The Experts below are selected from a list of 435030 Experts worldwide ranked by ideXlab platform
Miriam Greenspan - One of the best experts on this subject based on the ideXlab platform.
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a new window into nurse manager development teaching for the practice
Journal of Nursing Administration, 2012Co-Authors: Eloise Balasco Cathcart, Miriam GreenspanAbstract:An Important Domain that emerged from the interpretation of 91 nurse manager (NM) narratives was achieving the right relationship between a NM and a recalcitrant staff member. This article depicts the qualitative distinctions in 2 stages of NM practice to show the importance of reflection on experiential learning in the development of expertise. This work confirms that NM development is more complex than teaching a curriculum of business and management theory and should include teaching for mastery of the skilled know-how of clinical leadership practice and formation of the person as manager.
K Muniyappa - One of the best experts on this subject based on the ideXlab platform.
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correction for sharadamma et al defining the functionally Important Domain and amino acid residues in mycobacterium tuberculosis integration host factor for genome stability dna binding and integrative recombination
Journal of Bacteriology, 2018Co-Authors: Narayanaswamy Sharadamma, Yadumurthy Harshavardhana, K MuniyappaAbstract:Volume 199, no. 19, e00357-17, 2017, [https://doi.org/10.1128/JB.00357-17][1]. Page 13, Fig. 8B: Lanes 9 to 12 were nonuniformly enhanced. The corrected figure shown below accurately reflects the results in the original image. The correction of this error does not alter the results or conclusions of
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defining the functionally Important Domain and amino acid residues in mycobacterium tuberculosis integration host factor for genome stability dna binding and integrative recombination
Journal of Bacteriology, 2017Co-Authors: Narayanaswamy Sharadamma, Yadumurthy Harshavardhana, K MuniyappaAbstract:The integration host factor of Mycobacterium tuberculosis (mIHF) consists of a single polypeptide chain, the product of the ihf gene. We previously revealed that mIHF is a novel member of a new class of nucleoid-associated proteins that have Important roles in DNA damage response, nucleoid compaction, and integrative recombination. The mIHF contains a region of 86 amino acids at its N terminus, absent from both alpha- and beta-subunits of Escherichia coli IHF. However, the functional significance of an extra 86-amino-acid region in the full-length protein remains unknown. Here, we report the structure/function relationship of the DNA-binding and integrative recombination-stimulating activity of mIHF. Deletion mutagenesis showed that an extra 86-amino-acid region at the N terminus is dispensable; the C-terminal region possesses the sequences essential for its known biological functions, including the ability to suppress the sensitivity of E. coli Delta ihfA and.ihfB cells to DNA-damaging agents, DNA binding, DNA multimerization-circularization, and stimulation of phage L5 integrase-catalyzed integrative recombination. Single and double alanine substitutions at positions Arg170 and Arg171, located at the mIHF DNA-binding site, abrogated its capacity to suppress the sensitivity of E. coli Delta ihfA and.ihfB cells to DNA-damaging agents. The variants encoded by these mutant alleles failed to bind DNA and stimulate integrative recombination. Interestingly, the DNA-binding activity of the mIHF-R173A variant remained largely unaffected; however, it was unable to stimulate integrative recombination, thus revealing a separation-of-function allele of mIHF. The functional and structural characterization of this separation-of-function allele of mIHF could reveal previously unknown functions of IHF. IMPORTANCE The integration host factor of Mycobacterium tuberculosis is a novel nucleoid-associated protein. mIHF plays a vital role in DNA damage response, nucleoid compaction, and integrative recombination. Intriguingly, mIHF contains an extra 86-amino-acid region at its N terminus, absent from both alpha- and beta-subunits of Escherichia coli IHF, whose functional significance is unknown. Furthermore, a triad of arginine residues located at the mIHF-DNA interface have been implicated in a range of its functions. Here, we reveal the roles of N-and C-terminal regions of mIHF and the individual residues in the Arg triad for their ability to provide protection in vivo against DNA damage, bind DNA, and stimulate integrase-catalyzed site-specific recombination.
Staffan Truve - One of the best experts on this subject based on the ideXlab platform.
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temporal analytics for predictive cyber threat intelligence
The Web Conference, 2016Co-Authors: Staffan TruveAbstract:Recorded Future has developed its Temporal Analytics Engine as a general purpose platform for harvesting and analyzing unstructured text from the open, deep, and dark web, and for transforming that content into a structured representation suitable for different analyses. In this paper we present some of the key components of our system, and show how it has been adapted to the increasingly Important Domain of cyber threat intelligence. We also describe how our data can be used for predictive analytics, e.g. to predict the likelihood of a product vulnerability being exploited or to assess the maliciousness of an IP address.
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WWW (Companion Volume) - Temporal Analytics for Predictive Cyber Threat Intelligence
Proceedings of the 25th International Conference Companion on World Wide Web - WWW '16 Companion, 2016Co-Authors: Staffan TruveAbstract:Recorded Future has developed its Temporal Analytics Engine as a general purpose platform for harvesting and analyzing unstructured text from the open, deep, and dark web, and for transforming that content into a structured representation suitable for different analyses. In this paper we present some of the key components of our system, and show how it has been adapted to the increasingly Important Domain of cyber threat intelligence. We also describe how our data can be used for predictive analytics, e.g. to predict the likelihood of a product vulnerability being exploited or to assess the maliciousness of an IP address.
Eloise Balasco Cathcart - One of the best experts on this subject based on the ideXlab platform.
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a new window into nurse manager development teaching for the practice
Journal of Nursing Administration, 2012Co-Authors: Eloise Balasco Cathcart, Miriam GreenspanAbstract:An Important Domain that emerged from the interpretation of 91 nurse manager (NM) narratives was achieving the right relationship between a NM and a recalcitrant staff member. This article depicts the qualitative distinctions in 2 stages of NM practice to show the importance of reflection on experiential learning in the development of expertise. This work confirms that NM development is more complex than teaching a curriculum of business and management theory and should include teaching for mastery of the skilled know-how of clinical leadership practice and formation of the person as manager.
Patricia M. Doney - One of the best experts on this subject based on the ideXlab platform.
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research methods in the leading small business entrepreneurship journals a critical review with recommendations for future research
Journal of Small Business Management, 2009Co-Authors: Michael R Mulle, Desislava G Udeva, Patricia M. DoneyAbstract:Small business and entrepreneurship scholars have made significant progress toward advancing the field and gaining recognition as an Important Domain of scientific inquiry. However, the authors suggest that a strong methodological foundation built on state-of-the-art research technologies is necessary to support further paradigmatic growth and maturation. Using Chandler and Lyon's study as a benchmark for research methods through the 1990s, the study critiques research methodologies used by small business and entrepreneurship researchers over the ensuing years. The analysis includes all 665 papers published between 2001 and February of 2008 in the Journal of Small Business Management, Journal of Business Venturing, and Entrepreneurship Theory and Practice. The research outlines key methodological issues, assesses recent methodological practice, identifies current trends, and offers recommendations for researchers in adopting existing and emerging research technologies.
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Research Methods in the Leading Small Business–Entrepreneurship Journals: A Critical Review with Recommendations for Future Research**
Journal of Small Business Management, 2009Co-Authors: Michael R. Mullen, Desislava G. Budeva, Patricia M. DoneyAbstract:Small business and entrepreneurship scholars have made significant progress toward advancing the field and gaining recognition as an Important Domain of scientific inquiry. However, the authors sug...
