The Experts below are selected from a list of 552 Experts worldwide ranked by ideXlab platform
George P Chrousos - One of the best experts on this subject based on the ideXlab platform.
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hypothalamic pituitary adrenal axis activation and stimulation of systemic Vasopressin Secretion by recombinant interleukin 6 in humans potential implications for the syndrome of Inappropriate Vasopressin Secretion
The Journal of Clinical Endocrinology and Metabolism, 1994Co-Authors: George Mastorakos, Jeffrey S Weber, M A Magiakou, H Gunn, George P ChrousosAbstract:We recently demonstrated that sc administered interleukin-6 (IL-6) strongly stimulates the human hypothalamic-pituitary-adrenal (HPA) axis, with mild toxicity and no hypotensive effects. In this study, we evaluated the response of the human HPA axis to escalating iv doses of recombinant IL-6 in six patients with cancer and good performance status who received daily, every 8 h, three equal doses of 0.3-30 micrograms/kg IL-6. The plasma levels of IL-6 assayed by a specific enzyme-linked immunosorbent assay during the 4 h following the first IL-6 injection were elevated for 2-4 h, proportionally to the amount of injected IL-6. Administration of the cytokine was followed by marked elevations of plasma ACTH (53.0-98.6 pmol/L) and cortisol (824.9-1729.9 nmol/L) independently of the IL-6 dose administered, suggesting that the doses employed were at the top of the dose-response curve for these hormones. Interestingly, plasma arginine Vasopressin (AVP) levels were also elevated during the 2 h after IL-6 injection ...
Wook Bum Pyun - One of the best experts on this subject based on the ideXlab platform.
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Variant Angina: By Chance? or with a Chance?
2015Co-Authors: Subclinical Hypothyroidism, Thyroid Autoimmunity, In Sook Kang, Wook Bum PyunAbstract:Refer to the page 125-130 Proper functioning of thyroid is of importance due to its effects on the cardiovascular system.1)2) Furthermore, the relationship be-tween hyperthyroidism and coronary vasospasm is well-known and has been continuously reported since the first description in a case report in 1979.3-5) The most important treatment of thyroid disease is the control of thyrotoxicosis and the majority of cases showed excellent outcomes after treatment of thyroid problems.5) While the relationship with hypothyroidism, including subclini-cal hypothyroidism, and coronary vasospasm has not been well-es-tablished until date, Nishikawa et al.6) reported their experience with variant angina in a patient of isolated adrenocorticotropin deficiency, Inappropriate Vasopressin Secretion, and Hashimoto’s thyroiditis. However, the patient had additional endocrine problems and the au-thors concluded that this variant angina was more related with the isolated adrenocorticotropin deficiency rather than Hashimoto’s thy-roiditis. In 1979, an earlier report demonstrated a case of variant an-gina that was well controlled with nitrate administration, and aggra-vated with the development of hypothyroidism and concurrent use of propranolol. Authors extrapolated aggravation of variant angina by working on beta blockers, which mediated alpha-mediated coro
Lucyna Papierska - One of the best experts on this subject based on the ideXlab platform.
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personality and behavioural disturbances with delusional hallucinatory and delirium episodes in the course of hyponatremia due to paraneoplastic Inappropriate Vasopressin Secretion siadh
Psychiatria Polska, 2006Co-Authors: Maria Zaluska, Bertrand Janota, Lucyna PapierskaAbstract:AIM: To broaden the knowledge about somatic mechanisms of psychic disturbances. METHOD: Presentation of a 54 year old male with psychic disturbances and hyponatremia. RESULTS: After six months with head ache, nausea, exhaustion, irritability, lacking drive, and appetite--acute psychic disturbances abruptly arose. These recurrent episodes with agitation, aggression, delusions, hallucinations, sometimes--disorientation and memory loss; appearing simultaneously with hyponatremia (Na in blood 104-118 mEq/L); were classified as organic delusional disturbances, and (in case of disorientation and memory loss) as delirium (F06.2, F05 - in ICD-10). The symptoms were manifested for 6 months and were classified as personality disturbances due to brain dysfunction (F07.8 in ICD 10). The acute psychic disturbances interrupted the hospitalization in the medical ward, twice and caused three psychiatric hospitalizations; until the diagnosis of hyponatremia in the course of Inappropriate Vasopressin Secretion (SIADH), due to small cell carcinoma of the left lung was established. CONCLUSION: The SIADH syndrome with hyponatremia, and polymorphic psychic disturbances had preceded the clinical and radiological manifestations of the hidden development of left lung small cell carcinoma for a long time. The legitimated involuntary admission to a psychotic ward in a general hospital with easy access to specialized laboratory tests and consultations facilitated establishing the diagnosis. The restriction of water administration with oral salt supplementation stabilized the psychic state and enabled treatment in the Institute of Oncology. The case illustrates the complicated somatic mechanisms of psychic disturbances and the necessity of multi-specialist cooperation in the border area between psychiatry and other medical disciplines.
George Mastorakos - One of the best experts on this subject based on the ideXlab platform.
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hypothalamic pituitary adrenal axis activation and stimulation of systemic Vasopressin Secretion by recombinant interleukin 6 in humans potential implications for the syndrome of Inappropriate Vasopressin Secretion
The Journal of Clinical Endocrinology and Metabolism, 1994Co-Authors: George Mastorakos, Jeffrey S Weber, M A Magiakou, H Gunn, George P ChrousosAbstract:We recently demonstrated that sc administered interleukin-6 (IL-6) strongly stimulates the human hypothalamic-pituitary-adrenal (HPA) axis, with mild toxicity and no hypotensive effects. In this study, we evaluated the response of the human HPA axis to escalating iv doses of recombinant IL-6 in six patients with cancer and good performance status who received daily, every 8 h, three equal doses of 0.3-30 micrograms/kg IL-6. The plasma levels of IL-6 assayed by a specific enzyme-linked immunosorbent assay during the 4 h following the first IL-6 injection were elevated for 2-4 h, proportionally to the amount of injected IL-6. Administration of the cytokine was followed by marked elevations of plasma ACTH (53.0-98.6 pmol/L) and cortisol (824.9-1729.9 nmol/L) independently of the IL-6 dose administered, suggesting that the doses employed were at the top of the dose-response curve for these hormones. Interestingly, plasma arginine Vasopressin (AVP) levels were also elevated during the 2 h after IL-6 injection ...
Aschieri L - One of the best experts on this subject based on the ideXlab platform.
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Inappropriate antidiuretic hormone Secretion in a patient with systemic sarcoidosis
1992Co-Authors: Antonelli A, Carmassi F, Saracino A, Gambuzza C, Neri S, Aschieri LAbstract:A 59 year old man presenting fever, serum hyponatremia and hypoosmolality in association with hyperosmotic urine was hospitalized in our unit in February 1988. We demonstrated evidence of systemic sarcoidosis and Inappropriate Secretion of antidiuretic hormone (ADH). The patient was treated with corticosteroid therapy for a period of about 1 year, with regression of signs of the Inappropriate Vasopressin Secretion as well as the symptomatology related to systemic sarcoidosis. This study identified systemic sarcoidosis as a definite cause of "syndrome of Inappropriate ADH Secretion"
