The Experts below are selected from a list of 168123 Experts worldwide ranked by ideXlab platform
Kenneth M. Tramposch - One of the best experts on this subject based on the ideXlab platform.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
Xina Nair - One of the best experts on this subject based on the ideXlab platform.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
Gordon Todderud - One of the best experts on this subject based on the ideXlab platform.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
Lynda Beth Davern - One of the best experts on this subject based on the ideXlab platform.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
Alejandro Aruffo - One of the best experts on this subject based on the ideXlab platform.
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inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
-
inhibition of Immune Complex induced inflammation by a small molecular weight selectin antagonist
Mediators of Inflammation, 1994Co-Authors: Xina Nair, Gordon Todderud, Lynda Beth Davern, Alejandro Aruffo, Kenneth M. TramposchAbstract:The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to Immune Complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of Immune Complex mediated diseases.
