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Manfred Dietel - One of the best experts on this subject based on the ideXlab platform.
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subcutaneous crystal storing histiocytosis associated with lymphoplasmacytic lymphoma Immunocytoma
Pathology Research and Practice, 1996Co-Authors: Olaf Kaufmann, Arne Hansen, P Deicke, Gerd R Burmester, Manfred DietelAbstract:SUMMARY A case ofmassive crystal-storing histiocytosis with extensive involvement ofthe subcutaneus adipose tissue in a 61-year-old caucasian woman with a lymphoplasmacytic lymphoma (Immunocytoma) in transformation to a large cell lymphoma is presented. Paraffin-section immunohistochemistry demonstrated a monoclonal IgM/ kappa immunphenotype of the lymphoma cells and revealed IgM/kappa and, to a lesser extent, IgG/lambda in the crystal-containing histiocytes. Ultrastructurally, the electron dense intracytoplasmic crystals had variable shapes, were occasionally membrane-bound and measured up to 6 μm. The findings are briefly discussed.
Manuel Cunha - One of the best experts on this subject based on the ideXlab platform.
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imunocitoma iga a proposito de um caso clinico Immunocytoma iga case report
2009Co-Authors: Bebiana Conde, Ana Luisa Godoy Fernandes, Manuel Cunha, Abel AfonsoAbstract:Immunocytoma is a non-Hodgkin’s indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA. We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work -up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo
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Immunocytoma iga case report
Revista Portuguesa De Pneumologia, 2009Co-Authors: Bebiana Conde, Ana Luisa Godoy Fernandes, Manuel Cunha, Abel AfonsoAbstract:Immunocytoma is a non-Hodgkin's indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA. We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work -up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo- phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years.
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Imunocitoma IgA. A propósito de um caso clÃnico
Elsevier, 2009Co-Authors: Bebiana Conde, Manuel Cunha, Ana Fernandes, Abel AfonsoAbstract:Resumo: O imunocitoma é um linfoma não Hodgkin (LNH) de células B, com evolução habitualmente indolente. Representa aproximadamente 1-3% dos LNH e atinge habitualmente adultos com mais de 50 anos, podendo manifestar-se por adenomegalias, hepatomegalia, esplenomegalia e linfocitose em 15 a 30% dos casos. Raramente tem envolvimento pulmonar. Com frequência ocorrendo picos monoclonais de imunoglobulinas, séricos, frequentemente IgM e raramente IgA.Como exemplo desta patologia apresentamos o caso clÃnico de um doente do sexo masculino, 52 anos, com clÃnica de infecções respiratórias bacterianas de repetição, com necessidade de internamentos sucessivos, cuja investigação identificou um imunocitoma IgA, estádio IV.Assumindo-se o diagnóstico de um linfoma indolente, decidiu-se iniciar terapêutica profiláctica com imunoglobulinas humanas poliespecÃficas, tendo havido diminuição das infecções respiratórias. Posteriormente, a evidência de progressão do linfoma condicionou o inÃcio de poliquimioterapia, com o esquema ciclofosfamida, vincristina, prednisolona (CVP) e rituximab®, tendo-se alcançado uma resposta parcial, que se manteve durante dois anos.Rev Port Pneumol 2009; XV (1): 121-127 Abstract: Immunocytoma is a non-Hodgkinâs indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15-30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA.We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work-up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo-phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years.Rev Port Pneumol 2009; XV (1): 121-127 Palavras-chave: Imunocitoma, linfoma não Hodgkin, envolvimento pulmonar, Key-words: Immunocytoma, non-Hodgkinâs lymphoma, pulmonary involvemen
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Imunocitoma IgA. A propósito de um caso clÃnico
Elsevier, 2009Co-Authors: Bebiana Conde, Manuel Cunha, Abel Afonso, Ana FernandesAbstract:Resumo: O imunocitoma é um linfoma não Hodgkin (LNH) de células B, com evolução habitualmente indolente. Representa aproximadamente 1â3% dos LNH e atinge habitualmente adultos com mais de 50 anos, podendo manifestar-se por adenomegalias, hepatomegalia, esplenomegalia e linfocitose em 15 a 30% dos casos. Raramente tem envolvimento pulmonar. Com frequência ocorrendo picos monoclonais de imunoglobulinas, séricos, frequentemente IgM e raramente IgA.Como exemplo desta patologia apresentamos o caso clÃnico de um doente do sexo masculino, 52 anos, com clÃnica de infecções respiratórias bacterianas de repetição, com necessidade de internamentos sucessivos, cuja investigação identificou um imunocitoma IgA, estádio IV.Assumindo-se o diagnóstico de um linfoma indolente, decidiu-se iniciar terapêutica profiláctica com imunoglobulinas humanas poliespecÃficas, tendo havido diminuição das infecções respiratórias. Posteriormente, a evidência de progressão do linfoma condicionou o inÃcio de poliquimioterapia, com o esquema ciclofosfamida, vincristina, prednisolona (CVP) e rituximab®, tendo-se alcançado uma resposta parcial, que se manteve durante dois anos. Abstract: Immunocytoma is a non-Hodgkin's indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA.We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work-up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years. Palavras chave: Imunocitoma, linfoma não Hodgkin, envolvimento pulmonar, Key words: Immunocytoma, non-Hodgkin's lymphoma, pulmonary involvemen
Abel Afonso - One of the best experts on this subject based on the ideXlab platform.
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imunocitoma iga a proposito de um caso clinico Immunocytoma iga case report
2009Co-Authors: Bebiana Conde, Ana Luisa Godoy Fernandes, Manuel Cunha, Abel AfonsoAbstract:Immunocytoma is a non-Hodgkin’s indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA. We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work -up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo
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Immunocytoma iga case report
Revista Portuguesa De Pneumologia, 2009Co-Authors: Bebiana Conde, Ana Luisa Godoy Fernandes, Manuel Cunha, Abel AfonsoAbstract:Immunocytoma is a non-Hodgkin's indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA. We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work -up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo- phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years.
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Imunocitoma IgA. A propósito de um caso clÃnico
Elsevier, 2009Co-Authors: Bebiana Conde, Manuel Cunha, Ana Fernandes, Abel AfonsoAbstract:Resumo: O imunocitoma é um linfoma não Hodgkin (LNH) de células B, com evolução habitualmente indolente. Representa aproximadamente 1-3% dos LNH e atinge habitualmente adultos com mais de 50 anos, podendo manifestar-se por adenomegalias, hepatomegalia, esplenomegalia e linfocitose em 15 a 30% dos casos. Raramente tem envolvimento pulmonar. Com frequência ocorrendo picos monoclonais de imunoglobulinas, séricos, frequentemente IgM e raramente IgA.Como exemplo desta patologia apresentamos o caso clÃnico de um doente do sexo masculino, 52 anos, com clÃnica de infecções respiratórias bacterianas de repetição, com necessidade de internamentos sucessivos, cuja investigação identificou um imunocitoma IgA, estádio IV.Assumindo-se o diagnóstico de um linfoma indolente, decidiu-se iniciar terapêutica profiláctica com imunoglobulinas humanas poliespecÃficas, tendo havido diminuição das infecções respiratórias. Posteriormente, a evidência de progressão do linfoma condicionou o inÃcio de poliquimioterapia, com o esquema ciclofosfamida, vincristina, prednisolona (CVP) e rituximab®, tendo-se alcançado uma resposta parcial, que se manteve durante dois anos.Rev Port Pneumol 2009; XV (1): 121-127 Abstract: Immunocytoma is a non-Hodgkinâs indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15-30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA.We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work-up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo-phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years.Rev Port Pneumol 2009; XV (1): 121-127 Palavras-chave: Imunocitoma, linfoma não Hodgkin, envolvimento pulmonar, Key-words: Immunocytoma, non-Hodgkinâs lymphoma, pulmonary involvemen
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Imunocitoma IgA. A propósito de um caso clÃnico
Elsevier, 2009Co-Authors: Bebiana Conde, Manuel Cunha, Abel Afonso, Ana FernandesAbstract:Resumo: O imunocitoma é um linfoma não Hodgkin (LNH) de células B, com evolução habitualmente indolente. Representa aproximadamente 1â3% dos LNH e atinge habitualmente adultos com mais de 50 anos, podendo manifestar-se por adenomegalias, hepatomegalia, esplenomegalia e linfocitose em 15 a 30% dos casos. Raramente tem envolvimento pulmonar. Com frequência ocorrendo picos monoclonais de imunoglobulinas, séricos, frequentemente IgM e raramente IgA.Como exemplo desta patologia apresentamos o caso clÃnico de um doente do sexo masculino, 52 anos, com clÃnica de infecções respiratórias bacterianas de repetição, com necessidade de internamentos sucessivos, cuja investigação identificou um imunocitoma IgA, estádio IV.Assumindo-se o diagnóstico de um linfoma indolente, decidiu-se iniciar terapêutica profiláctica com imunoglobulinas humanas poliespecÃficas, tendo havido diminuição das infecções respiratórias. Posteriormente, a evidência de progressão do linfoma condicionou o inÃcio de poliquimioterapia, com o esquema ciclofosfamida, vincristina, prednisolona (CVP) e rituximab®, tendo-se alcançado uma resposta parcial, que se manteve durante dois anos. Abstract: Immunocytoma is a non-Hodgkin's indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA.We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work-up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years. Palavras chave: Imunocitoma, linfoma não Hodgkin, envolvimento pulmonar, Key words: Immunocytoma, non-Hodgkin's lymphoma, pulmonary involvemen
Olaf Kaufmann - One of the best experts on this subject based on the ideXlab platform.
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subcutaneous crystal storing histiocytosis associated with lymphoplasmacytic lymphoma Immunocytoma
Pathology Research and Practice, 1996Co-Authors: Olaf Kaufmann, Arne Hansen, P Deicke, Gerd R Burmester, Manfred DietelAbstract:SUMMARY A case ofmassive crystal-storing histiocytosis with extensive involvement ofthe subcutaneus adipose tissue in a 61-year-old caucasian woman with a lymphoplasmacytic lymphoma (Immunocytoma) in transformation to a large cell lymphoma is presented. Paraffin-section immunohistochemistry demonstrated a monoclonal IgM/ kappa immunphenotype of the lymphoma cells and revealed IgM/kappa and, to a lesser extent, IgG/lambda in the crystal-containing histiocytes. Ultrastructurally, the electron dense intracytoplasmic crystals had variable shapes, were occasionally membrane-bound and measured up to 6 μm. The findings are briefly discussed.
Bebiana Conde - One of the best experts on this subject based on the ideXlab platform.
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imunocitoma iga a proposito de um caso clinico Immunocytoma iga case report
2009Co-Authors: Bebiana Conde, Ana Luisa Godoy Fernandes, Manuel Cunha, Abel AfonsoAbstract:Immunocytoma is a non-Hodgkin’s indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA. We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work -up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo
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Immunocytoma iga case report
Revista Portuguesa De Pneumologia, 2009Co-Authors: Bebiana Conde, Ana Luisa Godoy Fernandes, Manuel Cunha, Abel AfonsoAbstract:Immunocytoma is a non-Hodgkin's indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA. We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work -up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo- phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years.
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Imunocitoma IgA. A propósito de um caso clÃnico
Elsevier, 2009Co-Authors: Bebiana Conde, Manuel Cunha, Ana Fernandes, Abel AfonsoAbstract:Resumo: O imunocitoma é um linfoma não Hodgkin (LNH) de células B, com evolução habitualmente indolente. Representa aproximadamente 1-3% dos LNH e atinge habitualmente adultos com mais de 50 anos, podendo manifestar-se por adenomegalias, hepatomegalia, esplenomegalia e linfocitose em 15 a 30% dos casos. Raramente tem envolvimento pulmonar. Com frequência ocorrendo picos monoclonais de imunoglobulinas, séricos, frequentemente IgM e raramente IgA.Como exemplo desta patologia apresentamos o caso clÃnico de um doente do sexo masculino, 52 anos, com clÃnica de infecções respiratórias bacterianas de repetição, com necessidade de internamentos sucessivos, cuja investigação identificou um imunocitoma IgA, estádio IV.Assumindo-se o diagnóstico de um linfoma indolente, decidiu-se iniciar terapêutica profiláctica com imunoglobulinas humanas poliespecÃficas, tendo havido diminuição das infecções respiratórias. Posteriormente, a evidência de progressão do linfoma condicionou o inÃcio de poliquimioterapia, com o esquema ciclofosfamida, vincristina, prednisolona (CVP) e rituximab®, tendo-se alcançado uma resposta parcial, que se manteve durante dois anos.Rev Port Pneumol 2009; XV (1): 121-127 Abstract: Immunocytoma is a non-Hodgkinâs indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15-30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA.We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work-up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo-phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years.Rev Port Pneumol 2009; XV (1): 121-127 Palavras-chave: Imunocitoma, linfoma não Hodgkin, envolvimento pulmonar, Key-words: Immunocytoma, non-Hodgkinâs lymphoma, pulmonary involvemen
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Imunocitoma IgA. A propósito de um caso clÃnico
Elsevier, 2009Co-Authors: Bebiana Conde, Manuel Cunha, Abel Afonso, Ana FernandesAbstract:Resumo: O imunocitoma é um linfoma não Hodgkin (LNH) de células B, com evolução habitualmente indolente. Representa aproximadamente 1â3% dos LNH e atinge habitualmente adultos com mais de 50 anos, podendo manifestar-se por adenomegalias, hepatomegalia, esplenomegalia e linfocitose em 15 a 30% dos casos. Raramente tem envolvimento pulmonar. Com frequência ocorrendo picos monoclonais de imunoglobulinas, séricos, frequentemente IgM e raramente IgA.Como exemplo desta patologia apresentamos o caso clÃnico de um doente do sexo masculino, 52 anos, com clÃnica de infecções respiratórias bacterianas de repetição, com necessidade de internamentos sucessivos, cuja investigação identificou um imunocitoma IgA, estádio IV.Assumindo-se o diagnóstico de um linfoma indolente, decidiu-se iniciar terapêutica profiláctica com imunoglobulinas humanas poliespecÃficas, tendo havido diminuição das infecções respiratórias. Posteriormente, a evidência de progressão do linfoma condicionou o inÃcio de poliquimioterapia, com o esquema ciclofosfamida, vincristina, prednisolona (CVP) e rituximab®, tendo-se alcançado uma resposta parcial, que se manteve durante dois anos. Abstract: Immunocytoma is a non-Hodgkin's indolent evolution B cell lymphoma. It accounts for approximately 1-3% of non-Hodgkin's limphomas and usually onsets in adults aged over 50 years old. It manifests as lymphadenopathy, splenomegaly, hepatomegaly and lymphcytosis in 15 -30% of cases and is rarely seen with pulmonary involvement. Monocloncal peaks of serum immunoglobulin often occur. These are IgM and rarely IgA.We present as an example a male patient aged 52 years old, with recurrent respiratory infections. Clinical work-up identified an Immunocytoma IgA stage IV. Diagnosing an indolent lymphoma, we prophylactic polyspecific human immunoglobulin to treat the respiratory infection. Evidence of lymphoma progression leads us to prescribe combined cyclo phosphamide (C), vincristine (V), prednisone (P) e rituximab (R) (CVP-R), which has obtained a partial response over two years. Palavras chave: Imunocitoma, linfoma não Hodgkin, envolvimento pulmonar, Key words: Immunocytoma, non-Hodgkin's lymphoma, pulmonary involvemen
