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Seokwon Park - One of the best experts on this subject based on the ideXlab platform.
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regression of the increased common carotid artery intima media thickness in subclinical Hypothyroidism after thyroid hormone replacement
Endocrine Journal, 2009Co-Authors: Kyungsun Park, Seokwon ParkAbstract:The association between subclinical Hypothyroidism and cardiovascular disease and the beneficial effect of levothyroxine replacement in subclinical Hypothyroidism are still under debate. The present study was designed to determine whether subclinical Hypothyroidism is associated with an increase in the intima-media thickness of the common carotid artery (C-IMT) and whether thyroid hormone replacement can reverse this change in the C-IMT. Patients with newly-diagnosed subclinical (n=36) and overt (n=40) Hypothyroidism and healthy euthyroid individuals (n=32) participated in this study. All the patients were examined for clinical characteristics, and the serum lipid levels and the C-IMT were measured. Patients with subclinical Hypothyroidism had a C-IMT measurement after 18 months of levothyroxine replacement. There were meaningful differences in total cholesterol and LDL-cholesterol levels between patients with subclinical Hypothyroidism and euthyroidism. The subjects with subclinical and overt Hypothyroidism had a greater C-IMT compared with euthyroid controls (0.66± 0.10 and 0.70± 0.11 vs. 0.57± 0.08 mm, respectively; P < 0.05). After 12 months of euthyroidism, 28 of 36 patients with subclinical Hypothyroidism completed the follow-up study. Thyroid hormone replacement significantly decreased the C-IMT (0.67± 0.11 to 0.60± 0.10 mm; P = 0.021) and improved the lipid profile. Based on multiple regression analysis, the decrement in LDL-cholesterol was independently associated with the regression of the C-IMT. Subclinical Hypothyroidism was closely related to an increased C-IMT. Thyroid hormone replacement resulted in regression of the increased C-IMT, which was attributed to the improvement in the lipid profile.
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comparison of common carotid artery intima media thickness between subclinical Hypothyroidism and euthyroidism
Journal of Korean Endocrine Society, 2006Co-Authors: Kyungsun Park, Seokwon Park, Youngkil ChoiAbstract:Background: Common carotid artery intima-media thickness (IMT), which is increased in patients with overt Hypothyroidism, is an independent risk factor of the atherosclerosis-related disease. This study was performed to compare serum lipid level and common carotid artery IMT among patients with overt Hypothyroidism, subclinical Hypothyroidism and euthyroidism. Methods: Patients with newly-diagnosed subclinical (n=32) and overt (n=32) Hypothyroidism were selected for this study. All of the patients and an age- and sex-matched euthyroidism cohort were checked for clinical characteristics and serum lipid levels. Common carotid artery IMT was also measured using high resolution B-mode ultrasonography. Results: Statistically significant differences were observed between the total cholesterol levels of patients with subclinical Hypothyroidism and those with euthyroidism. When common carotid artery IMT measured by ultrasonography, subclinical (0.67 ± 0.11 mm) and overt (0.71 ± 0.12 mm)) Hypothyroidism showed significantly increased mean IMT compared to that of euthyroidism (0.58 ± 0.07 mm, P < 0.05, respectively), but no differences were found between subclinical and overt Hypothyroidism. Conclusion: We concluded that subclinical Hypothyroidism is related to increased common carotid artery IMT as well as dyslipidemia. Therefore, we recommend that treatment principle of subclinical Hypothyroidism be established through large-scale, prospective studies performed to determine the effect of thyroid hormone replacement on the reduction of common carotid artery IMT. (J Kor Endocrinol Soc 21:490~496, 2006)
Kyungsun Park - One of the best experts on this subject based on the ideXlab platform.
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regression of the increased common carotid artery intima media thickness in subclinical Hypothyroidism after thyroid hormone replacement
Endocrine Journal, 2009Co-Authors: Kyungsun Park, Seokwon ParkAbstract:The association between subclinical Hypothyroidism and cardiovascular disease and the beneficial effect of levothyroxine replacement in subclinical Hypothyroidism are still under debate. The present study was designed to determine whether subclinical Hypothyroidism is associated with an increase in the intima-media thickness of the common carotid artery (C-IMT) and whether thyroid hormone replacement can reverse this change in the C-IMT. Patients with newly-diagnosed subclinical (n=36) and overt (n=40) Hypothyroidism and healthy euthyroid individuals (n=32) participated in this study. All the patients were examined for clinical characteristics, and the serum lipid levels and the C-IMT were measured. Patients with subclinical Hypothyroidism had a C-IMT measurement after 18 months of levothyroxine replacement. There were meaningful differences in total cholesterol and LDL-cholesterol levels between patients with subclinical Hypothyroidism and euthyroidism. The subjects with subclinical and overt Hypothyroidism had a greater C-IMT compared with euthyroid controls (0.66± 0.10 and 0.70± 0.11 vs. 0.57± 0.08 mm, respectively; P < 0.05). After 12 months of euthyroidism, 28 of 36 patients with subclinical Hypothyroidism completed the follow-up study. Thyroid hormone replacement significantly decreased the C-IMT (0.67± 0.11 to 0.60± 0.10 mm; P = 0.021) and improved the lipid profile. Based on multiple regression analysis, the decrement in LDL-cholesterol was independently associated with the regression of the C-IMT. Subclinical Hypothyroidism was closely related to an increased C-IMT. Thyroid hormone replacement resulted in regression of the increased C-IMT, which was attributed to the improvement in the lipid profile.
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comparison of common carotid artery intima media thickness between subclinical Hypothyroidism and euthyroidism
Journal of Korean Endocrine Society, 2006Co-Authors: Kyungsun Park, Seokwon Park, Youngkil ChoiAbstract:Background: Common carotid artery intima-media thickness (IMT), which is increased in patients with overt Hypothyroidism, is an independent risk factor of the atherosclerosis-related disease. This study was performed to compare serum lipid level and common carotid artery IMT among patients with overt Hypothyroidism, subclinical Hypothyroidism and euthyroidism. Methods: Patients with newly-diagnosed subclinical (n=32) and overt (n=32) Hypothyroidism were selected for this study. All of the patients and an age- and sex-matched euthyroidism cohort were checked for clinical characteristics and serum lipid levels. Common carotid artery IMT was also measured using high resolution B-mode ultrasonography. Results: Statistically significant differences were observed between the total cholesterol levels of patients with subclinical Hypothyroidism and those with euthyroidism. When common carotid artery IMT measured by ultrasonography, subclinical (0.67 ± 0.11 mm) and overt (0.71 ± 0.12 mm)) Hypothyroidism showed significantly increased mean IMT compared to that of euthyroidism (0.58 ± 0.07 mm, P < 0.05, respectively), but no differences were found between subclinical and overt Hypothyroidism. Conclusion: We concluded that subclinical Hypothyroidism is related to increased common carotid artery IMT as well as dyslipidemia. Therefore, we recommend that treatment principle of subclinical Hypothyroidism be established through large-scale, prospective studies performed to determine the effect of thyroid hormone replacement on the reduction of common carotid artery IMT. (J Kor Endocrinol Soc 21:490~496, 2006)
Guizhi Lu - One of the best experts on this subject based on the ideXlab platform.
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distribution of immunoglobulin g subclasses of anti thyroid peroxidase antibody in sera from patients with hashimoto s thyroiditis with different thyroid functional status
Clinical and Experimental Immunology, 2008Co-Authors: Mengtao Li, Guizhi LuAbstract:Summary The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of IgG subclasses of TPOAb in sera from patients with HT with different thyroid functional status. Sera from 168 patients with newly diagnosed HT were collected and divided into three groups according to thyroid function: patients with Hypothyroidism (n = 66), subclinical Hypothyroidism (n = 60) and euthyroidism (n = 42). Antigen-specific enzyme-linked immunosorbent assay was used to detect the distribution of TPOAb IgG subclasses. The prevalence of TPOAb IgG subclasses in all patients’ sera with HT was IgG1 70·2%, IgG2 35·1%, IgG3 19·6% and IgG4 66·1% respectively. The prevalence of IgG2 in sera from patients with Hypothyroidism (51·5%) was significantly higher than that of subclinical Hypothyroidism (33·3%) (P < 0·05), and the latter was also significantly higher than that of euthyroidism (11·9%) (P < 0·05). The positive percentage of IgG2 subclass in sera from patients with Hypothyroidism and subclinical Hypothyroidism was significantly higher than that of euthyroidism (P < 0·05), the prevalence and positive percentage of IgG4 subclass in sera from patients with Hypothyroidism and subclinical Hypothyroidism was significantly higher than that of euthyroidism respectively (P < 0·05). The predominant TPOAb IgG subclasses in sera from patients with HT were IgG1 and IgG4. Patients with high levels of TPOAb IgG2, IgG4 subclasses might be at high risk of developing overt Hypothyroidism.
Jan Kvetny - One of the best experts on this subject based on the ideXlab platform.
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impaired fertility associated with subclinical Hypothyroidism and thyroid autoimmunity the danish general suburban population study
Journal of Pregnancy, 2015Co-Authors: Annedorthe Feldthusen, Palle Pedersen, Jacob Larsen, Tina Toft Kristensen, Christina Ellervik, Jan KvetnyAbstract:Introduction. The aim of this study was to estimate the significance of TSH, thyroid peroxidase antibody (TPOAb), and mild (subclinical) Hypothyroidism in women from The Danish General Suburban Population Study (GESUS) on the number of children born, the number of pregnancies, and the number of spontaneous abortions. Methods. Retrospective cross sectional study of 11254 women participating in GESUS. Data included biochemical measurements and a self-administrated questionnaire. Results. 6.7% had mild (subclinical) Hypothyroidism and 9.4% prevalent Hypothyroidism. In women with mild Hypothyroidism TPOAb was significantly elevated and age at first child was older compared to controls. TSH and TPOAb were negatively linearly associated with the number of children born and the number of pregnancies in the full cohort in age-adjusted and multiadjusted models. TSH or TPOAb was not associated with spontaneous abortions. Mild (subclinical) Hypothyroidism was associated with a risk of not having children and a risk of not getting pregnant in age-adjusted and multiadjusted models. Prevalent Hypothyroidism was not associated with the number of children born, the number of pregnancies, or spontaneous abortions. Conclusion. Impaired fertility is associated with TSH, TPOAb, and mild (subclinical) Hypothyroidism in a Danish population of women.
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subclinical Hypothyroidism is associated with a low grade inflammation increased triglyceride levels and predicts cardiovascular disease in males below 50 years
Clinical Endocrinology, 2004Co-Authors: Jan Kvetny, P E Heldgaard, Elsemarie Bladbjerg, J GramAbstract:OBJECTIVE Mild thyroid failure is associated with an increased risk for development of atherosclerosis, but whether subclinical Hypothyroidism is related to risk for cardiovascular disease is controversial. The purpose of the present study was to examine a possible association between subclinical Hypothyroidism and cardiovascular disease. DESIGN Cross-sectional study of a general population. PATIENTS Twelve hundred and twelve subjects, men and women, between 20 and 69 years old without thyroid disease not treated with drugs interfering with thyroid function or analysis of TSH were included. MEASUREMENTS Clinical signs of cardiovascular disease based on a questionnaire and medical records and laboratory analysis of lipids, atherothrombotic risk markers, C-reactive protein and TSH. RESULTS The main findings were a high incidence of subclinical Hypothyroidism (19.7%) in a general population. Subclinical Hypothyroidism was associated with higher concentrations of triglycerides and C-reactive protein. Below 50 years of age cardiovascular disease was more frequent in males with subclinical Hypothyroidism compared to euthyroid males. Subclinical Hypothyroidism was a predictor of cardiovascular disease in males below 50 years with an odds ratio of 3.4 (95% confidence interval 1.6-6.8) for developing cardiovascular disease compared to euthyroid age-matched males. CONCLUSION Our study demonstrates that patients with subclinical Hypothyroidism have increased levels of triglycerides and signs of low-grade inflammation (raised C-reactive protein levels) and that subclinical Hypothyroidism might be a risk factor for development of cardiovascular disease in younger males.
Julio Abucham - One of the best experts on this subject based on the ideXlab platform.
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diagnosis of subclinical central Hypothyroidism in patients with hypothalamic pituitary disease by doppler echocardiography
European Journal of Endocrinology, 2012Co-Authors: Fabio Luiz Casanova Doin, Mariana Rosaborges, Manoel Ricardo Alves Martins, Valdir Ambrosio Moises, Julio AbuchamAbstract:Objective: The diagnosis of subclinical central Hypothyroidism in hypothalamic–pituitary patients cannot be established by serum markers of thyroid hormone action. Myocardial function by echocardiography has been shown to reflect thyroid hormone action in primary thyroid dysfunction. We evaluated the performance of echocardiography in diagnosing subclinical central Hypothyroidism. Design: Cross-sectional and before and after. Methods: Echocardiography and serum thyroid hormones were assessed in overt primary (nZ20) and central (nZ10) Hypothyroidism, subclinical primary Hypothyroidism (nZ10), hypothalamic–pituitary disease with normal free thyroxine (FT4; nZ25), and controls (nZ28). Receiver operating characteristic (ROC) curves were generated using overt Hypothyroidism patients and selected cut-off values were applied to detect both primary and central subclinical Hypothyroidism. After levothyroxine (L-T4) intervention, patients were echocardiographically reevaluated at predefined targets: normal thyrotropin (TSH) in primary Hypothyroidism, normal FT4 in overt central Hypothyroidism, and higher than pretreatment FT4 in echo-defined subclinical central Hypothyroidism. Results: Parameters with highest areas under the ROC curves (area under the curve (AUC) R0.94) were as follows: isovolumic contraction time (ICT), ICT/ejection time (ET), and myocardial performance index. Highest diagnostic accuracy (93%) was obtained when at least one parameter was increased (positive and negative predictive values: 93%). Hypothyroidism was echocardiographically diagnosed in eight of ten patients with subclinical primary Hypothyroidism and in 14 of 25 patients (56%) with hypothalamic–pituitary disease and normal serum FT4. Echocardiographic abnormalities improved significantly after L-T4 and correlated (0.05!P!0.001) with changes in FT4 (K0.62!r!K0.55) and TSH (0.63!r!0.68) in primary Hypothyroidism and with FT4 in central Hypothyroidism (K0.72!r!K0.50). Conclusion: Echocardiography can be useful in diagnosing subclinical central Hypothyroidism in patients with hypothalamic–pituitary disease. European Journal of Endocrinology 166 631–640
