The Experts below are selected from a list of 44556 Experts worldwide ranked by ideXlab platform
Jun Shen - One of the best experts on this subject based on the ideXlab platform.
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Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment Immunomodulation in neurotmesis.
Muscle & nerve, 2020Co-Authors: Zehong Yang, Chushan Zheng, Fang Zhang, Binglin Lin, Minghui Cao, Xuwei Tian, Jingzhong Zhang, Xiao Zhang, Jun ShenAbstract:INTRODUCTION The immuno-microenvironment of injured nerves adversely affects mesenchymal stem cell (MSC) therapy for neurotmesis. Magnetic resonance imaging (MRI) can be used noninvasively to monitor nerve degeneration and regeneration. The aim of this study was to investigate nerve repair after MSC transplantation combined with microenvironment Immunomodulation in neurotmesis by using multiparametric MRI. METHODS Rats with sciatic nerve transection and surgical coaptation were treated with MSCs combined with Immunomodulation or MSCs alone. Serial multiparametric MRI examinations were performed over an 8-week period after surgery. RESULTS Nerves treated with MSCs combined with Immunomodulation showed better functional recovery, rapid recovery of nerve T2, fractional anisotropy and radial diffusivity values, and more rapid restoration of the fiber tracks than nerves treated with MSCs alone. DISCUSSION Transplantation of MSCs in combination with Immunomodulation can exert a synergistic repair effect on neurotmesis, which can be monitored by multiparametric MRI.
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Assessment of the synergic effect of Immunomodulation on nerve repair using multiparametric magnetic resonance imaging
Muscle & nerve, 2017Co-Authors: Chushan Zheng, Fang Zhang, Xiang Zhang, Yue-yao Chen, Xiaohui Duan, Meiwei Chen, Jun ShenAbstract:Introduction The immune system plays a pivotal role in nerve injury. The aim of this study was to determine the role of multiparametric magnetic resonance imaging (MRI) in evaluation of the synergic effect of Immunomodulation on nerve regeneration in neurotmesis. Methods Rats with sciatic nerve neurotmesis and surgical repair underwent serial multiparametric MR examinations over an 8-week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate-buffered saline (PBS) alone. Results Nerves treated with Immunomodulation showed more prominent regeneration than those treated with LPS or PBS alone and more rapid restoration toward normal T2, fractional anisotropy (FA), and radial diffusivity (RD) values than nerves injected with LPS or PBS. Discussion Nerves treated with Immunomodulation exert synergic beneficial effects on nerve regeneration that can be predicted by T2 measurements and FA and RD values. Muscle Nerve 57: E38–E45, 2018
Chushan Zheng - One of the best experts on this subject based on the ideXlab platform.
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Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment Immunomodulation in neurotmesis.
Muscle & nerve, 2020Co-Authors: Zehong Yang, Chushan Zheng, Fang Zhang, Binglin Lin, Minghui Cao, Xuwei Tian, Jingzhong Zhang, Xiao Zhang, Jun ShenAbstract:INTRODUCTION The immuno-microenvironment of injured nerves adversely affects mesenchymal stem cell (MSC) therapy for neurotmesis. Magnetic resonance imaging (MRI) can be used noninvasively to monitor nerve degeneration and regeneration. The aim of this study was to investigate nerve repair after MSC transplantation combined with microenvironment Immunomodulation in neurotmesis by using multiparametric MRI. METHODS Rats with sciatic nerve transection and surgical coaptation were treated with MSCs combined with Immunomodulation or MSCs alone. Serial multiparametric MRI examinations were performed over an 8-week period after surgery. RESULTS Nerves treated with MSCs combined with Immunomodulation showed better functional recovery, rapid recovery of nerve T2, fractional anisotropy and radial diffusivity values, and more rapid restoration of the fiber tracks than nerves treated with MSCs alone. DISCUSSION Transplantation of MSCs in combination with Immunomodulation can exert a synergistic repair effect on neurotmesis, which can be monitored by multiparametric MRI.
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Assessment of the synergic effect of Immunomodulation on nerve repair using multiparametric magnetic resonance imaging
Muscle & nerve, 2017Co-Authors: Chushan Zheng, Fang Zhang, Xiang Zhang, Yue-yao Chen, Xiaohui Duan, Meiwei Chen, Jun ShenAbstract:Introduction The immune system plays a pivotal role in nerve injury. The aim of this study was to determine the role of multiparametric magnetic resonance imaging (MRI) in evaluation of the synergic effect of Immunomodulation on nerve regeneration in neurotmesis. Methods Rats with sciatic nerve neurotmesis and surgical repair underwent serial multiparametric MR examinations over an 8-week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate-buffered saline (PBS) alone. Results Nerves treated with Immunomodulation showed more prominent regeneration than those treated with LPS or PBS alone and more rapid restoration toward normal T2, fractional anisotropy (FA), and radial diffusivity (RD) values than nerves injected with LPS or PBS. Discussion Nerves treated with Immunomodulation exert synergic beneficial effects on nerve regeneration that can be predicted by T2 measurements and FA and RD values. Muscle Nerve 57: E38–E45, 2018
Neil Blumberg - One of the best experts on this subject based on the ideXlab platform.
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Transfusion Immunomodulation from a clinical perspective: an update.
Expert review of hematology, 2013Co-Authors: Majed A. Refaai, Neil BlumbergAbstract:Accumulated evidence demonstrates that allogeneic blood transfusions have clinically significant effects on the recipient's immune system. This transfusion Immunomodulation effect is associated with an increased rate of cancer recurrence (uncertain causality) and post-operative infection (established causality). The exact mechanisms of transfusion Immunomodulation are still unknown. Data suggests that transfusion Immunomodulation is a biologic effect strongly associated with the infusion of allogeneic leukocytes. Soluble mediators that accumulate in transfused red cells and platelets during storage are also possible causes of post-transfusion complications. Some approaches can mitigate these effects. Most important is adopting more conservative transfusion practices. Leukoreduction (proven) and plasma depletion (proposed) are other methods to significantly reduce transfusion Immunomodulation and its clinical sequela.
Fang Zhang - One of the best experts on this subject based on the ideXlab platform.
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Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment Immunomodulation in neurotmesis.
Muscle & nerve, 2020Co-Authors: Zehong Yang, Chushan Zheng, Fang Zhang, Binglin Lin, Minghui Cao, Xuwei Tian, Jingzhong Zhang, Xiao Zhang, Jun ShenAbstract:INTRODUCTION The immuno-microenvironment of injured nerves adversely affects mesenchymal stem cell (MSC) therapy for neurotmesis. Magnetic resonance imaging (MRI) can be used noninvasively to monitor nerve degeneration and regeneration. The aim of this study was to investigate nerve repair after MSC transplantation combined with microenvironment Immunomodulation in neurotmesis by using multiparametric MRI. METHODS Rats with sciatic nerve transection and surgical coaptation were treated with MSCs combined with Immunomodulation or MSCs alone. Serial multiparametric MRI examinations were performed over an 8-week period after surgery. RESULTS Nerves treated with MSCs combined with Immunomodulation showed better functional recovery, rapid recovery of nerve T2, fractional anisotropy and radial diffusivity values, and more rapid restoration of the fiber tracks than nerves treated with MSCs alone. DISCUSSION Transplantation of MSCs in combination with Immunomodulation can exert a synergistic repair effect on neurotmesis, which can be monitored by multiparametric MRI.
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Assessment of the synergic effect of Immunomodulation on nerve repair using multiparametric magnetic resonance imaging
Muscle & nerve, 2017Co-Authors: Chushan Zheng, Fang Zhang, Xiang Zhang, Yue-yao Chen, Xiaohui Duan, Meiwei Chen, Jun ShenAbstract:Introduction The immune system plays a pivotal role in nerve injury. The aim of this study was to determine the role of multiparametric magnetic resonance imaging (MRI) in evaluation of the synergic effect of Immunomodulation on nerve regeneration in neurotmesis. Methods Rats with sciatic nerve neurotmesis and surgical repair underwent serial multiparametric MR examinations over an 8-week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate-buffered saline (PBS) alone. Results Nerves treated with Immunomodulation showed more prominent regeneration than those treated with LPS or PBS alone and more rapid restoration toward normal T2, fractional anisotropy (FA), and radial diffusivity (RD) values than nerves injected with LPS or PBS. Discussion Nerves treated with Immunomodulation exert synergic beneficial effects on nerve regeneration that can be predicted by T2 measurements and FA and RD values. Muscle Nerve 57: E38–E45, 2018
Majed A. Refaai - One of the best experts on this subject based on the ideXlab platform.
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Transfusion Immunomodulation from a clinical perspective: an update.
Expert review of hematology, 2013Co-Authors: Majed A. Refaai, Neil BlumbergAbstract:Accumulated evidence demonstrates that allogeneic blood transfusions have clinically significant effects on the recipient's immune system. This transfusion Immunomodulation effect is associated with an increased rate of cancer recurrence (uncertain causality) and post-operative infection (established causality). The exact mechanisms of transfusion Immunomodulation are still unknown. Data suggests that transfusion Immunomodulation is a biologic effect strongly associated with the infusion of allogeneic leukocytes. Soluble mediators that accumulate in transfused red cells and platelets during storage are also possible causes of post-transfusion complications. Some approaches can mitigate these effects. Most important is adopting more conservative transfusion practices. Leukoreduction (proven) and plasma depletion (proposed) are other methods to significantly reduce transfusion Immunomodulation and its clinical sequela.
