The Experts below are selected from a list of 207 Experts worldwide ranked by ideXlab platform
N El M Beih - One of the best experts on this subject based on the ideXlab platform.
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studies on date waste dietary fibers as Hypolipidemic Agent in rats
European Journal of Nutrition, 1996Co-Authors: Etidal W Jwanny, Mona M Rashad, Sorial A Moharib, N El M BeihAbstract:Date waste dietary fibers were examined as a Hypolipidemic Agent. White albino rats were fed on three experimental diets: I) high carbohydrate diet free of fiber; II) and III) diets consisted of diet I substituted with 100 g/kg of date waste dietary fibers cultured withEndomycopsis fibuligera at zero time and after 60 h of culturing respectively for 8 weeks. The total lipids, total cholesterol, triglycerides and phospholipids in the liver of rats given diets II and III were significantly decreased over those rats fed the control diet throughout the feeding period (8 weeks). The highest decrease in content of all these parameters was produced by diet III.
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Studies on date waste dietary fibers as Hypolipidemic Agent in rats
Zeitschrift für Ernährungswissenschaft, 1996Co-Authors: Etidal W Jwanny, Mona M Rashad, Sorial A Moharib, N El M BeihAbstract:Date waste dietary fibers were examined as a Hypolipidemic Agent. White albino rats were fed on three experimental diets: I) high carbohydrate diet free of fiber; II) and III) diets consisted of diet I substituted with 100 g/kg of date waste dietary fibers cultured with Endomycopsis fibuligera at zero time and after 60 h of culturing respectively for 8 weeks. The total lipids, total cholesterol, triglycerides and phospholipids in the liver of rats given diets II and III were significantly decreased over those rats fed the control diet throughout the feeding period (8 weeks). The highest decrease in content of all these parameters was produced by diet III. Comparing diets II and III with the control diet I, total serum lipids and low density lipoprotein cholesterol (LDL-cholesterol) were decreased by 32–48 %, while serum triglycerides and total cholesterol levels were lowered in the groups fed diets II and III by 23–35 % respectively. Concerning high density lipoprotein cholesterol (HDL-cholesterol), the decrease was only 2–6 % in rats fed diets II and III. The highest decrease level was shown in the phospholipids content (51–56 %) during all of the experimental period (8 weeks). Albino-Ratten wurden für 8 Wochen 3 Diäten unterworfen. Diät I bestand aus nicht-faseriger hoch-halliger Kohlenhydratkostform. Diät II und Diät III enthielten zusäzlich 100 g/kg mit Endomycopsis fibuligera kultivierte faserige Dattelabfälle. Die Kultivierungszeit betrug 0 (II) und 60 Stunden (III). Die Gesamtlipide, das Gesamtcholesterol, die Triglyzeride und die Phospholipide nahmen in den Lebern der Ratten, die mit Diät II und III gefüttert wurden, deutlicher ab, als bei denjenigen, die mit Diät I gefüttert wurden. Bei der Diät III zeigte sich die höchste Abnahme der verschiedenen Untersuchungsparametern. Vergleicht man Diät II und III mit Diät I, so ergibt sich, daß die Serumgesamtlipide und das Lipoprotein-Cholesterol niedrigerer Dichte (LDL-Cholesterol) um 32–48 % abnehmen, während Serumtriglyzeride und Gesamtcholesterol in mit Dät II und Diät III gefütterten Ratten um 23–35 % erniedrigt sind. Bei mit Diät II und III gefütterten Ratten betrug die Abnahme des HDL-Cholesterols nur 2–6 %. Phospholipide zeigten die höchste Abnahme (51–56 %) während der ganzen Versuchsperiode (8 Wochen).
Ruitang Deng - One of the best experts on this subject based on the ideXlab platform.
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Hypolipidemic Agent z guggulsterone metabolism interplays with induction of carboxylesterase and bile salt export pump
Journal of Lipid Research, 2012Co-Authors: Dongfang Yang, Jian Yang, Da Xiao, Yitzai Chen, Christopher B Black, Ruitang DengAbstract:Z-Guggulsterone is a major ingredient in the Indian traditional Hypolipidemic remedy guggul. A study in mice has established that its Hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally assumed that the antagonism leads to induction of cytochrome P450 7A1 (CYP7A1), the rate-limiting enzyme converting free cholesterol to bile acids. In this study, we tested whether Z-guggulsterone indeed induces human CYP7A1. In addition, the expression of cholesteryl ester hydrolase CES1 and bile salt export pump (BSEP) was monitored. Contrary to the general assumption, Z-guggulsterone did not induce CYP7A1. Instead, this phytosterol significantly induced CES1 and BSEP through transactivation. Z-Guggulsterone underwent metabolism by CYP3A4, and the metabolites greatly increased the induction potency on BSEP but not on CES1. BSEP induction favors cholesterol elimination, whereas CES1 involves both elimination and retention (probably when excessively induced). Interestingly, clinical trials reported the Hypolipidemic response rates from 18% to 80% and showed that higher dosages actually increased VLDL cholesterol. Our findings predict that better Hypolipidemic outcomes likely occur in individuals who have a relatively higher capacity of metabolizing Z-guggulsterone with moderate CES1 induction, a scenario possibly achieved by lowering the dosing regimens.
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the Hypolipidemic Agent guggulsterone regulates the expression of human bile salt export pump dominance of transactivation over farsenoid x receptor mediated antagonism
Journal of Pharmacology and Experimental Therapeutics, 2007Co-Authors: Ruitang Deng, Dongfang Yang, Amy Radke, Jian YangAbstract:Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7α-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP). The expression of CYP7A1 and BSEP is coordinately regulated by a negative feedback and positive feed-forward mechanism, respectively, through bile acid-mediated activation of farsenoid X receptor (FXR). It is well established that Hypolipidemic Agent guggulsterone is an FXR antagonist and down-regulates FXR target genes. In this study, however, we have demonstrated that guggulsterone synergistically induced the expression of BSEP in cells treated with FXR agonist bile acids. A dissection study located in the BSEP promoter an activating protein (AP)-1 site supporting the action of guggulsterone. Deletion or mutation of the AP-1 element was diminished, whereas insertion of the AP-1 element into a heterologous promoter enhanced activation of the promoter by guggulsterone. Selective c-Jun N-terminal kinase and extracellular signal-regulated kinase inhibitors markedly decreased the transactivation, suggesting an involvement of AP-1 activation pathway in the up-regulation of BSEP by guggulsterone. Consistent with its FXR antagonism, guggulsterone antagonized bile acid-mediated transactivation of BSEP promoter when the AP-1 element was disrupted. In conclusion, guggulsterone regulates BSEP expression through composite mechanisms, and the transactivation through the AP-1 element is dominant over the FXR-mediated antagonism. The up-regulation of BSEP expression by guggulsterone without activating FXR pathway as an FXR agonist to suppress CYP7A1 expression represents a possible mechanism for guggulsterone-mediated Hypolipidemic effect.
Jian Yang - One of the best experts on this subject based on the ideXlab platform.
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Hypolipidemic Agent z guggulsterone metabolism interplays with induction of carboxylesterase and bile salt export pump
Journal of Lipid Research, 2012Co-Authors: Dongfang Yang, Jian Yang, Da Xiao, Yitzai Chen, Christopher B Black, Ruitang DengAbstract:Z-Guggulsterone is a major ingredient in the Indian traditional Hypolipidemic remedy guggul. A study in mice has established that its Hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally assumed that the antagonism leads to induction of cytochrome P450 7A1 (CYP7A1), the rate-limiting enzyme converting free cholesterol to bile acids. In this study, we tested whether Z-guggulsterone indeed induces human CYP7A1. In addition, the expression of cholesteryl ester hydrolase CES1 and bile salt export pump (BSEP) was monitored. Contrary to the general assumption, Z-guggulsterone did not induce CYP7A1. Instead, this phytosterol significantly induced CES1 and BSEP through transactivation. Z-Guggulsterone underwent metabolism by CYP3A4, and the metabolites greatly increased the induction potency on BSEP but not on CES1. BSEP induction favors cholesterol elimination, whereas CES1 involves both elimination and retention (probably when excessively induced). Interestingly, clinical trials reported the Hypolipidemic response rates from 18% to 80% and showed that higher dosages actually increased VLDL cholesterol. Our findings predict that better Hypolipidemic outcomes likely occur in individuals who have a relatively higher capacity of metabolizing Z-guggulsterone with moderate CES1 induction, a scenario possibly achieved by lowering the dosing regimens.
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the Hypolipidemic Agent guggulsterone regulates the expression of human bile salt export pump dominance of transactivation over farsenoid x receptor mediated antagonism
Journal of Pharmacology and Experimental Therapeutics, 2007Co-Authors: Ruitang Deng, Dongfang Yang, Amy Radke, Jian YangAbstract:Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7α-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP). The expression of CYP7A1 and BSEP is coordinately regulated by a negative feedback and positive feed-forward mechanism, respectively, through bile acid-mediated activation of farsenoid X receptor (FXR). It is well established that Hypolipidemic Agent guggulsterone is an FXR antagonist and down-regulates FXR target genes. In this study, however, we have demonstrated that guggulsterone synergistically induced the expression of BSEP in cells treated with FXR agonist bile acids. A dissection study located in the BSEP promoter an activating protein (AP)-1 site supporting the action of guggulsterone. Deletion or mutation of the AP-1 element was diminished, whereas insertion of the AP-1 element into a heterologous promoter enhanced activation of the promoter by guggulsterone. Selective c-Jun N-terminal kinase and extracellular signal-regulated kinase inhibitors markedly decreased the transactivation, suggesting an involvement of AP-1 activation pathway in the up-regulation of BSEP by guggulsterone. Consistent with its FXR antagonism, guggulsterone antagonized bile acid-mediated transactivation of BSEP promoter when the AP-1 element was disrupted. In conclusion, guggulsterone regulates BSEP expression through composite mechanisms, and the transactivation through the AP-1 element is dominant over the FXR-mediated antagonism. The up-regulation of BSEP expression by guggulsterone without activating FXR pathway as an FXR agonist to suppress CYP7A1 expression represents a possible mechanism for guggulsterone-mediated Hypolipidemic effect.
Anjoy Majhi - One of the best experts on this subject based on the ideXlab platform.
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synthetic applications of baylis hillman chemistry an efficient and solely stereoselective synthesis of e α methylcinnamic acids and potent Hypolipidemic Agent lk 903 from unmodified baylis hillman adducts
Chemical & Pharmaceutical Bulletin, 2006Co-Authors: Joydeep Banerjee, Nikhil Chowdhury, Anjoy MajhiAbstract:An efficient and solely stereoselective synthesis of (E)-α-methylcinnamic acids has been accomplished in single pot by reduction of the unmodified Baylis–Hillman adducts, methyl-3-hydroxy-3-aryl-2-methylenepropanoates with I2/NaBH4 reAgent system at room temperature followed by hydrolysis. The efficacy of this method has been proved in the total synthesis of 1-[p-(myristyloxy)-α-methylcinnamoyl]glycerol, LK-903, a highly active Hypolipidemic Agent.
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Synthetic Applications of Baylis–Hillman Chemistry: An Efficient and Solely Stereoselective Synthesis of ( E )-α-Methylcinnamic Acids and Potent Hypolipidemic Agent LK-903 from Unmodified Baylis–Hillman Adducts
Chemical & Pharmaceutical Bulletin, 2006Co-Authors: Joydeep Banerjee, Nikhil Chowdhury, Anjoy MajhiAbstract:An efficient and solely stereoselective synthesis of (E)-α-methylcinnamic acids has been accomplished in single pot by reduction of the unmodified Baylis–Hillman adducts, methyl-3-hydroxy-3-aryl-2-methylenepropanoates with I2/NaBH4 reAgent system at room temperature followed by hydrolysis. The efficacy of this method has been proved in the total synthesis of 1-[p-(myristyloxy)-α-methylcinnamoyl]glycerol, LK-903, a highly active Hypolipidemic Agent.
Etidal W Jwanny - One of the best experts on this subject based on the ideXlab platform.
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studies on date waste dietary fibers as Hypolipidemic Agent in rats
European Journal of Nutrition, 1996Co-Authors: Etidal W Jwanny, Mona M Rashad, Sorial A Moharib, N El M BeihAbstract:Date waste dietary fibers were examined as a Hypolipidemic Agent. White albino rats were fed on three experimental diets: I) high carbohydrate diet free of fiber; II) and III) diets consisted of diet I substituted with 100 g/kg of date waste dietary fibers cultured withEndomycopsis fibuligera at zero time and after 60 h of culturing respectively for 8 weeks. The total lipids, total cholesterol, triglycerides and phospholipids in the liver of rats given diets II and III were significantly decreased over those rats fed the control diet throughout the feeding period (8 weeks). The highest decrease in content of all these parameters was produced by diet III.
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Studies on date waste dietary fibers as Hypolipidemic Agent in rats
Zeitschrift für Ernährungswissenschaft, 1996Co-Authors: Etidal W Jwanny, Mona M Rashad, Sorial A Moharib, N El M BeihAbstract:Date waste dietary fibers were examined as a Hypolipidemic Agent. White albino rats were fed on three experimental diets: I) high carbohydrate diet free of fiber; II) and III) diets consisted of diet I substituted with 100 g/kg of date waste dietary fibers cultured with Endomycopsis fibuligera at zero time and after 60 h of culturing respectively for 8 weeks. The total lipids, total cholesterol, triglycerides and phospholipids in the liver of rats given diets II and III were significantly decreased over those rats fed the control diet throughout the feeding period (8 weeks). The highest decrease in content of all these parameters was produced by diet III. Comparing diets II and III with the control diet I, total serum lipids and low density lipoprotein cholesterol (LDL-cholesterol) were decreased by 32–48 %, while serum triglycerides and total cholesterol levels were lowered in the groups fed diets II and III by 23–35 % respectively. Concerning high density lipoprotein cholesterol (HDL-cholesterol), the decrease was only 2–6 % in rats fed diets II and III. The highest decrease level was shown in the phospholipids content (51–56 %) during all of the experimental period (8 weeks). Albino-Ratten wurden für 8 Wochen 3 Diäten unterworfen. Diät I bestand aus nicht-faseriger hoch-halliger Kohlenhydratkostform. Diät II und Diät III enthielten zusäzlich 100 g/kg mit Endomycopsis fibuligera kultivierte faserige Dattelabfälle. Die Kultivierungszeit betrug 0 (II) und 60 Stunden (III). Die Gesamtlipide, das Gesamtcholesterol, die Triglyzeride und die Phospholipide nahmen in den Lebern der Ratten, die mit Diät II und III gefüttert wurden, deutlicher ab, als bei denjenigen, die mit Diät I gefüttert wurden. Bei der Diät III zeigte sich die höchste Abnahme der verschiedenen Untersuchungsparametern. Vergleicht man Diät II und III mit Diät I, so ergibt sich, daß die Serumgesamtlipide und das Lipoprotein-Cholesterol niedrigerer Dichte (LDL-Cholesterol) um 32–48 % abnehmen, während Serumtriglyzeride und Gesamtcholesterol in mit Dät II und Diät III gefütterten Ratten um 23–35 % erniedrigt sind. Bei mit Diät II und III gefütterten Ratten betrug die Abnahme des HDL-Cholesterols nur 2–6 %. Phospholipide zeigten die höchste Abnahme (51–56 %) während der ganzen Versuchsperiode (8 Wochen).