The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform

Rinkoo Dalan - One of the best experts on this subject based on the ideXlab platform.

  • adipsic diabetes insipidus the challenging combination of polyuria and adipsia a case report and review of literature
    Frontiers in Endocrinology, 2019
    Co-Authors: Rinkoo Dalan, Hanxin Chin, Jeremy K M Hoe, Abel Weiliang Chen, Huiling Tan, Bernhard O Boehm, Karen Suigeok Chua
    Abstract:

    Adipsic Diabetes Insipidus is a rare Hypothalamic Disorder characterized by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analog treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, etiology, clinical presentation, acute and chronic management, and prognosis.

  • adipsic diabetes insipidus the challenging combination of polyuria and adipsia a case report and review of literature
    Frontiers in Endocrinology, 2019
    Co-Authors: Rinkoo Dalan, Hanxin Chin, Abel Weiliang Chen, Bernhard O Boehm, Karen Suigeok Chua
    Abstract:

    Adipsic Diabetes Insipidus is a rare Hypothalamic Disorder characterised by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analogue treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, aetiology, clinical presentation, acute and chronic management and prognosis.

Karen Suigeok Chua - One of the best experts on this subject based on the ideXlab platform.

  • adipsic diabetes insipidus the challenging combination of polyuria and adipsia a case report and review of literature
    Frontiers in Endocrinology, 2019
    Co-Authors: Rinkoo Dalan, Hanxin Chin, Jeremy K M Hoe, Abel Weiliang Chen, Huiling Tan, Bernhard O Boehm, Karen Suigeok Chua
    Abstract:

    Adipsic Diabetes Insipidus is a rare Hypothalamic Disorder characterized by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analog treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, etiology, clinical presentation, acute and chronic management, and prognosis.

  • adipsic diabetes insipidus the challenging combination of polyuria and adipsia a case report and review of literature
    Frontiers in Endocrinology, 2019
    Co-Authors: Rinkoo Dalan, Hanxin Chin, Abel Weiliang Chen, Bernhard O Boehm, Karen Suigeok Chua
    Abstract:

    Adipsic Diabetes Insipidus is a rare Hypothalamic Disorder characterised by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analogue treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, aetiology, clinical presentation, acute and chronic management and prognosis.

Bernhard O Boehm - One of the best experts on this subject based on the ideXlab platform.

  • adipsic diabetes insipidus the challenging combination of polyuria and adipsia a case report and review of literature
    Frontiers in Endocrinology, 2019
    Co-Authors: Rinkoo Dalan, Hanxin Chin, Jeremy K M Hoe, Abel Weiliang Chen, Huiling Tan, Bernhard O Boehm, Karen Suigeok Chua
    Abstract:

    Adipsic Diabetes Insipidus is a rare Hypothalamic Disorder characterized by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analog treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, etiology, clinical presentation, acute and chronic management, and prognosis.

  • adipsic diabetes insipidus the challenging combination of polyuria and adipsia a case report and review of literature
    Frontiers in Endocrinology, 2019
    Co-Authors: Rinkoo Dalan, Hanxin Chin, Abel Weiliang Chen, Bernhard O Boehm, Karen Suigeok Chua
    Abstract:

    Adipsic Diabetes Insipidus is a rare Hypothalamic Disorder characterised by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analogue treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, aetiology, clinical presentation, acute and chronic management and prognosis.

Denis Burdakov - One of the best experts on this subject based on the ideXlab platform.

  • narcolepsy clinical spectrum aetiopathophysiology diagnosis and treatment
    Nature Reviews Neurology, 2019
    Co-Authors: Claudio L Bassetti, Antoine Roger Adamantidis, Denis Burdakov, Fang Han, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R Kornum
    Abstract:

    Narcolepsy is a rare brain Disorder that reflects a selective loss or dysfunction of orexin (also known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is characterized by excessive daytime sleepiness and cataplexy, accompanied by sleep-wake symptoms, such as hallucinations, sleep paralysis and disturbed sleep. Diagnosis is based on these clinical features and supported by biomarkers: evidence of rapid eye movement sleep periods soon after sleep onset; cerebrospinal fluid orexin deficiency; and positivity for HLA-DQB1*06:02. Symptomatic treatment with stimulant and anticataplectic drugs is usually efficacious. This Review focuses on our current understanding of how genetic, environmental and immune-related factors contribute to a prominent (but not isolated) orexin signalling deficiency in patients with NT1. Data supporting the view of NT1 as a Hypothalamic Disorder affecting not only sleep-wake but also motor, psychiatric, emotional, cognitive, metabolic and autonomic functions are presented, along with uncertainties concerning the 'narcoleptic borderland', including narcolepsy type 2 (NT2). The limitations of current diagnostic criteria for narcolepsy are discussed, and a possible new classification system incorporating the borderland conditions is presented. Finally, advances and obstacles in the symptomatic and causal treatment of narcolepsy are reviewed.

Brigitte R Kornum - One of the best experts on this subject based on the ideXlab platform.

  • narcolepsy clinical spectrum aetiopathophysiology diagnosis and treatment
    Nature Reviews Neurology, 2019
    Co-Authors: Claudio L Bassetti, Antoine Roger Adamantidis, Denis Burdakov, Fang Han, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R Kornum
    Abstract:

    Narcolepsy is a rare brain Disorder that reflects a selective loss or dysfunction of orexin (also known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is characterized by excessive daytime sleepiness and cataplexy, accompanied by sleep-wake symptoms, such as hallucinations, sleep paralysis and disturbed sleep. Diagnosis is based on these clinical features and supported by biomarkers: evidence of rapid eye movement sleep periods soon after sleep onset; cerebrospinal fluid orexin deficiency; and positivity for HLA-DQB1*06:02. Symptomatic treatment with stimulant and anticataplectic drugs is usually efficacious. This Review focuses on our current understanding of how genetic, environmental and immune-related factors contribute to a prominent (but not isolated) orexin signalling deficiency in patients with NT1. Data supporting the view of NT1 as a Hypothalamic Disorder affecting not only sleep-wake but also motor, psychiatric, emotional, cognitive, metabolic and autonomic functions are presented, along with uncertainties concerning the 'narcoleptic borderland', including narcolepsy type 2 (NT2). The limitations of current diagnostic criteria for narcolepsy are discussed, and a possible new classification system incorporating the borderland conditions is presented. Finally, advances and obstacles in the symptomatic and causal treatment of narcolepsy are reviewed.