The Experts below are selected from a list of 130197 Experts worldwide ranked by ideXlab platform
Erwin Von Angerer - One of the best experts on this subject based on the ideXlab platform.
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aroyl hydrazones of 2 phenylindole 3 carbaldehydes as novel antimitotic agents
Bioorganic & Medicinal Chemistry, 2008Co-Authors: Susanne Vogel, Michaela Pojarova, Doris Kaufmann, Patrick J Bednarski, Christine Muller, Tobias Pfaller, Sybille Kuhne, Erwin Von AngererAbstract:Cell cycle arrest of malignant cells is an Important Option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of various benzoic and pyridine carboxylic acids. The resulting hydrazones inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values of 20-30 nM for the most potent derivatives. These 2-phenylindole derivatives also exerted an inhibitory effect on the growth of both proliferating and resting U-373 MG glioblastoma cells. Though the hydrazones exhibited similar structure-activity relationships as the aldehydes, they did not inhibit tubulin polymerization as the aldehydes but were capable of blocking the cell cycle in G(2)/M phase. The cell cycle arrest was accompanied by apoptosis as demonstrated by the activation of caspase-3. Since these 2-phenylindole-based hydrazones display no structural similarity with other antitumor drugs they are interesting candidates for further development.
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2 phenylindol 3 yl methylene propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in g2 m phase and apoptosis
Bioorganic & Medicinal Chemistry, 2007Co-Authors: Michaela Pojarova, Doris Kaufmann, R Gastpar, Tsuyuki Nishino, Przemyslaw Reszka, Patrick J Bednarski, Erwin Von AngererAbstract:Cell cycle arrest of malignant cells is an Important Option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with malononitrile. The resulting methylene propanedinitriles inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values below 100 nM. Though they exhibited similar structure-activity relationships as the aldehydes, they did not inhibit tubulin polymerization but were capable of blocking the cell cycle in G(2)/M phase. The cell cycle arrest was accompanied by apoptosis as demonstrated by the activation of caspases 3 and 9. Since the new 2-phenylindole derivatives also inhibited the growth of transplanted MXT mouse mammary tumors, they are interesting candidates for further development.
Paul F Lachiewicz - One of the best experts on this subject based on the ideXlab platform.
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dual mobility for recurrent dislocation double trouble
Orthopaedic Proceedings, 2018Co-Authors: Paul F LachiewiczAbstract:Dual mobility components for total hip arthroplasty provide for an additional articular surface, with the goals of improving range of motion, jump distance, and overall stability of the prosthetic hip joint. A large polyethylene head articulates with a polished metal acetabular component, and an additional smaller metal head is snap-fit into the large polyethylene. New components have been released for use in North America over the past three years. In some European centers, these components are routinely used for primary total hip arthroplasty. However, their greatest utility may be to manage recurrent dislocation in the setting of revision total hip arthroplasty. Several small retrospective series have shown satisfactory results for this indication at short- to medium-term follow-up times. However, there are Important concerns with polyethylene wear, late intra-prosthetic dislocation, and the lack of long-term follow-up data. These components are an Important Option in the treatment of recurrent disloca...
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dual mobility for recurrent dislocation double trouble
Journal of Bone and Joint Surgery-british Volume, 2014Co-Authors: Paul F LachiewiczAbstract:Dual mobility components for total hip arthroplasty provide for an additional articular surface, with the goals of improving range of motion, jump distance, and overall stability of the prosthetic hip joint. A large polyethylene head articulates with a polished metal acetabular component, and an additional smaller metal head is snap-fit into the large polyethylene. New components have been released for use in North America over the past three years. In some European centers, these components are routinely used for primary total hip arthroplasty. However, their greatest utility may be to manage recurrent dislocation in the setting of revision total hip arthroplasty. Several small retrospective series have shown satisfactory results for this indication at short- to medium-term follow-up times. However, there are Important concerns with polyethylene wear, late intra-prosthetic dislocation, and the lack of long-term follow-up data. These components are an Important Option in the treatment of recurrent dislocation in younger patients, revision of failed metal-metal resurfacing, and salvage of failed constrained liners. Until further long-term results are available, caution is advised in the routine use of dual mobility components in primary or revision total hip arthroplasty.
Jonathan P Braman - One of the best experts on this subject based on the ideXlab platform.
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hemiarthroplasty and total shoulder arthroplasty conversion to reverse total shoulder arthroplasty
Current Reviews in Musculoskeletal Medicine, 2020Co-Authors: Alicia K Harrison, Michael L Knudsen, Jonathan P BramanAbstract:Purpose of review The incidence of shoulder arthroplasty is increasing dramatically for primary arthroplasty but also for revision arthroplasty. Revision to reverse total shoulder arthroplasty is increasingly the salvage operation for failed primary arthroplasty. The purpose of this review is to explore the indications for and results of revision reverse total shoulder arthroplasty. Recent findings Despite relatively high complication and reoperation rates with revision shoulder replacement, revision of failed hemiarthroplasty or total shoulder arthroplasty to reverse total shoulder arthroplasty improves outcomes for many patients. A failed hemiarthroplasty or total shoulder arthroplasty is frequently disabling for the patient and because the surgical revision Options are often limited only to reverse total shoulder arthroplasty, the potential improvement is often worth the higher surgical complication or reoperation rate. Due to the challenges inherent in revision arthroplasty, revision of primary arthroplasty to reverse total shoulder arthroplasty, outcomes are poorer than primary reverse total shoulder arthroplasty. Despite these limitations, patient postoperative pain and function do increase from preoperative levels making conversion of hemiarthroplasty or anatomic total shoulder to reverse total shoulder arthroplasty an Important Option for a challenging problem.
Michaela Pojarova - One of the best experts on this subject based on the ideXlab platform.
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aroyl hydrazones of 2 phenylindole 3 carbaldehydes as novel antimitotic agents
Bioorganic & Medicinal Chemistry, 2008Co-Authors: Susanne Vogel, Michaela Pojarova, Doris Kaufmann, Patrick J Bednarski, Christine Muller, Tobias Pfaller, Sybille Kuhne, Erwin Von AngererAbstract:Cell cycle arrest of malignant cells is an Important Option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of various benzoic and pyridine carboxylic acids. The resulting hydrazones inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values of 20-30 nM for the most potent derivatives. These 2-phenylindole derivatives also exerted an inhibitory effect on the growth of both proliferating and resting U-373 MG glioblastoma cells. Though the hydrazones exhibited similar structure-activity relationships as the aldehydes, they did not inhibit tubulin polymerization as the aldehydes but were capable of blocking the cell cycle in G(2)/M phase. The cell cycle arrest was accompanied by apoptosis as demonstrated by the activation of caspase-3. Since these 2-phenylindole-based hydrazones display no structural similarity with other antitumor drugs they are interesting candidates for further development.
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2 phenylindol 3 yl methylene propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in g2 m phase and apoptosis
Bioorganic & Medicinal Chemistry, 2007Co-Authors: Michaela Pojarova, Doris Kaufmann, R Gastpar, Tsuyuki Nishino, Przemyslaw Reszka, Patrick J Bednarski, Erwin Von AngererAbstract:Cell cycle arrest of malignant cells is an Important Option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with malononitrile. The resulting methylene propanedinitriles inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values below 100 nM. Though they exhibited similar structure-activity relationships as the aldehydes, they did not inhibit tubulin polymerization but were capable of blocking the cell cycle in G(2)/M phase. The cell cycle arrest was accompanied by apoptosis as demonstrated by the activation of caspases 3 and 9. Since the new 2-phenylindole derivatives also inhibited the growth of transplanted MXT mouse mammary tumors, they are interesting candidates for further development.
Alicia K Harrison - One of the best experts on this subject based on the ideXlab platform.
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hemiarthroplasty and total shoulder arthroplasty conversion to reverse total shoulder arthroplasty
Current Reviews in Musculoskeletal Medicine, 2020Co-Authors: Alicia K Harrison, Michael L Knudsen, Jonathan P BramanAbstract:Purpose of review The incidence of shoulder arthroplasty is increasing dramatically for primary arthroplasty but also for revision arthroplasty. Revision to reverse total shoulder arthroplasty is increasingly the salvage operation for failed primary arthroplasty. The purpose of this review is to explore the indications for and results of revision reverse total shoulder arthroplasty. Recent findings Despite relatively high complication and reoperation rates with revision shoulder replacement, revision of failed hemiarthroplasty or total shoulder arthroplasty to reverse total shoulder arthroplasty improves outcomes for many patients. A failed hemiarthroplasty or total shoulder arthroplasty is frequently disabling for the patient and because the surgical revision Options are often limited only to reverse total shoulder arthroplasty, the potential improvement is often worth the higher surgical complication or reoperation rate. Due to the challenges inherent in revision arthroplasty, revision of primary arthroplasty to reverse total shoulder arthroplasty, outcomes are poorer than primary reverse total shoulder arthroplasty. Despite these limitations, patient postoperative pain and function do increase from preoperative levels making conversion of hemiarthroplasty or anatomic total shoulder to reverse total shoulder arthroplasty an Important Option for a challenging problem.
