The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Scott Mcnitt - One of the best experts on this subject based on the ideXlab platform.

  • relationship between age and inappropriate implantable cardioverter defibrillator therapy in madit rit multicenter automatic defibrillator implantation trial reduce inappropriate therapy
    Heart Rhythm, 2016
    Co-Authors: Arthur J Moss, Yitschak Biton, David T Huang, Ilan Goldenberg, Spencer Rosero, Valentina Kutyifa, Scott Mcnitt
    Abstract:

    Background There is limited data regarding the relationship between age and inappropriate therapy among patients with an implantable cardioverter-defibrillator (ICD) and resynchronization therapy. Objectives We aimed to investigate this relationship and the effect of ICD programming on inappropriate therapy by age. Methods In the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT) 1500 patients were randomized to 3 ICD programming arms: (A) conventional with ventricular tachycardia (VT) therapy ≥170; (B) high-rate cutoff with VT therapy ≥200, and (C) prolonged 60-second delay for VT therapy ≥170. We investigated the relationship between age, the risk of inappropriate ICD therapy (including antitachycardia pacing [ATP] or shock), and ICD programming. Results Cumulative incidence function Kaplan-Meier graphs showed an inverse relationship between increasing quartiles of age (Q1: ≤55, Q2: 56–64, Q3: 65–71, and Q4: ≥72 years) and the risk for inappropriate therapy. Multivariate analyses showed that each increasing decade of life was associated with 34% ( P P P P Conclusions Among patients with a primary prevention indication for an ICD, there is an inverse relationship between age and inappropriate ICD therapy. Innovative ICD programming of high-rate cutoff or prolonged delay for VT therapy is associated with significant reductions in inappropriate therapy among all age groups.

  • influence of diabetes mellitus on inappropriate and appropriate implantable cardioverter defibrillator therapy and mortality in the multicenter automatic defibrillator implantation trial reduce inappropriate therapy madit rit trial
    Circulation, 2013
    Co-Authors: Martin H Ruwald, Wojciech Zareba, Scott Mcnitt, Christian Jons, Claire Zhang, Annechristine Ruwald, Brian Olshansky, Poul Erik Bloch Thomsen, Morio Shoda, Bela Merkely
    Abstract:

    Background—The relationship between diabetes mellitus and risk of inappropriate or appropriate therapy in patients receiving an implantable cardioverter-defibrillator (ICD) and resynchronization therapy has not been investigated thoroughly. The effect of innovative ICD programming on therapy delivery in these patients is unknown. Methods and Results—The Multicenter Automatic Defibrillator Implantation Trial–Reduce Inappropriate Therapy (MADIT-RIT) randomized patients with a primary prophylactic ICD indication to 3 different types of ICD programming: conventional programming with a ventricular tachycardia zone of 170 to 199 bpm (arm A), high-rate cutoff with a ventricular tachycardia zone ≥200 bpm (arm B), or 60-second-delayed therapy (arm C). The end points of inappropriate therapy, appropriate therapy, and death were assessed among 485 patients with and 998 without diabetes mellitus. Innovative ICD programming reduced the risk of inappropriate therapy regardless of diabetes mellitus, although a trend tow...

  • effects of beta blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy from the multicenter automatic defibrillator implantation trial ii
    American Journal of Cardiology, 2005
    Co-Authors: William N Brodine, Robert T Tung, John K Lee, Eric Hockstad, Arthur J Moss, Wojciech Zareba, Jackson W Hall, Mark L Andrews, Scott Mcnitt, James P Daubert
    Abstract:

    This study examined the effects of beta blockers on (1) appropriate implantable cardioverter defibrillator (ICD) therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF), (2) inappropriate ICD therapy for atrial fibrillation or supraventricular tachycardia, and (3) survival in 691 patients who received ICDs in the Multicenter Automatic Defibrillator Implantation Trial-II. The study population involved 258 patients who were not receiving beta blockers and 433 who were receiving metoprolol (n = 192), atenolol (n = 58), or carvedilol (n = 182). Patients receiving beta blockers were divided into the upper quartile and lower 3 quartiles of the drug doses they were taking. Patients receiving the higher doses of beta blockers (those in the top quartile of doses) had a significant reduction in the risk for VT or VF requiring ICD therapy compared with patients not receiving beta blockers (hazard ratio 0.48, p = 0.02). The frequency of inappropriate ICD therapy for supraventricular tachyarrhythmias was not significantly different among the 3 treatment groups (p = 0.32). Beta-blocker use at the 2 dosage levels was associated with significant improvement in survival compared with the nonuse of beta blockers (hazard ratios 0.42 to 0.44, p <0.01). In conclusion, beta blockers reduce the risk for VT or VF and improve survival in ICD-treated patients with ischemic cardiomyopathy.

Yitschak Biton - One of the best experts on this subject based on the ideXlab platform.

  • relationship between age and inappropriate implantable cardioverter defibrillator therapy in madit rit multicenter automatic defibrillator implantation trial reduce inappropriate therapy
    Heart Rhythm, 2016
    Co-Authors: Arthur J Moss, Yitschak Biton, David T Huang, Ilan Goldenberg, Spencer Rosero, Valentina Kutyifa, Scott Mcnitt
    Abstract:

    Background There is limited data regarding the relationship between age and inappropriate therapy among patients with an implantable cardioverter-defibrillator (ICD) and resynchronization therapy. Objectives We aimed to investigate this relationship and the effect of ICD programming on inappropriate therapy by age. Methods In the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT) 1500 patients were randomized to 3 ICD programming arms: (A) conventional with ventricular tachycardia (VT) therapy ≥170; (B) high-rate cutoff with VT therapy ≥200, and (C) prolonged 60-second delay for VT therapy ≥170. We investigated the relationship between age, the risk of inappropriate ICD therapy (including antitachycardia pacing [ATP] or shock), and ICD programming. Results Cumulative incidence function Kaplan-Meier graphs showed an inverse relationship between increasing quartiles of age (Q1: ≤55, Q2: 56–64, Q3: 65–71, and Q4: ≥72 years) and the risk for inappropriate therapy. Multivariate analyses showed that each increasing decade of life was associated with 34% ( P P P P Conclusions Among patients with a primary prevention indication for an ICD, there is an inverse relationship between age and inappropriate ICD therapy. Innovative ICD programming of high-rate cutoff or prolonged delay for VT therapy is associated with significant reductions in inappropriate therapy among all age groups.

Bela Merkely - One of the best experts on this subject based on the ideXlab platform.

Wojciech Zareba - One of the best experts on this subject based on the ideXlab platform.

  • influence of diabetes mellitus on inappropriate and appropriate implantable cardioverter defibrillator therapy and mortality in the multicenter automatic defibrillator implantation trial reduce inappropriate therapy madit rit trial
    Circulation, 2013
    Co-Authors: Martin H Ruwald, Wojciech Zareba, Scott Mcnitt, Christian Jons, Claire Zhang, Annechristine Ruwald, Brian Olshansky, Poul Erik Bloch Thomsen, Morio Shoda, Bela Merkely
    Abstract:

    Background—The relationship between diabetes mellitus and risk of inappropriate or appropriate therapy in patients receiving an implantable cardioverter-defibrillator (ICD) and resynchronization therapy has not been investigated thoroughly. The effect of innovative ICD programming on therapy delivery in these patients is unknown. Methods and Results—The Multicenter Automatic Defibrillator Implantation Trial–Reduce Inappropriate Therapy (MADIT-RIT) randomized patients with a primary prophylactic ICD indication to 3 different types of ICD programming: conventional programming with a ventricular tachycardia zone of 170 to 199 bpm (arm A), high-rate cutoff with a ventricular tachycardia zone ≥200 bpm (arm B), or 60-second-delayed therapy (arm C). The end points of inappropriate therapy, appropriate therapy, and death were assessed among 485 patients with and 998 without diabetes mellitus. Innovative ICD programming reduced the risk of inappropriate therapy regardless of diabetes mellitus, although a trend tow...

  • effects of beta blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy from the multicenter automatic defibrillator implantation trial ii
    American Journal of Cardiology, 2005
    Co-Authors: William N Brodine, Robert T Tung, John K Lee, Eric Hockstad, Arthur J Moss, Wojciech Zareba, Jackson W Hall, Mark L Andrews, Scott Mcnitt, James P Daubert
    Abstract:

    This study examined the effects of beta blockers on (1) appropriate implantable cardioverter defibrillator (ICD) therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF), (2) inappropriate ICD therapy for atrial fibrillation or supraventricular tachycardia, and (3) survival in 691 patients who received ICDs in the Multicenter Automatic Defibrillator Implantation Trial-II. The study population involved 258 patients who were not receiving beta blockers and 433 who were receiving metoprolol (n = 192), atenolol (n = 58), or carvedilol (n = 182). Patients receiving beta blockers were divided into the upper quartile and lower 3 quartiles of the drug doses they were taking. Patients receiving the higher doses of beta blockers (those in the top quartile of doses) had a significant reduction in the risk for VT or VF requiring ICD therapy compared with patients not receiving beta blockers (hazard ratio 0.48, p = 0.02). The frequency of inappropriate ICD therapy for supraventricular tachyarrhythmias was not significantly different among the 3 treatment groups (p = 0.32). Beta-blocker use at the 2 dosage levels was associated with significant improvement in survival compared with the nonuse of beta blockers (hazard ratios 0.42 to 0.44, p <0.01). In conclusion, beta blockers reduce the risk for VT or VF and improve survival in ICD-treated patients with ischemic cardiomyopathy.

Arthur J Moss - One of the best experts on this subject based on the ideXlab platform.

  • relationship between age and inappropriate implantable cardioverter defibrillator therapy in madit rit multicenter automatic defibrillator implantation trial reduce inappropriate therapy
    Heart Rhythm, 2016
    Co-Authors: Arthur J Moss, Yitschak Biton, David T Huang, Ilan Goldenberg, Spencer Rosero, Valentina Kutyifa, Scott Mcnitt
    Abstract:

    Background There is limited data regarding the relationship between age and inappropriate therapy among patients with an implantable cardioverter-defibrillator (ICD) and resynchronization therapy. Objectives We aimed to investigate this relationship and the effect of ICD programming on inappropriate therapy by age. Methods In the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT) 1500 patients were randomized to 3 ICD programming arms: (A) conventional with ventricular tachycardia (VT) therapy ≥170; (B) high-rate cutoff with VT therapy ≥200, and (C) prolonged 60-second delay for VT therapy ≥170. We investigated the relationship between age, the risk of inappropriate ICD therapy (including antitachycardia pacing [ATP] or shock), and ICD programming. Results Cumulative incidence function Kaplan-Meier graphs showed an inverse relationship between increasing quartiles of age (Q1: ≤55, Q2: 56–64, Q3: 65–71, and Q4: ≥72 years) and the risk for inappropriate therapy. Multivariate analyses showed that each increasing decade of life was associated with 34% ( P P P P Conclusions Among patients with a primary prevention indication for an ICD, there is an inverse relationship between age and inappropriate ICD therapy. Innovative ICD programming of high-rate cutoff or prolonged delay for VT therapy is associated with significant reductions in inappropriate therapy among all age groups.

  • effects of beta blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy from the multicenter automatic defibrillator implantation trial ii
    American Journal of Cardiology, 2005
    Co-Authors: William N Brodine, Robert T Tung, John K Lee, Eric Hockstad, Arthur J Moss, Wojciech Zareba, Jackson W Hall, Mark L Andrews, Scott Mcnitt, James P Daubert
    Abstract:

    This study examined the effects of beta blockers on (1) appropriate implantable cardioverter defibrillator (ICD) therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF), (2) inappropriate ICD therapy for atrial fibrillation or supraventricular tachycardia, and (3) survival in 691 patients who received ICDs in the Multicenter Automatic Defibrillator Implantation Trial-II. The study population involved 258 patients who were not receiving beta blockers and 433 who were receiving metoprolol (n = 192), atenolol (n = 58), or carvedilol (n = 182). Patients receiving beta blockers were divided into the upper quartile and lower 3 quartiles of the drug doses they were taking. Patients receiving the higher doses of beta blockers (those in the top quartile of doses) had a significant reduction in the risk for VT or VF requiring ICD therapy compared with patients not receiving beta blockers (hazard ratio 0.48, p = 0.02). The frequency of inappropriate ICD therapy for supraventricular tachyarrhythmias was not significantly different among the 3 treatment groups (p = 0.32). Beta-blocker use at the 2 dosage levels was associated with significant improvement in survival compared with the nonuse of beta blockers (hazard ratios 0.42 to 0.44, p <0.01). In conclusion, beta blockers reduce the risk for VT or VF and improve survival in ICD-treated patients with ischemic cardiomyopathy.