Ictal Phenomena

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Antonio Gambardella - One of the best experts on this subject based on the ideXlab platform.

  • Age At Onset Predicts Good Seizure Outcome In Sporadic Non-Lesional and Mesial Temporal Sclerosis Based Temporal Lobe Epilepsy
    Journal of Neurology Neurosurgery and Psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Sara Gasperini, Aldo Quattrone, Antonio Gambardella
    Abstract:

    Purpose. To study prognosis and prognostic predictors of sporadic, non-lesional temporal lobe epilepsy (TLE). Method. Four hundred seventy-four patients with TLE were consecutively seen from April 1987 to April 2004. One hundred-ninety had a sporadic, non lesional TLE and a follow-up longer than two years. Two hundred eighty four patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2-hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS, and interIctal EEG. The end point was time to 24-month seizure freedom after treatment onset. Chi-square test, Student's t test, Kaplan-Meier survival curves with log-rank test (univariate analysis) and Cox proportional-hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results. At univariate analysis, patients achieving 24-month seizure freedom had significantly older age at onset of epilepsy (33.5 +19.9 vs. 17.2 +14.4 years), lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs. 35.6%). The chance of remission was directly correlated to the age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion. Older age at onset predicts better prognosis in sporadic, non-lesional TLE

  • Age at onset predicts good seizure outcome in sporadic non-lesional and mesial temporal sclerosis based temporal lobe epilepsy
    Journal of neurology neurosurgery and psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Aldo Quattrone, Sara Gasparini, Antonio Gambardella
    Abstract:

    Purpose To study prognosis and prognostic predictors of sporadic non-lesional temporal lobe epilepsy (TLE). Method 474 patients with TLE were consecutively seen from April 1987 to April 2004. 190 had a sporadic non-lesional TLE and a follow-up longer than 2 years. 284 patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2 hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS and interIctal EEG. The end point was time to 24 month seizure freedom after treatment onset. The χ 2 test, Student9s t test, Kaplan–Meier survival curves with log rank test (univariate analysis) and Cox proportional hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results At univariate analysis, patients achieving 24 month seizure freedom had a significantly older age at onset of epilepsy (33.5 ±19.9 vs 17.2 ±14.4 years), and lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs 35.6%). The chance of remission was directly correlated to age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion Older age at onset predicts better prognosis in sporadic non-lesional TLE.

  • Photic-induced epileptic negative myoclonus: a case report.
    Epilepsia, 1996
    Co-Authors: Antonio Gambardella, Umberto Aguglia, R. L. Oliveri, Franco Pucci, Mario Zappia, Aldo Quattrone
    Abstract:

    We present the first documented case of photic-induced epileptic negative myoclonus. A 17-year-old girl had experienced two generalized tonic-clonic seizures (GTCS) while watching television. The only EEG abnormality was a photoparoxysmal response (PPR), which was sometimes accompanied by loss of postural tone in both arms. Valproate was effective in abolishing photosensitivity. Negative myoclonus should be included among the Ictal Phenomena accompanying PPR.

Umberto Aguglia - One of the best experts on this subject based on the ideXlab platform.

  • Age At Onset Predicts Good Seizure Outcome In Sporadic Non-Lesional and Mesial Temporal Sclerosis Based Temporal Lobe Epilepsy
    Journal of Neurology Neurosurgery and Psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Sara Gasperini, Aldo Quattrone, Antonio Gambardella
    Abstract:

    Purpose. To study prognosis and prognostic predictors of sporadic, non-lesional temporal lobe epilepsy (TLE). Method. Four hundred seventy-four patients with TLE were consecutively seen from April 1987 to April 2004. One hundred-ninety had a sporadic, non lesional TLE and a follow-up longer than two years. Two hundred eighty four patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2-hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS, and interIctal EEG. The end point was time to 24-month seizure freedom after treatment onset. Chi-square test, Student's t test, Kaplan-Meier survival curves with log-rank test (univariate analysis) and Cox proportional-hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results. At univariate analysis, patients achieving 24-month seizure freedom had significantly older age at onset of epilepsy (33.5 +19.9 vs. 17.2 +14.4 years), lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs. 35.6%). The chance of remission was directly correlated to the age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion. Older age at onset predicts better prognosis in sporadic, non-lesional TLE

  • Age at onset predicts good seizure outcome in sporadic non-lesional and mesial temporal sclerosis based temporal lobe epilepsy
    Journal of neurology neurosurgery and psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Aldo Quattrone, Sara Gasparini, Antonio Gambardella
    Abstract:

    Purpose To study prognosis and prognostic predictors of sporadic non-lesional temporal lobe epilepsy (TLE). Method 474 patients with TLE were consecutively seen from April 1987 to April 2004. 190 had a sporadic non-lesional TLE and a follow-up longer than 2 years. 284 patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2 hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS and interIctal EEG. The end point was time to 24 month seizure freedom after treatment onset. The χ 2 test, Student9s t test, Kaplan–Meier survival curves with log rank test (univariate analysis) and Cox proportional hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results At univariate analysis, patients achieving 24 month seizure freedom had a significantly older age at onset of epilepsy (33.5 ±19.9 vs 17.2 ±14.4 years), and lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs 35.6%). The chance of remission was directly correlated to age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion Older age at onset predicts better prognosis in sporadic non-lesional TLE.

  • Photic-induced epileptic negative myoclonus: a case report.
    Epilepsia, 1996
    Co-Authors: Antonio Gambardella, Umberto Aguglia, R. L. Oliveri, Franco Pucci, Mario Zappia, Aldo Quattrone
    Abstract:

    We present the first documented case of photic-induced epileptic negative myoclonus. A 17-year-old girl had experienced two generalized tonic-clonic seizures (GTCS) while watching television. The only EEG abnormality was a photoparoxysmal response (PPR), which was sometimes accompanied by loss of postural tone in both arms. Valproate was effective in abolishing photosensitivity. Negative myoclonus should be included among the Ictal Phenomena accompanying PPR.

Aldo Quattrone - One of the best experts on this subject based on the ideXlab platform.

  • Age At Onset Predicts Good Seizure Outcome In Sporadic Non-Lesional and Mesial Temporal Sclerosis Based Temporal Lobe Epilepsy
    Journal of Neurology Neurosurgery and Psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Sara Gasperini, Aldo Quattrone, Antonio Gambardella
    Abstract:

    Purpose. To study prognosis and prognostic predictors of sporadic, non-lesional temporal lobe epilepsy (TLE). Method. Four hundred seventy-four patients with TLE were consecutively seen from April 1987 to April 2004. One hundred-ninety had a sporadic, non lesional TLE and a follow-up longer than two years. Two hundred eighty four patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2-hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS, and interIctal EEG. The end point was time to 24-month seizure freedom after treatment onset. Chi-square test, Student's t test, Kaplan-Meier survival curves with log-rank test (univariate analysis) and Cox proportional-hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results. At univariate analysis, patients achieving 24-month seizure freedom had significantly older age at onset of epilepsy (33.5 +19.9 vs. 17.2 +14.4 years), lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs. 35.6%). The chance of remission was directly correlated to the age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion. Older age at onset predicts better prognosis in sporadic, non-lesional TLE

  • Age at onset predicts good seizure outcome in sporadic non-lesional and mesial temporal sclerosis based temporal lobe epilepsy
    Journal of neurology neurosurgery and psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Aldo Quattrone, Sara Gasparini, Antonio Gambardella
    Abstract:

    Purpose To study prognosis and prognostic predictors of sporadic non-lesional temporal lobe epilepsy (TLE). Method 474 patients with TLE were consecutively seen from April 1987 to April 2004. 190 had a sporadic non-lesional TLE and a follow-up longer than 2 years. 284 patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2 hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS and interIctal EEG. The end point was time to 24 month seizure freedom after treatment onset. The χ 2 test, Student9s t test, Kaplan–Meier survival curves with log rank test (univariate analysis) and Cox proportional hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results At univariate analysis, patients achieving 24 month seizure freedom had a significantly older age at onset of epilepsy (33.5 ±19.9 vs 17.2 ±14.4 years), and lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs 35.6%). The chance of remission was directly correlated to age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion Older age at onset predicts better prognosis in sporadic non-lesional TLE.

  • Photic-induced epileptic negative myoclonus: a case report.
    Epilepsia, 1996
    Co-Authors: Antonio Gambardella, Umberto Aguglia, R. L. Oliveri, Franco Pucci, Mario Zappia, Aldo Quattrone
    Abstract:

    We present the first documented case of photic-induced epileptic negative myoclonus. A 17-year-old girl had experienced two generalized tonic-clonic seizures (GTCS) while watching television. The only EEG abnormality was a photoparoxysmal response (PPR), which was sometimes accompanied by loss of postural tone in both arms. Valproate was effective in abolishing photosensitivity. Negative myoclonus should be included among the Ictal Phenomena accompanying PPR.

Andreas Schulzebonhage - One of the best experts on this subject based on the ideXlab platform.

  • age dependent semiology of frontal lobe seizures
    Epilepsy Research, 2019
    Co-Authors: Mandy Hintz, Valentina Krenz, Andreas Schulzebonhage
    Abstract:

    Abstract Introduction Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of Ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not been analyzed so far. Material and methods We retrospectively analyzed video-documented semiological signs in a cohort of 122 consecutive patients aged 0–70 years (mean age: 24.9 years) with EEG/MR evidence for frontal lobe epilepsy undergoing video-EEG telemetry assessment between 1999 und 2016. Results In this patient cohort, most common etiologies were focal cortical dysplasia (48%) and tumors (16%). Most frequent Ictal manifestations overall were impaired language comprehension (60.3%), unilateral tonic posturing (58.9%), unilateral cloni (46.6%), versive movements (44.5%), vocalization (42.5%) and impaired reactivity to non-verbal stimuli (40.4%). With increasing age, sign of four (p = 0.019), dystonic posturing (p = 0.026), changes in heart rate (p = 0.014) and impaired reactivity to non-verbal stimuli (p = 0.009) occurred significantly more frequently. In contrast, myoclonic components were significantly less frequent observed in the higher age group (p = 0.037). Conclusions Frontal lobe seizures can be categorized into different behavioral manifestations related to involved symptomatic brain regions, including clonic, bilateral asymmetric tonic seizures and complex motor Phenomena. In this cross-sectional study, we found age-related changes in the frequency of both, motor and non-motor semiological elements. Especially simple lateralized motor signs like dystonic posturing, sign of four and version were more common with increasing age. Age-dependent alterations in phenomenology may reflect maturation in connectivity and seizure propagation within and beyond the frontal lobe, and affect the localizing and lateralizing value of Ictal Phenomena.

  • seizure anticipation by patients with focal and generalized epilepsy a multicentre assessment of premonitory symptoms
    Epilepsy Research, 2006
    Co-Authors: Andreas Schulzebonhage, Christoph Kurth, Astrid Carius, B J Steinhoff, Thomas Mayer
    Abstract:

    Abstract Purpose To assess subjective seizure anticipation in patients with focal and generalized epilepsy. Methods Five hundred consecutively recruited out-patients (251 male, 249 female, mean age 38.1 year) from three German tertiary epilepsy referral centres filled out questionnaires regarding subjective anticipation of seizures by at least 30 min and to timing and semiologic characteristics of their premonitory symptoms versus those of Ictal Phenomena. Patients were not regarded as having prodromi if the semiology of symptoms reported long before a seizure was identical to auras. Results 6.2% of patients reported that they were able to anticipate seizures. Premonitory symptoms were classified as stereotyped in all but one patient. An intraindividual semiologic analysis showed that the majority of these patients had symptoms, which were distinct from Ictal experiences during auras. Seizure anticipation was reported both by patients with focal and idiopathic generalized epilepsy. The median estimated time interval between occurrence of premonitory symptoms and seizure onset was 90 min. Conclusions This study gives evidence that both patients with focal and idiopathic generalized epilepsy may subjectively anticipate the occurrence of epileptic seizures. Premonitory symptoms are distinct from auras in terms of semiology and time of occurrence. The lower percentage of patients regarded as having premonitory symptoms as compared to some earlier reports may be related to stricter criteria and to the exclusion of auras, which could directly evolve into seizures, and other Ictal events. Premonitory symptoms occur at similar periods prior to seizures as anticipatory EEG-changes have been reported using methods from time series analysis.

Vittoria Cianci - One of the best experts on this subject based on the ideXlab platform.

  • Age At Onset Predicts Good Seizure Outcome In Sporadic Non-Lesional and Mesial Temporal Sclerosis Based Temporal Lobe Epilepsy
    Journal of Neurology Neurosurgery and Psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Sara Gasperini, Aldo Quattrone, Antonio Gambardella
    Abstract:

    Purpose. To study prognosis and prognostic predictors of sporadic, non-lesional temporal lobe epilepsy (TLE). Method. Four hundred seventy-four patients with TLE were consecutively seen from April 1987 to April 2004. One hundred-ninety had a sporadic, non lesional TLE and a follow-up longer than two years. Two hundred eighty four patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2-hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS, and interIctal EEG. The end point was time to 24-month seizure freedom after treatment onset. Chi-square test, Student's t test, Kaplan-Meier survival curves with log-rank test (univariate analysis) and Cox proportional-hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results. At univariate analysis, patients achieving 24-month seizure freedom had significantly older age at onset of epilepsy (33.5 +19.9 vs. 17.2 +14.4 years), lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs. 35.6%). The chance of remission was directly correlated to the age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion. Older age at onset predicts better prognosis in sporadic, non-lesional TLE

  • Age at onset predicts good seizure outcome in sporadic non-lesional and mesial temporal sclerosis based temporal lobe epilepsy
    Journal of neurology neurosurgery and psychiatry, 2010
    Co-Authors: Umberto Aguglia, Ettore Beghi, Angelo Labate, Francesca Condino, Vittoria Cianci, Laura Mumoli, Aldo Quattrone, Sara Gasparini, Antonio Gambardella
    Abstract:

    Purpose To study prognosis and prognostic predictors of sporadic non-lesional temporal lobe epilepsy (TLE). Method 474 patients with TLE were consecutively seen from April 1987 to April 2004. 190 had a sporadic non-lesional TLE and a follow-up longer than 2 years. 284 patients were excluded because of family history for TLE, incomplete history, poor compliance with treatment, psychogenic seizures, no brain MRI study, presence of intracranial lesions except for scattered T2 hyperintense spots on hemispheric white matter or mesial temporal sclerosis (MTS). The following prognostic predictors were considered: age at onset of epilepsy, gender, family history of non-TLE or febrile seizures, perinatal factors, history of febrile seizures, Ictal Phenomena, MTS and interIctal EEG. The end point was time to 24 month seizure freedom after treatment onset. The χ 2 test, Student9s t test, Kaplan–Meier survival curves with log rank test (univariate analysis) and Cox proportional hazards regression models (multivariate analysis) were used to assess seizure prognosis and prognostic predictors. Results At univariate analysis, patients achieving 24 month seizure freedom had a significantly older age at onset of epilepsy (33.5 ±19.9 vs 17.2 ±14.4 years), and lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs 35.6%). The chance of remission was directly correlated to age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion Older age at onset predicts better prognosis in sporadic non-lesional TLE.