The Experts below are selected from a list of 1866 Experts worldwide ranked by ideXlab platform
Fiona Coyer - One of the best experts on this subject based on the ideXlab platform.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Faculty of Health; Institute of Health and Biomedical Innovation, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient.
Intensive care medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Intensive Care Medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
Natasha Koroloff - One of the best experts on this subject based on the ideXlab platform.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Faculty of Health; Institute of Health and Biomedical Innovation, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient.
Intensive care medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Intensive Care Medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
Kunikazu Moribe - One of the best experts on this subject based on the ideXlab platform.
-
Effect of Drug-Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance.
Molecular pharmaceutics, 2019Co-Authors: Yuya Ishizuka, Keisuke Ueda, Hitomi Okada, Junpei Takeda, Masatoshi Karashima, Koji Yazawa, Kenjirou Higashi, Kohsaku Kawakami, Yukihiro Ikeda, Kunikazu MoribeAbstract:The present study evaluated the specific intermolecular interactions between carbamazepine (CBZ) and substituents of Hypromellose acetate succinate (HPMC-AS), as well as the mechanism of inhibition of recrystallization of solid dispersions (SDs) using Fourier-transform infrared (FTIR) and solid-state nuclear magnetic resonance (NMR) spectroscopy. CBZ and HPMC derivatives, including HPMC, Hypromellose acetate (HPMC-A), and Hypromellose succinate (HPMC-S), were spray-dried to prepare CBZ/polymer spray-dried samples (SPDs). CBZ/HPMC SPD and CBZ/HPMC-A SPD recrystallized within 10 days at 60 °C and 0% relative humidity, whereas CBZ/HPMC-S SPD maintained its amorphous state for a longer period. FTIR and solid-state NMR measurements using 13C cross polarization (CP), 1H single-pulse, and 1H–15N CP-based heteronuclear single quantum correlation filter experiment with very fast magic angle spinning (MAS) at 70 kHz identified molecular interactions in CBZ/polymer SPDs. Although the HPMC backbone and substituents d...
-
Effect of Drug-Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance.
Molecular pharmaceutics, 2019Co-Authors: Yuya Ishizuka, Keisuke Ueda, Hitomi Okada, Junpei Takeda, Masatoshi Karashima, Koji Yazawa, Kenjirou Higashi, Kohsaku Kawakami, Yukihiro Ikeda, Kunikazu MoribeAbstract:The present study evaluated the specific intermolecular interactions between carbamazepine (CBZ) and substituents of Hypromellose acetate succinate (HPMC-AS), as well as the mechanism of inhibition...
-
Effect of Drug–Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance
2019Co-Authors: Yuya Ishizuka, Keisuke Ueda, Hitomi Okada, Junpei Takeda, Masatoshi Karashima, Koji Yazawa, Kenjirou Higashi, Kohsaku Kawakami, Yukihiro Ikeda, Kunikazu MoribeAbstract:The present study evaluated the specific intermolecular interactions between carbamazepine (CBZ) and substituents of Hypromellose acetate succinate (HPMC-AS), as well as the mechanism of inhibition of recrystallization of solid dispersions (SDs) using Fourier-transform infrared (FTIR) and solid-state nuclear magnetic resonance (NMR) spectroscopy. CBZ and HPMC derivatives, including HPMC, Hypromellose acetate (HPMC-A), and Hypromellose succinate (HPMC-S), were spray-dried to prepare CBZ/polymer spray-dried samples (SPDs). CBZ/HPMC SPD and CBZ/HPMC-A SPD recrystallized within 10 days at 60 °C and 0% relative humidity, whereas CBZ/HPMC-S SPD maintained its amorphous state for a longer period. FTIR and solid-state NMR measurements using 13C cross polarization (CP), 1H single-pulse, and 1H–15N CP-based heteronuclear single quantum correlation filter experiment with very fast magic angle spinning (MAS) at 70 kHz identified molecular interactions in CBZ/polymer SPDs. Although the HPMC backbone and substituents did not interact notably with CBZ and disrupt CBZ–CBZ intermolecular interactions (formed in the amorphous CBZ), acetate and succinate substituents on HPMC-A and HPMC-S disrupted CBZ–CBZ intermolecular interactions through formation of CBZ/polymer interactions. The acetate substituent formed a hydrogen bond with the NH2 group of CBZ, whereas the succinate substituent formed molecular interactions with both the CO and NH2 groups of CBZ. Formation of relatively strong molecular interactions between CBZ and the succinate substituent followed by disruption of CBZ–CBZ intermolecular interactions effectively stabilized the amorphous state of CBZ in CBZ/HPMC-S SPD. The correlation between CBZ–polymer interactions and ability of polymers to effectively inhibit CBZ recrystallization is reflected in various commercial HPMC-AS. For example, HPMC-AS LF grade, containing higher amounts of the succinate group, was found to effectively inhibit the recrystallization of CBZ through strong molecular interactions as compared with the HPMC-AS HF grade. The present study demonstrated that a detailed investigation of molecular interactions between the drug and the polymer using FTIR and solid-state NMR spectroscopy could contribute to a suitable selection of the SD carrier
Robert J. Boots - One of the best experts on this subject based on the ideXlab platform.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Faculty of Health; Institute of Health and Biomedical Innovation, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient.
Intensive care medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Intensive Care Medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
Jeffrey Lipman - One of the best experts on this subject based on the ideXlab platform.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Faculty of Health; Institute of Health and Biomedical Innovation, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients. Design Randomised-controlled trial. Setting University affiliated, tertiary referral hospital. Patients and participants One hundred ten patients with a reduced or absent blink reflex were followed through until they regained consciousness, were discharged from the facility during study enrolment, died or developed a positive corneal ulcer or eye infection. Interventions All patients received standard eye cleansing every 2 h. In addition to this, group one (n=60) received a treatment combining Hypromellose drops and Lacri-Lube (HL) to each eye every 2 h. Group two (n=50) had polyethylene covers only placed over the eye to create a moisture chamber. Measurements and results Corneal ulceration was determined using corneal fluorescein stains and mobile slit lamp evaluation, performed daily. No patients had corneal ulceration in the polyethylene cover group, but 4 patients had corneal ulceration in the HL group. Conclusions Polyethylene covers are as effective as HL in reducing the incidence of corneal damage in intensive care patients.
-
A randomised controlled study of the efficacy of Hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient.
Intensive care medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.
-
a randomised controlled study of the efficacy of Hypromellose and lacri lube combination versus polyethylene cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient
Intensive Care Medicine, 2004Co-Authors: Natasha Koroloff, Robert J. Boots, Jeffrey Lipman, Peter Thomas, Claire M. Rickard, Fiona CoyerAbstract:Objective To compare the efficacy of two forms of eye care (Hypromellose and Lacri-Lube combination vs polyethylene/Cling wrap covers) for intensive care patients.