The Experts below are selected from a list of 5070 Experts worldwide ranked by ideXlab platform
Gedu Satyanarayana - One of the best experts on this subject based on the ideXlab platform.
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Palladium-Catalyzed Acylations: One-Pot Synthesis of Indenones.
The Journal of Organic Chemistry, 2016Co-Authors: Basuli Suchand, Gedu SatyanarayanaAbstract:An efficient, one-pot synthesis of substituted indenones was accomplished starting from simple o-iodoketones and aldehydes. [Pd]-catalyzed direct acylation of o-iodoketones with aldehydes was employed as the key step. Subsequent intramolecular aldol condensation afforded the indenones. Notably, a variety of indenones were achieved. Significantly, the natural product neolignan was accomplished in one pot.
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Palladium-Catalyzed Acylations: One-Pot Synthesis of Indenones
2016Co-Authors: Basuli Suchand, Gedu SatyanarayanaAbstract:An efficient, one-pot synthesis of substituted indenones was accomplished starting from simple o-iodoketones and aldehydes. [Pd]-catalyzed direct acylation of o-iodoketones with aldehydes was employed as the key step. Subsequent intramolecular aldol condensation afforded the indenones. Notably, a variety of indenones were achieved. Significantly, the natural product neolignan was accomplished in one pot
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superacid mediated intramolecular condensation facile synthesis of indenones and Indanones
ChemInform, 2016Co-Authors: B, Venkat Ramulu, Gedu SatyanarayanaAbstract:It is shown that the intramolecular acylation leads to a rearrangement of the olefin bond to the exo-position of the five-membered rings.
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Superacid-Promoted Dual C–C Bond Formation by Friedel–Crafts Alkylation/Acylation of Cinnamate Esters: Synthesis of Indanones
Synthesis, 2015Co-Authors: Gedu Satyanarayana, Bokka Ramulu, Pedireddi NiharikaAbstract:Superacid-Promoted Dual C–C Bond Formation by Friedel–Crafts Alkylation/Acylation of Cinnamate Esters: Synthesis of Indanones
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Superacid mediated intramolecular condensation: facile synthesis of indenones and Indanones
RSC Advances, 2015Co-Authors: B, Venkat Ramulu, Gedu SatyanarayanaAbstract:Superacid promoted intramolecular acylation is described for the synthesis of indenones. Interestingly, in all resulting indenones, the olefin bond is rearranged to the exo position of the five membered rings. Significantly, the method is further applied to the synthesis of Indanones via the formation of two C–C bonds by in situ treatment of indenones with an external arene, in one-pot. Most importantly, the present sequential method for the synthesis of Indanones is advantageous, as it limits even more electron rich external arenes only to the Friedel–Crafts alkylation. This is not possible in previous reports wherein both cinnamic acid ester and the external arenes are treated together in the presence of an acid, wherein the relatively more reactive arene is preferred to facilitate the acylation step.
Yang Zhen - One of the best experts on this subject based on the ideXlab platform.
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A rhodium-catalyzed tandem reaction of N-sulfonyl triazoles with indoles: access to indole-substituted Indanones
CHEMICAL COMMUNICATIONS, 2017Co-Authors: Yuan Hao, Gong Jianxian, Yang ZhenAbstract:An efficient strategy for the synthesis of structurally diverse indole-substituted Indanones via a rhodium(II)-catalyzed tandem reaction of N-sulfonyltriazoles with indoles was developed. The reaction involves rhodium(II)-catalyzed denitrogenation of the N-sulfonyltriazoles to form an oxonium ylide, followed by nucleophilic addition of the indoles and subsequent skeletal rearrangement. This strategy provides straightforward access to indanone frameworks bearing quaternary carbon centers.National Science Foundation of China [21572009, 21402002]; Guangdong Natural Science Foundation [2014A030312004, 2016A030306011]; Shenzhen Municipal Development and Reform Commission (Disciplinary Development Program for Chemical Biology)SCI(E)ARTICLE659089-90925
Xiuling Han - One of the best experts on this subject based on the ideXlab platform.
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synthesis of indole substituted Indanones via palladium ii catalyzed tandem reaction of ortho electron deficient alkynyl substituted aryl aldehydes with indoles
Organic Letters, 2016Co-Authors: Jianbo Zhang, Xiuling HanAbstract:A Pd(OAc)2-catalyzed cyclization reaction of ortho-electron-deficient alkynyl-substituted aryl aldehydes with indoles was accomplished, providing an efficient and economical way to synthesize indole-substituted Indanones. The electron-withdrawing group attached to the alkyne and the nucleophilic indole play important roles in the formation of the indanone ring.
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Synthesis of Indole-Substituted Indanones via Palladium(II)-Catalyzed Tandem Reaction of ortho-Electron-Deficient Alkynyl-Substituted Aryl Aldehydes with Indoles
2016Co-Authors: Jianbo Zhang, Xiuling HanAbstract:A Pd(OAc)2-catalyzed cyclization reaction of ortho-electron-deficient alkynyl-substituted aryl aldehydes with indoles was accomplished, providing an efficient and economical way to synthesize indole-substituted Indanones. The electron-withdrawing group attached to the alkyne and the nucleophilic indole play important roles in the formation of the indanone ring
Yi Pan - One of the best experts on this subject based on the ideXlab platform.
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highly efficient and generalized asymmetric synthesis of quaternary stereogenic carbon containing β amino Indanones indanoles via mannich type additions between 1 Indanones and n tert butanesulfinylketimines
ChemInform, 2014Co-Authors: Chen Xie, Haibo Mei, Vadim A Soloshonok, Jianlin Han, Yi PanAbstract:Compound (IIIa) can be further transformed to the corresponding β-amino alcohol by stereoselective reduction of its ketone moiety.
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highly efficient and generalized asymmetric synthesis of quaternary stereogenic carbon containing β amino Indanones indanoles via mannich type additions between 1 Indanones and n tert butanesulfinylketimines
Organic and Biomolecular Chemistry, 2014Co-Authors: Chen Xie, Haibo Mei, Vadim A Soloshonok, Jianlin Han, Yi PanAbstract:Here we report that, unlike other ketones, 1-indanone and acetophenone derived enolates undergo Mannich-type addition reactions with N-tert-butanesulfinyl ketimines with excellent yields (up to 98%) and diastereoselectivity (>99/1). The resulting compounds represent a new type of biologically relevant β-aminoketone derivative bearing quaternary stereogenic carbon, which could be further converted into the corresponding β-amino ketones and β-amino alcohols, possessing three consecutive stereogenic centres.
Yuan Hao - One of the best experts on this subject based on the ideXlab platform.
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A rhodium-catalyzed tandem reaction of N-sulfonyl triazoles with indoles: access to indole-substituted Indanones
CHEMICAL COMMUNICATIONS, 2017Co-Authors: Yuan Hao, Gong Jianxian, Yang ZhenAbstract:An efficient strategy for the synthesis of structurally diverse indole-substituted Indanones via a rhodium(II)-catalyzed tandem reaction of N-sulfonyltriazoles with indoles was developed. The reaction involves rhodium(II)-catalyzed denitrogenation of the N-sulfonyltriazoles to form an oxonium ylide, followed by nucleophilic addition of the indoles and subsequent skeletal rearrangement. This strategy provides straightforward access to indanone frameworks bearing quaternary carbon centers.National Science Foundation of China [21572009, 21402002]; Guangdong Natural Science Foundation [2014A030312004, 2016A030306011]; Shenzhen Municipal Development and Reform Commission (Disciplinary Development Program for Chemical Biology)SCI(E)ARTICLE659089-90925
