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Shi-wen Wang - One of the best experts on this subject based on the ideXlab platform.

  • Effects of Imidapril on heterogeneity of action potential and calcium current of ventricular myocytes in infarcted rabbits.
    Acta pharmacologica Sinica, 2004
    Co-Authors: Qiao Xue, Cun-tai Zhang, Ping Qiu, Lin Wang, Wei Gao, Rei Cheng, Shi-wen Wang
    Abstract:

    AIM: To investigate the effects of chronic treatment with Imidapril on the electrophysiologic heterogeneous change of the noninfarcted myocardium of rabbits after myocardial infarction and the mechanism of its antiarrhythmic efficacy. METHODS: Rabbits with left coronary artery ligation were prepared and allowed to recover for 8 weeks. Myocytes were isolated from subendocardial, midmyocardial, and subepicardial regions of the noninfarcted left ventricular wall. Action potentials and calcium current were recorded using whole-cell patch clamp technique. RESULTS: The action potential duration of repolarization 90 % (APD 9 0 ) was more prolonged in midmyocardium rather than in subepicardium and subendocardium with healed myocardial infarction. The transmural dispersion of repolarization (TDR) was increased in the three ventricular regions. The amplitude of I C a - L was enhanced but its density was decreased in noninfarcted ventricular myocytes due to increased cell membrane capacitance. The increased differences of calcium currents among subepicardium, midmyocardium, and subendocardium were also discovered. Normalization of heterogeneous changes in repolarization after treatment with Imidapril was observed and decrease of TDR in noninfarcted area was measured. Early after depolarization (EAD) events of noninfarcted midmyocardium were markedly decreased by Imidapril. CONCLUSION: Imidapril reduced the electrophysiologic heterogeneities in noninfarcted area in rabbits after myocardial infarction. This ability of Imidapril may contribute to its antiarrhythmic efficacy.

Hiroshi Iwao - One of the best experts on this subject based on the ideXlab platform.

  • Imidapril inhibits increased transforming growth factor-β1 expression in remnant kidney model
    European journal of pharmacology, 1997
    Co-Authors: Akinori Hamaguchi, Shokei Kim, Hideki Wanibuchi, Hiroshi Iwao
    Abstract:

    Abstract To elucidate the effect of Imidapril, an angiotensin-converting enzyme inhibitor, on molecular events in progressive glomerulosclerosis, we administered Imidapril to 5/6 nephrectomized rats and measured the glomerular expression of genes for transforming growth factor (TGF)-β1, fibronectin and collagen IV. Glomerular TGF-β1, fibronectin and collagen IV mRNAs in nephrectomized rats were significantly higher than those in sham-operated rats. Treatment with Imidapril for 10 weeks significantly reduced the enhanced glomerular expression of TGF-β1 and collagen IV mRNA in nephrectomized rats, and prevented the associated proteinuria and glomerulosclerosis. Thus, Imidapril may arrest progressive glomerulosclerosis by inhibiting the expression of TGF-β1 and collagen IV.

Qiao Xue - One of the best experts on this subject based on the ideXlab platform.

  • Effects of Imidapril on heterogeneity of action potential and calcium current of ventricular myocytes in infarcted rabbits.
    Acta pharmacologica Sinica, 2004
    Co-Authors: Qiao Xue, Cun-tai Zhang, Ping Qiu, Lin Wang, Wei Gao, Rei Cheng, Shi-wen Wang
    Abstract:

    AIM: To investigate the effects of chronic treatment with Imidapril on the electrophysiologic heterogeneous change of the noninfarcted myocardium of rabbits after myocardial infarction and the mechanism of its antiarrhythmic efficacy. METHODS: Rabbits with left coronary artery ligation were prepared and allowed to recover for 8 weeks. Myocytes were isolated from subendocardial, midmyocardial, and subepicardial regions of the noninfarcted left ventricular wall. Action potentials and calcium current were recorded using whole-cell patch clamp technique. RESULTS: The action potential duration of repolarization 90 % (APD 9 0 ) was more prolonged in midmyocardium rather than in subepicardium and subendocardium with healed myocardial infarction. The transmural dispersion of repolarization (TDR) was increased in the three ventricular regions. The amplitude of I C a - L was enhanced but its density was decreased in noninfarcted ventricular myocytes due to increased cell membrane capacitance. The increased differences of calcium currents among subepicardium, midmyocardium, and subendocardium were also discovered. Normalization of heterogeneous changes in repolarization after treatment with Imidapril was observed and decrease of TDR in noninfarcted area was measured. Early after depolarization (EAD) events of noninfarcted midmyocardium were markedly decreased by Imidapril. CONCLUSION: Imidapril reduced the electrophysiologic heterogeneities in noninfarcted area in rabbits after myocardial infarction. This ability of Imidapril may contribute to its antiarrhythmic efficacy.

Jin-ming Wang - One of the best experts on this subject based on the ideXlab platform.

  • diverse effects of long term treatment with Imidapril and irbesartan on cell growth signal apoptosis and collagen type i expression in the left ventricle of spontaneously hypertensive rats
    Life Sciences, 2004
    Co-Authors: Jin-ming Wang, Zhong-sheng Zhu, Ying Wang, Meichun Zhang, Yi Zou, Xuejun Jiang
    Abstract:

    To compare diverse effects of angiotensin II type 1 receptor antagonists (irbesartan) and angiotensin converting enzyme inhibitors (Imidapril) on left ventricular remodeling in spontaneously hypertensive rats (SHR). Thirty male SHR were randomly divided into three groups: SHR-IR (treated with irbesartan, 50 mg/kg), SHR-IM (Imidapril, 3 mg/kg), SHR-C (placebo). Ten male Wistar Kyoto rats (WKY) treated with placebo acted as the control. All treatments were administered once daily from 14 to 27 weeks of age. Imidapril and irbesartan have the similar inhibitor effects on blood pressure and left ventricular mass indexes in SHR. Despite both drugs suppressed ERK-1 protein expression, decreased cardiomyocytes apoptosis index, blocked collagen type I deposition, reduced TGF-β1 gene expression in SHR, Imidapril elicits a stronger inhibitory effect. Irbesartan had little effect on MKP-1 protein expression, but Imidapril decreased it significantly. As a result, the ERK-1/MKP-1 ratio in SHR-IR was significantly greater than that in SHR-IM (P < 0.05). These results suggest that the balance between MKP-1 and ERKs in myocardial tissue is important for cardiac cell proliferation and growth. They also indicate that the similar efficacy of antihypertensive treatment in reducing blood pressure does not predict the similar capacity to control the individual facet of left ventricular remodeling. Irbesartan is more effective in regressing the homeostasis between ERK-1 and MKP-1, however Imidapril is superior in suppressing apoptosis and collagen synthesis in cardiac tissue.

  • Mesenteric artery remodeling and effects of Imidapril and irbesartan on it in spontaneously hypertensive rats.
    World journal of gastroenterology, 2004
    Co-Authors: Zhong-sheng Zhu, Jin-ming Wang, Shao-liang Chen
    Abstract:

    AIM: To investigate the remodeling of mesenteric artery and the expression of TGF-β1, c-Jun in mesenteric artery and effects of Imidapril and irbesartan on the remodeling in spontaneously hypertensive rats (SHR). METHODS: Thirty SHR (male/female, 21/9), aged 13 wk, were randomly divided into 3 groups (7 male rats and 3 female rats each group): SHR group, Imidapril group (Imidapril 3 mg/kg·d was given in drinking water for 14 wk), and irbesartan group (irbesartan 50 mg/kg·d was given in drinking water foe 14 wk). Ten homogenous Wistar Kyoto rats, 5 males and 5 females, weighing 206 ± 49 g, were selected as normal control group (WKY group). Systolic pressure was measured on day 1, 2, 4, 6, 8, 10, 12 and 14 during the experiment and the rats were killed at the end of the experiment. Angiotensin II (Ang II) level in plasma and mesenteric arteries was measured by radioimmunoassay. The morphology of the secondary branches of mesenteric artery were examined by light microscopy and electron microscopy. Reverse transcription polymerase chain reaction (RT-PCR) was used to detect the expression of transforming growth factor TGF-β1 and c-Jun mRNA. RESULTS: Compared with Imidapril group and irbesartan group, the blood pressure was remarkably increased in SHR group. Ang II level in plasma and mesenteric arteries in SHR group was the same or lower than that in WKY group, and was higher in irbesartan group and lower in Imidapril group. The remodeling of mesenteric arteries in SHR group was mostly obvious among the 4 groups. The ratio of TGF-β1 absorbed light value to GAPDH absorbed light value in the SHR group was 0.887 ± 0.019, which was significantly higher than that in WKY group, Imidapril group, and irbesartan group with the ratios of 0.780 ± 0.018, 0.803 ± 0.005, and 0.847 ± 0.017, respectively (P < 0.01). Ang II level in plasma and mesenteric arteries in Imidapril group was significantly lower than that in irbesartan group (P < 0.05). The c-Jun absorbed light value/GAPDH absorbed light value of mesenteric arteries in the SHR group was 0.850 ± 0.015, which was significantly higher than that in the WKY, Imidapril, and irbesartan groups (0.582 ± 0.013, 0.743 ± 0.012, and 0.789 ± 0.013, respectively, P < 0.01), and was significantly lower in Imidapril group than in irbesartan group (P < 0.05). CONCLUSION: Imidapril and irbesartan can not only control blood pressure but also inhibit mesenteric arteries remodeling and mRNA expression of TGF-β1, c-Jun in SHR. Imidapril is more effective than irbesartan.

Xuejun Jiang - One of the best experts on this subject based on the ideXlab platform.

  • diverse effects of long term treatment with Imidapril and irbesartan on cell growth signal apoptosis and collagen type i expression in the left ventricle of spontaneously hypertensive rats
    Life Sciences, 2004
    Co-Authors: Jin-ming Wang, Zhong-sheng Zhu, Ying Wang, Meichun Zhang, Yi Zou, Xuejun Jiang
    Abstract:

    To compare diverse effects of angiotensin II type 1 receptor antagonists (irbesartan) and angiotensin converting enzyme inhibitors (Imidapril) on left ventricular remodeling in spontaneously hypertensive rats (SHR). Thirty male SHR were randomly divided into three groups: SHR-IR (treated with irbesartan, 50 mg/kg), SHR-IM (Imidapril, 3 mg/kg), SHR-C (placebo). Ten male Wistar Kyoto rats (WKY) treated with placebo acted as the control. All treatments were administered once daily from 14 to 27 weeks of age. Imidapril and irbesartan have the similar inhibitor effects on blood pressure and left ventricular mass indexes in SHR. Despite both drugs suppressed ERK-1 protein expression, decreased cardiomyocytes apoptosis index, blocked collagen type I deposition, reduced TGF-β1 gene expression in SHR, Imidapril elicits a stronger inhibitory effect. Irbesartan had little effect on MKP-1 protein expression, but Imidapril decreased it significantly. As a result, the ERK-1/MKP-1 ratio in SHR-IR was significantly greater than that in SHR-IM (P < 0.05). These results suggest that the balance between MKP-1 and ERKs in myocardial tissue is important for cardiac cell proliferation and growth. They also indicate that the similar efficacy of antihypertensive treatment in reducing blood pressure does not predict the similar capacity to control the individual facet of left ventricular remodeling. Irbesartan is more effective in regressing the homeostasis between ERK-1 and MKP-1, however Imidapril is superior in suppressing apoptosis and collagen synthesis in cardiac tissue.