The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
Fernando Torrealba - One of the best experts on this subject based on the ideXlab platform.
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the histaminergic tuberomammillary nucleus is critical for motivated Arousal
European Journal of Neuroscience, 2010Co-Authors: Jose Luis Valdes, Cristian Salas Sanchez, Paula Farias, Patrizio Blandina, Marco Contreras, Maria Eugenia Riveros, Fernando TorrealbaAbstract:Obtaining food, shelter or water, or finding a mating partner are examples of motivated behaviors, which are essential to preserve the species. The full expression of such behaviors requires a high but optimal Arousal state. We tested the idea that tuberomammillary nucleus (TMN) histamine neurons are crucial to generate such motivated Arousal, using a model of the appetitive phase of feeding behavior. Hungry rats enticed with food within a wire mesh box showed intense goal-directed motor activity aimed at opening the box, an Increase in core temperature, a fast histamine release in the hypothalamus and an early Increase in Fos immunoreactivity in TMN and cortical neurons. Enticing with stronger-tasting food induced stronger motor, temperature and Fos immunoreactivity brain responses than ordinary food pellets. TMN lesion greatly decreased all of those responses. We conclude that histamine neurons Increase Arousal and vegetative activity, allowing the normal unfolding of voluntary, goal-directed behavior such as obtaining food.
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Arousal and differential Fos expression in histaminergic neurons of the ascending Arousal system during a feeding‐related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, Adrián Ocampo-garcés, N. Cortés, María Serón-ferré, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
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Arousal and differential fos expression in histaminergic neurons of the ascending Arousal system during a feeding related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, N. Cortés, Adrian Ocampogarces, Maria Seronferre, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
Jose Luis Valdes - One of the best experts on this subject based on the ideXlab platform.
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the histaminergic tuberomammillary nucleus is critical for motivated Arousal
European Journal of Neuroscience, 2010Co-Authors: Jose Luis Valdes, Cristian Salas Sanchez, Paula Farias, Patrizio Blandina, Marco Contreras, Maria Eugenia Riveros, Fernando TorrealbaAbstract:Obtaining food, shelter or water, or finding a mating partner are examples of motivated behaviors, which are essential to preserve the species. The full expression of such behaviors requires a high but optimal Arousal state. We tested the idea that tuberomammillary nucleus (TMN) histamine neurons are crucial to generate such motivated Arousal, using a model of the appetitive phase of feeding behavior. Hungry rats enticed with food within a wire mesh box showed intense goal-directed motor activity aimed at opening the box, an Increase in core temperature, a fast histamine release in the hypothalamus and an early Increase in Fos immunoreactivity in TMN and cortical neurons. Enticing with stronger-tasting food induced stronger motor, temperature and Fos immunoreactivity brain responses than ordinary food pellets. TMN lesion greatly decreased all of those responses. We conclude that histamine neurons Increase Arousal and vegetative activity, allowing the normal unfolding of voluntary, goal-directed behavior such as obtaining food.
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Arousal and differential Fos expression in histaminergic neurons of the ascending Arousal system during a feeding‐related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, Adrián Ocampo-garcés, N. Cortés, María Serón-ferré, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
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Arousal and differential fos expression in histaminergic neurons of the ascending Arousal system during a feeding related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, N. Cortés, Adrian Ocampogarces, Maria Seronferre, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
Paula Farias - One of the best experts on this subject based on the ideXlab platform.
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the histaminergic tuberomammillary nucleus is critical for motivated Arousal
European Journal of Neuroscience, 2010Co-Authors: Jose Luis Valdes, Cristian Salas Sanchez, Paula Farias, Patrizio Blandina, Marco Contreras, Maria Eugenia Riveros, Fernando TorrealbaAbstract:Obtaining food, shelter or water, or finding a mating partner are examples of motivated behaviors, which are essential to preserve the species. The full expression of such behaviors requires a high but optimal Arousal state. We tested the idea that tuberomammillary nucleus (TMN) histamine neurons are crucial to generate such motivated Arousal, using a model of the appetitive phase of feeding behavior. Hungry rats enticed with food within a wire mesh box showed intense goal-directed motor activity aimed at opening the box, an Increase in core temperature, a fast histamine release in the hypothalamus and an early Increase in Fos immunoreactivity in TMN and cortical neurons. Enticing with stronger-tasting food induced stronger motor, temperature and Fos immunoreactivity brain responses than ordinary food pellets. TMN lesion greatly decreased all of those responses. We conclude that histamine neurons Increase Arousal and vegetative activity, allowing the normal unfolding of voluntary, goal-directed behavior such as obtaining food.
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Arousal and differential Fos expression in histaminergic neurons of the ascending Arousal system during a feeding‐related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, Adrián Ocampo-garcés, N. Cortés, María Serón-ferré, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
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Arousal and differential fos expression in histaminergic neurons of the ascending Arousal system during a feeding related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, N. Cortés, Adrian Ocampogarces, Maria Seronferre, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
N. Cortés - One of the best experts on this subject based on the ideXlab platform.
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Arousal and differential Fos expression in histaminergic neurons of the ascending Arousal system during a feeding‐related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, Adrián Ocampo-garcés, N. Cortés, María Serón-ferré, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
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Arousal and differential fos expression in histaminergic neurons of the ascending Arousal system during a feeding related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, N. Cortés, Adrian Ocampogarces, Maria Seronferre, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
Adrián Ocampo-garcés - One of the best experts on this subject based on the ideXlab platform.
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Arousal and differential Fos expression in histaminergic neurons of the ascending Arousal system during a feeding‐related motivated behaviour
European Journal of Neuroscience, 2005Co-Authors: Jose Luis Valdes, Paula Farias, Adrián Ocampo-garcés, N. Cortés, María Serón-ferré, Fernando TorrealbaAbstract:: Arousal depends on the concerted activity of the ascending Arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural Arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of Arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong Arousal and an early Increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by Increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not Increase Arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active Arousal of the motivated rats, passive Arousal induced by sensory stimulation was associated with Increased Fos-ir in the locus coeruleus and the orexin neurons, but not with Increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the Arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other Arousal-related nuclei become active later on.
