The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
Roxana Mehran - One of the best experts on this subject based on the ideXlab platform.
-
embedding a randomized clinical trial into an ongoing registry infrastructure unique opportunities for efficiency in design of the study of access site for enhancement of percutaneous coronary intervention for women safe pci for women
American Heart Journal, 2013Co-Authors: Connie N Hess, Sunil V Rao, David F Kong, Laura H Aberle, Kevin J Anstrom, Michael C Gibson, Ian C Gilchrist, Alice K Jacobs, Sanjit S Jolly, Roxana MehranAbstract:Women are at higher risk than men for bleeding and vascular complications after percutaneous coronary intervention (PCI). Compared with femoral access, radial access reduces these complications but may be more challenging in women because of higher rates of radial artery spasm, tortuosity, and occlusion as well as lower rates of Procedure success. Whether the safety advantages of radial versus femoral access in women undergoing PCI are outweighed by reduced effectiveness has not been studied. The Study of Access site For Enhancement of PCI for Women is a prospective, randomized clinical trial comparing radial with femoral arterial access in women undergoing PCI. In conjunction with the US Food and Drug Administration's Critical Path Cardiac Safety Research Consortium, this study embeds the randomized clinical trial into the existing infrastructure of the National Cardiovascular Data Registry™ CathPCI Registry™ through the National Institute of Health's National Cardiovascular Research Infrastructure. The primary efficacy end point is a composite of bleeding (Bleeding Academic Research Consortium types 2, 3, or 5) or vascular complication requiring intervention occurring at 72 hours after PCI or by hospital discharge. The primary feasibility end point is Procedure success. Secondary end points Include Procedure duration, contrast volume, radiation dose, quality of life, and a composite of 30-day death, vascular complication, or unplanned revascularization.
Mary Ann Clark - One of the best experts on this subject based on the ideXlab platform.
-
TCT-897 Variation in Use, Costs, and Hospital Profitability for Aortic Valve Replacement Procedures: A Descriptive Analysis
Journal of the American College of Cardiology, 2012Co-Authors: Laura Okpala, Randel E. Richner, Mary Ann ClarkAbstract:As Medicare coverage policies around utilization of new aortic valve technologies are beginning to Include Procedure utilization requirements for hospital certification, it is increasingly important to know more about the geographic variation of current aortic valve replacement (AVR) Procedures. The
Yuichiro Maekawa - One of the best experts on this subject based on the ideXlab platform.
-
development and validation of a pre percutaneous coronary intervention risk model of contrast induced acute kidney injury with an integer scoring system
American Journal of Cardiology, 2015Co-Authors: Taku Inohara, Shun Kohsaka, Hiroaki Miyata, Yohei Numasawa, Ikuko Ueda, Yutaro Nishi, Kotaro Naito, Masaru Shibata, Kentaro Hayashida, Yuichiro MaekawaAbstract:Previous models for contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) Include Procedure-related variables in addition to pre-procedural variables. We sought to develop a risk model for CI-AKI based on pre-procedural variables and compare its predictability with a conventional risk model and also to develop an integer score system based on selected variables. A total of 5,936 consecutive PCIs registered in the Japanese Cardiovascular Database were analyzed (derivation cohort, n = 3,957; validation cohort, n = 1,979). CI-AKI was defined as an increase in serum creatinine of 50% or 0.3 mg/dl compared with baseline. From the derivation cohort, 2 different CI-AKI risk models were generated using logistic regression analyses: a pre-procedural model and a conventional model including both pre-procedural and Procedure-related variables. The predictabilities of the models were compared by c-statistics. An integer score was assigned to each variable in proportion to each estimated regression coefficient for the final model. In our derivation cohort, the proportion of CI-AKI was 9.0% (n = 358). Predictors for CI-AKI Included older age, heart failure, diabetes, previous PCI, hypertension, higher baseline creatinine level, and acute coronary syndrome. Presence of Procedure-related complications and insertion of intra-aortic balloon pumping were Included as Procedure-related variables in the conventional model. Both the conventional model (c-statistics 0.789) and the pre-procedural model (c-statistics 0.799) demonstrated reasonable discrimination. The integer risk-scoring method demonstrated good agreement between the expected and observed risks of CI-AKI in the validation cohort. In conclusion, the pre-procedural risk model for CI-AKI had acceptable discrimination compared with the conventional model and may aid in risk stratification of CI-AKI before PCI.
Connie N Hess - One of the best experts on this subject based on the ideXlab platform.
-
embedding a randomized clinical trial into an ongoing registry infrastructure unique opportunities for efficiency in design of the study of access site for enhancement of percutaneous coronary intervention for women safe pci for women
American Heart Journal, 2013Co-Authors: Connie N Hess, Sunil V Rao, David F Kong, Laura H Aberle, Kevin J Anstrom, Michael C Gibson, Ian C Gilchrist, Alice K Jacobs, Sanjit S Jolly, Roxana MehranAbstract:Women are at higher risk than men for bleeding and vascular complications after percutaneous coronary intervention (PCI). Compared with femoral access, radial access reduces these complications but may be more challenging in women because of higher rates of radial artery spasm, tortuosity, and occlusion as well as lower rates of Procedure success. Whether the safety advantages of radial versus femoral access in women undergoing PCI are outweighed by reduced effectiveness has not been studied. The Study of Access site For Enhancement of PCI for Women is a prospective, randomized clinical trial comparing radial with femoral arterial access in women undergoing PCI. In conjunction with the US Food and Drug Administration's Critical Path Cardiac Safety Research Consortium, this study embeds the randomized clinical trial into the existing infrastructure of the National Cardiovascular Data Registry™ CathPCI Registry™ through the National Institute of Health's National Cardiovascular Research Infrastructure. The primary efficacy end point is a composite of bleeding (Bleeding Academic Research Consortium types 2, 3, or 5) or vascular complication requiring intervention occurring at 72 hours after PCI or by hospital discharge. The primary feasibility end point is Procedure success. Secondary end points Include Procedure duration, contrast volume, radiation dose, quality of life, and a composite of 30-day death, vascular complication, or unplanned revascularization.
Laura Okpala - One of the best experts on this subject based on the ideXlab platform.
-
TCT-897 Variation in Use, Costs, and Hospital Profitability for Aortic Valve Replacement Procedures: A Descriptive Analysis
Journal of the American College of Cardiology, 2012Co-Authors: Laura Okpala, Randel E. Richner, Mary Ann ClarkAbstract:As Medicare coverage policies around utilization of new aortic valve technologies are beginning to Include Procedure utilization requirements for hospital certification, it is increasingly important to know more about the geographic variation of current aortic valve replacement (AVR) Procedures. The
