The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform
W. Reith - One of the best experts on this subject based on the ideXlab platform.
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Tumoren der Sellaregion
Der Radiologe, 2009Co-Authors: W. ReithAbstract:Tumors of the pituitary gland can lead to limitation of Hypophysis Function (Hypophysis insufficiency) or hypersecretion of different hormones (acromegaly, Cushing's syndrome, prolactinoma, TSH-secreting adenoma). The optic chiasma lies in close proximity to the pituitary gland and can be compressed by tumors leading to visual disturbances (bilateral hemianopsia). Tumors can be separated into hormone secreting and hormone inactive tumors, as well as into microadenoma with a diameter 10 mm. A rare group of tumors of the Hypophysis region are craniopharyngiomas, meningiomas, germinomas, gliomas, metastases and granulomotous inflammations, such as sarcoidosis and tuberculosis.
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Tumoren der Sellaregion
Der Radiologe, 2009Co-Authors: W. ReithAbstract:Bei Tumoren der Hypophysenregion kann es zu einer Einschränkung der Hypophysenfunktion (Hypophyseninsuffizienz) kommen, aber auch zu einem Hypersekretionssyndrom (Akromegalie, Cushing-Syndrom, Prolaktinom, TSH-sezernierendes Adenom). Unmittelbar über der Hypophysenregion liegt das Chiasma opticum, wodurch es bei Tumoren der Hypophysenregion zur Beeinträchtigung des Sehens kommen kann, meist als Verschlechterung des Sehfeldes beider Augen nach lateral (bitemporale Hemianopsie). Man unterscheidet hormonaktive und -inaktive Tumoren. Es werden Mikroadenome mit einem Durchmesser bis 10 mm und Makroadenome, die größer als 10 mm sind, unterschieden. Eine seltenere Gruppe von Tumoren der Hypophysenregion sind die Kraniopharyngeome, Meningeome, Germinome, Gliome, Metastasen und granulomatöse Entzündungen (Sarkoidose, Tuberkulose). Tumors of the pituitary gland can lead to limitation of Hypophysis Function (Hypophysis insufficiency) or hypersecretion of different hormones (acromegaly, Cushing’s syndrome, prolactinoma, TSH-secreting adenoma). The optic chiasma lies in close proximity to the pituitary gland and can be compressed by tumors leading to visual disturbances (bilateral hemianopsia). Tumors can be separated into hormone secreting and hormone inactive tumors, as well as into microadenoma with a diameter 10 mm. A rare group of tumors of the Hypophysis region are craniopharyngiomas, meningiomas, germinomas, gliomas, metastases and granulomotous inflammations, such as sarcoidosis and tuberculosis.
Kutdusova A.m. - One of the best experts on this subject based on the ideXlab platform.
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Dynamics of hormonal status in women of different age groups in hemorrhagic fever with renal syndrome
Saratov State Medical University, 2012Co-Authors: Murzabaeva R.Т., Kutdusova A.m.Abstract:Objective: To study the hormonal parameters in women of different age groups in hemorrhagic fever with renal syndrome. Materials and methods: We have studied the content of cortisol, thyrotropic hormone (TTH), triiodothyro-nine (T3), free thyroxin (FT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, estradiol, progesterone, prolactin in blood serum of 62 women with moderate (33) and severe (29) HFRS forms age (17-62). They were divided into 2 groups: the first group (33 patients) women with the normal menstrual cycle, the second group (29 women) consisted of patients in climacteric period. Results: TTH secretion increase, T3 and FT4 — decrease with their normalization to the recovery period were registered in the thyroid system of the compared groups. Blood cortisol level was high during the illness. Gonadotropic Hypophysis Function study demonstrated that LH and blood prolactin concentrations were increased since oliguria period; FSH was authentic reduced. The indices of these hormones were restored to the normal level by the reconvalescence period. LH and FSH contents were authentic higher in women of the second group in comparison with the first group. The hyperprolactinemia was observed in both women groups during the whole period of disease. The increased progesterone and testosterone concentrations have been manifested in blood serum. The estradiol concentration had different direction tendencies. Conclusion: Thus, the complex study of hypophysic- thyreoid and gonadotropic hormone state of adrenal system and the sexual hormone levels in women of different age groups in HFRS revealed the hormone status indces changes due to the period and severity of the disease, connected with the virus action, intoxication, the general inflammation reactions and their age
J. Vymazal - One of the best experts on this subject based on the ideXlab platform.
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Gamma knife radiosurgery for endocrine-inactive pituitary adenomas
Acta Neurochirurgica, 2007Co-Authors: R. Liščák, V. Vladyka, J. Marek, G. Šimonová, J. VymazalAbstract:Background. The goal of nonsecreting pituitary adenoma radiosurgery is to halt tumour growth and to maintain normal performance of the Hypophysis and the Functionally important structures around the sella. The effectiveness of gamma knife radiosurgery was evaluated. Method. Over a period of 10 years (1993–2003), 140 patients with nonsecreting pituitary adenoma were treated by Leksell gamma knife at our Centre. Seventy-nine of them were followed up for longer than 3 years. Their age range was 24–73 years, with a median of 54 years. Eighty-five percent of them had previous open surgery. Fifteen patients had adenoma contact with the optic tract. Fourteen patients had a normally Functioning Hypophysis, 48 patients had complete panhypopituitarism, while the rest retained partial Functions of the normal Hypophysis. Adenoma volumes ranged between 0.1 and 31.3, the median being 3.45 ccm. The marginal dose ranged between 12 and −35 Gy, with a median of 20 Gy. Findings. The follow-up ranged from 36 to 122 months, with a median of 60 months. No adenoma growth was detected; 89% of treated adenomas decreased in size, with a median volume reduction of 61%. There was no perimeter vision impairment after radiosurgery, while 4 out of 52 patients with abnormal perimeter vision reported improvement. There was no impairment of oculomotor nerve Function. Impairment of Hypophysis Function was observed in 2 patients. Conclusions. Radiosurgery has a reliable antiproliferative effect on nonsecreting pituitary adenomas. It is a safe treatment with a low risk of morbidity. Short contact between a nonsecreting pituitary adenoma and the optic pathway is not an absolute contraindication for Gamma knife radiosurgery.
Murzabaeva R.Т. - One of the best experts on this subject based on the ideXlab platform.
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Dynamics of hormonal status in women of different age groups in hemorrhagic fever with renal syndrome
Saratov State Medical University, 2012Co-Authors: Murzabaeva R.Т., Kutdusova A.m.Abstract:Objective: To study the hormonal parameters in women of different age groups in hemorrhagic fever with renal syndrome. Materials and methods: We have studied the content of cortisol, thyrotropic hormone (TTH), triiodothyro-nine (T3), free thyroxin (FT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, estradiol, progesterone, prolactin in blood serum of 62 women with moderate (33) and severe (29) HFRS forms age (17-62). They were divided into 2 groups: the first group (33 patients) women with the normal menstrual cycle, the second group (29 women) consisted of patients in climacteric period. Results: TTH secretion increase, T3 and FT4 — decrease with their normalization to the recovery period were registered in the thyroid system of the compared groups. Blood cortisol level was high during the illness. Gonadotropic Hypophysis Function study demonstrated that LH and blood prolactin concentrations were increased since oliguria period; FSH was authentic reduced. The indices of these hormones were restored to the normal level by the reconvalescence period. LH and FSH contents were authentic higher in women of the second group in comparison with the first group. The hyperprolactinemia was observed in both women groups during the whole period of disease. The increased progesterone and testosterone concentrations have been manifested in blood serum. The estradiol concentration had different direction tendencies. Conclusion: Thus, the complex study of hypophysic- thyreoid and gonadotropic hormone state of adrenal system and the sexual hormone levels in women of different age groups in HFRS revealed the hormone status indces changes due to the period and severity of the disease, connected with the virus action, intoxication, the general inflammation reactions and their age
R. Liščák - One of the best experts on this subject based on the ideXlab platform.
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Gamma knife radiosurgery for endocrine-inactive pituitary adenomas
Acta Neurochirurgica, 2007Co-Authors: R. Liščák, V. Vladyka, J. Marek, G. Šimonová, J. VymazalAbstract:Background. The goal of nonsecreting pituitary adenoma radiosurgery is to halt tumour growth and to maintain normal performance of the Hypophysis and the Functionally important structures around the sella. The effectiveness of gamma knife radiosurgery was evaluated. Method. Over a period of 10 years (1993–2003), 140 patients with nonsecreting pituitary adenoma were treated by Leksell gamma knife at our Centre. Seventy-nine of them were followed up for longer than 3 years. Their age range was 24–73 years, with a median of 54 years. Eighty-five percent of them had previous open surgery. Fifteen patients had adenoma contact with the optic tract. Fourteen patients had a normally Functioning Hypophysis, 48 patients had complete panhypopituitarism, while the rest retained partial Functions of the normal Hypophysis. Adenoma volumes ranged between 0.1 and 31.3, the median being 3.45 ccm. The marginal dose ranged between 12 and −35 Gy, with a median of 20 Gy. Findings. The follow-up ranged from 36 to 122 months, with a median of 60 months. No adenoma growth was detected; 89% of treated adenomas decreased in size, with a median volume reduction of 61%. There was no perimeter vision impairment after radiosurgery, while 4 out of 52 patients with abnormal perimeter vision reported improvement. There was no impairment of oculomotor nerve Function. Impairment of Hypophysis Function was observed in 2 patients. Conclusions. Radiosurgery has a reliable antiproliferative effect on nonsecreting pituitary adenomas. It is a safe treatment with a low risk of morbidity. Short contact between a nonsecreting pituitary adenoma and the optic pathway is not an absolute contraindication for Gamma knife radiosurgery.