The Experts below are selected from a list of 20784 Experts worldwide ranked by ideXlab platform
Rolando Cimaz - One of the best experts on this subject based on the ideXlab platform.
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Juvenile rheumatoid arthritis.
Current Opinion in Rheumatology, 2000Co-Authors: Fernanda Falcini, Rolando CimazAbstract:A satisfactory classification of arthritis in childhood has still to be defined, and a system that can facilitate communication among physicians has been proposed by an international committee. The Immunopathogenesis of the diseases that are encompassed by the term juvenile rheumatoid arthritis is c
Terry L. Moore - One of the best experts on this subject based on the ideXlab platform.
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Immunopathogenesis of juvenile rheumatoid arthritis.
Current Opinion in Rheumatology, 1999Co-Authors: Terry L. MooreAbstract:The immunopathogenic mechanisms of juvenile rheumatoid arthritis (JRA) have been debated. A possible cellular-mediated hypothesis versus a possible B cell hyperreactivity have been entertained. This review will focus on some recent cellular work in JRA and also further evaluation of cytokine levels
Fernanda Falcini - One of the best experts on this subject based on the ideXlab platform.
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Juvenile rheumatoid arthritis.
Current Opinion in Rheumatology, 2000Co-Authors: Fernanda Falcini, Rolando CimazAbstract:A satisfactory classification of arthritis in childhood has still to be defined, and a system that can facilitate communication among physicians has been proposed by an international committee. The Immunopathogenesis of the diseases that are encompassed by the term juvenile rheumatoid arthritis is c
Iain B Mcinnes - One of the best experts on this subject based on the ideXlab platform.
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Immunopathogenesis of rheumatoid arthritis
Immunity, 2017Co-Authors: Gary S Firestein, Iain B McinnesAbstract:Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that together propogate chronic inflammation and articular destruction. A pre-RA phase lasting months to years may be characterized by the presence of circulating autoantibodies, increasing concentration and range of inflammatory cytokines and chemokines, and altered metabolism. Clinical disease onset comprises synovitis and systemic comorbidities affecting the vasculature, metabolism, and bone. Targeted immune therapeutics and aggressive treatment strategies have substantially improved clinical outcomes and informed pathogenetic understanding, but no cure as yet exists. Herein we review recent data that support intriguing models of disease pathogenesis. They allude to the possibility of restoration of immunologic homeostasis and thus a state of tolerance associated with drug-free remission. This target represents a bold vision for the future of RA therapeutics.
Stephan R. Targan - One of the best experts on this subject based on the ideXlab platform.
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Immunopathogenesis of inflammatory bowel disease
World journal of gastroenterology, 2008Co-Authors: David Q. Shih, Stephan R. TarganAbstract:Crohn’s disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn’s disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the Immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis.