no further decrease was measured when both isoflurane and oxygen were administered, [ 64 Cu]-CuATSM did show an additional significant decrease in TMR. When using the same anaestheti

  • Overall mean tumor uptake for [99mTc]-HL91 as a function of time by dynamic planar SPECT imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.

  • Schematic representation of the anaesthesia regimes used.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    *Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine;∥Awake breathing oxygen;¶Awake breathing room air.

  • Arterial pO2, pCO2 and sO2 levels at 90 min post anaesthesia induction for different anaesthesia regimes (n = 5/group).
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    Results are expressed as average ± standard deviation.*Anaesthetised using Isoflurane in Oxygen;†Anaesthetised using Isoflurane in room air;‡Anaesthetised using Hypnorm/Hypnovel;§Anaesthetised using Ketamine/Xylazine.

  • Overall mean heart and tumor uptake for [18F]-FMISO as a function of time by kinetic PET imaging.
    2013
    Co-Authors: Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D. Allen, Nadia Falzone, Sally A. Hill, Jonathan R. Dilworth, Veronique Gouverneur
    Abstract:

    (A) Heart and (B) Tumour uptake. HHA: Anaesthetised using Hypnorm/Hypnovel; IA: Anaesthetised using Isoflurane in room air; IO: Anaesthetised using Isoflurane in Oxygen; KXA: Anaesthetised using Ketamine/Xylazine.