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Gustav F Jirikowski - One of the best experts on this subject based on the ideXlab platform.

  • co transport of sex hormone binding globulin shbg with oxytocin in transport vesicles of the hypothalamo hypophyseal System
    Hormone and Metabolic Research, 2006
    Co-Authors: Z Herbert, E Pollak, L Molnar, Jack D Caldwell, Gustav F Jirikowski
    Abstract:

    The intrinsic expression of sex hormone binding globulin (SHBG) in magnocellular hypothalamic neurons, in part co-localized with either vasopressin or oxytocin, was recently described. This study is focused on the ultrastructural localization of SHBG in the hypothalamo-neurohypophyseal pathway in rats. Immunostaining for SHBG in the hypothalamic perikarya was increased by colchicine treatment, indicating that the steroid-binding globulin is subject to rapid axoplasmic transport along with the classical posterior lobe peptides. With immunoelectron-microscopic double labeling, we found co-localization of oxytocin and sex hormone binding globulin in a portion of the large dense-core vesicles in paraventricular and supraoptic perikarya and in axonal varicosities in the median eminence and in the posterior lobe. Our observations show that SHBG is processed, transported and stored along with oxytocin suggesting that SHBG is released from nerve terminals in the posterior lobe, the median eminence and possibly the brain similarly to and in conjunction with oxytocin.

Z Herbert - One of the best experts on this subject based on the ideXlab platform.

  • co transport of sex hormone binding globulin shbg with oxytocin in transport vesicles of the hypothalamo hypophyseal System
    Hormone and Metabolic Research, 2006
    Co-Authors: Z Herbert, E Pollak, L Molnar, Jack D Caldwell, Gustav F Jirikowski
    Abstract:

    The intrinsic expression of sex hormone binding globulin (SHBG) in magnocellular hypothalamic neurons, in part co-localized with either vasopressin or oxytocin, was recently described. This study is focused on the ultrastructural localization of SHBG in the hypothalamo-neurohypophyseal pathway in rats. Immunostaining for SHBG in the hypothalamic perikarya was increased by colchicine treatment, indicating that the steroid-binding globulin is subject to rapid axoplasmic transport along with the classical posterior lobe peptides. With immunoelectron-microscopic double labeling, we found co-localization of oxytocin and sex hormone binding globulin in a portion of the large dense-core vesicles in paraventricular and supraoptic perikarya and in axonal varicosities in the median eminence and in the posterior lobe. Our observations show that SHBG is processed, transported and stored along with oxytocin suggesting that SHBG is released from nerve terminals in the posterior lobe, the median eminence and possibly the brain similarly to and in conjunction with oxytocin.

Agustin Gonzalez - One of the best experts on this subject based on the ideXlab platform.

  • distribution of neuropeptide ff like immunoreactive structures in the lamprey central nervous System and its relation to catecholaminergic neuronal structures
    Peptides, 2006
    Co-Authors: Manuel A Pombal, Jesus M Lopez, Maria Del Carmen De Arriba, Manuel Megias, Agustin Gonzalez
    Abstract:

    The neuropeptide FF (NPFF) is an octapeptide of the RFamide-related peptides (FaRPs) that was primarily isolated from the bovine brain. Its distribution in the CNS has been reported in several mammalian species, as well as in some amphibians. Therefore, in order to gain insight in the evolution on the expression pattern of this neuropeptide in vertebrates, we carried out an immunohistochemical study in the sea lamprey, Petromyzon marinus. The distribution of NPFF-like-immunoreactive (NPFF-ir) structures in the lamprey brain is, in general, comparable to that previously described in other vertebrate species. In lamprey, most of the NPFF-ir cells were found in the hypothalamus, particularly in two large populations, the bed nucleus of the tract of the postoptic commissure and the tuberomammillary area. Numerous NPFF-ir cells were also observed in the rostral rhombencephalon, including a population in the dorsal isthmic gray and the reticular formation. Additional labeled neurons were found inside the preoptic region, the parapineal vesicle, the periventricular mesencephalic tegmentum, the descending trigeminal tract, the nucleus of the solitary tract, as well as in the gray matter of the spinal cord. The NPFF-ir fibers were widely distributed in the brain and the spinal cord, being, in general, more concentrated throughout the basal plate. The presence of NPFF-ir fibers in the lamprey neurohypophysis suggests that the involvement of NPFF-like substances in the Hypothalamo-Hypophyseal System had emerged early during evolution.

Adrio F. - One of the best experts on this subject based on the ideXlab platform.

  • Chemical neuroanatomy of the Hypothalamo-Hypophyseal System in sturgeons
    'Springer Science and Business Media LLC', 2018
    Co-Authors: Kah O., Adrio F.
    Abstract:

    International audienceThe preoptic-Hypothalamo-Hypophyseal System of sturgeons, located at the base of the brain, has a neurosecretory role exerted by hypophysiotropic neurons most of them located in the preoptic and hypothalamic periventricular region. The majority of those cells are of the cerebrospinal fluid-contacting type and exhibit short processes reaching the ventricular lumen. Moreover, the processes of those hypophysiotropic neurons course along the hypothalamic floor toward the hypophysis forming a preoptic-Hypothalamo-Hypophyseal tract. This chapter summarizes available data on the distribution of several hypophysiotropic factors, such as galanin, neurophysin, somatostatin, or gonadotropin-releasing hormone, in the preoptic-Hypothalamo-Hypophyseal System of sturgeons obtained by the use of immunohistochemical techniques. Immunoreactive neurons to those substances were found in the preoptic and hypothalamic nuclei, and immunoreactive fibers were observed along the preoptic-Hypothalamo-Hypophyseal tract and in the hypophysis, indicating their hypophysiotrophic role in the brain of sturgeons. Thus, most of the neuropeptides and neurohormones found in tetrapods are also present in sturgeons, suggesting that their common ancestors already possessed such regulatory Systems. Unfortunately, because of the difficulty in approaching the physiology of sturgeons (size, cost, etc.), the number of experimental studies aiming at deciphering the roles of such neuropeptides and neurohormones is very limited, although we can speculate that part of the functions supported by these neurohormones would be similar. © Springer International Publishing AG, part of Springer Nature 2018. All rights reserved

L Molnar - One of the best experts on this subject based on the ideXlab platform.

  • co transport of sex hormone binding globulin shbg with oxytocin in transport vesicles of the hypothalamo hypophyseal System
    Hormone and Metabolic Research, 2006
    Co-Authors: Z Herbert, E Pollak, L Molnar, Jack D Caldwell, Gustav F Jirikowski
    Abstract:

    The intrinsic expression of sex hormone binding globulin (SHBG) in magnocellular hypothalamic neurons, in part co-localized with either vasopressin or oxytocin, was recently described. This study is focused on the ultrastructural localization of SHBG in the hypothalamo-neurohypophyseal pathway in rats. Immunostaining for SHBG in the hypothalamic perikarya was increased by colchicine treatment, indicating that the steroid-binding globulin is subject to rapid axoplasmic transport along with the classical posterior lobe peptides. With immunoelectron-microscopic double labeling, we found co-localization of oxytocin and sex hormone binding globulin in a portion of the large dense-core vesicles in paraventricular and supraoptic perikarya and in axonal varicosities in the median eminence and in the posterior lobe. Our observations show that SHBG is processed, transported and stored along with oxytocin suggesting that SHBG is released from nerve terminals in the posterior lobe, the median eminence and possibly the brain similarly to and in conjunction with oxytocin.