The Experts below are selected from a list of 135303 Experts worldwide ranked by ideXlab platform
Yi Zhao - One of the best experts on this subject based on the ideXlab platform.
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the hypothalamic pituitary adrenal axis and serotonin metabolism in Individual Brain nuclei of mice with genetic disruption of the nk1 receptor exposed to acute stress
Cellular and Molecular Neurobiology, 2018Co-Authors: Juraj Culman, Stephan Muhlenhoff, Annegret Blume, J Hedderich, Ulf Lutzen, Stephen P Hunt, N M J Rupniak, Yi ZhaoAbstract:Mice lacking the substance P (SP) neurokinin-1 (NK1) receptor (NK1R−/−mice) were used to investigate whether SP affects serotonin (5-HT) function in the Brain and to assess the effects of acute immobilisation stress on the hypothalamic–pituitary–adrenocortical (HPA) axis and 5-HT turnover in Individual Brain nuclei. Basal HPA activity and the expression of hypothalamic corticotropin-releasing hormone (CRH) in wild-type (WT)- and NK1R−/− mice were identical. Stress-induced increases in plasma ACTH concentration were considerably higher in NK1R−/− mice than in WT mice while corticosterone concentrations were equally elevated in both mouse lines. Acute stress did not alter the expression of CRH. In the dorsal raphe nucleus (DRN), basal 5-HT turnover was increased in NK1R−/− mice and a 15 min stress further magnified 5-HT utilisation in this region. In the frontoparietal cortex, medial prefrontal cortex, central nucleus of amygdala, and the hippocampal CA1 region, stress increased 5-HT and/or 5-hydroxyindoleacetic acid (5-HIAA) concentrations to a similar extent in WT and NK1R−/− mice. 5-HT turnover in the hypothalamic paraventricular nucleus was not affected by stress, but stress induced similar increases in 5-HT and 5-HIAA in the ventromedial and dorsomedial hypothalamic nuclei in WT and NK1R−/− mice. Our findings indicate that NK1 receptor activation suppresses ACTH release during acute stress but does not exert sustained inhibition of the HPA axis. Genetic deletion of the NK1 receptor accelerates 5-HT turnover in DRN under basal and stress conditions. No differences between the responses of serotonergic system to acute stress in WT and NK1R−/− mice occur in foreBrain nuclei linked to the regulation of anxiety and neuroendocrine stress responses.
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The Hypothalamic–Pituitary–Adrenal Axis and Serotonin Metabolism in Individual Brain Nuclei of Mice with Genetic Disruption of the NK1 Receptor Exposed to Acute Stress
Cellular and molecular neurobiology, 2018Co-Authors: Juraj Culman, Stephan Muhlenhoff, Annegret Blume, J Hedderich, Ulf Lutzen, Stephen P Hunt, N M J Rupniak, Yi ZhaoAbstract:Mice lacking the substance P (SP) neurokinin-1 (NK1) receptor (NK1R−/−mice) were used to investigate whether SP affects serotonin (5-HT) function in the Brain and to assess the effects of acute immobilisation stress on the hypothalamic–pituitary–adrenocortical (HPA) axis and 5-HT turnover in Individual Brain nuclei. Basal HPA activity and the expression of hypothalamic corticotropin-releasing hormone (CRH) in wild-type (WT)- and NK1R−/− mice were identical. Stress-induced increases in plasma ACTH concentration were considerably higher in NK1R−/− mice than in WT mice while corticosterone concentrations were equally elevated in both mouse lines. Acute stress did not alter the expression of CRH. In the dorsal raphe nucleus (DRN), basal 5-HT turnover was increased in NK1R−/− mice and a 15 min stress further magnified 5-HT utilisation in this region. In the frontoparietal cortex, medial prefrontal cortex, central nucleus of amygdala, and the hippocampal CA1 region, stress increased 5-HT and/or 5-hydroxyindoleacetic acid (5-HIAA) concentrations to a similar extent in WT and NK1R−/− mice. 5-HT turnover in the hypothalamic paraventricular nucleus was not affected by stress, but stress induced similar increases in 5-HT and 5-HIAA in the ventromedial and dorsomedial hypothalamic nuclei in WT and NK1R−/− mice. Our findings indicate that NK1 receptor activation suppresses ACTH release during acute stress but does not exert sustained inhibition of the HPA axis. Genetic deletion of the NK1 receptor accelerates 5-HT turnover in DRN under basal and stress conditions. No differences between the responses of serotonergic system to acute stress in WT and NK1R−/− mice occur in foreBrain nuclei linked to the regulation of anxiety and neuroendocrine stress responses.
Juraj Culman - One of the best experts on this subject based on the ideXlab platform.
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the hypothalamic pituitary adrenal axis and serotonin metabolism in Individual Brain nuclei of mice with genetic disruption of the nk1 receptor exposed to acute stress
Cellular and Molecular Neurobiology, 2018Co-Authors: Juraj Culman, Stephan Muhlenhoff, Annegret Blume, J Hedderich, Ulf Lutzen, Stephen P Hunt, N M J Rupniak, Yi ZhaoAbstract:Mice lacking the substance P (SP) neurokinin-1 (NK1) receptor (NK1R−/−mice) were used to investigate whether SP affects serotonin (5-HT) function in the Brain and to assess the effects of acute immobilisation stress on the hypothalamic–pituitary–adrenocortical (HPA) axis and 5-HT turnover in Individual Brain nuclei. Basal HPA activity and the expression of hypothalamic corticotropin-releasing hormone (CRH) in wild-type (WT)- and NK1R−/− mice were identical. Stress-induced increases in plasma ACTH concentration were considerably higher in NK1R−/− mice than in WT mice while corticosterone concentrations were equally elevated in both mouse lines. Acute stress did not alter the expression of CRH. In the dorsal raphe nucleus (DRN), basal 5-HT turnover was increased in NK1R−/− mice and a 15 min stress further magnified 5-HT utilisation in this region. In the frontoparietal cortex, medial prefrontal cortex, central nucleus of amygdala, and the hippocampal CA1 region, stress increased 5-HT and/or 5-hydroxyindoleacetic acid (5-HIAA) concentrations to a similar extent in WT and NK1R−/− mice. 5-HT turnover in the hypothalamic paraventricular nucleus was not affected by stress, but stress induced similar increases in 5-HT and 5-HIAA in the ventromedial and dorsomedial hypothalamic nuclei in WT and NK1R−/− mice. Our findings indicate that NK1 receptor activation suppresses ACTH release during acute stress but does not exert sustained inhibition of the HPA axis. Genetic deletion of the NK1 receptor accelerates 5-HT turnover in DRN under basal and stress conditions. No differences between the responses of serotonergic system to acute stress in WT and NK1R−/− mice occur in foreBrain nuclei linked to the regulation of anxiety and neuroendocrine stress responses.
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The Hypothalamic–Pituitary–Adrenal Axis and Serotonin Metabolism in Individual Brain Nuclei of Mice with Genetic Disruption of the NK1 Receptor Exposed to Acute Stress
Cellular and molecular neurobiology, 2018Co-Authors: Juraj Culman, Stephan Muhlenhoff, Annegret Blume, J Hedderich, Ulf Lutzen, Stephen P Hunt, N M J Rupniak, Yi ZhaoAbstract:Mice lacking the substance P (SP) neurokinin-1 (NK1) receptor (NK1R−/−mice) were used to investigate whether SP affects serotonin (5-HT) function in the Brain and to assess the effects of acute immobilisation stress on the hypothalamic–pituitary–adrenocortical (HPA) axis and 5-HT turnover in Individual Brain nuclei. Basal HPA activity and the expression of hypothalamic corticotropin-releasing hormone (CRH) in wild-type (WT)- and NK1R−/− mice were identical. Stress-induced increases in plasma ACTH concentration were considerably higher in NK1R−/− mice than in WT mice while corticosterone concentrations were equally elevated in both mouse lines. Acute stress did not alter the expression of CRH. In the dorsal raphe nucleus (DRN), basal 5-HT turnover was increased in NK1R−/− mice and a 15 min stress further magnified 5-HT utilisation in this region. In the frontoparietal cortex, medial prefrontal cortex, central nucleus of amygdala, and the hippocampal CA1 region, stress increased 5-HT and/or 5-hydroxyindoleacetic acid (5-HIAA) concentrations to a similar extent in WT and NK1R−/− mice. 5-HT turnover in the hypothalamic paraventricular nucleus was not affected by stress, but stress induced similar increases in 5-HT and 5-HIAA in the ventromedial and dorsomedial hypothalamic nuclei in WT and NK1R−/− mice. Our findings indicate that NK1 receptor activation suppresses ACTH release during acute stress but does not exert sustained inhibition of the HPA axis. Genetic deletion of the NK1 receptor accelerates 5-HT turnover in DRN under basal and stress conditions. No differences between the responses of serotonergic system to acute stress in WT and NK1R−/− mice occur in foreBrain nuclei linked to the regulation of anxiety and neuroendocrine stress responses.
Victor Solo - One of the best experts on this subject based on the ideXlab platform.
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On the Reliability of Individual Brain Activity Networks
IEEE Transactions on Medical Imaging, 2018Co-Authors: Ben Cassidy, Dubois F. Bowman, Victor SoloAbstract:There is intense interest in fMRI research on whole-Brain functional connectivity, and however, two fundamental issues are still unresolved: the impact of spatiotemporal data resolution (spatial parcellation and temporal sampling) and the impact of the network construction method on the reliability of functional Brain networks. In particular, the impact of spatiotemporal data resolution on the resulting connectivity findings has not been sufficiently investigated. In fact, a number of studies have already observed that functional networks often give different conclusions across different parcellation scales. If the interpretations from functional networks are inconsistent across spatiotemporal scales, then the whole validity of the functional network paradigm is called into question. This paper investigates the consistency of resting state network structure when using different temporal sampling or spatial parcellation, or different methods for constructing the networks. To pursue this, we develop a novel network comparison framework based on persistent homology from a topological data analysis. We use the new network comparison tools to characterize the spatial and temporal scales under which consistent functional networks can be constructed. The methods are illustrated on Human Connectome Project data, showing that the DISCOH2 network construction method outperforms other approaches at most data spatiotemporal resolutions.
Ana Luisa Pinho - One of the best experts on this subject based on the ideXlab platform.
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Individual Brain Charting dataset extension, second release of high-resolution fMRI data for cognitive mapping
Scientific Data, 2020Co-Authors: Ana Luisa Pinho, Alexis Amadon, Elvis Dohmatob, Chantal Ginisty, Baptiste Gauthier, Nicolas Clairis, André Knops, Sarah Genon, Juan Jesús Torre, Séverine Becuwe-desmidtAbstract:Measurement(s) functional Brain measurement • regional part of Brain • Brain measurement • cognition Technology Type(s) functional magnetic resonance imaging Factor Type(s) type of task Sample Characteristic - Organism Homo sapiens Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.12958181 We present an extension of the Individual Brain Charting dataset –a high spatial-resolution, multi-task, functional Magnetic Resonance Imaging dataset, intended to support the investigation on the functional principles governing cognition in the human Brain. The concomitant data acquisition from the same 12 participants, in the same environment, allows to obtain in the long run finer cognitive topographies, free from inter-subject and inter-site variability. This second release provides more data from psychological domains present in the first release, and also yields data featuring new ones. It includes tasks on e.g. mental time travel, reward, theory-of-mind, pain, numerosity, self-reference effect and speech recognition. In total, 13 tasks with 86 contrasts were added to the dataset and 63 new components were included in the cognitive description of the ensuing contrasts. As the dataset becomes larger, the collection of the corresponding topographies becomes more comprehensive, leading to better Brain-atlasing frameworks. This dataset is an open-access facility; raw data and derivatives are publicly available in neuroimaging repositories.
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Individual Brain Charting dataset extension, second release of high-resolution fMRI data for cognitive mapping.
Scientific data, 2020Co-Authors: Ana Luisa Pinho, Alexis Amadon, Elvis Dohmatob, Chantal Ginisty, Baptiste Gauthier, Nicolas Clairis, André Knops, Sarah Genon, Juan Jesús Torre, Séverine Becuwe-desmidtAbstract:We present an extension of the Individual Brain Charting dataset -a high spatial-resolution, multi-task, functional Magnetic Resonance Imaging dataset, intended to support the investigation on the functional principles governing cognition in the human Brain. The concomitant data acquisition from the same 12 participants, in the same environment, allows to obtain in the long run finer cognitive topographies, free from inter-subject and inter-site variability. This second release provides more data from psychological domains present in the first release, and also yields data featuring new ones. It includes tasks on e.g. mental time travel, reward, theory-of-mind, pain, numerosity, self-reference effect and speech recognition. In total, 13 tasks with 86 contrasts were added to the dataset and 63 new components were included in the cognitive description of the ensuing contrasts. As the dataset becomes larger, the collection of the corresponding topographies becomes more comprehensive, leading to better Brain-atlasing frameworks. This dataset is an open-access facility; raw data and derivatives are publicly available in neuroimaging repositories.
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Individual Brain charting a high resolution fmri dataset for cognitive mapping
Scientific Data, 2018Co-Authors: Ana Luisa Pinho, Alexis Amadon, Torsten Ruest, Murielle Fabre, Elvis Dohmatob, Isabelle Denghien, Chantal Ginisty, Severine Becuwedesmidt, Severine Roger, Laurence LaurierAbstract:Functional Magnetic Resonance Imaging (fMRI) has furthered Brain mapping on perceptual, motor, as well as higher-level cognitive functions. However, to date, no data collection has systematically addressed the functional mapping of cognitive mechanisms at a fine spatial scale. The Individual Brain Charting (IBC) project stands for a high-resolution multi-task fMRI dataset that intends to provide the objective basis toward a comprehensive functional atlas of the human Brain. The data refer to a cohort of 12 participants performing many different tasks. The large amount of task-fMRI data on the same subjects yields a precise mapping of the underlying functions, free from both inter-subject and inter-site variability. The present article gives a detailed description of the first release of the IBC dataset. It comprises a dozen of tasks, addressing both low- and high- level cognitive functions. This openly available dataset is thus intended to become a reference for cognitive Brain mapping.
Séverine Becuwe-desmidt - One of the best experts on this subject based on the ideXlab platform.
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Individual Brain Charting dataset extension, second release of high-resolution fMRI data for cognitive mapping.
Scientific data, 2020Co-Authors: Ana Luisa Pinho, Alexis Amadon, Elvis Dohmatob, Chantal Ginisty, Baptiste Gauthier, Nicolas Clairis, André Knops, Sarah Genon, Juan Jesús Torre, Séverine Becuwe-desmidtAbstract:We present an extension of the Individual Brain Charting dataset -a high spatial-resolution, multi-task, functional Magnetic Resonance Imaging dataset, intended to support the investigation on the functional principles governing cognition in the human Brain. The concomitant data acquisition from the same 12 participants, in the same environment, allows to obtain in the long run finer cognitive topographies, free from inter-subject and inter-site variability. This second release provides more data from psychological domains present in the first release, and also yields data featuring new ones. It includes tasks on e.g. mental time travel, reward, theory-of-mind, pain, numerosity, self-reference effect and speech recognition. In total, 13 tasks with 86 contrasts were added to the dataset and 63 new components were included in the cognitive description of the ensuing contrasts. As the dataset becomes larger, the collection of the corresponding topographies becomes more comprehensive, leading to better Brain-atlasing frameworks. This dataset is an open-access facility; raw data and derivatives are publicly available in neuroimaging repositories.
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Individual Brain Charting dataset extension, second release of high-resolution fMRI data for cognitive mapping
Scientific Data, 2020Co-Authors: Ana Luisa Pinho, Alexis Amadon, Elvis Dohmatob, Chantal Ginisty, Baptiste Gauthier, Nicolas Clairis, André Knops, Sarah Genon, Juan Jesús Torre, Séverine Becuwe-desmidtAbstract:Measurement(s) functional Brain measurement • regional part of Brain • Brain measurement • cognition Technology Type(s) functional magnetic resonance imaging Factor Type(s) type of task Sample Characteristic - Organism Homo sapiens Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.12958181 We present an extension of the Individual Brain Charting dataset –a high spatial-resolution, multi-task, functional Magnetic Resonance Imaging dataset, intended to support the investigation on the functional principles governing cognition in the human Brain. The concomitant data acquisition from the same 12 participants, in the same environment, allows to obtain in the long run finer cognitive topographies, free from inter-subject and inter-site variability. This second release provides more data from psychological domains present in the first release, and also yields data featuring new ones. It includes tasks on e.g. mental time travel, reward, theory-of-mind, pain, numerosity, self-reference effect and speech recognition. In total, 13 tasks with 86 contrasts were added to the dataset and 63 new components were included in the cognitive description of the ensuing contrasts. As the dataset becomes larger, the collection of the corresponding topographies becomes more comprehensive, leading to better Brain-atlasing frameworks. This dataset is an open-access facility; raw data and derivatives are publicly available in neuroimaging repositories.
