Implantation Procedure

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Mats Brittberg - One of the best experts on this subject based on the ideXlab platform.

  • cell carriers as the next generation of cell therapy for cartilage repair a review of the matrix induced autologous chondrocyte Implantation Procedure
    American Journal of Sports Medicine, 2010
    Co-Authors: Mats Brittberg
    Abstract:

    Background: Since the first patient was implanted with autologous cultured chondrocytes more than 20 years ago, new variations of cell therapies for cartilage repair have appeared. Autologous chondrocyte Implantation, a first-generation cell therapy, uses suspended autologous cultured chondrocytes in combination with a periosteal patch. Collagen-covered autologous cultured chondrocyte Implantation, a second-generation cell therapy, uses suspended cultured chondrocytes with a collagen type I/III membrane. Today’s demand for transarthroscopic Procedures has resulted in the development of third-generation cell therapies that deliver autologous cultured chondrocytes using cell carriers or cell-seeded scaffolds.Purpose: To review the current evidence of the matrix-induced autologous chondrocyte Implantation Procedure, the most widely used carrier system to date. Also discussed are the characteristics of type I/III collagen membranes, behavior of cells associated with the membrane, surgical technique, rehabilit...

Robert J Siegel - One of the best experts on this subject based on the ideXlab platform.

  • percutaneous interventions for left atrial appendage exclusion options assessment and imaging using 2d and 3d echocardiography
    Jacc-cardiovascular Imaging, 2015
    Co-Authors: Nina Wunderlich, Roy Beigel, Martin J Swaans, Siew Yen Ho, Robert J Siegel
    Abstract:

    Percutaneous left atrial appendage (LAA) exclusion is an evolving treatment to prevent embolic events in patients with nonvalvular atrial fibrillation. In the past few years multiple percutaneous devices have been developed to exclude the LAA from the body of the left atrium and thus from the systemic circulation. Two- and 3-dimensional transesophageal echocardiography (TEE) is used to assess the LAA anatomy and its suitability for percutaneous closure to select the type and size of the closure device and to guide the device Implantation Procedure in conjunction with fluoroscopy. In addition, 2- and 3-dimensional TEE is also used to assess the effectiveness of device Implantation acutely and on subsequent follow-up examination. Knowledge of the Implantation options that are currently available along with their specific characteristics is essential for choosing the appropriate device for a given patient with a specific LAA anatomy. We present the currently available LAA exclusion devices and the echocardiographic imaging approaches for evaluation of the LAA before, during, and after LAA occlusion.

  • percutaneous interventions for left atrial appendage exclusion options assessment and imaging using 2d and 3d echocardiography
    Jacc-cardiovascular Imaging, 2015
    Co-Authors: Nina Wunderlich, Roy Beigel, Martin J Swaans, Robert J Siegel
    Abstract:

    Percutaneous left atrial appendage (LAA) exclusion is an evolving treatment to prevent embolic events in patients with nonvalvular atrial fibrillation. In the past few years multiple percutaneous devices have been developed to exclude the LAA from the body of the left atrium and thus from the systemic circulation. Two- and 3-dimensional transesophageal echocardiography (TEE) is used to assess the LAA anatomy and its suitability for percutaneous closure to select the type and size of the closure device and to guide the device Implantation Procedure in conjunction with fluoroscopy. In addition, 2- and 3-dimensional TEE is also used to assess the effectiveness of device Implantation acutely and on subsequent follow-up examination. Knowledge of the Implantation options that are currently available along with their specific characteristics is essential for choosing the appropriate device for a given patient with a specific LAA anatomy. We present the currently available LAA exclusion devices and the echocardiographic imaging approaches for evaluation of the LAA before, during, and after LAA occlusion.

Roberto Plasenzotti - One of the best experts on this subject based on the ideXlab platform.

  • in vitro and in vivo measurement of the animal s middle ear acoustical response by partially implantable fiber optic sensing system
    Biosensors and Bioelectronics, 2018
    Co-Authors: Z Djinovic, Helga Bergmeister, Robert Pavelka, Milos Tomic, Georg Mathias Sprinzl, Hanns Plenk, U Losert, Roberto Plasenzotti
    Abstract:

    Abstract The main obstacle in realization of a totally implantable hearing aid is a lack of reliable implantable microphone. In this paper we have described a potentially miniature fiber-optic vibrometer based on a modified Michelson interferometer, designed to serve as a middle-ear microphone for totally implantable cochlear- or middle-ear hearing aids. A model of the sensing system was used for in-vitro and in-vivo investigation of acoustical response of sheep's middle-ear ossicles. Surgical and Implantation Procedure of introducing the sensing optical fiber into the middle-ear and its aiming at the incus was investigated and described here in detail. The frequency responses of the incus was measured while a cadaver and living sheep was exposed to the sinusoidal acoustical excitation of 40–90 dB SPL, in the frequency range from 100 Hz to 10 kHz. The amplitude of the incus vibration was found to be in the range between 10 pm to 100 nm, strongly depending on the frequency, with a lot of resonant peaks, corresponding mainly to the natural outer ear canal gain. The noise floor in the experiments was about 2 pm/Hz1/2, but recently we have decreased it to

  • extended in vivo evaluation of a miniaturized axial flow pump with a novel inflow cannula for a minimal invasive Implantation Procedure
    Journal of Heart and Lung Transplantation, 2014
    Co-Authors: Heinrich Schima, Philipp Zrunek, Jeff Larose, Charles R Shambaugh, Dan Tamez, Zeno Deckert, Roberto Plasenzotti, Martin Stoiber, Helga Bergmeister, Georg Wieselthaler
    Abstract:

    Background Minimally invasive techniques are desirable to minimize surgical trauma during left ventricular assist device (LVAD) Implantation. This is particularly challenging for full-flow support. In this study, a minimally invasive Implantation technique was developed for a microaxial rotary pump. The system was evaluated in a chronic sheep model. Methods A HeartWare MVAD (HeartWare, Miami Lakes, FL) pump (length, 50 mm; diameter, 21 mm; maximum flow, 7–8 liters/min) was combined with a novel inflow cannula, including a new flow-optimized tip. The device was implanted into sheep (range, 60–80 kg, mean, 71.6 ± 6.8 kg) through a right-sided minithoracotomy. The inflow cannula was inserted through the superior pulmonary vein, passing through the left atrium into the left ventricle. Scheduled implant period was 30 days for 8 sheep and 100 days for 3 sheep. Mean support flow was set to half of the nominal cardiac output. Results Six of 8 sheep finished the scheduled 30-day investigation period (one failed due to early non-pump-related post-operative bleeding and one due to prototype controller failure). The 3 sheep scheduled for 100 days reached the study end point. Peak pump flows of up to 6.9 liters/min were achieved. At necropsy, no signs of mitral valve lesions or thrombus formation around the cannula, the tip, or the insertion site were observed, except for valve leaflet erosion in 1 animal, where the cannula had been entangled in the sub-valvular chords due to lack of ultrasound monitoring. Conclusions The minimally invasive Implantation technique using the HeartWare MVAD pump, together with a new cannula, provided excellent results in a chronic animal model.

John G Webb - One of the best experts on this subject based on the ideXlab platform.

  • multidetector computed tomography in transcatheter aortic valve Implantation
    Jacc-cardiovascular Imaging, 2011
    Co-Authors: Jonathon Leipsic, Ronen Gurvitch, Troy M Labounty, James K Min, David A Wood, Mark S Johnson, Amr M Ajlan, Namal Wijesinghe, John G Webb
    Abstract:

    Aortic stenosis is a common disorder. Aortic valve replacement is indicated in symptomatic patients with severe aortic stenosis, as the prognosis of untreated patients is poor. Nevertheless, many patients pose a prohibitively high surgical risk and are not candidates for surgical valve replacement. Transcatheter aortic valve Implantation (TAVI) is a novel method to treat selected high-risk patients with aortic stenosis. Patient screening and anatomic measurements of the aortic root are of great importance to ensure procedural success and appropriate patient selection. Multidetector computed tomography (CT) is playing an increasingly important role in patient screening protocols before TAVI, provides detailed anatomic assessment of the aortic root and valve annulus, assesses the suitability of iliofemoral access, and determines appropriate coaxial angles to optimize the valve Implantation Procedure. Additionally, CT is providing a greater understanding of medium-term valve durability and integrity. This review outlines an evolving role for CT angiography in support of a TAVI program and describe step by step how CT can be used to enhance the Procedure and provide a practical guide for the utilization of CT angiography in support of a transcatheter aortic valve program.

Bernhard Meier - One of the best experts on this subject based on the ideXlab platform.

  • long term results after fluoroscopy guided closure of patent foramen ovale for secondary prevention of paradoxical embolism
    Heart, 2008
    Co-Authors: Andreas Wahl, Martin Kunz, Aris Moschovitis, Thuraia Nageh, Markus Schwerzmann, Christian Seiler, Heinrich Mattle, Stephan Windecker, Bernhard Meier
    Abstract:

    Objectives: To carry out long-term follow-up after percutaneous closure of patent foramen ovale (PFO) in patients with cryptogenic stroke. Design: Prospective cohort study. Setting: Single tertiary care centre. Participants: 525 consecutive patients (mean (SD) age 51 (12) years; 56% male). Interventions: Percutaneous PFO closure without intraprocedural echocardiography. Main outcome measures: Freedom from recurrent embolic events. Results: A mean (SD) of 1.7 (1.0) clinically apparent embolic events occurred for each patient, and 186 patients (35%) had >1 event. An atrial septal aneurysm was associated with the PFO in 161 patients (31%). All patients were followed up prospectively for up to 11 years. The Implantation Procedure failed in two patients (0.4%). There were 13 procedural complications (2.5%) without any long-term sequelae. Contrast transoesophageal echocardiography at 6 months showed complete closure in 86% of patients, and a minimal, moderate or large residual shunt in 9%, 3% and 2%, respectively. Patients with small occluders ( Conclusions: This study attests to the long-term safety and efficacy of percutaneous PFO closure guided by fluoroscopy only for secondary prevention of paradoxical embolism in a large cohort of consecutive patients.