The Experts below are selected from a list of 1953 Experts worldwide ranked by ideXlab platform
Khosrow Adeli - One of the best experts on this subject based on the ideXlab platform.
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canadian laboratory initiative on pediatric reference interval database caliper pediatric reference intervals for an integrated clinical chemistry and Immunoassay Analyzer abbott architect ci8200
Clinical Biochemistry, 2009Co-Authors: Man Khun Chan, Isolde Seidenlong, Mujdat Aytekin, Frank Quinn, Tricia Ravalico, David Ambruster, Khosrow AdeliAbstract:Abstract Objectives A comprehensive set of age- and gender-specific pediatric reference intervals is essential for accurate interpretation of laboratory tests in a pediatric setting. Design and methods 1459 serum/plasma from children attending select outpatient clinics and deemed to be metabolically stable, were collected from five age groups; 0–12 months, 1–5 years, 6–10 years, 11–14 years and 15–20 years. Samples were analyzed for 24 chemistries and 15 Immunoassays on ARCHITECT ci8200. Results Reference intervals were established according to CLSI/IFCC C28-P3 guidelines by the Robust statistical method. The ranges reflect the central 95% confidence intervals for the population tested. Age and gender were partitioned using the Harris–Boyd method. Conclusions While these intervals are ci8200 method specific, they not only provide robust intervals for users of this system but are also useful for any laboratory requiring pediatric intervals if they can be shown to be transferable and if validated for the local patient population.
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Analytical performance and workflow evaluation of the Roche E170 modular Immunoassay Analyzer in a pediatric setting.
Clinical biochemistry, 2005Co-Authors: Betty Wan, Roy Augustin, Man Khun Chan, John Leblond, Zulfikarali Verjee, Khosrow AdeliAbstract:Abstract Objectives: To evaluate the analytical performance of the Roche E170 modular analytics Immunoassay Analyzer and assess its impact on workflow efficiency and ability to consolidate workstations in a pediatric setting. Design and methods: Analytical performance of eleven common Immunoassays was assessed. Total imprecision was determined using Roche PreciControl Universal controls, Bio-Rad Lyphochek Immuno Plus, Anemia controls, and a human serum pool. Method comparison was performed with approximately 100 patient specimens. High dose hook effect, sample carryover, and results comparison between the two measuring channels were evaluated. For the workflow study, the time required for sample and reagent handling, instrument preparation, and hands-on time were assessed. Results: Correlation coefficients with existing methods ranged from 0.941 to 0.999. Biases of −19% to 70% were observed. Total imprecision ranged from 1.1 to 7.6%. No sample carryovers were encountered. Results from both measuring channels were comparable. Conclusion: E170 is suitable for use in a pediatric setting. The analytical performance is acceptable and gives equivalent results to our existing systems. The precision is comparable and acceptable. Some improvement in efficiency, workflow, cost saving, and consolidation of workstations is possible. Significant workflow improvements can only be realized when integrated with the chemistry modules.
Annie Armston - One of the best experts on this subject based on the ideXlab platform.
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Effect of hemolysis on insulin determination by the Beckman Coulter Unicell DXI 800 Immunoassay Analyzer.
Clinical biochemistry, 2010Co-Authors: Paul Cook, Christine Glenn, Annie ArmstonAbstract:Abstract Objectives: To evaluate the effect of hemolysis on the measurement of insulin using the Beckman Coulter Unicell DXI 800 Immunoassay Analyzer. Design and methods: Insulin concentrations were measured using the Beckman Coulter Unicell DXI 800. Interference studies were conducted by mixing plasma of known insulin concentrations with hemolysates of increasing hemoglobin concentration. Hemolysates were prepared by osmotic shock. A change of > 10% from baseline results was taken as evidence of significant interference. Results: Hemolysates mediated a concentration-dependent reduction in insulin concentration. Conclusions: A concentration-dependent negative bias in the measurement of insulin is associated with increasing degrees of hemolysis on the Beckman Coulter Unicell DXI 800.
Man Khun Chan - One of the best experts on this subject based on the ideXlab platform.
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canadian laboratory initiative on pediatric reference interval database caliper pediatric reference intervals for an integrated clinical chemistry and Immunoassay Analyzer abbott architect ci8200
Clinical Biochemistry, 2009Co-Authors: Man Khun Chan, Isolde Seidenlong, Mujdat Aytekin, Frank Quinn, Tricia Ravalico, David Ambruster, Khosrow AdeliAbstract:Abstract Objectives A comprehensive set of age- and gender-specific pediatric reference intervals is essential for accurate interpretation of laboratory tests in a pediatric setting. Design and methods 1459 serum/plasma from children attending select outpatient clinics and deemed to be metabolically stable, were collected from five age groups; 0–12 months, 1–5 years, 6–10 years, 11–14 years and 15–20 years. Samples were analyzed for 24 chemistries and 15 Immunoassays on ARCHITECT ci8200. Results Reference intervals were established according to CLSI/IFCC C28-P3 guidelines by the Robust statistical method. The ranges reflect the central 95% confidence intervals for the population tested. Age and gender were partitioned using the Harris–Boyd method. Conclusions While these intervals are ci8200 method specific, they not only provide robust intervals for users of this system but are also useful for any laboratory requiring pediatric intervals if they can be shown to be transferable and if validated for the local patient population.
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Analytical performance and workflow evaluation of the Roche E170 modular Immunoassay Analyzer in a pediatric setting.
Clinical biochemistry, 2005Co-Authors: Betty Wan, Roy Augustin, Man Khun Chan, John Leblond, Zulfikarali Verjee, Khosrow AdeliAbstract:Abstract Objectives: To evaluate the analytical performance of the Roche E170 modular analytics Immunoassay Analyzer and assess its impact on workflow efficiency and ability to consolidate workstations in a pediatric setting. Design and methods: Analytical performance of eleven common Immunoassays was assessed. Total imprecision was determined using Roche PreciControl Universal controls, Bio-Rad Lyphochek Immuno Plus, Anemia controls, and a human serum pool. Method comparison was performed with approximately 100 patient specimens. High dose hook effect, sample carryover, and results comparison between the two measuring channels were evaluated. For the workflow study, the time required for sample and reagent handling, instrument preparation, and hands-on time were assessed. Results: Correlation coefficients with existing methods ranged from 0.941 to 0.999. Biases of −19% to 70% were observed. Total imprecision ranged from 1.1 to 7.6%. No sample carryovers were encountered. Results from both measuring channels were comparable. Conclusion: E170 is suitable for use in a pediatric setting. The analytical performance is acceptable and gives equivalent results to our existing systems. The precision is comparable and acceptable. Some improvement in efficiency, workflow, cost saving, and consolidation of workstations is possible. Significant workflow improvements can only be realized when integrated with the chemistry modules.
Betty Wan - One of the best experts on this subject based on the ideXlab platform.
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Analytical performance and workflow evaluation of the Roche E170 modular Immunoassay Analyzer in a pediatric setting.
Clinical biochemistry, 2005Co-Authors: Betty Wan, Roy Augustin, Man Khun Chan, John Leblond, Zulfikarali Verjee, Khosrow AdeliAbstract:Abstract Objectives: To evaluate the analytical performance of the Roche E170 modular analytics Immunoassay Analyzer and assess its impact on workflow efficiency and ability to consolidate workstations in a pediatric setting. Design and methods: Analytical performance of eleven common Immunoassays was assessed. Total imprecision was determined using Roche PreciControl Universal controls, Bio-Rad Lyphochek Immuno Plus, Anemia controls, and a human serum pool. Method comparison was performed with approximately 100 patient specimens. High dose hook effect, sample carryover, and results comparison between the two measuring channels were evaluated. For the workflow study, the time required for sample and reagent handling, instrument preparation, and hands-on time were assessed. Results: Correlation coefficients with existing methods ranged from 0.941 to 0.999. Biases of −19% to 70% were observed. Total imprecision ranged from 1.1 to 7.6%. No sample carryovers were encountered. Results from both measuring channels were comparable. Conclusion: E170 is suitable for use in a pediatric setting. The analytical performance is acceptable and gives equivalent results to our existing systems. The precision is comparable and acceptable. Some improvement in efficiency, workflow, cost saving, and consolidation of workstations is possible. Significant workflow improvements can only be realized when integrated with the chemistry modules.
Paul Cook - One of the best experts on this subject based on the ideXlab platform.
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Effect of hemolysis on insulin determination by the Beckman Coulter Unicell DXI 800 Immunoassay Analyzer.
Clinical biochemistry, 2010Co-Authors: Paul Cook, Christine Glenn, Annie ArmstonAbstract:Abstract Objectives: To evaluate the effect of hemolysis on the measurement of insulin using the Beckman Coulter Unicell DXI 800 Immunoassay Analyzer. Design and methods: Insulin concentrations were measured using the Beckman Coulter Unicell DXI 800. Interference studies were conducted by mixing plasma of known insulin concentrations with hemolysates of increasing hemoglobin concentration. Hemolysates were prepared by osmotic shock. A change of > 10% from baseline results was taken as evidence of significant interference. Results: Hemolysates mediated a concentration-dependent reduction in insulin concentration. Conclusions: A concentration-dependent negative bias in the measurement of insulin is associated with increasing degrees of hemolysis on the Beckman Coulter Unicell DXI 800.
