The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Daniel A. Johnson - One of the best experts on this subject based on the ideXlab platform.
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Cutaneous Hypopigmentation following a posterior sub-tenon triamcinolone injection
American journal of ophthalmology, 2004Co-Authors: Mark J. Gallardo, Daniel A. JohnsonAbstract:PURPOSE: To report a case of cutaneous skin Hypopigmentation following a posterior sub-Tenon triamcinolone acetonide injection for uveitis. DESIGN: Observational case report. METHODS: A 28-year-old African American female with Adamantiades-Behcet disease and panuveitis was administered a posterior sub-Tenon injection of triamcinolone acetonide and developed cutaneous Hypopigmentation. RESULTS: The patient developed skin Hypopigmentation of the upper eyelid adjacent to the site of the sub-Tenon injection. CONCLUSION: Injection of corticosteroids into the sub-Tenon space can cause Hypopigmentation of the adjacent tissues, especially in heavily pigmented individuals.
Mark J. Gallardo - One of the best experts on this subject based on the ideXlab platform.
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Cutaneous Hypopigmentation following a posterior sub-tenon triamcinolone injection
American journal of ophthalmology, 2004Co-Authors: Mark J. Gallardo, Daniel A. JohnsonAbstract:PURPOSE: To report a case of cutaneous skin Hypopigmentation following a posterior sub-Tenon triamcinolone acetonide injection for uveitis. DESIGN: Observational case report. METHODS: A 28-year-old African American female with Adamantiades-Behcet disease and panuveitis was administered a posterior sub-Tenon injection of triamcinolone acetonide and developed cutaneous Hypopigmentation. RESULTS: The patient developed skin Hypopigmentation of the upper eyelid adjacent to the site of the sub-Tenon injection. CONCLUSION: Injection of corticosteroids into the sub-Tenon space can cause Hypopigmentation of the adjacent tissues, especially in heavily pigmented individuals.
Young Chul Kye - One of the best experts on this subject based on the ideXlab platform.
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Analysis of hyperpigmentation and Hypopigmentation after Er:YAG laser skin resurfacing.
Lasers in surgery and medicine, 2005Co-Authors: Yong Ju Kim, Soo Nam Kim, Ho-sup Lee, Sang-wook Son, Young Chul KyeAbstract:Background and Objectives Pigmentary disorders—such as hyperpigmentation and Hypopigmentation, are devastating complications of erbium:yttrium-aluminum-garnet (Er:YAG) laser resurfacing. This study was undertaken to assess the clinical and histopathologic features of hyperpigmentation and Hypopigmentation following Er:YAG laser resurfacing, especially in darker skin. Study Design/Materials and Methods One hundred and ninety patients (skin phototypes III and above), treated with Er:YAG lasers—short-pulsed and modulated (variable-pulsed and dual-mode) Er:YAG lasers—for skin resurfacing were recruited. The clinical features of hyperpigmentation and Hypopigmentation were evaluated retrospectively using medical charts and serial photographs. For histopathologic examinations, skin biopsies were performed in three patients at hyperpigmentation sites and in four patients at Hypopigmentation sites. Results Hyperpigmentation was observed in 38.4% of the patients. Mean onset and duration were 3.5 and 7.2 weeks, and then it has faded away within 16 weeks in 93.2% of cases. Hypopigmentation was observed in 13.7% of the patients; its mean onset was 2 months after treatment, and it faded within 1 year in 85% of cases. The incidences and mean durations of these side effects were more intense and longer in patients treated with short-pulsed, variable-pulsed, and dual-mode Er:YAG lasers, in increasing order. In terms of histopathologic examinations, melanin amounts in the epidermal basal layer were observed to vary. Conclusions Hyperpigmentation and Hypopigmentation are frequent complications of Er:YAG laser resurfacing. Long pulse duration-induced thermal damage seems to be the most important factor in terms of the induction of pigmentary disorders. Lasers Surg. Med. 36:47–51, 2005. © 2005 Wiley-Liss, Inc.
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Hypopigmentation Occurred After Er: YAG Laser Resurfacing
Journal of Clinical Dermatology, 2004Co-Authors: Eul Sang Hwang, Sang Hyuk Woo, Hwan Tae Sung, Soo Nam Kim, Young Chul KyeAbstract:Background: Hypopigmentation is one of the complications developed after laser resurfacing. There have been few data about Hypopigmentation developed after Er:YAG laser resurfacing, especially in darker skin. Objective: The objective of this study was to assess the clinical and histopathologic features of Hypopigmentation developed after Er:YAG laser resurfacing. Methods: One hundred and ninety patients have been included in this study. Ninety seven patients were treated with short pulsed Er:YAG laser, 2mm spot sized handpiece at the setting of 12.5-15.0 J/cm2 . Fifty two patients were treated with variable pulsed Er:YAG laser, 5 mm spot sized handpiece at the setting of 7.0-7.5 J/cm and 7 msec pulse duration. Forty one patients were treated with dual mode Er:YAG laser, 4 mm spot sized scanner at the setting of 17.5 J/cm2 ablation mode and 3.15 J/cm coagulation mode. Incidence, time of onset, duration of Hypopigmentation were evaluated throughout the medical charts and serially checked photographs. Skin biopsy was performed in four patients at the Hypopigmentation site for histopathologic and electron microscopic examinations with informed consents. Results: Hypopigmentation was observed in twenty six patients; eight in short pulsed Er:YAG laser, eight in variable pulsed Er:YAG laser, ten in dual mode Er:YAG laser. According to the time of onset of Hypopigmentation, twelve patients developed Hypopigmentation within one month, five patients in two months, three patients within three months, three patients within four months, two patients within five months, and one patient within six months. Twenty out of twenty six patients recovered skin coloration within six months, and two patients within twelve months. On the other hand, four patients had persisted Hypopigmentation for more than one year. Melanosome appeared to be decreased but melanocytes appeared to be present in normal numbers on the histopathologic and electron microscopic examinations. Conclusion: Although Hypopigmentation is one of the frequent complicaions of Er:YAG laser resurfacing, it is temporary in most cases. Thermal damage due to long pulse duration of laser seems to be a very important factor in inducing Hypopigmentation. (Korean J Dermatol 2004;42(7):833-838)
Bertram Brenig - One of the best experts on this subject based on the ideXlab platform.
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A genome-wide association study reveals a locus for bilateral iridal Hypopigmentation in Holstein Friesian cattle
BMC Genetics, 2017Co-Authors: Anne K. Hollmann, Martina Bleyer, Jasmin Neßler, Wilhelm Wemheuer, Ekkehard Schütz, Andrea Tipold, Bertram BrenigAbstract:Eye pigmentation abnormalities in cattle are often related to albinism, Chediak-Higashi or Tietz like syndrome. However, mutations only affecting pigmentation of coat color and eye have also been described. Herein 18 Holstein Friesian cattle affected by bicolored and hypopigmented irises have been investigated. Affected animals did not reveal any ophthalmological or neurological abnormalities besides the specific iris color differences. Coat color of affected cattle did not differ from controls. Histological examination revealed a reduction of melanin pigment in the iridal anterior border layer and stroma in cases as cause of iris Hypopigmentation. To analyze the genetics of the iris pigmentation differences, a genome-wide association study was performed using Illumina BovineSNP50 BeadChip genotypes of the 18 cases and 172 randomly chosen control animals. A significant association on bovine chromosome 8 (BTA8) was identified at position 60,990,733 with a -log10(p) = 9.17. Analysis of genotypic and allelic dependences between cases of iridal Hypopigmentation and an additional set of 316 randomly selected Holstein Friesian cattle controls showed that allele A at position 60,990,733 on BTA8 (P = 4.0e–08, odds ratio = 6.3, 95% confidence interval 3.02–13.17) significantly increased the chance of iridal Hypopigmentation. The clinical appearance of the iridal Hypopigmentation differed from previously reported cases of pigmentation abnormalities in syndromes like Chediak-Higashi or Tietz and seems to be mainly of cosmetic character. Iridal Hypopigmentation is caused by a reduced content of melanin pigment in the anterior border layer and iridal stroma. A single genomic position on BTA8 was detected to be significantly associated with iridal Hypopigmentation in examined cattle. To our knowledge this is the first report about this phenotype in Holstein Friesian cattle.
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A genome-wide association study reveals a locus for bilateral iridal Hypopigmentation in Holstein Friesian cattle
BMC Genetics, 2017Co-Authors: Anne K. Hollmann, Martina Bleyer, Jasmin Neßler, Wilhelm Wemheuer, Ekkehard Schütz, Andrea Tipold, Bertram BrenigAbstract:Background Eye pigmentation abnormalities in cattle are often related to albinism, Chediak-Higashi or Tietz like syndrome. However, mutations only affecting pigmentation of coat color and eye have also been described. Herein 18 Holstein Friesian cattle affected by bicolored and hypopigmented irises have been investigated. Results Affected animals did not reveal any ophthalmological or neurological abnormalities besides the specific iris color differences. Coat color of affected cattle did not differ from controls. Histological examination revealed a reduction of melanin pigment in the iridal anterior border layer and stroma in cases as cause of iris Hypopigmentation. To analyze the genetics of the iris pigmentation differences, a genome-wide association study was performed using Illumina BovineSNP50 BeadChip genotypes of the 18 cases and 172 randomly chosen control animals. A significant association on bovine chromosome 8 (BTA8) was identified at position 60,990,733 with a -log_10( p ) = 9.17. Analysis of genotypic and allelic dependences between cases of iridal Hypopigmentation and an additional set of 316 randomly selected Holstein Friesian cattle controls showed that allele A at position 60,990,733 on BTA8 ( P = 4.0e–08, odds ratio = 6.3, 95% confidence interval 3.02–13.17) significantly increased the chance of iridal Hypopigmentation. Conclusions The clinical appearance of the iridal Hypopigmentation differed from previously reported cases of pigmentation abnormalities in syndromes like Chediak-Higashi or Tietz and seems to be mainly of cosmetic character. Iridal Hypopigmentation is caused by a reduced content of melanin pigment in the anterior border layer and iridal stroma. A single genomic position on BTA8 was detected to be significantly associated with iridal Hypopigmentation in examined cattle. To our knowledge this is the first report about this phenotype in Holstein Friesian cattle.
Philippine Garret - One of the best experts on this subject based on the ideXlab platform.
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Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome
Nature Genetics, 2019Co-Authors: Pierre Vabres, Arthur Sorlin, Stanislav S. Kholmanskikh, Bénédicte Demeer, Judith St-onge, Yannis Duffourd, Paul Kuentz, Jean-benoît Courcet, Virginie Carmignac, Philippine GarretAbstract:Postzygotic inactivating mutations in RHOA cause a mosaic neuroectodermal syndrome characterized by linear Hypopigmentation, leukoencephalopathy and craniofacial anomalies, highlighting the role of RHOA in human development and disease. Hypopigmentation along Blaschko’s lines is a hallmark of a poorly defined group of mosaic syndromes whose genetic causes are unknown. Here we show that postzygotic inactivating mutations of RHOA cause a neuroectodermal syndrome combining linear Hypopigmentation, alopecia, apparently asymptomatic leukoencephalopathy, and facial, ocular, dental and acral anomalies. Our findings pave the way toward elucidating the etiology of pigmentary mosaicism and highlight the role of RHOA in human development and disease.
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Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome
Nature Genetics, 2019Co-Authors: Pierre Vabres, Arthur Sorlin, Stanislav S. Kholmanskikh, Bénédicte Demeer, Judith St-onge, Yannis Duffourd, Paul Kuentz, Jean-benoît Courcet, Virginie Carmignac, Philippine GarretAbstract:Hypopigmentation along Blaschko's lines is a hallmark of a poorly defined group of mosaic syndromes whose genetic causes are unknown. Here we show that postzygotic inactivating mutations of RHOA cause a neuroectodermal syndrome combining linear Hypopigmentation, alopecia, apparently asymptomatic leukoencephalopathy, and facial, ocular, dental and acral anomalies. Our findings pave the way toward elucidating the etiology of pigmentary mosaicism and highlight the role of RHOA in human development and disease.