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Yuan Shao - One of the best experts on this subject based on the ideXlab platform.
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il1a IL1B genetic polymorphisms are risk factors for thyroid cancer in a chinese han population
International Immunopharmacology, 2019Co-Authors: Na Duan, Qing Zhang, Yuan ShaoAbstract:Abstract Introduction Thyroid carcinoma accounts for a large proportion of endocrine neoplasia, and the relationship between inflammation and thyroid cancer has been previously validated. IL-1α (Interleukin 1 alpha) and IL-1β (Interleukin 1 beta), encoded by IL1A and IL1B, respectively, are implicated in numerous inflammatory responses and in tumor progression. The objective of this research was to assess the association of genetic polymorphisms of IL1A and IL1B with the risk of thyroid cancer in a Chinese Han population. Materials and methods Genotypes of the 12 candidate SNPs in IL1A and IL1B were identified among 208 thyroid cancer patients and 279 healthy controls using an Agena MassARRY method. Genetic model analysis was carried out to evaluate the significant links between the variants and thyroid cancer risk. HaploReg v4.1 and the GTEx database were used for SNP functional annotation and expression quantitative trait loci (eQTL) analysis, respectively. Results Significant associations were detected between IL1A rs3783521 and an increased thyroid cancer risk in our study population (p 48 years. Additionally, bioinformatics and eQTLs analysis also provided supporting evidence for the effects of the SNPs on gene regulation. Conclusions Our study is the first to report that IL1A and IL1B polymorphisms are risk factors for thyroid carcinoma in a Chinese Han population.
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IL1A & IL1B genetic polymorphisms are risk factors for thyroid cancer in a Chinese Han population.
International immunopharmacology, 2019Co-Authors: Na Duan, Qing Zhang, Yuan ShaoAbstract:Thyroid carcinoma accounts for a large proportion of endocrine neoplasia, and the relationship between inflammation and thyroid cancer has been previously validated. IL-1α (Interleukin 1 alpha) and IL-1β (Interleukin 1 beta), encoded by IL1A and IL1B, respectively, are implicated in numerous inflammatory responses and in tumor progression. The objective of this research was to assess the association of genetic polymorphisms of IL1A and IL1B with the risk of thyroid cancer in a Chinese Han population. Genotypes of the 12 candidate SNPs in IL1A and IL1B were identified among 208 thyroid cancer patients and 279 healthy controls using an Agena MassARRY method. Genetic model analysis was carried out to evaluate the significant links between the variants and thyroid cancer risk. HaploReg v4.1 and the GTEx database were used for SNP functional annotation and expression quantitative trait loci (eQTL) analysis, respectively. Significant associations were detected between IL1A rs3783521 and an increased thyroid cancer risk in our study population (p < 0.05). IL1A rs3783546 and rs3783521 were associated with an increased cancer risk in men, and IL1B rs3136558 and rs1143623 were associated with an decreased cancer risk in women. Meanwhile, rs3783550, rs3783546, rs1609682, and rs3783521 in IL1A were identified as biomarkers of risk among individuals aged ≤48 years. Rs3136558 and rs1143623 in the IL1B gene showed strong correlations with a susceptibility to thyroid cancer among individuals aged >48 years. Additionally, bioinformatics and eQTLs analysis also provided supporting evidence for the effects of the SNPs on gene regulation. Our study is the first to report that IL1A and IL1B polymorphisms are risk factors for thyroid carcinoma in a Chinese Han population. Copyright © 2019 Elsevier B.V. All rights reserved.
Yu Huei Liu - One of the best experts on this subject based on the ideXlab platform.
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association of interleukin 1β IL1B polymorphisms with graves ophthalmopathy in taiwan chinese patients
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Yu Huei Liu, Rong Hsing Chen, Wen Ling Liao, Wen Chi Chen, Yuhsin Tsai, Chang Hai Tsai, Lei WanAbstract:PURPOSE To evaluate whether variations in the IL1B gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease (GD). METHOD This case-control study included 471 Taiwan Chinese patients with GD (200 with GO and 271 without GO) and 160 healthy volunteers. Eight single-nucleotide polymorphisms (SNPs) in IL1B were genotyped with an allele-specific extension and ligation assay. RESULTS In the IL1B SNPs examined, the C allele of rs1143634 was associated with GD, whereas the T/T genotype of the SNPs rs1143634 and rs16944 were less associated with the disease. The A/A genotype of the SNPs rs3917368 and rs1143643, which had the strongest interaction, may increase the risk of GO (P = 0.024 and P = 0.017, respectively). Several GD susceptibility and insusceptibility IL1B haplotypes have been identified, and the Ht4-GCGCCTCC haplotype, composed of eight SNPs and associated with low circulating IL1β levels, may be protective against the development of GO (P = 0.025). Moreover, that the GO-susceptible genotype was associated with lower plasma IL1β concentrations implies that the origin of GO may go beyond the IL1B polymorphism-associated elevation of circulating IL1β. CONCLUSIONS The data for IL1B polymorphisms and the association of GD and GO with plasma IL1β levels show that IL1B polymorphisms may be associated with the development of GD and GO.
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Association Of interleukin-1β (IL1B) polymorphisms with graves' ophthalmopathy in Taiwan Chinese Patients
Investigative ophthalmology & visual science, 2010Co-Authors: Yu Huei Liu, Rong Hsing Chen, Wen Ling Liao, Wen Chi Chen, Yuhsin Tsai, Chang Hai Tsai, Lei Wan, Fuu Jen TsaiAbstract:To evaluate whether variations in the IL1B gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease (GD). This case-control study included 471 Taiwan Chinese patients with GD (200 with GO and 271 without GO) and 160 healthy volunteers. Eight single-nucleotide polymorphisms (SNPs) in IL1B were genotyped with an allele-specific extension and ligation assay. In the IL1B SNPs examined, the C allele of rs1143634 was associated with GD, whereas the T/T genotype of the SNPs rs1143634 and rs16944 were less associated with the disease. The A/A genotype of the SNPs rs3917368 and rs1143643, which had the strongest interaction, may increase the risk of GO (P = 0.024 and P = 0.017, respectively). Several GD susceptibility and insusceptibility IL1B haplotypes have been identified, and the Ht4-GCGCCTCC haplotype, composed of eight SNPs and associated with low circulating IL1β levels, may be protective against the development of GO (P = 0.025). Moreover, that the GO-susceptible genotype was associated with lower plasma IL1β concentrations implies that the origin of GO may go beyond the IL1B polymorphism-associated elevation of circulating IL1β. The data for IL1B polymorphisms and the association of GD and GO with plasma IL1β levels show that IL1B polymorphisms may be associated with the development of GD and GO.
Helmut H. Wolff - One of the best experts on this subject based on the ideXlab platform.
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investigation of selected cytokine genes suggests that il2ra and the tnf lta locus are risk factors for severe alopecia areata
British Journal of Dermatology, 2012Co-Authors: Silke Redler, F. Albert, Felix F. Brockschmidt, Christine Herold, Sandra Hanneken, Sibylle Eigelshoven, Kathrin A. Giehl, Rudolf Kruse, Gerhard Lutz, Helmut H. WolffAbstract:Summary Background Alopecia areata (AA) is the second most common cause of hair loss in humans, and has a genetically complex inheritance. The hypothesis that AA is autoimmune in nature is supported by previous studies. These report an association with specific HLA alleles, as well as genetic variants of other genes implicated in autoimmunity, such as various cytokine genes. However, these cannot yet be considered proven susceptibility loci, as many of these association findings were derived from small patient samples. Objectives To investigate the association between AA and selected cytokine genes using a sample of 768 patients with AA and 658 controls of Central European origin. Methods Eleven single-nucleotide polymorphisms (SNPs) from cytokine genes implicated in previous AA studies were genotyped. These genes were IL1B, IL1A, IL1RN, MIF, IFNG and the TNF/LTA gene region. We also genotyped 15 SNPs selected from cytokine genes that have shown significant association with other autoimmune diseases. These genes were IL10, IL36RN, IL12B, IL6, IL2, IL23, IL2RA and IL4R. Results Significant association was found for two variants within both IL2RA and TNF/LTA. In the overall sample, the most significant results were obtained for the IL2RA variant rs706778 (P = 0·00038) and the TNF/LTA locus variant rs1800629 (P = 0·0017). In subgroup analyses, according to severity, age at onset and family history these effects were stronger in the severely affected patients, with the lowest P-values being obtained for rs706778 (P = 3·8 × 10−6). Conclusions Our results point to the involvement of IL2RA and the TNF/LTA region in the aetiology of AA, in particular severe AA, and provide further support for the hypothesis that AA is autoimmune in nature.
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Investigation of selected cytokine genes suggests that IL2RA and the TNF/LTA locus are risk factors for severe alopecia areata
The British journal of dermatology, 2012Co-Authors: Silke Redler, F. Albert, Felix F. Brockschmidt, Christine Herold, Sandra Hanneken, Sibylle Eigelshoven, Kathrin A. Giehl, Rudolf Kruse, Gerhard Lutz, Helmut H. WolffAbstract:Summary Background Alopecia areata (AA) is the second most common cause of hair loss in humans, and has a genetically complex inheritance. The hypothesis that AA is autoimmune in nature is supported by previous studies. These report an association with specific HLA alleles, as well as genetic variants of other genes implicated in autoimmunity, such as various cytokine genes. However, these cannot yet be considered proven susceptibility loci, as many of these association findings were derived from small patient samples. Objectives To investigate the association between AA and selected cytokine genes using a sample of 768 patients with AA and 658 controls of Central European origin. Methods Eleven single-nucleotide polymorphisms (SNPs) from cytokine genes implicated in previous AA studies were genotyped. These genes were IL1B, IL1A, IL1RN, MIF, IFNG and the TNF/LTA gene region. We also genotyped 15 SNPs selected from cytokine genes that have shown significant association with other autoimmune diseases. These genes were IL10, IL36RN, IL12B, IL6, IL2, IL23, IL2RA and IL4R. Results Significant association was found for two variants within both IL2RA and TNF/LTA. In the overall sample, the most significant results were obtained for the IL2RA variant rs706778 (P = 0·00038) and the TNF/LTA locus variant rs1800629 (P = 0·0017). In subgroup analyses, according to severity, age at onset and family history these effects were stronger in the severely affected patients, with the lowest P-values being obtained for rs706778 (P = 3·8 × 10−6). Conclusions Our results point to the involvement of IL2RA and the TNF/LTA region in the aetiology of AA, in particular severe AA, and provide further support for the hypothesis that AA is autoimmune in nature.
Lei Wan - One of the best experts on this subject based on the ideXlab platform.
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association of interleukin 1β IL1B polymorphisms with graves ophthalmopathy in taiwan chinese patients
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Yu Huei Liu, Rong Hsing Chen, Wen Ling Liao, Wen Chi Chen, Yuhsin Tsai, Chang Hai Tsai, Lei WanAbstract:PURPOSE To evaluate whether variations in the IL1B gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease (GD). METHOD This case-control study included 471 Taiwan Chinese patients with GD (200 with GO and 271 without GO) and 160 healthy volunteers. Eight single-nucleotide polymorphisms (SNPs) in IL1B were genotyped with an allele-specific extension and ligation assay. RESULTS In the IL1B SNPs examined, the C allele of rs1143634 was associated with GD, whereas the T/T genotype of the SNPs rs1143634 and rs16944 were less associated with the disease. The A/A genotype of the SNPs rs3917368 and rs1143643, which had the strongest interaction, may increase the risk of GO (P = 0.024 and P = 0.017, respectively). Several GD susceptibility and insusceptibility IL1B haplotypes have been identified, and the Ht4-GCGCCTCC haplotype, composed of eight SNPs and associated with low circulating IL1β levels, may be protective against the development of GO (P = 0.025). Moreover, that the GO-susceptible genotype was associated with lower plasma IL1β concentrations implies that the origin of GO may go beyond the IL1B polymorphism-associated elevation of circulating IL1β. CONCLUSIONS The data for IL1B polymorphisms and the association of GD and GO with plasma IL1β levels show that IL1B polymorphisms may be associated with the development of GD and GO.
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Association Of interleukin-1β (IL1B) polymorphisms with graves' ophthalmopathy in Taiwan Chinese Patients
Investigative ophthalmology & visual science, 2010Co-Authors: Yu Huei Liu, Rong Hsing Chen, Wen Ling Liao, Wen Chi Chen, Yuhsin Tsai, Chang Hai Tsai, Lei Wan, Fuu Jen TsaiAbstract:To evaluate whether variations in the IL1B gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease (GD). This case-control study included 471 Taiwan Chinese patients with GD (200 with GO and 271 without GO) and 160 healthy volunteers. Eight single-nucleotide polymorphisms (SNPs) in IL1B were genotyped with an allele-specific extension and ligation assay. In the IL1B SNPs examined, the C allele of rs1143634 was associated with GD, whereas the T/T genotype of the SNPs rs1143634 and rs16944 were less associated with the disease. The A/A genotype of the SNPs rs3917368 and rs1143643, which had the strongest interaction, may increase the risk of GO (P = 0.024 and P = 0.017, respectively). Several GD susceptibility and insusceptibility IL1B haplotypes have been identified, and the Ht4-GCGCCTCC haplotype, composed of eight SNPs and associated with low circulating IL1β levels, may be protective against the development of GO (P = 0.025). Moreover, that the GO-susceptible genotype was associated with lower plasma IL1β concentrations implies that the origin of GO may go beyond the IL1B polymorphism-associated elevation of circulating IL1β. The data for IL1B polymorphisms and the association of GD and GO with plasma IL1β levels show that IL1B polymorphisms may be associated with the development of GD and GO.
Chang Hai Tsai - One of the best experts on this subject based on the ideXlab platform.
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association of interleukin 1β IL1B polymorphisms with graves ophthalmopathy in taiwan chinese patients
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Yu Huei Liu, Rong Hsing Chen, Wen Ling Liao, Wen Chi Chen, Yuhsin Tsai, Chang Hai Tsai, Lei WanAbstract:PURPOSE To evaluate whether variations in the IL1B gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease (GD). METHOD This case-control study included 471 Taiwan Chinese patients with GD (200 with GO and 271 without GO) and 160 healthy volunteers. Eight single-nucleotide polymorphisms (SNPs) in IL1B were genotyped with an allele-specific extension and ligation assay. RESULTS In the IL1B SNPs examined, the C allele of rs1143634 was associated with GD, whereas the T/T genotype of the SNPs rs1143634 and rs16944 were less associated with the disease. The A/A genotype of the SNPs rs3917368 and rs1143643, which had the strongest interaction, may increase the risk of GO (P = 0.024 and P = 0.017, respectively). Several GD susceptibility and insusceptibility IL1B haplotypes have been identified, and the Ht4-GCGCCTCC haplotype, composed of eight SNPs and associated with low circulating IL1β levels, may be protective against the development of GO (P = 0.025). Moreover, that the GO-susceptible genotype was associated with lower plasma IL1β concentrations implies that the origin of GO may go beyond the IL1B polymorphism-associated elevation of circulating IL1β. CONCLUSIONS The data for IL1B polymorphisms and the association of GD and GO with plasma IL1β levels show that IL1B polymorphisms may be associated with the development of GD and GO.
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Association Of interleukin-1β (IL1B) polymorphisms with graves' ophthalmopathy in Taiwan Chinese Patients
Investigative ophthalmology & visual science, 2010Co-Authors: Yu Huei Liu, Rong Hsing Chen, Wen Ling Liao, Wen Chi Chen, Yuhsin Tsai, Chang Hai Tsai, Lei Wan, Fuu Jen TsaiAbstract:To evaluate whether variations in the IL1B gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease (GD). This case-control study included 471 Taiwan Chinese patients with GD (200 with GO and 271 without GO) and 160 healthy volunteers. Eight single-nucleotide polymorphisms (SNPs) in IL1B were genotyped with an allele-specific extension and ligation assay. In the IL1B SNPs examined, the C allele of rs1143634 was associated with GD, whereas the T/T genotype of the SNPs rs1143634 and rs16944 were less associated with the disease. The A/A genotype of the SNPs rs3917368 and rs1143643, which had the strongest interaction, may increase the risk of GO (P = 0.024 and P = 0.017, respectively). Several GD susceptibility and insusceptibility IL1B haplotypes have been identified, and the Ht4-GCGCCTCC haplotype, composed of eight SNPs and associated with low circulating IL1β levels, may be protective against the development of GO (P = 0.025). Moreover, that the GO-susceptible genotype was associated with lower plasma IL1β concentrations implies that the origin of GO may go beyond the IL1B polymorphism-associated elevation of circulating IL1β. The data for IL1B polymorphisms and the association of GD and GO with plasma IL1β levels show that IL1B polymorphisms may be associated with the development of GD and GO.
