The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform

Stefan Bleich - One of the best experts on this subject based on the ideXlab platform.

  • CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation—relevance for craving of male alcohol-dependent patients?
    Psychopharmacology, 2014
    Co-Authors: Marc Andre Nicolas Muschler, Bernd Lenz, Cornelia Kraus, Helge Frieling, Thomas Hillemacher, Johannes Kornhuber, Stefan Bleich
    Abstract:

    RationalePrevious findings of the Franconian Alcoholism Research Studies showed that both the CAGn of the androgen receptor (AR) and the promoter methylation of the Hypothalamic Peptide proopiomelanocortin (POMC) were associated with craving of male alcohol-dependent patients.ObjectivesBased on the strong interactions between the Hypothalamic–pituitary–gonadal (HPG) and the Hypothalamic–pituitary–adrenal axis (HPA), this study investigated the relationships between the CAGn repeat of the AR, POMC promoter methylation and craving of male alcohol-dependent patients.MethodsThis analysis covers 84 male patients with a diagnosis of alcohol dependence (DSM-IV). We sequenced the POMC gene promoter using bisulfite modified DNA to display the methylation status. Furthermore, we sequenced the CAGn repeat within exon 1 of the AR gene. Craving was quantified by the Obsessive Compulsive Drinking Scale.ResultsWe found an inverse correlation between the number of CAGn repeats of the AR and the POMC methylation status in this study. Altogether, the POMC promoter methylation accounted for 33 % of the relationship between CAGn AR polymorphism and craving.ConclusionsThis work shows that the AR and the POMC gene might functionally interact with each other and subsequently mediate craving in alcohol-dependent patients. The paper discusses different mechanisms which might underlie our findings involving sex hormones' and sex determining region of Y-gene's regulatory function on DNA-methyltransferase activity. In conclusion, the results give insight in the interaction between HPG and HPA axis. This study is a further step on the way to a better understanding of genetic and non-genetic factors underlying craving for alcohol.

  • CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation—relevance for craving of male alcohol-dependent patients?
    Psychopharmacology, 2013
    Co-Authors: Marc Andre Nicolas Muschler, Bernd Lenz, Cornelia Kraus, Helge Frieling, Thomas Hillemacher, Johannes Kornhuber, Stefan Bleich
    Abstract:

    Rationale Previous findings of the Franconian Alcoholism Research Studies showed that both the CAGn of the androgen receptor (AR) and the promoter methylation of the Hypothalamic Peptide proopiomelanocortin (POMC) were associated with craving of male alcohol-dependent patients.

Marc Andre Nicolas Muschler - One of the best experts on this subject based on the ideXlab platform.

  • CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation—relevance for craving of male alcohol-dependent patients?
    Psychopharmacology, 2014
    Co-Authors: Marc Andre Nicolas Muschler, Bernd Lenz, Cornelia Kraus, Helge Frieling, Thomas Hillemacher, Johannes Kornhuber, Stefan Bleich
    Abstract:

    RationalePrevious findings of the Franconian Alcoholism Research Studies showed that both the CAGn of the androgen receptor (AR) and the promoter methylation of the Hypothalamic Peptide proopiomelanocortin (POMC) were associated with craving of male alcohol-dependent patients.ObjectivesBased on the strong interactions between the Hypothalamic–pituitary–gonadal (HPG) and the Hypothalamic–pituitary–adrenal axis (HPA), this study investigated the relationships between the CAGn repeat of the AR, POMC promoter methylation and craving of male alcohol-dependent patients.MethodsThis analysis covers 84 male patients with a diagnosis of alcohol dependence (DSM-IV). We sequenced the POMC gene promoter using bisulfite modified DNA to display the methylation status. Furthermore, we sequenced the CAGn repeat within exon 1 of the AR gene. Craving was quantified by the Obsessive Compulsive Drinking Scale.ResultsWe found an inverse correlation between the number of CAGn repeats of the AR and the POMC methylation status in this study. Altogether, the POMC promoter methylation accounted for 33 % of the relationship between CAGn AR polymorphism and craving.ConclusionsThis work shows that the AR and the POMC gene might functionally interact with each other and subsequently mediate craving in alcohol-dependent patients. The paper discusses different mechanisms which might underlie our findings involving sex hormones' and sex determining region of Y-gene's regulatory function on DNA-methyltransferase activity. In conclusion, the results give insight in the interaction between HPG and HPA axis. This study is a further step on the way to a better understanding of genetic and non-genetic factors underlying craving for alcohol.

  • CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation—relevance for craving of male alcohol-dependent patients?
    Psychopharmacology, 2013
    Co-Authors: Marc Andre Nicolas Muschler, Bernd Lenz, Cornelia Kraus, Helge Frieling, Thomas Hillemacher, Johannes Kornhuber, Stefan Bleich
    Abstract:

    Rationale Previous findings of the Franconian Alcoholism Research Studies showed that both the CAGn of the androgen receptor (AR) and the promoter methylation of the Hypothalamic Peptide proopiomelanocortin (POMC) were associated with craving of male alcohol-dependent patients.

Xiaohong Ding - One of the best experts on this subject based on the ideXlab platform.

  • Kisspeptin and Polycystic Ovary Syndrome
    Frontiers in Endocrinology, 2019
    Co-Authors: Rong Tang, Xiaohong Ding
    Abstract:

    Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamus-pituitary-gonad (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a Hypothalamic Peptide encoded by KISS1 gene, is widely reported as a key factor in the regulation of luteinizing hormone (LH)/ follicular-stimulating hormone (FSH) secretion, which may be potentially involved with the development of PCOS. Objective: The objective of this study is to summarize the existing knowledge in the literature in terms of the circulating kisspeptin concentration in PCOS women, kisspeptin and metabolic profiles in PCOS women,kisspeptin expression in PCOS animal models. Method: A systematic literature search was conducted using “Pubmed”, “Embase”, “Web of Science” for all English language articles published up to July 2018 with the terms “PCOS”, “Stein-Leventhal Syndrome”, “Polycystic ovary syndrome”, “metastins” and “kisspeptin”. Conclusion: Overall, kisspeptin level is higher in PCOS population, which supports the hypothesis that over-activated KISS1 system lead to an enhanced HPG-axis activity, thereby cause irregular menstrual cycle and excessive androgen release in PCOS women.

  • Kisspeptin and Polycystic Ovary Syndrome
    Frontiers Media S.A., 2019
    Co-Authors: Rong Tang, Xiaohong Ding, Jianghu Zhu
    Abstract:

    Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of Hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a Hypothalamic Peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation of luteinizing hormone (LH)/ follicular-stimulating hormone (FSH) secretion, which may be potentially involved with the development of PCOS.Objective: The objective of this study is to summarize the existing knowledge in the literature in terms of the circulating kisspeptin concentration in PCOS women, kisspeptin and metabolic profiles in PCOS women and kisspeptin expression in PCOS animal models.Method: A systematic literature search was conducted using “Pubmed,” “Embase,” “Web of Science” for all English language articles published up to July 2018 with the terms “PCOS,” “Stein-Leventhal Syndrome,” “Polycystic ovary syndrome,” “metastins” and “kisspeptin”.Conclusion: Overall, kisspeptin levels are higher in the PCOS population, which supports the hypothesis that an over-active KISS1 system leads to enhanced HPG-axis activity, thereby causing irregular menstrual cycles and excessive androgen release in PCOS women

A Arimura - One of the best experts on this subject based on the ideXlab platform.

  • pituitary adenylate cyclase activating Peptide a novel vasoactive intestinal Peptide like neuroPeptide in the gut
    Neuroscience, 1992
    Co-Authors: F Sundler, Eva Ekblad, A Absood, R Hakanson, K Koves, A Arimura
    Abstract:

    Abstract Pituitary adenylate cyclase activating Peptide (PACAP) is a vasoactive intestinal Peptide (VIP)-like Hypothalamic Peptide occurring in two forms, PACAP-27 and the C-terminally extended PACAP-38. The predicted rat and human PACAP sequence is identical to the isolated ovine one. In the present study, the occurrence and distribution of PACAP-like Peptides were examined in the gut of several species by immunocytochemistry and immunochemistry using an antibody raised against PACAP-27. PACAP-like immunoreactivity was observed in nerve fibers in the gut wall of all species examined (chicken, mouse, rat, hamster, guinea-pig, ferret, cat, pig, sheep and man). In the chicken and human gut, immunoreactive fibers were numerous in all layers. In the other species examined the fibers were predominantly found in the myenteric ganglia and smooth muscle. Delicate PACAP-immunoreactive fibers were seen in the gastric mucosa of mouse, rat, hamster and man but not in the other species examined. The chicken proventriculus harbored numerous PACAP-immunoreactive endocrine cells which were identical with the serotonin-containing cells storing gastrin-releasing Peptide. PACAP-immunoreactive nerve cell bodies were numerous in the submucous ganglia and moderate in number in the myenteric ganglia of the human gut. They were few in the intramural ganglia of the other species examined. Extrinsic denervation (performed on segments of rat and guinea-pig small intestine) did not visibly affect the PACAP innervation, indicating an intramural origin of most PACAP-immunoreactive fibers. Double immunostaining for VIP and PACAP revealed co-existence of the two Peptides in nerve cell bodies and nerve fibers of the human and chicken gut and in fibers in the gastric mucosa of mouse and rat. In all other species examined and in all other locations in the gut PACAP-immunoreactive nerve cell bodies and nerve fibers were distinct from those storing VIP; many of them contained gastrin-releasing Peptide instead. Immunochemistry revealed PACAP-like Peptides in gut extracts of all species studied; upon high performance liquid chromatography the immunoreactive material co-eluted with synthetic PACAP-27. The distribution of PACAP-immunoreactive nerve cell bodies and nerve fibers in the gut wall suggests their involvement in the regulation of both motor and secretory activities.

Rong Tang - One of the best experts on this subject based on the ideXlab platform.

  • Kisspeptin and Polycystic Ovary Syndrome
    Frontiers in Endocrinology, 2019
    Co-Authors: Rong Tang, Xiaohong Ding
    Abstract:

    Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamus-pituitary-gonad (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a Hypothalamic Peptide encoded by KISS1 gene, is widely reported as a key factor in the regulation of luteinizing hormone (LH)/ follicular-stimulating hormone (FSH) secretion, which may be potentially involved with the development of PCOS. Objective: The objective of this study is to summarize the existing knowledge in the literature in terms of the circulating kisspeptin concentration in PCOS women, kisspeptin and metabolic profiles in PCOS women,kisspeptin expression in PCOS animal models. Method: A systematic literature search was conducted using “Pubmed”, “Embase”, “Web of Science” for all English language articles published up to July 2018 with the terms “PCOS”, “Stein-Leventhal Syndrome”, “Polycystic ovary syndrome”, “metastins” and “kisspeptin”. Conclusion: Overall, kisspeptin level is higher in PCOS population, which supports the hypothesis that over-activated KISS1 system lead to an enhanced HPG-axis activity, thereby cause irregular menstrual cycle and excessive androgen release in PCOS women.

  • Kisspeptin and Polycystic Ovary Syndrome
    Frontiers Media S.A., 2019
    Co-Authors: Rong Tang, Xiaohong Ding, Jianghu Zhu
    Abstract:

    Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of Hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a Hypothalamic Peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation of luteinizing hormone (LH)/ follicular-stimulating hormone (FSH) secretion, which may be potentially involved with the development of PCOS.Objective: The objective of this study is to summarize the existing knowledge in the literature in terms of the circulating kisspeptin concentration in PCOS women, kisspeptin and metabolic profiles in PCOS women and kisspeptin expression in PCOS animal models.Method: A systematic literature search was conducted using “Pubmed,” “Embase,” “Web of Science” for all English language articles published up to July 2018 with the terms “PCOS,” “Stein-Leventhal Syndrome,” “Polycystic ovary syndrome,” “metastins” and “kisspeptin”.Conclusion: Overall, kisspeptin levels are higher in the PCOS population, which supports the hypothesis that an over-active KISS1 system leads to enhanced HPG-axis activity, thereby causing irregular menstrual cycles and excessive androgen release in PCOS women