The Experts below are selected from a list of 3477 Experts worldwide ranked by ideXlab platform
Robert J Smith - One of the best experts on this subject based on the ideXlab platform.
-
intestinal adaptation after extensive small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and Ileum
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...
-
Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in Ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.
Thomas R Ziegler - One of the best experts on this subject based on the ideXlab platform.
-
intestinal adaptation after extensive small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and Ileum
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...
-
Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in Ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.
Mark P Mantell - One of the best experts on this subject based on the ideXlab platform.
-
intestinal adaptation after extensive small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and Ileum
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...
-
Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in Ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.
Jessie C Chow - One of the best experts on this subject based on the ideXlab platform.
-
intestinal adaptation after extensive small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and Ileum
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...
-
Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in Ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.
John L Rombeau - One of the best experts on this subject based on the ideXlab platform.
-
intestinal adaptation after extensive small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and Ileum
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...
-
Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
Endocrinology, 1998Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J SmithAbstract:The distal small bowel exhibits greater adaptive growth than proximal segments after partial small intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and Ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in Ileum. Resection increased IGF-I mRNA in both jejunum (183%) and Ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in Ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in Ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.
