Ichtadenovirus

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Mária Benkő - One of the best experts on this subject based on the ideXlab platform.

  • Adenoviruses across the animal kingdom: a walk in the zoo.
    FEBS Letters, 2019
    Co-Authors: Balázs Harrach, Zoltán László Tarján, Mária Benkő
    Abstract:

    Adenoviruses (AdVs) infect representatives of numerous species from almost every major vertebrate class, albeit their incidence shows great variability. AdVs infecting birds, reptiles, and bats are the most common and diverse, whereas only one AdV has been so far isolated both from fish and amphibians. The family Adenoviridae is divided into five genera, each corresponding to an independent evolutionary lineage that supposedly coevolved with its respective vertebrate hosts. Members of genera Mastadenovirus and Aviadenovirus seem to infect exclusively mammals and birds, respectively. The genus Ichtadenovirus includes the single known AdV from fish. The majority of AdVs in the genus Atadenovirus originated from squamate reptiles (lizards and snakes), but also certain mammalian and avian AdVs are classified within this genus. The genus Siadenovirus contains the only AdV isolated from frog, along with numerous avian AdVs. In turtles, members of a sixth AdV lineage have been discovered, pending official recognition as an independent genus. The most likely scenario for AdV evolution includes long-term cospeciation with the hosts, as well as occasional switches between closely or, rarely, more distantly related hosts.

  • unconventional gene arrangement and content revealed by full genome analysis of the white sturgeon adenovirus the single member of the genus Ichtadenovirus
    Infection Genetics and Evolution, 2019
    Co-Authors: Andor Doszpoly, Balázs Harrach, Scott E Lapatra, Mária Benkő
    Abstract:

    Abstract Adenoviruses are commonly found in members of almost every vertebrate lineage except fish and amphibians, from each of which only a single isolate is available as yet. In this work, the complete genomic sequence of a fish adenovirus, originating from the white sturgeon ( Acipenser transmontanus ), was determined and analyzed. Several exceptional features were observed including the longest hitherto known genome size (of 48,395 bp) and a strange location of the putative fiber genes resulting in an unconventional organization pattern. The left genome end contained four fiber-like genes, three of them in a tandem position on the r (rightward transcribed) strand, followed by a fourth one on the l strand. Rightward from these, the conserved adenoviral gene cassette, encompassing 16 family-common genes, was identified. In the right-hand part, amounting for >42% of the entire genome, the presence of 28 ORFs, with a coding capacity of larger than 50 amino acids, was revealed. Interestingly, most of these showed no similarity to any adenoviral genes except two ORFs, resembling slightly the parvoviral NS gene, homologues of which occur in certain avian adenoviruses. These specific traits, together with the results of phylogeny reconstructions, fully justified the separation of the white sturgeon adenovirus into the recently established new genus Ichtadenovirus . Targeted attempts to find additional adenoviruses in any other fish species were to no avail as yet. Thus the founding member, WSAdV-1 still remains the only representative of Ichtadenoviruses.

Andor Doszpoly - One of the best experts on this subject based on the ideXlab platform.

  • unconventional gene arrangement and content revealed by full genome analysis of the white sturgeon adenovirus the single member of the genus Ichtadenovirus
    Infection Genetics and Evolution, 2019
    Co-Authors: Andor Doszpoly, Balázs Harrach, Scott E Lapatra, Mária Benkő
    Abstract:

    Abstract Adenoviruses are commonly found in members of almost every vertebrate lineage except fish and amphibians, from each of which only a single isolate is available as yet. In this work, the complete genomic sequence of a fish adenovirus, originating from the white sturgeon ( Acipenser transmontanus ), was determined and analyzed. Several exceptional features were observed including the longest hitherto known genome size (of 48,395 bp) and a strange location of the putative fiber genes resulting in an unconventional organization pattern. The left genome end contained four fiber-like genes, three of them in a tandem position on the r (rightward transcribed) strand, followed by a fourth one on the l strand. Rightward from these, the conserved adenoviral gene cassette, encompassing 16 family-common genes, was identified. In the right-hand part, amounting for >42% of the entire genome, the presence of 28 ORFs, with a coding capacity of larger than 50 amino acids, was revealed. Interestingly, most of these showed no similarity to any adenoviral genes except two ORFs, resembling slightly the parvoviral NS gene, homologues of which occur in certain avian adenoviruses. These specific traits, together with the results of phylogeny reconstructions, fully justified the separation of the white sturgeon adenovirus into the recently established new genus Ichtadenovirus . Targeted attempts to find additional adenoviruses in any other fish species were to no avail as yet. Thus the founding member, WSAdV-1 still remains the only representative of Ichtadenoviruses.

Balázs Harrach - One of the best experts on this subject based on the ideXlab platform.

  • Adenoviruses across the animal kingdom: a walk in the zoo.
    FEBS Letters, 2019
    Co-Authors: Balázs Harrach, Zoltán László Tarján, Mária Benkő
    Abstract:

    Adenoviruses (AdVs) infect representatives of numerous species from almost every major vertebrate class, albeit their incidence shows great variability. AdVs infecting birds, reptiles, and bats are the most common and diverse, whereas only one AdV has been so far isolated both from fish and amphibians. The family Adenoviridae is divided into five genera, each corresponding to an independent evolutionary lineage that supposedly coevolved with its respective vertebrate hosts. Members of genera Mastadenovirus and Aviadenovirus seem to infect exclusively mammals and birds, respectively. The genus Ichtadenovirus includes the single known AdV from fish. The majority of AdVs in the genus Atadenovirus originated from squamate reptiles (lizards and snakes), but also certain mammalian and avian AdVs are classified within this genus. The genus Siadenovirus contains the only AdV isolated from frog, along with numerous avian AdVs. In turtles, members of a sixth AdV lineage have been discovered, pending official recognition as an independent genus. The most likely scenario for AdV evolution includes long-term cospeciation with the hosts, as well as occasional switches between closely or, rarely, more distantly related hosts.

  • unconventional gene arrangement and content revealed by full genome analysis of the white sturgeon adenovirus the single member of the genus Ichtadenovirus
    Infection Genetics and Evolution, 2019
    Co-Authors: Andor Doszpoly, Balázs Harrach, Scott E Lapatra, Mária Benkő
    Abstract:

    Abstract Adenoviruses are commonly found in members of almost every vertebrate lineage except fish and amphibians, from each of which only a single isolate is available as yet. In this work, the complete genomic sequence of a fish adenovirus, originating from the white sturgeon ( Acipenser transmontanus ), was determined and analyzed. Several exceptional features were observed including the longest hitherto known genome size (of 48,395 bp) and a strange location of the putative fiber genes resulting in an unconventional organization pattern. The left genome end contained four fiber-like genes, three of them in a tandem position on the r (rightward transcribed) strand, followed by a fourth one on the l strand. Rightward from these, the conserved adenoviral gene cassette, encompassing 16 family-common genes, was identified. In the right-hand part, amounting for >42% of the entire genome, the presence of 28 ORFs, with a coding capacity of larger than 50 amino acids, was revealed. Interestingly, most of these showed no similarity to any adenoviral genes except two ORFs, resembling slightly the parvoviral NS gene, homologues of which occur in certain avian adenoviruses. These specific traits, together with the results of phylogeny reconstructions, fully justified the separation of the white sturgeon adenovirus into the recently established new genus Ichtadenovirus . Targeted attempts to find additional adenoviruses in any other fish species were to no avail as yet. Thus the founding member, WSAdV-1 still remains the only representative of Ichtadenoviruses.

Scott E Lapatra - One of the best experts on this subject based on the ideXlab platform.

  • unconventional gene arrangement and content revealed by full genome analysis of the white sturgeon adenovirus the single member of the genus Ichtadenovirus
    Infection Genetics and Evolution, 2019
    Co-Authors: Andor Doszpoly, Balázs Harrach, Scott E Lapatra, Mária Benkő
    Abstract:

    Abstract Adenoviruses are commonly found in members of almost every vertebrate lineage except fish and amphibians, from each of which only a single isolate is available as yet. In this work, the complete genomic sequence of a fish adenovirus, originating from the white sturgeon ( Acipenser transmontanus ), was determined and analyzed. Several exceptional features were observed including the longest hitherto known genome size (of 48,395 bp) and a strange location of the putative fiber genes resulting in an unconventional organization pattern. The left genome end contained four fiber-like genes, three of them in a tandem position on the r (rightward transcribed) strand, followed by a fourth one on the l strand. Rightward from these, the conserved adenoviral gene cassette, encompassing 16 family-common genes, was identified. In the right-hand part, amounting for >42% of the entire genome, the presence of 28 ORFs, with a coding capacity of larger than 50 amino acids, was revealed. Interestingly, most of these showed no similarity to any adenoviral genes except two ORFs, resembling slightly the parvoviral NS gene, homologues of which occur in certain avian adenoviruses. These specific traits, together with the results of phylogeny reconstructions, fully justified the separation of the white sturgeon adenovirus into the recently established new genus Ichtadenovirus . Targeted attempts to find additional adenoviruses in any other fish species were to no avail as yet. Thus the founding member, WSAdV-1 still remains the only representative of Ichtadenoviruses.

É. Nagy - One of the best experts on this subject based on the ideXlab platform.

  • Adenoviruses of Fish
    Aquaculture Virology, 2020
    Co-Authors: É. Nagy
    Abstract:

    Abstract Adenoviruses have been isolated from humans and a wide range of animal species. However, infection of fish with adenoviruses is rather rare and only a few cases have been reported. These include epidermal hyperplasia in Atlantic cod and dab, and hyperplasia in Japanese red sea bream. The only known adenovirus disease is sturgeon wasting disease of cultured white sturgeon (Acipenser transmontanus) and this chronic infection is associated with white sturgeon adenovirus 1 (WSAdV-1). Sequence analysis of some genes of WSAdV-1 revealed the uniqueness of this virus that has served as the basis to establish a separate genus, Ichtadenovirus, within the family Adenoviridae.