The Experts below are selected from a list of 60 Experts worldwide ranked by ideXlab platform
Klaus Rajewsky - One of the best experts on this subject based on the ideXlab platform.
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development of Immunoglobulin Lambda Chain ndash positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, Christoph J Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating IB kinase (IKK)-mediated activation of the transcription factor NF-B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin -Chain–positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin -Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-B signaling. During the first phase, in which NF-B signaling is dispensable, predominantly -Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly -Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding -Chain. This second phase of development is dependent on NF-B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
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development of Immunoglobulin Lambda Chain positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, J C Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin Lambda-Chain-positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin kappa-Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappa B signaling. During the first phase, in which NF-kappa B signaling is dispensable, predominantly kappa-Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly Lambda-Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding kappa-Chain. This second phase of development is dependent on NF-kappa B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
Emmanuel Derudder - One of the best experts on this subject based on the ideXlab platform.
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development of Immunoglobulin Lambda Chain ndash positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, Christoph J Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating IB kinase (IKK)-mediated activation of the transcription factor NF-B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin -Chain–positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin -Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-B signaling. During the first phase, in which NF-B signaling is dispensable, predominantly -Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly -Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding -Chain. This second phase of development is dependent on NF-B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
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development of Immunoglobulin Lambda Chain positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, J C Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin Lambda-Chain-positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin kappa-Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappa B signaling. During the first phase, in which NF-kappa B signaling is dispensable, predominantly kappa-Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly Lambda-Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding kappa-Chain. This second phase of development is dependent on NF-kappa B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
Emily J Cadera - One of the best experts on this subject based on the ideXlab platform.
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development of Immunoglobulin Lambda Chain ndash positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, Christoph J Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating IB kinase (IKK)-mediated activation of the transcription factor NF-B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin -Chain–positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin -Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-B signaling. During the first phase, in which NF-B signaling is dispensable, predominantly -Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly -Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding -Chain. This second phase of development is dependent on NF-B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
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development of Immunoglobulin Lambda Chain positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, J C Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin Lambda-Chain-positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin kappa-Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappa B signaling. During the first phase, in which NF-kappa B signaling is dispensable, predominantly kappa-Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly Lambda-Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding kappa-Chain. This second phase of development is dependent on NF-kappa B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
Jing Wang - One of the best experts on this subject based on the ideXlab platform.
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development of Immunoglobulin Lambda Chain ndash positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, Christoph J Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating IB kinase (IKK)-mediated activation of the transcription factor NF-B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin -Chain–positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin -Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-B signaling. During the first phase, in which NF-B signaling is dispensable, predominantly -Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly -Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding -Chain. This second phase of development is dependent on NF-B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
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development of Immunoglobulin Lambda Chain positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, J C Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin Lambda-Chain-positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin kappa-Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappa B signaling. During the first phase, in which NF-kappa B signaling is dispensable, predominantly kappa-Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly Lambda-Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding kappa-Chain. This second phase of development is dependent on NF-kappa B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
Marc Schmidtsupprian - One of the best experts on this subject based on the ideXlab platform.
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development of Immunoglobulin Lambda Chain ndash positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, Christoph J Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating IB kinase (IKK)-mediated activation of the transcription factor NF-B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin -Chain–positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin -Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-B signaling. During the first phase, in which NF-B signaling is dispensable, predominantly -Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly -Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding -Chain. This second phase of development is dependent on NF-B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
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development of Immunoglobulin Lambda Chain positive b cells but not editing of Immunoglobulin kappa Chain depends on nf kappa b signals
Nature Immunology, 2009Co-Authors: Emmanuel Derudder, Emily J Cadera, J C Vahl, Marc Schmidtsupprian, Mark S. Schlissel, Manolis Pasparakis, Jing Wang, Klaus RajewskyAbstract:By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which Immunoglobulin Lambda-Chain-positive B cells are generated in the absence of rearrangements in the locus encoding Immunoglobulin kappa-Chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappa B signaling. During the first phase, in which NF-kappa B signaling is dispensable, predominantly kappa-Chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly Lambda-Chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding kappa-Chain. This second phase of development is dependent on NF-kappa B signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.
