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Dan J. Stein - One of the best experts on this subject based on the ideXlab platform.
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compulsive sexual behavior Disorder in obsessive compulsive Disorder prevalence and associated comorbidity
Journal of behavioral addictions, 2019Co-Authors: Johannes Fuss, Dan J. Stein, Christine Lochner, Peer BrikenAbstract:Background and aimsCompulsive sexual behavior Disorder (CSBD) will be included in ICD-11 as an Impulse-Control Disorder. CSBD also shares clinical features with obsessive–compulsive spectrum disord...
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trichotillomania hair pulling Disorder skin picking Disorder and stereotypic movement Disorder toward dsm v
Depression and Anxiety, 2010Co-Authors: Dan J. Stein, Christine Lochner, Martin E. Franklin, E Jon M D J D Grant, Nancy J Keuthen, S Harvey M D Singer, Douglas W WoodsAbstract:In DSM-IV-TR, trichotillomania (TTM) is classified as an Impulse Control Disorder (not classified elsewhere), skin picking lacks its own diagnostic category (but might be diagnosed as an Impulse Control Disorder not otherwise specified), and stereotypic movement Disorder is classified as a Disorder usually first diagnosed in infancy, childhood, or adolescence. ICD-10 classifies TTM as a habit and Impulse Disorder, and includes stereotyped movement Disorders in a section on other behavioral and emotional Disorders with onset usually occurring in childhood and adolescence. This article provides a focused review of nosological issues relevant to DSM-V, given recent empirical findings. This review presents a number of options and preliminary recommendations to be considered for DSM-V: (1) Although TTM fits optimally into a category of body-focused repetitive behavioral Disorders, in a nosology comprised of relatively few major categories it fits best within a category of motoric obsessive–compulsive spectrum Disorders, (2) available evidence does not support continuing to include (current) diagnostic criteria B and C for TTM in DSM-V, (3) the text for TTM should be updated to describe subtypes and forms of hair pulling, (4) there are persuasive reasons for referring to TTM as ‘‘hair pulling Disorder (trichotillomania),’’ (5) diagnostic criteria for skin picking Disorder should be included in DSM-V or in DSM-Vs Appendix of Criteria Sets Provided for Further Study, and (6) the diagnostic criteria for stereotypic movement Disorder should be clarified and simplified, bringing them in line with those for hair pulling and skin picking Disorder. Depression and Anxiety 27:611–626, 2010. r 2010 Wiley-Liss, Inc.
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an a b c model of habit Disorders hair pulling skin picking and other stereotypic conditions
Cns Spectrums, 2006Co-Authors: Dan J. Stein, Samuel R Chamberlain, Naomi A FinebergAbstract:Severe hair-pulling is characteristic of trichotillomania, an Impulse Control Disorder not otherwise classified. Other pathological habits, including severe nail-biting and skin-picking, are also prevalent and are potentially diagnosable as stereotypic movement Disorder. There is increasing awareness of the morbidity associated with these kind of habit Disorders but, to date, relatively few randomized Controlled trials of pharmacotherapy or psychotherapy have been undertaken. Advances in the understanding of the underlying cognitive-affective mechanisms driving stereotypies in animals and humans may ultimately lead to new approaches. An affect regulation, behavioral addiction, and cognitive Control (A-B-C) approach is outlined to conceptualizing and managing these conditions.
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trichotillomania and skin picking a phenomenological comparison
Depression and Anxiety, 2002Co-Authors: Christine Lochner, Daphne Simeon, Dana J.h. Niehaus, Dan J. SteinAbstract:Although trichotillomania and pathological skin-picking are both characterized by repetitive self-injurious stereotypic behaviors, the former is classified as an Impulse Control Disorder, while the latter is not given a specific diagnostic category in the Diagnostic and Statistical Manual of Mental Disorders (4th edition) [APA, 1994]. There are, however, few empirical data on phenomenological similarities and differences between these Disorders. Patients with trichotillomania and pathological skin-picking were compared in terms of several demographic (age, gender), clinical (comorbid axis I and II Disorders), and personality variables. Trichotillomania and pathological skin-picking were very similar in demographics, psychiatric comorbidity, and personality dimensions. Dissociative symptoms may be more common in trichotillomania than in pathological skin-picking. These data support the concept of phenomenological overlap between trichotillomania and pathological skin-picking. Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful.
Daniel Weintraub - One of the best experts on this subject based on the ideXlab platform.
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is rapid eye movement sleep behavior Disorder a risk factor for Impulse Control Disorder in parkinson disease
Annals of Neurology, 2020Co-Authors: Maria Livia Fantini, Daniel Weintraub, Janel Fedler, Bruno Pereira, A Marques, Franck DurifAbstract:OBJECTIVE To assess the association between rapid eye movement sleep behavior Disorder (RBD) and other determinants and incident Impulse Control Disorder behaviors (ICBs) in patients with early Parkinson disease (PD) using longitudinal data from the Parkinson's Progression Markers Initiative. METHODS Four hundred one newly diagnosed PD patients were prospectively evaluated at baseline (BL), month 6, and annually for 5 years. Probable RBD (pRBD) was assessed with the RBD Screening Questionnaire (RBDSQ) and dichotomized using a cutoff value of ≥6. The association of BL and time-dependent (TD) pRBD and other covariates with the development of ICB symptoms was evaluated using Cox proportional hazards regression and general estimating equation logistic regression. Models considered adjustment for age, sex, Movement Disorders Society Unified Parkinson's Disease Rating Scale part III, Geriatric Depression Scale (GDS-15), RBD medication use, total levodopa equivalent daily dose, and dopamine agonist (DA) and antidepressant medication use. RESULTS Both BL pRBD and TD pRBD were not associated with an increased risk for incident ICB symptoms after adjustment for covariates (adjusted hazard ratio [HR] = 1.17, p = 0.458 and HR = 1.27, p = 0.257, respectively). In a modified TD pRBD model (ie, considering subjects as pRBD onward from the first time point with RBDSQ score ≥ 6), the risk for incident ICB symptoms was higher in pRBD in unadjusted (HR = 1.48, p = 0.038) but not adjusted (HR = 1.29, p = 0.203) models. TD DA use (HR = 1.64, p = 0.039), TD GDS-15 score (HR = 1.12, p < 0.001), and male sex (year 3: HR = 2.10, p = 0.009; year 4: HR = 3.04, p = 0.006; year 5: HR = 4.40, p = 0.007) were associated with increased ICB symptom risk. INTERPRETATION pRBD is not clearly associated with ICB symptom development in early PD, in contrast to DA use, depression, and male sex. ANN NEUROL 2020;88:759-770.
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Impulse Control Disorder related behaviours during long term rotigotine treatment a post hoc analysis
European Journal of Neurology, 2016Co-Authors: Angelo Antonini, Kallol Ray Chaudhuri, Babak Boroojerdi, Mahnaz Asgharnejad, Lars Bauer, Frank Grieger, Daniel WeintraubAbstract:Background and purpose Dopamine agonists in Parkinson's disease (PD) are associated with Impulse Control Disorders (ICDs) and other compulsive behaviours (together called ICD behaviours). The frequency of ICD behaviours reported as adverse events (AEs) in long-term studies of rotigotine transdermal patch in PD was evaluated. Methods This was a post hoc analysis of six open-label extension studies up to 6 years in duration. Analyses included patients treated with rotigotine for at least 6 months and administered the modified Minnesota Impulse Disorders Interview. ICD behaviours reported as AEs were identified and categorized. Results For 786 patients, the mean (±SD) exposure to rotigotine was 49.4 ± 17.6 months. 71 (9.0%) patients reported 106 ICD AEs cumulatively. Occurrence was similar across categories: 2.5% patients reported ‘compulsive sexual behaviour’, 2.3% ‘buying Disorder’, 2.0% ‘compulsive gambling’, 1.7% ‘compulsive eating’ and 1.7% ‘punding behaviour’. Examining at 6-month intervals, the incidence was relatively low during the first 30 months; it was higher over the next 30 months, peaking in the 54–60-month period. No ICD AEs were serious, and 97% were mild or moderate in intensity. Study discontinuation occurred in seven (9.9%) patients with ICD AEs; these then resolved in five patients. Dose reduction occurred for 23 AEs, with the majority (73.9%) resolving. Conclusions In this analysis of >750 patients with PD treated with rotigotine, the frequency of ICD behaviour AEs was 9.0%, with a specific incidence timeline observed. Active surveillance as duration of treatment increases may help early identification and management; once ICD behaviours are present rotigotine dose reduction may be considered.
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Incident Impulse Control Disorder symptoms and dopamine transporter imaging in Parkinson disease
2015Co-Authors: Kara M Smith, Sharon X Xie, Daniel WeintraubAbstract:OBJECTIVE: To describe the incidence of, and clinical and neurobiological risk factors for, new-onset Impulse Control Disorder (ICD) symptoms and related behaviours in early Parkinson disease (PD). METHODS: The Parkinson's Progression Markers Initiative is an international, multicenter, prospective study of de novo patients with PD untreated at baseline and assessed annually, including serial dopamine transporter imaging (DAT-SPECT) and ICD assessment (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease short form, QUIP). Participants were included if they screened negative on the QUIP at baseline. Kaplan-Meier curves and generalised estimating equations examined frequency and predictors of incident ICD symptoms. RESULTS: Participants were seen at baseline (n=320), year 1 (n=284), year 2 (n=217) and year 3 (n=96). Estimated cumulative incident rates of ICD symptoms and related behaviours were 8% (year 1), 18% (year 2) and 25% (year 3) and increased each year in those on dopamine replacement therapy (DRT) and decreased in those not on DRT. In participants on DRT, risk factors for incident ICD symptoms were younger age (OR=0.97, p=0.05), a greater decrease in right caudate (OR=4.03, p=0.01) and mean striatal (OR=6.90, p=0.04) DAT availability over the first year, and lower right putamen (OR=0.06, p=0.01) and mean total striatal (OR=0.25, p=0.04) DAT availability at any post-baseline visit. CONCLUSIONS: The rate of incident ICD symptoms increases with time and initiation of DRT in early PD. In this preliminary study, a greater decrease or lower DAT binding over time increases risk of incident ICD symptoms, conferring additional risk to those taking DRT. CLINICAL TRIAL REGISTRATION: NCT01141023.
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questionnaire for impulsive compulsive Disorders in parkinson s disease rating scale
Movement Disorders, 2012Co-Authors: Daniel Weintraub, Sharon X Xie, Eugenia Mamikonyan, Kimberly Papay, Judith A Shea, Andrew SiderowfAbstract:Impulse Control Disorders and related Disorders (hobbyism-punding and dopamine dysregulation syndrome) occur in 15% to 20% of Parkinson's disease (PD) patients. We assessed the validity and reliability of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS), a rating scale designed to measure severity of symptoms and support a diagnosis of Impulse Control Disorders and related Disorders in PD. A convenience sample of PD patients at a movement Disorders clinic self-completed the QUIP-RS and were administered a semistructured diagnostic interview by a blinded trained rater to assess discriminant validity for Impulse Control Disorders (n = 104) and related Disorders (n = 77). Subsets of patients were assessed to determine interrater reliability (n = 104), retest reliability (n = 63), and responsiveness to change (n = 29). Adequate cutoff points (both sensitivity and specificity values >80% plus acceptable likelihood ratios) were established for each Impulse Control Disorder and hobbyism-punding. Interrater and retest reliability (intraclass correlation coefficient r) were >0.60 for all Disorders. Participants in an Impulse Control Disorder treatment study who experienced full (t = 3.65, P = .004) or partial (t = 2.98, P = .01) response demonstrated significant improvement on the rating scale over time, while nonresponders did not (t = 0.12, P = .91). The QUIP-RS appears to be valid and reliable as a rating scale for Impulse Control Disorders and related Disorders in PD. Preliminary results suggest that it can be used to support a diagnosis of these Disorders, as well as to monitor changes in symptom severity over time.
Maria Livia Fantini - One of the best experts on this subject based on the ideXlab platform.
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is rapid eye movement sleep behavior Disorder a risk factor for Impulse Control Disorder in parkinson disease
Annals of Neurology, 2020Co-Authors: Maria Livia Fantini, Daniel Weintraub, Janel Fedler, Bruno Pereira, A Marques, Franck DurifAbstract:OBJECTIVE To assess the association between rapid eye movement sleep behavior Disorder (RBD) and other determinants and incident Impulse Control Disorder behaviors (ICBs) in patients with early Parkinson disease (PD) using longitudinal data from the Parkinson's Progression Markers Initiative. METHODS Four hundred one newly diagnosed PD patients were prospectively evaluated at baseline (BL), month 6, and annually for 5 years. Probable RBD (pRBD) was assessed with the RBD Screening Questionnaire (RBDSQ) and dichotomized using a cutoff value of ≥6. The association of BL and time-dependent (TD) pRBD and other covariates with the development of ICB symptoms was evaluated using Cox proportional hazards regression and general estimating equation logistic regression. Models considered adjustment for age, sex, Movement Disorders Society Unified Parkinson's Disease Rating Scale part III, Geriatric Depression Scale (GDS-15), RBD medication use, total levodopa equivalent daily dose, and dopamine agonist (DA) and antidepressant medication use. RESULTS Both BL pRBD and TD pRBD were not associated with an increased risk for incident ICB symptoms after adjustment for covariates (adjusted hazard ratio [HR] = 1.17, p = 0.458 and HR = 1.27, p = 0.257, respectively). In a modified TD pRBD model (ie, considering subjects as pRBD onward from the first time point with RBDSQ score ≥ 6), the risk for incident ICB symptoms was higher in pRBD in unadjusted (HR = 1.48, p = 0.038) but not adjusted (HR = 1.29, p = 0.203) models. TD DA use (HR = 1.64, p = 0.039), TD GDS-15 score (HR = 1.12, p < 0.001), and male sex (year 3: HR = 2.10, p = 0.009; year 4: HR = 3.04, p = 0.006; year 5: HR = 4.40, p = 0.007) were associated with increased ICB symptom risk. INTERPRETATION pRBD is not clearly associated with ICB symptom development in early PD, in contrast to DA use, depression, and male sex. ANN NEUROL 2020;88:759-770.
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sleep and rem sleep behaviour Disorder in parkinson s disease with Impulse Control Disorder
Journal of Neurology Neurosurgery and Psychiatry, 2018Co-Authors: Maria Livia Fantini, Maurizio Zibetti, Bruno Pereira, Michela Figorilli, Monica Puligheddu, Isabelle Arnulf, P Beudin, Florence Cormierdequaire, Lucette Lacomblez, Eve BenchetritAbstract:Introduction Because the association between rapid eye movement sleep behaviour Disorder (RBD) and Impulse Control Disorders (ICDs) in Parkinson’s disease (PD) has been debated, we assessed the sleep characteristics and the frequency of RBD using video-polysomnography (v-PSG) in patients with PD with versus without ICDs. Methods Eighty non-demented patients with PD consecutively identified during routine evaluation at three movement Disorders centres were enrolled in a case–Control study. Forty patients (22 men; mean age: 62.6±9.7 years, Hoehn & Yahr: 2.1±0.6) with one or more current ICDs were age-matched and sex-matched with 40 patients with no history of ICDs (22 men, mean age: 64.9±7.8 years, Hoehn & Yahr: 2.2±0.6). They underwent a detailed sleep interview followed by a full-night in-lab v-PSG. Sleep was scored blindly to ICDs condition and RBD diagnosis included a clinical complaint of enacted dreams and/or documented behaviour during rapid eye movement (REM) sleep, with the presence of quantified REM sleep without atonia (RSWA). Results Patients with ICDs had a higher arousal index and higher RSWA than those without ICDs (51.9%±28.2%vs 32.2±27.1%, p=0.004). In addition, RBD was more frequent in the ICD group (85%vs53%, p=0.0001). RBD was still associated with ICDs in a multivariate regression analysis including age of onset, PD duration and severity, treatment duration, levodopa-equivalent and dopamine agonist-equivalent daily doses and antidepressant use (OR: 4.9 (95% CI 1.3 to 18.5), p=0.02). Conclusions This large, Controlled series of patients with PD with ICDs assessed by v-PSG confirms the association between ICDs and RBD. Increased surveillance of symptoms of ICDs should be recommended in patients with PD with RBD.
Christine Lochner - One of the best experts on this subject based on the ideXlab platform.
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compulsive sexual behavior Disorder in obsessive compulsive Disorder prevalence and associated comorbidity
Journal of behavioral addictions, 2019Co-Authors: Johannes Fuss, Dan J. Stein, Christine Lochner, Peer BrikenAbstract:Background and aimsCompulsive sexual behavior Disorder (CSBD) will be included in ICD-11 as an Impulse-Control Disorder. CSBD also shares clinical features with obsessive–compulsive spectrum disord...
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trichotillomania hair pulling Disorder skin picking Disorder and stereotypic movement Disorder toward dsm v
Depression and Anxiety, 2010Co-Authors: Dan J. Stein, Christine Lochner, Martin E. Franklin, E Jon M D J D Grant, Nancy J Keuthen, S Harvey M D Singer, Douglas W WoodsAbstract:In DSM-IV-TR, trichotillomania (TTM) is classified as an Impulse Control Disorder (not classified elsewhere), skin picking lacks its own diagnostic category (but might be diagnosed as an Impulse Control Disorder not otherwise specified), and stereotypic movement Disorder is classified as a Disorder usually first diagnosed in infancy, childhood, or adolescence. ICD-10 classifies TTM as a habit and Impulse Disorder, and includes stereotyped movement Disorders in a section on other behavioral and emotional Disorders with onset usually occurring in childhood and adolescence. This article provides a focused review of nosological issues relevant to DSM-V, given recent empirical findings. This review presents a number of options and preliminary recommendations to be considered for DSM-V: (1) Although TTM fits optimally into a category of body-focused repetitive behavioral Disorders, in a nosology comprised of relatively few major categories it fits best within a category of motoric obsessive–compulsive spectrum Disorders, (2) available evidence does not support continuing to include (current) diagnostic criteria B and C for TTM in DSM-V, (3) the text for TTM should be updated to describe subtypes and forms of hair pulling, (4) there are persuasive reasons for referring to TTM as ‘‘hair pulling Disorder (trichotillomania),’’ (5) diagnostic criteria for skin picking Disorder should be included in DSM-V or in DSM-Vs Appendix of Criteria Sets Provided for Further Study, and (6) the diagnostic criteria for stereotypic movement Disorder should be clarified and simplified, bringing them in line with those for hair pulling and skin picking Disorder. Depression and Anxiety 27:611–626, 2010. r 2010 Wiley-Liss, Inc.
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trichotillomania and skin picking a phenomenological comparison
Depression and Anxiety, 2002Co-Authors: Christine Lochner, Daphne Simeon, Dana J.h. Niehaus, Dan J. SteinAbstract:Although trichotillomania and pathological skin-picking are both characterized by repetitive self-injurious stereotypic behaviors, the former is classified as an Impulse Control Disorder, while the latter is not given a specific diagnostic category in the Diagnostic and Statistical Manual of Mental Disorders (4th edition) [APA, 1994]. There are, however, few empirical data on phenomenological similarities and differences between these Disorders. Patients with trichotillomania and pathological skin-picking were compared in terms of several demographic (age, gender), clinical (comorbid axis I and II Disorders), and personality variables. Trichotillomania and pathological skin-picking were very similar in demographics, psychiatric comorbidity, and personality dimensions. Dissociative symptoms may be more common in trichotillomania than in pathological skin-picking. These data support the concept of phenomenological overlap between trichotillomania and pathological skin-picking. Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful.
Federico Micheli - One of the best experts on this subject based on the ideXlab platform.
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a multicenter comparative study of Impulse Control Disorder in latin american patients with parkinson disease
Clinical Neuropharmacology, 2017Co-Authors: Carolina Candelaria Ramirez Gomez, Marcos Serrano Duenas, Oscar Bernal, Natalia Araoz, Michel Saenz Farret, Victoria Aldinio, Veronica Montilla, Federico MicheliAbstract:Objectives Impulse Control Disorder (ICD) is a common adverse effect in patients with Parkinson disease who receive dopamine agonists; however, other factors are involved in its manifestations. To study the frequency and factors involved in the development of this adverse effect in a Latin American population, we conducted a cross-sectional multicenter study. Methods Two hundred fifty-five patients in 3 Latin American centers were evaluated by examination and application of scales (Unified Parkinson’s Disease Rating Scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale, Hoehn and Yahr, Clinical Impression of Severity Index for Parkinson’s Disease). Results Of the patients, 27.4% had ICD, most of whom were on dopamine agonists. Other associated risk factors included a younger age at onset of Parkinson disease, moderate symptoms, a shorter evolution of the clinical manifestations, rapid eye movement (REM) sleep Disorder behavior, and the consumption of tea, mate, and alcohol. Conclusions The frequency of ICD is higher in Latin America than in Anglo-Saxon populations. Consuming tea and mate, in addition to the use of dopamine agonists, is a factor that may demonstrate a genetic link that predisposes patients to the establishment of an ICD.
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pet killing as a manifestation of Impulse Control Disorder secondary to pramipexol
Clinical Neuropharmacology, 2015Co-Authors: Federico Micheli, Alejandro Pellene, Daniela Arcushin, Aldo Calzinari, Michel Saenz FarretAbstract:Impulse Control Disorders are frequent in Parkinson disease and are commonly associated with dopamine agonists intake. Typical manifestations include punding, hypersexuality, pathological gambling, and other compulsive behaviors. Symptoms often promptly disappear when dopamine agonists are discontinued, but if the origin is misinterpreted, symptoms may become a problem. We here report the case of a patient with juvenile Parkinson disease treated with 4.5 mg/d of pramipexol, who developed the need to adopt cats. He adopted almost 50 of them, but after he adopted them, he felt the need to kill them. The case became well known, and he became depressed and isolated. He was admitted to a psychiatric hospital and thought that he was a psychotic. However, when pramipexol was replaced by levodopa, the symptoms disappeared. This case illustrates the wide range of manifestations of Impulse Control Disorders and warrants the inclusion of violent behaviors among them.
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Impulse Control Disorder and piribedil: report of 5 cases.
Clinical neuropharmacology, 2010Co-Authors: Lorena Tschopp, Zulema Salazar, Marco T. Gomez Botello, Claudia Uribe Roca, Federico MicheliAbstract:Recent studies suggest that Impulse Control Disorders (ICD) in Parkinson disease are not uncommon, and antiparkinsonian therapy, mainly the use of dopaminergic agonists, plays a causal role in the development of these symptoms. Pramipexole has been mainly related to the occurrence of ICDs, although these Disorders may occur when any dopaminergic agonist-based therapy is administered.In this paper, we describe 4 patients with Parkinson disease and 1 with multisystem atrophy who presented a history (several months or years) of pathological gambling, hypersexuality, punding, and pathological use of the Internet secondary to piribedil. This previously undescribed association suggests that the development of these Disorders might be also related to piribedil administration. It is also the first report of a patient with multisystem atrophy developing such adverse effects.
