The Experts below are selected from a list of 99 Experts worldwide ranked by ideXlab platform
Taichiro Takemura - One of the best experts on this subject based on the ideXlab platform.
-
flexible use of nuclear Import pathways by hiv 1
Cell Host & Microbe, 2010Co-Authors: Zandrea Ambrose, Ilker Oztop, Thomas D Martin, Alok Mulky, John G Julias, Nick Vandegraaff, Joerg G Baumann, Wendy Yuen, Rui Wang, Taichiro TakemuraAbstract:Summary HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion through nuclear pore complexes (NPCs), PICs use cellular nuclear transport mechanisms and nucleoporins (NUPs), the NPC components that permit selective nuclear-cytoplasmic exchange, but the details remain unclear. Here we identify a fragment of the cleavage and polyadenylation factor 6, CPSF6, as a potent inhibitor of HIV-1 infection. When enriched in the cytoplasm, CPSF6 prevents HIV-1 nuclear entry by targeting the viral capsid (CA). HIV-1 harboring the N74D mutation in CA fails to interact with CPSF6 and evades the nuclear Import Restriction. Interestingly, whereas wild-type HIV-1 requires NUP153, N74D HIV-1 mimics feline immunodeficiency virus nuclear Import requirements and is more sensitive to NUP155 depletion. These findings reveal a remarkable flexibility in HIV-1 nuclear transport and highlight a single residue in CA as essential in regulating interactions with NUPs.
Zandrea Ambrose - One of the best experts on this subject based on the ideXlab platform.
-
flexible use of nuclear Import pathways by hiv 1
Cell Host & Microbe, 2010Co-Authors: Zandrea Ambrose, Ilker Oztop, Thomas D Martin, Alok Mulky, John G Julias, Nick Vandegraaff, Joerg G Baumann, Wendy Yuen, Rui Wang, Taichiro TakemuraAbstract:Summary HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion through nuclear pore complexes (NPCs), PICs use cellular nuclear transport mechanisms and nucleoporins (NUPs), the NPC components that permit selective nuclear-cytoplasmic exchange, but the details remain unclear. Here we identify a fragment of the cleavage and polyadenylation factor 6, CPSF6, as a potent inhibitor of HIV-1 infection. When enriched in the cytoplasm, CPSF6 prevents HIV-1 nuclear entry by targeting the viral capsid (CA). HIV-1 harboring the N74D mutation in CA fails to interact with CPSF6 and evades the nuclear Import Restriction. Interestingly, whereas wild-type HIV-1 requires NUP153, N74D HIV-1 mimics feline immunodeficiency virus nuclear Import requirements and is more sensitive to NUP155 depletion. These findings reveal a remarkable flexibility in HIV-1 nuclear transport and highlight a single residue in CA as essential in regulating interactions with NUPs.
Evi Nurifah Julitasari - One of the best experts on this subject based on the ideXlab platform.
-
The Overview of Asean Rice Trade Toward Asean Integrated Food Security (AIFS)
Journal of Emerging Economies and Islamic Research, 2014Co-Authors: Evi Nurifah JulitasariAbstract:ASEAN takes serious effort to address the challenge of Food Security, within the region of Southeast Asia. Especially for rice trade among ASEAN country was taken place a long ago. In 2015 we would be integragted market. The aims of study are (1) to analysys the potential of rice supply and demand (2) the effect of trade Restriction (export and Import Restriction). The models were constructed by econometric simulation analysis with time series data from 1984-2007. The results shows: (1) the trend of ASEAN paddy production was increasing. The average increase of the ASEAN paddy production was 130,46 MT/year with the rate 2,84 percent/year (2) the effect of export Restriction will be increase an export price more than 10 percent, and the effect of Import Restriction will be increase an Import price in all Importer countries. Keywords : Restriction; rice traded; global market
-
DAMPAK RESTRIKSI PERDAGANGAN TERHADAP PENAWARAN DAN PERMINTAAN BERAS DI PASAR DUNIA DAN KINERJA PERBERASAN INDONESIA
2014Co-Authors: Evi Nurifah JulitasariAbstract:The aims of research is to analyze the effect of trade Restriction of rice exporter and Importer in the open market to influence he world rice supply and demand. Indonesian is the net Importer of rice so depend on quantity of market world rice. We use time series data from 198 4 to 2007’s and use simultaneous formulation with econometrical approach. The result show that’s export Restriction will increase the export volume and the world supply but the world price will turn exception for United of America Serikat. If there is no-export Restriction there is no effect for Indonesian’s rice. I mport Restriction will be increase an Import price in all Importer country . The effect of no -intervention Import Restriction will be decrease the domestic production, productivity and demand fertilizers. Suggestion for policy is the intervention in the Import Restriction is still neccesarry to increase Indonesian’s rice performance. Key words: trade Restriction, policy analysis, rice
-
The overview of Asean rice trade toward Asean Integrated Food Security (AIFS) / Evi Nurifah Julitasari
2014Co-Authors: Evi Nurifah JulitasariAbstract:ASEAN takes serious effort to address the challenge of Food Security, within the region of Southeast Asia. Especially for rice trade among ASEAN country was taken place a long ago. In 2015 we would be integragted market. The aims of study are (1) to analysys the potential of rice supply and demand (2) the effect of trade Restriction (export and Import Restriction). The models were constructed by econometric simulation analysis with time series data from 1984-2007. The results shows: (1) the trend of ASEAN paddy production was increasing. The average increase of the ASEAN paddy production was 130,46 MT/year with the rate 2,84 percent/year (2) the effect of export Restriction will be increase an export price more than 10 percent, and the effect of Import Restriction will be increase an Import price in all Importer countries.
Ilker Oztop - One of the best experts on this subject based on the ideXlab platform.
-
flexible use of nuclear Import pathways by hiv 1
Cell Host & Microbe, 2010Co-Authors: Zandrea Ambrose, Ilker Oztop, Thomas D Martin, Alok Mulky, John G Julias, Nick Vandegraaff, Joerg G Baumann, Wendy Yuen, Rui Wang, Taichiro TakemuraAbstract:Summary HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion through nuclear pore complexes (NPCs), PICs use cellular nuclear transport mechanisms and nucleoporins (NUPs), the NPC components that permit selective nuclear-cytoplasmic exchange, but the details remain unclear. Here we identify a fragment of the cleavage and polyadenylation factor 6, CPSF6, as a potent inhibitor of HIV-1 infection. When enriched in the cytoplasm, CPSF6 prevents HIV-1 nuclear entry by targeting the viral capsid (CA). HIV-1 harboring the N74D mutation in CA fails to interact with CPSF6 and evades the nuclear Import Restriction. Interestingly, whereas wild-type HIV-1 requires NUP153, N74D HIV-1 mimics feline immunodeficiency virus nuclear Import requirements and is more sensitive to NUP155 depletion. These findings reveal a remarkable flexibility in HIV-1 nuclear transport and highlight a single residue in CA as essential in regulating interactions with NUPs.
Thomas D Martin - One of the best experts on this subject based on the ideXlab platform.
-
flexible use of nuclear Import pathways by hiv 1
Cell Host & Microbe, 2010Co-Authors: Zandrea Ambrose, Ilker Oztop, Thomas D Martin, Alok Mulky, John G Julias, Nick Vandegraaff, Joerg G Baumann, Wendy Yuen, Rui Wang, Taichiro TakemuraAbstract:Summary HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion through nuclear pore complexes (NPCs), PICs use cellular nuclear transport mechanisms and nucleoporins (NUPs), the NPC components that permit selective nuclear-cytoplasmic exchange, but the details remain unclear. Here we identify a fragment of the cleavage and polyadenylation factor 6, CPSF6, as a potent inhibitor of HIV-1 infection. When enriched in the cytoplasm, CPSF6 prevents HIV-1 nuclear entry by targeting the viral capsid (CA). HIV-1 harboring the N74D mutation in CA fails to interact with CPSF6 and evades the nuclear Import Restriction. Interestingly, whereas wild-type HIV-1 requires NUP153, N74D HIV-1 mimics feline immunodeficiency virus nuclear Import requirements and is more sensitive to NUP155 depletion. These findings reveal a remarkable flexibility in HIV-1 nuclear transport and highlight a single residue in CA as essential in regulating interactions with NUPs.
