The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform
Antonio Martinezruiz - One of the best experts on this subject based on the ideXlab platform.
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nitrosothiols in the Immune System Signaling and protection
Antioxidants & Redox Signaling, 2013Co-Authors: Pablo Hernansanzagustin, Alicia Izquierdoalvarez, Almudena Garciaortiz, Sales Ibiza, Juan M Serrador, Antonio MartinezruizAbstract:Abstract Significance: In the Immune System, nitric oxide (NO) has been mainly associated with antibacterial defenses exerted through oxidative, nitrosative, and nitrative stress and signal transduction through cyclic GMP-dependent mechanisms. However, S-nitrosylation is emerging as a post-translational modification (PTM) involved in NO-mediated cell Signaling. Recent Advances: Precise roles for S-nitrosylation in Signaling pathways have been described both for innate and adaptive immunity. Denitrosylation may protect macrophages from their own S-nitrosylation, while maintaining nitrosative stress compartmentalized in the phagosomes. Nitrosothiols have also been shown to be beneficial in experimental models of autoImmune diseases, mainly through their role in modulating T-cell differentiation and function. Critical Issues: Relationship between S-nitrosylation, other thiol redox PTMs, and other NO-Signaling pathways has not been always taken into account, particularly in the context of Immune responses. Me...
Pablo Hernansanzagustin - One of the best experts on this subject based on the ideXlab platform.
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nitrosothiols in the Immune System Signaling and protection
Antioxidants & Redox Signaling, 2013Co-Authors: Pablo Hernansanzagustin, Alicia Izquierdoalvarez, Almudena Garciaortiz, Sales Ibiza, Juan M Serrador, Antonio MartinezruizAbstract:Abstract Significance: In the Immune System, nitric oxide (NO) has been mainly associated with antibacterial defenses exerted through oxidative, nitrosative, and nitrative stress and signal transduction through cyclic GMP-dependent mechanisms. However, S-nitrosylation is emerging as a post-translational modification (PTM) involved in NO-mediated cell Signaling. Recent Advances: Precise roles for S-nitrosylation in Signaling pathways have been described both for innate and adaptive immunity. Denitrosylation may protect macrophages from their own S-nitrosylation, while maintaining nitrosative stress compartmentalized in the phagosomes. Nitrosothiols have also been shown to be beneficial in experimental models of autoImmune diseases, mainly through their role in modulating T-cell differentiation and function. Critical Issues: Relationship between S-nitrosylation, other thiol redox PTMs, and other NO-Signaling pathways has not been always taken into account, particularly in the context of Immune responses. Me...
Gourisankar Ghosh - One of the best experts on this subject based on the ideXlab platform.
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nf κb iκb and ikk integral components of Immune System Signaling
Advances in Experimental Medicine and Biology, 2019Co-Authors: Maria Carmen Mulero, Tom Huxford, Gourisankar GhoshAbstract:The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the regulation of numerous biological processes including development of the Immune System, inflammation, and innate and adaptive Immune responses. Control over the Immune cell functions of NF-κB results from Signaling through one of two different routes: the canonical and noncanonical NF-κB Signaling pathways. Present at the end of both pathways are the proteins NF-κB, IκB, and the IκB kinase (IKK). These proteins work together to deliver the myriad outcomes that influence context-dependent transcriptional control in Immune cells. In the present chapter, we review the structural information available on NF-κB, IκB, and IKK, the critical terminal components of the NF-κB Signaling, in relation to their physiological function.
Beata Kaleta - One of the best experts on this subject based on the ideXlab platform.
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Role of Osteopontin in Systemic Lupus Erythematosus
Archivum Immunologiae et Therapiae Experimentalis, 2014Co-Authors: Beata KaletaAbstract:Systemic lupus erythematosus (SLE) is a multiSystemic disease, caused by a variety of factors, which lead to immunological abnormalities. Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and Immune System Signaling. OPN, produced by various cells, including Immune cells, plays a key role in regulating T-helper 1/T-helper 2 balance, stimulating B lymphocytes to produce antibodies, regulating macrophages, neutrophils and inducing dendritic cells. OPN expression is influenced by genetic polymorphisms of its promoter, hormones and cytokines. Over expression of OPN has been associated with the pathogenesis of Immune-mediated diseases. OPN has been implicated in the development of murine model of lupus and in humans with SLE. In this review, I will present current state of research on the role of OPN and OPN gene polymorphisms in pathogenesis and clinical course of SLE. A better understanding of the role of OPN in SLE will contribute to more precise diagnosis and treatment of the disease.
Alicia Izquierdoalvarez - One of the best experts on this subject based on the ideXlab platform.
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nitrosothiols in the Immune System Signaling and protection
Antioxidants & Redox Signaling, 2013Co-Authors: Pablo Hernansanzagustin, Alicia Izquierdoalvarez, Almudena Garciaortiz, Sales Ibiza, Juan M Serrador, Antonio MartinezruizAbstract:Abstract Significance: In the Immune System, nitric oxide (NO) has been mainly associated with antibacterial defenses exerted through oxidative, nitrosative, and nitrative stress and signal transduction through cyclic GMP-dependent mechanisms. However, S-nitrosylation is emerging as a post-translational modification (PTM) involved in NO-mediated cell Signaling. Recent Advances: Precise roles for S-nitrosylation in Signaling pathways have been described both for innate and adaptive immunity. Denitrosylation may protect macrophages from their own S-nitrosylation, while maintaining nitrosative stress compartmentalized in the phagosomes. Nitrosothiols have also been shown to be beneficial in experimental models of autoImmune diseases, mainly through their role in modulating T-cell differentiation and function. Critical Issues: Relationship between S-nitrosylation, other thiol redox PTMs, and other NO-Signaling pathways has not been always taken into account, particularly in the context of Immune responses. Me...
