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Shun Wan Chan - One of the best experts on this subject based on the ideXlab platform.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Chunwai Wan, Candy Ngaiyan Wong, Wingkwan Pin, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague-Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Candy Ngaiyan Wong, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Peter Hoifu Yu, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague–Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd.
Satoshi Nagaoka - One of the best experts on this subject based on the ideXlab platform.
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identification of a novel Hypocholesterolemic protein major royal jelly protein 1 derived from royal jelly
PLOS ONE, 2014Co-Authors: Yuri Kashima, Satoshi Kanematsu, Saori Asai, Mio Kusada, Suzuyo Watanabe, Takuji Kawashima, Tadashi Nakamura, Masaya Shimada, Tsuyoshi Goto, Satoshi NagaokaAbstract:Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study, we set out to identify the bile acid-binding protein contained in RJ, because dietary bile acid-binding proteins including soybean protein and its peptide are effective in ameliorating hypercholesterolemia. Using a cholic acid-conjugated column, we separated some bile acid-binding proteins from RJ and identified the major RJ protein 1 (MRJP1), MRJP2, and MRJP3 as novel bile acid-binding proteins from RJ, based on matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Purified MRJP1, which is the most abundant protein of the bile acid-binding proteins in RJ, exhibited taurocholate-binding activity in vitro. The micellar solubility of cholesterol was significantly decreased in the presence of MRJP1 compared with casein in vitro. Liver bile acids levels were significantly increased, and cholesterol 7α-hydroxylase (CYP7A1) mRNA and protein tended to increase by MRJP1 feeding compared with the control. CYP7A1 mRNA and protein levels were significantly increased by MRJP1 tryptic hydrolysate treatment compared with that of casein tryptic hydrolysate in hepatocytes. MRJP1 Hypocholesterolemic effect has been investigated in rats. The cholesterol-lowering action induced by MRJP1 occurs because MRJP1 interacts with bile acids induces a significant increase in fecal bile acids excretion and a tendency to increase in fecal cholesterol excretion and also enhances the hepatic cholesterol catabolism. We have identified, for the first time, a novel Hypocholesterolemic protein, MRJP1, in RJ. Interestingly, MRJP1 exhibits greater Hypocholesterolemic activity than the medicine β-sitosterol in rats.
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cacao procyanidins reduce plasma cholesterol and increase fecal steroid excretion in rats fed a high cholesterol diet
Biofactors, 2008Co-Authors: Akiko Yasuda, Seigo Baba, Midori Natsume, Kazue Sasaki, Yuko Nakamura, Minoru Kanegae, Satoshi NagaokaAbstract:Cocoa powder is rich in polyphenols, such as catechins and oligomeric procyanidins, and has a Hypocholesterolemic effect in humans. This study evaluated the principal active components and potential mechanism(s) for the Hypocholesterolemic effect of polyphenolic substances from cocoa powder in rats. Male Wistar rats were fed a 1% high-cholesterol diet (HC) or a high-cholesterol diet containing 1% polyphenol extract from cocoa powder (PE) or a mixture of 0.024% catechin and 0.058% epicatechin (CE) for 4 weeks. We also examined the effects of these polyphenolic substances on micellar cholesterol solubility in vitro. The PE group had significantly lower plasma cholesterol concentrations, and had significantly greater fecal cholesterol and total bile acids excretion than the HC group. The CE group diet did not influence plasma cholesterol concentrations, or fecal cholesterol or total bile acids excretion. Micellar solubility of cholesterol in vitro was significantly lower for procyanidin B2 (dimer), B5 (dimer), C1 (trimer) and A2 (tetramer), which are the main components of polyphenol extract from cocoa powder, compared to catechin and epicatechin. These results suggest that oligomeric procyanidins from cocoa powder are the principal active components responsible for the Hypocholesterolemic effect, and inhibit the intestinal absorption of cholesterol and bile acids through the decrease in micellar cholesterol solubility.
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a novel protein c phycocyanin plays a crucial role in the Hypocholesterolemic action of spirulina platensis concentrate in rats
Journal of Nutrition, 2005Co-Authors: Satoshi Nagaoka, Kazuo Shimizu, Hideki Kaneko, Fumi Shibayama, Kensei Morikawa, Yoshihiro Kanamaru, Ayako Otsuka, Tomohiro Hirahashi, Toshimitsu KatoAbstract:This study was designed to clarify the mechanisms of the Hypocholesterolemic action of Spirulina platensis concentrate (SPC) and identify the novel Hypocholesterolemic protein derived from SPC. We investigated the effects of casein or SPC on the solubility of cholesterol, taurocholate binding capacity in vitro, cholesterol absorption in Caco-2 cells, and cholesterol metabolism in rats for 10 d. We also evaluated the effects of SPC, C-phycocyanin (PHY), and PHY residue on cholesterol metabolism in rats fed a high-cholesterol diet for 5 d, and SPC or SPC-acetone extract for 10 d. SPC had a significantly greater bile acid-binding capacity than casein in vitro. Micellar cholesterol solubility and cholesterol uptake by Caco-2 cells was significantly lower in the presence of SPC compared with casein. Fecal excretion of cholesterol and bile acids was significantly greater in rats fed the SPC-supplemented diet than in those fed the casein control diet. Serum and liver cholesterol concentrations were significantly lower in rats fed SPC than in those fed casein. Thus, the Hypocholesterolemic action of SPC may involve the inhibition of both jejunal cholesterol absorption and ileal bile acid reabsorption. Although no studies to date have found a Hypocholesterolemic protein among the algal proteins, we report here the discovery of a Hypocholesterolemic effect in the novel protein C-phycocyanin. This study provides the first direct evidence that PHY, a novel Hypocholesterolemic protein derived from Spirulina platensis, can powerfully influence serum cholesterol concentrations and impart a stronger Hypocholesterolemic activity than SPC in animals.
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identification of novel Hypocholesterolemic peptides derived from bovine milk β lactoglobulin
Biochemical and Biophysical Research Communications, 2001Co-Authors: Satoshi Nagaoka, Yoshihiro Kanamaru, Yu Futamura, Keiji Miwa, Takako Awano, Kouhei Yamauchi, Kojima Tadashi, Tamotsu KuwataAbstract:This study was designed to clarify the mechanisms of Hypocholesterolemic action of β-lactoglobuline tryptic hydrolysate (LTH) and to identify the novel Hypocholesterolemic peptide derived from LTH by screening using Caco-2 cells and animal studies. Serum and liver cholesterol levels were significantly lower in rats fed LTH than in those fed casein tryptic hydrolysate (CTH). The present study suggests that the inhibition of micellar solubility of cholesterol which causes the suppression of cholesterol absorption by a direct interaction between cholesterol mixed micelles, and LTH in the jejunal epithelia is part of the mechanism underlying the Hypocholesterolemic action of LTH. Though no one could trace the Hypocholesterolemic peptide to any protein origin, we identified, for the first time, a novel Hypocholesterolemic peptide, Ile-Ile-Ala-Glu-Lys (IIAEK). Surprisingly, the present study provides the first direct evidence that a new Hypocholesterolemic peptide derived from β-lactoglobuline can powerfully influence serum cholesterol levels and exhibit a greater Hypocholesterolemic activity in comparison with that of medicine, β-sitosterol, in animal studies.
Candy Ngaiyan Wong - One of the best experts on this subject based on the ideXlab platform.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Chunwai Wan, Candy Ngaiyan Wong, Wingkwan Pin, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague-Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Candy Ngaiyan Wong, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Peter Hoifu Yu, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague–Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd.
Robbie Yatkan Chan - One of the best experts on this subject based on the ideXlab platform.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Chunwai Wan, Candy Ngaiyan Wong, Wingkwan Pin, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague-Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Candy Ngaiyan Wong, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Peter Hoifu Yu, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague–Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd.
Chingyee Kwok - One of the best experts on this subject based on the ideXlab platform.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Chunwai Wan, Candy Ngaiyan Wong, Wingkwan Pin, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague-Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA.
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chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hypercholesterolemic rats induced with a high cholesterol diet
Phytotherapy Research, 2013Co-Authors: Candy Ngaiyan Wong, Marcus Ho Yin Wong, Chingyee Kwok, Robbie Yatkan Chan, Peter Hoifu Yu, Shun Wan ChanAbstract:Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the Hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague–Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that Hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The Hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd.