The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Erin J Staples - One of the best experts on this subject based on the ideXlab platform.
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detection of anti yellow fever virus IMMunoglobulin M antibodies at 3 4 years following yellow fever vaccination
American Journal of Tropical Medicine and Hygiene, 2012Co-Authors: Katherine B Gibney, Srilatha Edupuganti, Amanda J Panella, Olga I Kosoy, Mark J Delorey, Robert S Lanciotti, Mark J Mulligan, Marc Fischer, Erin J StaplesAbstract:The duration of anti-yellow fever (YF) virus IMMunoglobulin M (IgM) antibodies following YF vaccination is unknown, Making it difficult to interpret positive IgM antibody results in previously vaccinated travelers. We evaluated the frequency and predictors of YF IgM antibody positivity 3-4 years following YF vaccination. Twenty-nine (73%) of 40 participants had YF IgM antibodies 3-4 years postvaccination. No deMographic or exposure variables were predictive of YF IgM positivity. However, persons who were YF IgM positive at 3-4 years postvaccination had earlier onset vireMia and higher neutralizing antibody geoMetric Mean titers at 1 Month and 3-4 years postvaccination coMpared with persons who were YF IgM negative. Detection of YF IgM antibodies several years postvaccination Might reflect reMote YF vaccination rather than recent YF vaccination or YF virus infection.
Katherine B Gibney - One of the best experts on this subject based on the ideXlab platform.
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detection of anti yellow fever virus IMMunoglobulin M antibodies at 3 4 years following yellow fever vaccination
American Journal of Tropical Medicine and Hygiene, 2012Co-Authors: Katherine B Gibney, Srilatha Edupuganti, Amanda J Panella, Olga I Kosoy, Mark J Delorey, Robert S Lanciotti, Mark J Mulligan, Marc Fischer, Erin J StaplesAbstract:The duration of anti-yellow fever (YF) virus IMMunoglobulin M (IgM) antibodies following YF vaccination is unknown, Making it difficult to interpret positive IgM antibody results in previously vaccinated travelers. We evaluated the frequency and predictors of YF IgM antibody positivity 3-4 years following YF vaccination. Twenty-nine (73%) of 40 participants had YF IgM antibodies 3-4 years postvaccination. No deMographic or exposure variables were predictive of YF IgM positivity. However, persons who were YF IgM positive at 3-4 years postvaccination had earlier onset vireMia and higher neutralizing antibody geoMetric Mean titers at 1 Month and 3-4 years postvaccination coMpared with persons who were YF IgM negative. Detection of YF IgM antibodies several years postvaccination Might reflect reMote YF vaccination rather than recent YF vaccination or YF virus infection.
Saleem Kamili - One of the best experts on this subject based on the ideXlab platform.
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serologic assays specific to IMMunoglobulin M antibodies against hepatitis e virus pangenotypic evaluation of perforMances
Clinical Infectious Diseases, 2010Co-Authors: Jan Drobeniuc, N. S. Khudyakova, Tracy Greenemontfort, Zoya Dimitrova, Jihong Meng, Saleem KamiliAbstract:: Six iMMunoassays for detecting IMMunoglobulin M antibodies to hepatitis E virus were evaluated. SeruM saMples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreeMent varied widely. Analytical sensitivity liMits also were deterMined and were found to be particularly disparate.
Jose G Montoya - One of the best experts on this subject based on the ideXlab platform.
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significance of a positive toxoplasMa IMMunoglobulin M test result in the united states
Journal of Clinical Microbiology, 2015Co-Authors: Reshika Dhakal, Kiran Gajurel, Christelle Pomares, Jeanne Talucod, Cynthia Press, Jose G MontoyaAbstract:A positive ToxoplasMa IMMunoglobulin M (IgM) result is often interpreted as a Marker of an acute infection. However, IgM can persist for several years, and ToxoplasMa coMMercial IgM diagnostic test kits can yield a nuMber of false-positive results. For these reasons, a chronic ToxoplasMa infection can be erroneously classified as an acute infection, resulting in serious adverse consequences, especially in pregnant woMen, leading to eMotional distress and unnecessary interventions, including terMination of pregnancy. Interpretation of ToxoplasMa serology at a reference laboratory can help differentiate a recently acquired infection froM a chronic infection. Serological test results for 451 patients with positive ToxoplasMa IgM and IgG test results obtained at nonreference laboratories (NRLs) that were referred to Palo Alto Medical Foundation ToxoplasMa Serology Laboratory (PAMF-TSL) to deterMine whether the patient was acutely or chronically infected were retrospectively reviewed. PAMF-TSL results established that of the 451 patients, 335 (74%) had a chronic infection, 100 (22%) had an acute infection, and 7 (2%) were not infected, and for 9 (2%), results were indeterMinate. Positive ToxoplasMa IgM and IgG test results obtained at NRLs cannot accurately distinguish between acute and chronic infections. To do so, testing at reference laboratories is required, as Mandated in 1997 in a letter froM the Food and Drug AdMinistration (FDA) to clinicians and laboratories in the United States.
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confirMatory serologic testing for acute toxoplasMosis and rate of induced abortions aMong woMen reported to have positive toxoplasMa IMMunoglobulin M antibody titers
American Journal of Obstetrics and Gynecology, 2001Co-Authors: Oliver Liesenfeld, Jose G Montoya, Naga J Tathineni, Meg Davis, Byron W Brown, Kristin Cobb, Julie Parsonnet, Jack S RemingtonAbstract:OBJECTIVE: Results obtained with coMMercial testing kits for IMMunoglobulin M ToxoplasMa antibodies May be inaccurate or May be inaccurately interpreted, which May influence whether a woMan decides to terMinate the pregnancy. This study was undertaken to deterMine whether confirMatory testing at a reference laboratory and coMMunication of the results and an expert interpretation to the patient's physician would affect the rate of induced abortions aMong pregnant woMen with positive results of testing for IMMunoglobulin M ToxoplasMa antibodies in outside laboratories. STUDY DESIGN: This was a retrospective cohort study of 811 consecutive pregnant woMen for whoM the toxoplasMa serologic profile was perforMed at a reference laboratory. AlMost all the patients had been inforMed by their physicians that a result of a test for IMMunoglobulin M ToxoplasMa antibodies perforMed in an outside laboratory was positive. WoMen were separated into those with a toxoplasMa serologic profile result suggestive of a recently acquired infection (group 1) and those with a result suggestive of an infection acquired in the More distant past (group 2). Physician reports of induced abortions were used to deterMine rates of induced abortion in groups 1 and 2. RESULTS: Of the 811 woMen 321 (39.6%) were considered likely to have a recent infection (group 1) and 490 (60.4%) were considered likely to have a past infection (group 2). Physicians reported pregnancy outcoMes for 433 (53.4%) of 811 woMen (65.1% and 45.7% in groups 1 and 2, respectively). Whereas 36 of 209 woMen in group 1 (17.2%) terMinated the pregnancy, only 1 of 224 woMen in group 2 (0.4%) chose abortion (P <.001). CONCLUSION: ConfirMatory serologic testing in a reference laboratory and coMMunication of the results and their correct interpretation by an expert to the patient's physician decreased the rate of unnecessary abortions by approxiMately 50% aMong woMen for whoM positive IMMunoglobulin M ToxoplasMa test results had been reported by outside laboratories.
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confirMatory serologic testing for acute toxoplasMosis and rate of induced abortions aMong woMen reported to have positive toxoplasMa IMMunoglobulin M antibody titers
American Journal of Obstetrics and Gynecology, 2001Co-Authors: Oliver Liesenfeld, Jose G Montoya, Naga J Tathineni, Meg Davis, Byron W Brown, Kristin Cobb, Julie Parsonnet, Jack S RemingtonAbstract:Abstract Objective: Results obtained with coMMercial testing kits for IMMunoglobulin M ToxoplasMa antibodies May be inaccurate or May be inaccurately interpreted, which May influence whether a woMan decides to terMinate the pregnancy. This study was undertaken to deterMine whether confirMatory testing at a reference laboratory and coMMunication of the results and an expert interpretation to the patient's physician would affect the rate of induced abortions aMong pregnant woMen with positive results of testing for IMMunoglobulin M ToxoplasMa antibodies in outside laboratories. Study Design: This was a retrospective cohort study of 811 consecutive pregnant woMen for whoM the toxoplasMa serologic profile was perforMed at a reference laboratory. AlMost all the patients had been inforMed by their physicians that a result of a test for IMMunoglobulin M ToxoplasMa antibodies perforMed in an outside laboratory was positive. WoMen were separated into those with a toxoplasMa serologic profile result suggestive of a recently acquired infection (group 1) and those with a result suggestive of an infection acquired in the More distant past (group 2). Physician reports of induced abortions were used to deterMine rates of induced abortion in groups 1 and 2. Results: Of the 811 woMen 321 (39.6%) were considered likely to have a recent infection (group 1) and 490 (60.4%) were considered likely to have a past infection (group 2). Physicians reported pregnancy outcoMes for 433 (53.4%) of 811 woMen (65.1% and 45.7% in groups 1 and 2, respectively). Whereas 36 of 209 woMen in group 1 (17.2%) terMinated the pregnancy, only 1 of 224 woMen in group 2 (0.4%) chose abortion ( P Conclusion: ConfirMatory serologic testing in a reference laboratory and coMMunication of the results and their correct interpretation by an expert to the patient's physician decreased the rate of unnecessary abortions by approxiMately 50% aMong woMen for whoM positive IMMunoglobulin M ToxoplasMa test results had been reported by outside laboratories. (AM J Obstet Gynecol 2001;184:140-5.)
Jihong Meng - One of the best experts on this subject based on the ideXlab platform.
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serologic assays specific to IMMunoglobulin M antibodies against hepatitis e virus pangenotypic evaluation of perforMances
Clinical Infectious Diseases, 2010Co-Authors: Jan Drobeniuc, N. S. Khudyakova, Tracy Greenemontfort, Zoya Dimitrova, Jihong Meng, Saleem KamiliAbstract:: Six iMMunoassays for detecting IMMunoglobulin M antibodies to hepatitis E virus were evaluated. SeruM saMples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreeMent varied widely. Analytical sensitivity liMits also were deterMined and were found to be particularly disparate.
