The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Fabio Malavasi - One of the best experts on this subject based on the ideXlab platform.
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CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia Cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanni D’arena, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38^+ CLL lymphocytes and CD31^+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
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cd38 cd31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Giovanni Darena, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38+ CLL lymphocytes and CD31+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
Silvia Deaglio - One of the best experts on this subject based on the ideXlab platform.
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CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia Cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanni D’arena, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38^+ CLL lymphocytes and CD31^+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
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cd38 cd31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Giovanni Darena, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38+ CLL lymphocytes and CD31+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
Maurizia Mello Grand - One of the best experts on this subject based on the ideXlab platform.
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CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia Cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanni D’arena, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38^+ CLL lymphocytes and CD31^+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
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cd38 cd31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Giovanni Darena, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38+ CLL lymphocytes and CD31+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
Tiziana Vaisitti - One of the best experts on this subject based on the ideXlab platform.
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CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia Cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanni D’arena, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38^+ CLL lymphocytes and CD31^+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
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cd38 cd31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Giovanni Darena, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38+ CLL lymphocytes and CD31+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
Semra Aydin - One of the best experts on this subject based on the ideXlab platform.
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CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia Cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanni D’arena, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38^+ CLL lymphocytes and CD31^+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
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cd38 cd31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells
Molecular Medicine, 2010Co-Authors: Silvia Deaglio, Maurizia Mello Grand, Luciana Bergui, Giovanna Chiorino, Semra Aydin, Tiziana Vaisitti, Giovanni Darena, Fabio MalavasiAbstract:Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31. CD38 expression above a critical threshold is a negative prognostic marker for chronic lymphocytic leukemia (CLL) patients. Activation of CD38 by means of agonistic monoclonal antibodies or the CD31 ligand induces proliferation and Immunoblast differentiation of CLL cells. Here we define the genetic signature that follows long-term in vitro interactions between CD38+ CLL lymphocytes and CD31+ cells. The emerging profile confirms that the CD31/CD38 axis activates genetic programs relevant for proliferative responses. It also indicates a contribution of this pathway to the processes mediating migration and homing. These results further support the notion that the CD31/CD38 axis is part of a network of accessory signals that modify the microenvironment, favoring localization of leukemic cells to growth-permissive sites.
