Imidazole Derivative

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Marimuthu Venkatesh Perumal - One of the best experts on this subject based on the ideXlab platform.

  • Studies on interaction between an Imidazole Derivative and bovine serum by spectral methods
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2012
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract The interaction between a trifluoromethyl substituted Imidazole Derivative 2-(4-(trifluoromethyl)phenyl)-1-phenyl-1H-imidazo[4,5-f] [1,10] phenanthroline (tfmppip) and bovine serum albumin (BSA) was investigated by solution spectral studies. The observed experimental result shows that the Imidazole Derivative has strong ability to quench the fluorescence of BSA by forming complex which is stabilized by electrostatic interactions. The effective quenching constants ( k sv ) were 2.79 × 10 4 , 2.51 × 10 4 , and 2.32 × 10 4 at 301, 310 and 318 K respectively. The Stern–Volmer quenching constant ( K sv ), binding site number ( n) , apparent binding constant ( K A ) and corresponding thermodynamic parameters (Δ G , Δ H and Δ S ) were calculated. The distance between the donor (BSA) and acceptor (tfmppip) was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence technique. The effect of metal ions such as Cu 2+ , Zn 2+ , Ca 2+ , Mg 2+ , Ni 2+ , Co 2+ and Fe 2+ on the binding constants between the Imidazole Derivative and BSA were also studied.

  • A study on the binding interaction between the Imidazole Derivative and bovine serum albumin by fluorescence spectroscopy
    Journal of Luminescence, 2012
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract The interaction between the Imidazole Derivative 2-(2,4-difluorophenyl)-1-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline (dfppip) and bovine serum albumin (BSA) was investigated by fluorescence and UV–vis absorbance spectroscopy. From the experimental results, it was found that the Imidazole Derivative has strong ability to quench the intrinsic fluorescence of BSA by forming complexes. Electrostatic interactions play an important role to stabilize the complex. The binding constants and the number of binding sites have been determined in detail. The distance (r) between the donor and the acceptor was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence spectroscopy. The effect of metal ions such as Cu 2+ , Zn 2+ , Ca 2+ , Mg 2+ , Ni 2+ , Co 2+ and Fe 2+ on the binding constants between the Imidazole Derivative and BSA were also studied.

  • Synthesis, spectral studies and solvatochromic analysis of novel Imidazole Derivatives
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2011
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Natesan Srinivasan, Marimuthu Venkatesh Perumal
    Abstract:

    Bioactive Imidazole Derivatives were synthesized and characterized by spectral techniques. The photophysical properties of Imidazole Derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the Imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive Imidazole Derivative and bovine serum albumin (BSA) was also investigated.

  • Physicochemical and solvatochromic analysis of an Imidazole Derivative as NLO material.
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2011
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract Bioactive Imidazole Derivative, 2-(2,4-difluorophenyl)-1-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline, has been synthesized and characterized by IR, UV–vis, NMR and elemental (CHN) analysis. The electric dipole moment (μ) and the hyperpolarizability (β) have been studied both experimentally and theoretically, which reveals that the synthesized Imidazole Derivative possesses non-linear optical (NLO) behavior. This chromophore possess more appropriate ratio of off-diagonal versus diagonal β tensorial component (r = βxyy/βxxx = −0.19) which reflects the in plane nonlinearity anisotropy. Since they have largest μβ0 value, the reported Imidazole can be used as potential NLO material. Within this context, reasonable conclusions concerning the steric hindrance in the chromospheres, push–pull character, hyperpolarizability of the Imidazole and their application as NLO materials will be drawn. The solvent effect on the absorption and fluorescence bands was analyzed by a multi-component linear regression in which several solvent parameters were analyzed simultaneously.

  • fluorescence resonance energy transfer from a bio active Imidazole Derivative 2 1 phenyl 1h imidazo 4 5 f 1 10 phenanthrolin 2 yl phenol to a bioactive indoloquinolizine system
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011
    Co-Authors: J Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal, Natesan Srinivasan
    Abstract:

    Abstract Novel donor Imidazole Derivative, 2-(1-phenyl-1H-imidazo [4,5-f][1,10]phenanthrolin-2-yl)-phenol (PIPP) was screened as highly sensitive chemisensor for transition metal ions and it can be used as a “multi-way” optically switchable material. Solvatochromic effects on the fluorescence behaviour of PIPP were studied in different solvents. The fluorescence of PIPP was highly sensitive to both the polarity as well as protic nature of the solvent. Fluorescence (Forster) resonance energy transfer (FRET) process from PIPP to a potent bioactive indoloquinolizine molecule was studied and it is argued that long-range dipole–dipole interaction is operating for the energy transfer mechanism. The energy transfer efficiency (E) and the distance between the acceptor and the donor (r0) have been determined.

Jayaraman Jayabharathi - One of the best experts on this subject based on the ideXlab platform.

  • Studies on interaction between an Imidazole Derivative and bovine serum by spectral methods
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2012
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract The interaction between a trifluoromethyl substituted Imidazole Derivative 2-(4-(trifluoromethyl)phenyl)-1-phenyl-1H-imidazo[4,5-f] [1,10] phenanthroline (tfmppip) and bovine serum albumin (BSA) was investigated by solution spectral studies. The observed experimental result shows that the Imidazole Derivative has strong ability to quench the fluorescence of BSA by forming complex which is stabilized by electrostatic interactions. The effective quenching constants ( k sv ) were 2.79 × 10 4 , 2.51 × 10 4 , and 2.32 × 10 4 at 301, 310 and 318 K respectively. The Stern–Volmer quenching constant ( K sv ), binding site number ( n) , apparent binding constant ( K A ) and corresponding thermodynamic parameters (Δ G , Δ H and Δ S ) were calculated. The distance between the donor (BSA) and acceptor (tfmppip) was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence technique. The effect of metal ions such as Cu 2+ , Zn 2+ , Ca 2+ , Mg 2+ , Ni 2+ , Co 2+ and Fe 2+ on the binding constants between the Imidazole Derivative and BSA were also studied.

  • Photosensitization of Imidazole Derivative by ZnO nanoparticle.
    Journal of fluorescence, 2012
    Co-Authors: Chockalingam Karunakaran, Jayaraman Jayabharathi, Kumar Brindha Devi, Karunamoorthy Jayamoorthy
    Abstract:

    A sensitive Imidazole based fluorescent sensor like 4, 5-diphenyl-2(E)-styryl-1H-Imidazole, for ZnO has been designed and synthesized via simple steps. The absorption, fluorescence, SEM, EDX and IR studies indicate that Imidazole Derivative is bound on the surface of ZnO semiconductor. Based on photo-induced electron transfer (PET) mechanism, fluorescent enhancement has been explained and apparent binding constant has been calculated. Ligand adsorption on ZnO nanoparticle lowers of the HOMO and LUMO energy levels of Imidazole Derivative and the chemical affinity between the nitrogen atom of the Imidazole and zinc ion on the surface of the nano oxide may be a reason for strong adsorption of the ligand on nanoparticle. The electron injection from photo excited Imidazole Derivative to the ZnO conduction band (S*→S+ + eCB−) accounts for the enhanced fluorescence.

  • Sensing rutile TiO2 through fluorescence of Imidazole Derivative
    Sensors and Actuators B: Chemical, 2012
    Co-Authors: Chockalingam Karunakaran, Jayaraman Jayabharathi, Karunamoorthy Jayamoorthy, Kumar Brindha Devi
    Abstract:

    Abstract A new kind of Imidazole Derivative, 4,5-diphenyl-2(E)-styryl-1H-Imidazole, has been synthesized. UV–vis absorption and fluorescence spectral studies show the interaction of the Imidazole Derivative with anatase and rutile phases of nanocrystalline TiO2. Anatase quenches the fluorescence emission of the Imidazole Derivative due to charge injection from the excited singlet state of Imidazole Derivative to the conduction band of anatase. On the other hand rutile enhances the fluorescence probably due to lowering of LUMO and HOMO levels of the Imidazole Derivative on ducking of the styryl moiety of the Imidazole molecule into the void space of rutile TiO2, the HOMO and LUMO energies have been deduced from cyclic voltammetric results. The selective enhancement of fluorescence is useful to deduct and estimate nanocrystalline TiO2 rutile.

  • A study on the binding interaction between the Imidazole Derivative and bovine serum albumin by fluorescence spectroscopy
    Journal of Luminescence, 2012
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract The interaction between the Imidazole Derivative 2-(2,4-difluorophenyl)-1-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline (dfppip) and bovine serum albumin (BSA) was investigated by fluorescence and UV–vis absorbance spectroscopy. From the experimental results, it was found that the Imidazole Derivative has strong ability to quench the intrinsic fluorescence of BSA by forming complexes. Electrostatic interactions play an important role to stabilize the complex. The binding constants and the number of binding sites have been determined in detail. The distance (r) between the donor and the acceptor was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence spectroscopy. The effect of metal ions such as Cu 2+ , Zn 2+ , Ca 2+ , Mg 2+ , Ni 2+ , Co 2+ and Fe 2+ on the binding constants between the Imidazole Derivative and BSA were also studied.

  • Photoinduced electron-transfer from Imidazole Derivative to nano-semiconductors.
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2011
    Co-Authors: Chockalingam Karunakaran, Jayaraman Jayabharathi, Karunamoorthy Jayamoorthy, K. Brindha Devi
    Abstract:

    Bioactive Imidazole Derivative absorbs in the UV region at 305 nm. The interaction of Imidazole Derivative with nanoparticulate WO3, Fe2O3, Fe3O4, CuO, ZrO2 and Al2O3 has been studied by UV-visible absorption, FT-IR and fluorescence spectroscopies. The Imidazole Derivative adsorbs strongly on the surfaces of nanosemiconductor, the apparent binding constants for the association between nanomaterials and Imidazole Derivative have been determined from the fluorescence quenching. In the case of nanocrystalline insulator, fluorescence quenching through electron transfer from the excited state of the Imidazole Derivative to alumina is not possible. However, a possible mechanism for the quenching of fluorescence by the insulator is energy transfer, that is, energy transferred from the organic molecule to the alumina lattice. Based on Forster's non-radiation energy transfer theory, the distance between the Imidazole Derivative and nanoparticles (r0∼2.00 nm) as well as the critical energy transfer distance (R0∼1.70 nm) has been calculated. The interaction between the Imidazole Derivative and nanosurfaces occurs through static quenching mechanism. The free energy change (ΔGet) for electron transfer process has been calculated by applying Rehm-Weller equation.

Venugopal Thanikachalam - One of the best experts on this subject based on the ideXlab platform.

  • Studies on interaction between an Imidazole Derivative and bovine serum by spectral methods
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2012
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract The interaction between a trifluoromethyl substituted Imidazole Derivative 2-(4-(trifluoromethyl)phenyl)-1-phenyl-1H-imidazo[4,5-f] [1,10] phenanthroline (tfmppip) and bovine serum albumin (BSA) was investigated by solution spectral studies. The observed experimental result shows that the Imidazole Derivative has strong ability to quench the fluorescence of BSA by forming complex which is stabilized by electrostatic interactions. The effective quenching constants ( k sv ) were 2.79 × 10 4 , 2.51 × 10 4 , and 2.32 × 10 4 at 301, 310 and 318 K respectively. The Stern–Volmer quenching constant ( K sv ), binding site number ( n) , apparent binding constant ( K A ) and corresponding thermodynamic parameters (Δ G , Δ H and Δ S ) were calculated. The distance between the donor (BSA) and acceptor (tfmppip) was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence technique. The effect of metal ions such as Cu 2+ , Zn 2+ , Ca 2+ , Mg 2+ , Ni 2+ , Co 2+ and Fe 2+ on the binding constants between the Imidazole Derivative and BSA were also studied.

  • A study on the binding interaction between the Imidazole Derivative and bovine serum albumin by fluorescence spectroscopy
    Journal of Luminescence, 2012
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract The interaction between the Imidazole Derivative 2-(2,4-difluorophenyl)-1-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline (dfppip) and bovine serum albumin (BSA) was investigated by fluorescence and UV–vis absorbance spectroscopy. From the experimental results, it was found that the Imidazole Derivative has strong ability to quench the intrinsic fluorescence of BSA by forming complexes. Electrostatic interactions play an important role to stabilize the complex. The binding constants and the number of binding sites have been determined in detail. The distance (r) between the donor and the acceptor was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence spectroscopy. The effect of metal ions such as Cu 2+ , Zn 2+ , Ca 2+ , Mg 2+ , Ni 2+ , Co 2+ and Fe 2+ on the binding constants between the Imidazole Derivative and BSA were also studied.

  • Synthesis, spectral studies and solvatochromic analysis of novel Imidazole Derivatives
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2011
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Natesan Srinivasan, Marimuthu Venkatesh Perumal
    Abstract:

    Bioactive Imidazole Derivatives were synthesized and characterized by spectral techniques. The photophysical properties of Imidazole Derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the Imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive Imidazole Derivative and bovine serum albumin (BSA) was also investigated.

  • Physicochemical and solvatochromic analysis of an Imidazole Derivative as NLO material.
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2011
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal
    Abstract:

    Abstract Bioactive Imidazole Derivative, 2-(2,4-difluorophenyl)-1-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline, has been synthesized and characterized by IR, UV–vis, NMR and elemental (CHN) analysis. The electric dipole moment (μ) and the hyperpolarizability (β) have been studied both experimentally and theoretically, which reveals that the synthesized Imidazole Derivative possesses non-linear optical (NLO) behavior. This chromophore possess more appropriate ratio of off-diagonal versus diagonal β tensorial component (r = βxyy/βxxx = −0.19) which reflects the in plane nonlinearity anisotropy. Since they have largest μβ0 value, the reported Imidazole can be used as potential NLO material. Within this context, reasonable conclusions concerning the steric hindrance in the chromospheres, push–pull character, hyperpolarizability of the Imidazole and their application as NLO materials will be drawn. The solvent effect on the absorption and fluorescence bands was analyzed by a multi-component linear regression in which several solvent parameters were analyzed simultaneously.

  • fluorescence resonance energy transfer from a bio active Imidazole Derivative 2 1 phenyl 1h imidazo 4 5 f 1 10 phenanthrolin 2 yl phenol to a bioactive indoloquinolizine system
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011
    Co-Authors: J Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal, Natesan Srinivasan
    Abstract:

    Abstract Novel donor Imidazole Derivative, 2-(1-phenyl-1H-imidazo [4,5-f][1,10]phenanthrolin-2-yl)-phenol (PIPP) was screened as highly sensitive chemisensor for transition metal ions and it can be used as a “multi-way” optically switchable material. Solvatochromic effects on the fluorescence behaviour of PIPP were studied in different solvents. The fluorescence of PIPP was highly sensitive to both the polarity as well as protic nature of the solvent. Fluorescence (Forster) resonance energy transfer (FRET) process from PIPP to a potent bioactive indoloquinolizine molecule was studied and it is argued that long-range dipole–dipole interaction is operating for the energy transfer mechanism. The energy transfer efficiency (E) and the distance between the acceptor and the donor (r0) have been determined.

Natesan Srinivasan - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis, spectral studies and solvatochromic analysis of novel Imidazole Derivatives
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2011
    Co-Authors: Jayaraman Jayabharathi, Venugopal Thanikachalam, Natesan Srinivasan, Marimuthu Venkatesh Perumal
    Abstract:

    Bioactive Imidazole Derivatives were synthesized and characterized by spectral techniques. The photophysical properties of Imidazole Derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the Imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive Imidazole Derivative and bovine serum albumin (BSA) was also investigated.

  • fluorescence resonance energy transfer from a bio active Imidazole Derivative 2 1 phenyl 1h imidazo 4 5 f 1 10 phenanthrolin 2 yl phenol to a bioactive indoloquinolizine system
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011
    Co-Authors: J Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal, Natesan Srinivasan
    Abstract:

    Abstract Novel donor Imidazole Derivative, 2-(1-phenyl-1H-imidazo [4,5-f][1,10]phenanthrolin-2-yl)-phenol (PIPP) was screened as highly sensitive chemisensor for transition metal ions and it can be used as a “multi-way” optically switchable material. Solvatochromic effects on the fluorescence behaviour of PIPP were studied in different solvents. The fluorescence of PIPP was highly sensitive to both the polarity as well as protic nature of the solvent. Fluorescence (Forster) resonance energy transfer (FRET) process from PIPP to a potent bioactive indoloquinolizine molecule was studied and it is argued that long-range dipole–dipole interaction is operating for the energy transfer mechanism. The energy transfer efficiency (E) and the distance between the acceptor and the donor (r0) have been determined.

Sylvie Pochet - One of the best experts on this subject based on the ideXlab platform.

  • 2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl Imidazoles as DNA polymerase substrates
    Organic and Biomolecular Chemistry, 2019
    Co-Authors: Sophie Vichier-guerre, Laurence Dugué, Sylvie Pochet
    Abstract:

    We developed a versatile access to a series of 4-substituted Imidazole 2'-deoxynucleoside triphosphate bearing functionalized phenyl or pyrimidinyl rings. 4-Iodo-1H-Imidazole was enzymatically converted into the corresponding 2'-deoxynucleoside, which was then chemically derived into its 5'-triphosphate, followed by 4-arylation via Suzuki-Miyaura coupling using (hetero)arylboronic acids. Both KF (exo-) and Deep Vent (exo-) DNA polymerases incorporated these modified nucleotides in primer-extension assays, adenine being the preferred pairing partner in the template. The 4-(3-aminophenyl)Imidazole Derivative (3APh) was the most efficiently inserted opposite A by KF (exo-) with only a 37-fold lower efficiency (Vmax/KM) than that of the correct dTTP. No further extension occurred after the incorporation of a single aryl-Imidazole nucleotide. Interestingly, the aryl-Imidazole dNTPs were found to undergo successive incorporation by calf thymus terminal deoxynucleotidyl transferase with different tailing efficiencies among this series and with a marked preference for 2APyr polymerization.