The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Yanzhong Li - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed oxidative dearomatization spirocyclization of Indole 2 carboxamides synthesis of 2 spiro pseudoindoxyls
Organic Letters, 2016Co-Authors: Lingkai Kong, Mengdan Wang, Murong Xu, Fangfang Zhang, Yanzhong LiAbstract:A copper-catalyzed oxidative dearomatization/spirocyclization of Indole-2-carboxamides using tert-butyl hydroperoxide (TBHP) as the oxidant has been developed that provides rapid and efficient access to C2-spiro-pseudoindoxyls. Two of the sp2 C–H bonds are functionalized during the reaction process, and the reaction likely proceeds via the formation of a highly reactive 3H-indol-3-one intermediate followed by aromatic electrophilic substitution with the N-aryl ring of the amide moiety.
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Copper-Catalyzed Oxidative Dearomatization/Spirocyclization of Indole-2-Carboxamides: Synthesis of 2-Spiro-pseudoindoxyls
Organic Letters, 2016Co-Authors: Lingkai Kong, Mengdan Wang, Murong Xu, Fangfang Zhang, Yanzhong LiAbstract:A copper-catalyzed oxidative dearomatization/spirocyclization of Indole-2-carboxamides using tert-butyl hydroperoxide (TBHP) as the oxidant has been developed that provides rapid and efficient access to C2-spiro-pseudoindoxyls. Two of the sp2 C–H bonds are functionalized during the reaction process, and the reaction likely proceeds via the formation of a highly reactive 3H-indol-3-one intermediate followed by aromatic electrophilic substitution with the N-aryl ring of the amide moiety.
Michael Rubin - One of the best experts on this subject based on the ideXlab platform.
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synthesis of spiro Indole 3 5 isoxazoles with anticancer activity via a formal 4 1 spirocyclization of nitroalkenes to Indoles
Journal of Organic Chemistry, 2019Co-Authors: A V Aksenov, Dmitrii A Aksenov, Nikolai A Arutiunov, N A Aksenov, Elena V Aleksandrova, Zhenze Zhao, Liqin Du, Alexander Kornienko, Michael RubinAbstract:An acid-assisted [4 + 1]-cycloaddition of Indoles with nitrostyrenes affords 4′H-spiro[Indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.
Lingkai Kong - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed oxidative dearomatization spirocyclization of Indole 2 carboxamides synthesis of 2 spiro pseudoindoxyls
Organic Letters, 2016Co-Authors: Lingkai Kong, Mengdan Wang, Murong Xu, Fangfang Zhang, Yanzhong LiAbstract:A copper-catalyzed oxidative dearomatization/spirocyclization of Indole-2-carboxamides using tert-butyl hydroperoxide (TBHP) as the oxidant has been developed that provides rapid and efficient access to C2-spiro-pseudoindoxyls. Two of the sp2 C–H bonds are functionalized during the reaction process, and the reaction likely proceeds via the formation of a highly reactive 3H-indol-3-one intermediate followed by aromatic electrophilic substitution with the N-aryl ring of the amide moiety.
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Copper-Catalyzed Oxidative Dearomatization/Spirocyclization of Indole-2-Carboxamides: Synthesis of 2-Spiro-pseudoindoxyls
Organic Letters, 2016Co-Authors: Lingkai Kong, Mengdan Wang, Murong Xu, Fangfang Zhang, Yanzhong LiAbstract:A copper-catalyzed oxidative dearomatization/spirocyclization of Indole-2-carboxamides using tert-butyl hydroperoxide (TBHP) as the oxidant has been developed that provides rapid and efficient access to C2-spiro-pseudoindoxyls. Two of the sp2 C–H bonds are functionalized during the reaction process, and the reaction likely proceeds via the formation of a highly reactive 3H-indol-3-one intermediate followed by aromatic electrophilic substitution with the N-aryl ring of the amide moiety.
Igor Larrosa - One of the best experts on this subject based on the ideXlab platform.
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room temperature and phosphine free palladium catalyzed direct c 2 arylation of Indoles
Journal of the American Chemical Society, 2008Co-Authors: Nathalie Lebrasseur, Igor LarrosaAbstract:We report the first room-temperature direct C-2 arylation of Indoles with iodoarenes by using a highly electrophilic palladium catalyst generated in situ from Pd(OAc)2 and a silver carboxylate. These mild conditions permit a broad set of functionalities both in the Indole and in the aryl iodide units such as free alcohols, phenols, aldehydes, bromides, or nitriles, thus allowing the synthesis of a variety of novel compounds in excellent yields.
Hojat Veisi - One of the best experts on this subject based on the ideXlab platform.
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the michael addition of Indoles and pyrrole to α β unsaturated ketones and double conjugate 1 4 addition of Indoles to symmetric enones promoted by pulverization activation method and thia michael addition catalyzed by wet cyanuric chloride
Molecular Diversity, 2010Co-Authors: Ramin Ghorbanivaghei, Hojat VeisiAbstract:A new, facile, and efficient procedure for conjugate addition of Indole and pyrrole with Michael acceptors have been developed for pulverization–activation reaction catalyzed by wet cyanuric chloride (2,4,6-trichloro-[1,3,5]-triazine or TCT) through grinding under solvent-free conditions at room temperature. Also, double-conjugate 1,4-addition of Indoles to dibenzylidenacetones and conjugate addition of thiols with Michael acceptors using wet-TCT as catalyst is reported.