The Experts below are selected from a list of 577842 Experts worldwide ranked by ideXlab platform
Mark M Davis - One of the best experts on this subject based on the ideXlab platform.
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Human Immune System variation
Nature Reviews Immunology, 2017Co-Authors: Petter Brodin, Mark M DavisAbstract:The human Immune System is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled Systems immunology analyses, which reveal the composition of Immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's Immune System is now becoming clearer. Human Immune Systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human Immune System is key for defining metrics of immunological health and understanding the risk of Immune-mediated and infectious diseases.
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Human Immune System variation
Nature Reviews Immunology, 2017Co-Authors: Petter Brodin, Mark M DavisAbstract:The human Immune System is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled Systems immunology analyses, which reveal the composition of Immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's Immune System is now becoming clearer. Human Immune Systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human Immune System is key for defining metrics of immunological health and understanding the risk of Immune-mediated and infectious diseases. Human Immune System composition and function are highly variable between healthy individuals, but they are relatively stable over time within a given individual. Human Immune Systems vary as a consequence of heritable and non-heritable influences, but non-heritable influences explain most of the variation. Understanding the specific factors that shape an individual's Immune System is key for understanding Immune competence and risk of Immune-mediated and infectious diseases. This Review provides a comprehensive overview of the influences on human Immune System variation. Systems immunology analyses have revealed that variations between individuals are mainly due to non-heritable influences such as age, sex, microbiota and the environment.
Petter Brodin - One of the best experts on this subject based on the ideXlab platform.
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Human Immune System variation
Nature Reviews Immunology, 2017Co-Authors: Petter Brodin, Mark M DavisAbstract:The human Immune System is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled Systems immunology analyses, which reveal the composition of Immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's Immune System is now becoming clearer. Human Immune Systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human Immune System is key for defining metrics of immunological health and understanding the risk of Immune-mediated and infectious diseases.
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Human Immune System variation
Nature Reviews Immunology, 2017Co-Authors: Petter Brodin, Mark M DavisAbstract:The human Immune System is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled Systems immunology analyses, which reveal the composition of Immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's Immune System is now becoming clearer. Human Immune Systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human Immune System is key for defining metrics of immunological health and understanding the risk of Immune-mediated and infectious diseases. Human Immune System composition and function are highly variable between healthy individuals, but they are relatively stable over time within a given individual. Human Immune Systems vary as a consequence of heritable and non-heritable influences, but non-heritable influences explain most of the variation. Understanding the specific factors that shape an individual's Immune System is key for understanding Immune competence and risk of Immune-mediated and infectious diseases. This Review provides a comprehensive overview of the influences on human Immune System variation. Systems immunology analyses have revealed that variations between individuals are mainly due to non-heritable influences such as age, sex, microbiota and the environment.
Adrian Liston - One of the best experts on this subject based on the ideXlab platform.
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MicroRNA in the Immune System, microRNA as an Immune System
Immunology, 2009Co-Authors: Li-fan Lu, Adrian ListonAbstract:The advent of microRNA has potentially uncovered a new level of complexity to be considered for every biological process. Through the modulation of transcription and translation, microRNA alter the basal state of cells and the outcome of stimulatory events. The exact effect of the microRNA network and individual microRNA on cellular processes is only just starting to be dissected. In the Immune System, microRNA appear to have a key role in the early differentiation and effector differentiation of B cells. In T cells, microRNA have been shown to be key regulators of the lineage induction pathways, and to have a strong role in the induction, function and maintenance of the regulatory T-cell lineage. MicroRNA are also important for regulating the differentiation of dendritic cells and macrophages via toll-like receptors, with responsibilities in suppressing effector function before activation and enhancing function after stimulation. In addition to regulating key processes in the Immune System, microRNA may also represent an archaic Immune System themselves. Small interfering RNA of viral origin has been shown to function as an intracellular mediator in the suppression of viral infection in eukaryotes as diverse as plants, insects, nematodes and fungi, and there is growing evidence that endogenous mammalian microRNA can have similar impacts. In this article we speculate that the anti-viral function of microRNA drove the expression of different subsets of microRNA in different cellular lineages, which may have, in turn, led to the myriad of roles microRNA play in lineage differentiation and stability.
Li-fan Lu - One of the best experts on this subject based on the ideXlab platform.
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MicroRNA in the Immune System, microRNA as an Immune System
Immunology, 2009Co-Authors: Li-fan Lu, Adrian ListonAbstract:The advent of microRNA has potentially uncovered a new level of complexity to be considered for every biological process. Through the modulation of transcription and translation, microRNA alter the basal state of cells and the outcome of stimulatory events. The exact effect of the microRNA network and individual microRNA on cellular processes is only just starting to be dissected. In the Immune System, microRNA appear to have a key role in the early differentiation and effector differentiation of B cells. In T cells, microRNA have been shown to be key regulators of the lineage induction pathways, and to have a strong role in the induction, function and maintenance of the regulatory T-cell lineage. MicroRNA are also important for regulating the differentiation of dendritic cells and macrophages via toll-like receptors, with responsibilities in suppressing effector function before activation and enhancing function after stimulation. In addition to regulating key processes in the Immune System, microRNA may also represent an archaic Immune System themselves. Small interfering RNA of viral origin has been shown to function as an intracellular mediator in the suppression of viral infection in eukaryotes as diverse as plants, insects, nematodes and fungi, and there is growing evidence that endogenous mammalian microRNA can have similar impacts. In this article we speculate that the anti-viral function of microRNA drove the expression of different subsets of microRNA in different cellular lineages, which may have, in turn, led to the myriad of roles microRNA play in lineage differentiation and stability.
Wei Wei - One of the best experts on this subject based on the ideXlab platform.
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Artificial Immune System and Its Application
Computer Engineering, 2003Co-Authors: Wei WeiAbstract:Artificial Immune System is a novel information processing System inspired by Immune System of human and other animals. The paper reviews several artificial Immune Systems and their applications in such areas as computer security, optimization, fault detection and design of controller. The potential application areas are also presented.
