Ileum Disease

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M J Rapoport - One of the best experts on this subject based on the ideXlab platform.

  • enhanced glucose dependent glucagon like peptide 1 and insulin secretion in crohn patients with terminal Ileum Disease is unrelated to Disease activity or ileal resection
    Scandinavian Journal of Gastroenterology, 2004
    Co-Authors: N Bendet, E Scapa, Ohad Cohen, O Bloch, D Aharoni, Y Ramot, Mordechai Weiss, A Halevi, M J Rapoport
    Abstract:

    Background: Enhanced secretion of glucagon‐like peptide‐1 (GLP‐1) has been reported in patients with Crohn Disease (CD). However, the correlation between the enteropancreatic axis and the activity of CD remains unclear. Methods: Plasma glucose, insulin, GLP‐1 levels and insulin sensitivity were determined before and after oral glucose tolerance tests in 13 patients with CD of the terminal Ileum, in 13 patients after resection of the terminal Ileum and in 7 healthy controls. Basal and stimulated insulin sensitivities were determined using the homeostasis model assessment (HOMA) and the insulin sensitivity index (ISI) methods, respectively. Results: Basal and stimulated glucose levels were comparable in patients and controls. The peak stimulated GLP‐1 secretion was significantly higher in the patient group compared to controls: 12.2 ± 1.24 pM/L and 8.1 ± 1.72 pM/L, respectively, P = 0.03. This was associated with 52% increased overall insulin secretion in the patients' group as compared to controls (P = 0.0...

N Bendet - One of the best experts on this subject based on the ideXlab platform.

  • enhanced glucose dependent glucagon like peptide 1 and insulin secretion in crohn patients with terminal Ileum Disease is unrelated to Disease activity or ileal resection
    Scandinavian Journal of Gastroenterology, 2004
    Co-Authors: N Bendet, E Scapa, Ohad Cohen, O Bloch, D Aharoni, Y Ramot, Mordechai Weiss, A Halevi, M J Rapoport
    Abstract:

    Background: Enhanced secretion of glucagon‐like peptide‐1 (GLP‐1) has been reported in patients with Crohn Disease (CD). However, the correlation between the enteropancreatic axis and the activity of CD remains unclear. Methods: Plasma glucose, insulin, GLP‐1 levels and insulin sensitivity were determined before and after oral glucose tolerance tests in 13 patients with CD of the terminal Ileum, in 13 patients after resection of the terminal Ileum and in 7 healthy controls. Basal and stimulated insulin sensitivities were determined using the homeostasis model assessment (HOMA) and the insulin sensitivity index (ISI) methods, respectively. Results: Basal and stimulated glucose levels were comparable in patients and controls. The peak stimulated GLP‐1 secretion was significantly higher in the patient group compared to controls: 12.2 ± 1.24 pM/L and 8.1 ± 1.72 pM/L, respectively, P = 0.03. This was associated with 52% increased overall insulin secretion in the patients' group as compared to controls (P = 0.0...

E Scapa - One of the best experts on this subject based on the ideXlab platform.

  • enhanced glucose dependent glucagon like peptide 1 and insulin secretion in crohn patients with terminal Ileum Disease is unrelated to Disease activity or ileal resection
    Scandinavian Journal of Gastroenterology, 2004
    Co-Authors: N Bendet, E Scapa, Ohad Cohen, O Bloch, D Aharoni, Y Ramot, Mordechai Weiss, A Halevi, M J Rapoport
    Abstract:

    Background: Enhanced secretion of glucagon‐like peptide‐1 (GLP‐1) has been reported in patients with Crohn Disease (CD). However, the correlation between the enteropancreatic axis and the activity of CD remains unclear. Methods: Plasma glucose, insulin, GLP‐1 levels and insulin sensitivity were determined before and after oral glucose tolerance tests in 13 patients with CD of the terminal Ileum, in 13 patients after resection of the terminal Ileum and in 7 healthy controls. Basal and stimulated insulin sensitivities were determined using the homeostasis model assessment (HOMA) and the insulin sensitivity index (ISI) methods, respectively. Results: Basal and stimulated glucose levels were comparable in patients and controls. The peak stimulated GLP‐1 secretion was significantly higher in the patient group compared to controls: 12.2 ± 1.24 pM/L and 8.1 ± 1.72 pM/L, respectively, P = 0.03. This was associated with 52% increased overall insulin secretion in the patients' group as compared to controls (P = 0.0...

Ohad Cohen - One of the best experts on this subject based on the ideXlab platform.

  • enhanced glucose dependent glucagon like peptide 1 and insulin secretion in crohn patients with terminal Ileum Disease is unrelated to Disease activity or ileal resection
    Scandinavian Journal of Gastroenterology, 2004
    Co-Authors: N Bendet, E Scapa, Ohad Cohen, O Bloch, D Aharoni, Y Ramot, Mordechai Weiss, A Halevi, M J Rapoport
    Abstract:

    Background: Enhanced secretion of glucagon‐like peptide‐1 (GLP‐1) has been reported in patients with Crohn Disease (CD). However, the correlation between the enteropancreatic axis and the activity of CD remains unclear. Methods: Plasma glucose, insulin, GLP‐1 levels and insulin sensitivity were determined before and after oral glucose tolerance tests in 13 patients with CD of the terminal Ileum, in 13 patients after resection of the terminal Ileum and in 7 healthy controls. Basal and stimulated insulin sensitivities were determined using the homeostasis model assessment (HOMA) and the insulin sensitivity index (ISI) methods, respectively. Results: Basal and stimulated glucose levels were comparable in patients and controls. The peak stimulated GLP‐1 secretion was significantly higher in the patient group compared to controls: 12.2 ± 1.24 pM/L and 8.1 ± 1.72 pM/L, respectively, P = 0.03. This was associated with 52% increased overall insulin secretion in the patients' group as compared to controls (P = 0.0...

O Bloch - One of the best experts on this subject based on the ideXlab platform.

  • enhanced glucose dependent glucagon like peptide 1 and insulin secretion in crohn patients with terminal Ileum Disease is unrelated to Disease activity or ileal resection
    Scandinavian Journal of Gastroenterology, 2004
    Co-Authors: N Bendet, E Scapa, Ohad Cohen, O Bloch, D Aharoni, Y Ramot, Mordechai Weiss, A Halevi, M J Rapoport
    Abstract:

    Background: Enhanced secretion of glucagon‐like peptide‐1 (GLP‐1) has been reported in patients with Crohn Disease (CD). However, the correlation between the enteropancreatic axis and the activity of CD remains unclear. Methods: Plasma glucose, insulin, GLP‐1 levels and insulin sensitivity were determined before and after oral glucose tolerance tests in 13 patients with CD of the terminal Ileum, in 13 patients after resection of the terminal Ileum and in 7 healthy controls. Basal and stimulated insulin sensitivities were determined using the homeostasis model assessment (HOMA) and the insulin sensitivity index (ISI) methods, respectively. Results: Basal and stimulated glucose levels were comparable in patients and controls. The peak stimulated GLP‐1 secretion was significantly higher in the patient group compared to controls: 12.2 ± 1.24 pM/L and 8.1 ± 1.72 pM/L, respectively, P = 0.03. This was associated with 52% increased overall insulin secretion in the patients' group as compared to controls (P = 0.0...