The Experts below are selected from a list of 207 Experts worldwide ranked by ideXlab platform

Juei-tang Cheng - One of the best experts on this subject based on the ideXlab platform.

  • PAEONIFLORIN REVERSES GUANETHIDINE‐Induced Hypotension VIA ACTIVATION OF CENTRAL ADENOSINE A1 RECEPTORS IN WISTAR RATS
    Clinical and experimental pharmacology & physiology, 1999
    Co-Authors: Juei-tang Cheng, Chia‐jane Wang, Feng‐lin Hsu
    Abstract:

    SUMMARY 1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine-Induced Hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. The action of paeoniflorin was not modified by 8-(p- sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine-Induced Hypotension via activation of adenosine A1 receptors in the brain of Wistar rats.

  • paeoniflorin reverses guanethidine Induced Hypotension via activation of central adenosine a1 receptors in wistar rats
    Clinical and Experimental Pharmacology and Physiology, 1999
    Co-Authors: Juei-tang Cheng, Chiajane Wang, Fenglin Hsu
    Abstract:

    SUMMARY 1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine-Induced Hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. The action of paeoniflorin was not modified by 8-(p- sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine-Induced Hypotension via activation of adenosine A1 receptors in the brain of Wistar rats.

Fenglin Hsu - One of the best experts on this subject based on the ideXlab platform.

  • paeoniflorin reverses guanethidine Induced Hypotension via activation of central adenosine a1 receptors in wistar rats
    Clinical and Experimental Pharmacology and Physiology, 1999
    Co-Authors: Juei-tang Cheng, Chiajane Wang, Fenglin Hsu
    Abstract:

    SUMMARY 1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine-Induced Hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. The action of paeoniflorin was not modified by 8-(p- sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine-Induced Hypotension via activation of adenosine A1 receptors in the brain of Wistar rats.

Feng‐lin Hsu - One of the best experts on this subject based on the ideXlab platform.

  • PAEONIFLORIN REVERSES GUANETHIDINE‐Induced Hypotension VIA ACTIVATION OF CENTRAL ADENOSINE A1 RECEPTORS IN WISTAR RATS
    Clinical and experimental pharmacology & physiology, 1999
    Co-Authors: Juei-tang Cheng, Chia‐jane Wang, Feng‐lin Hsu
    Abstract:

    SUMMARY 1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine-Induced Hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. The action of paeoniflorin was not modified by 8-(p- sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine-Induced Hypotension via activation of adenosine A1 receptors in the brain of Wistar rats.

Maurizio Simmaco - One of the best experts on this subject based on the ideXlab platform.

  • Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?
    Frontiers in pharmacology, 2017
    Co-Authors: Francesco Fazio, Albino Carrizzo, Luana Lionetto, Luca Capocci, Mariateresa Ambrosio, Giuseppe Battaglia, Valeria Bruno, Antonio D'amato, Michele Madonna, Maurizio Simmaco
    Abstract:

    The kynurenine pathway of tryptophan metabolism is activated by pro-inflammatory cytokines. L-kynurenine, an upstream metabolite of the pathway, acts as a putative endothelium-derived relaxing factor, and has been hypothesized to play a causative role in the pathophysiology of inflammation-Induced Hypotension. Here, we show that xanthurenic acid, the transamination product of 3-hydroxykynurenine, is more efficacious than L-kynurenine in causing relaxation of a resistance artery, but fails to relax pre-contracted aortic rings. In the mesenteric artery, xanthurenic acid enhanced activating phosphorylation of endothelial nitric oxide synthase (NOS), and the relaxing action of xanthurenic acid was abrogated by pharmacological inhibition of NOS and endothelial-derived hyperpolarizing factor (EDHF). Systemic injection of xanthurenic acid reduced blood pressure in mice, and serum levels of xanthurenic acid increased by several fold in response to a pulse with the endotoxin, lipopolysaccaride (LPS). LPS-Induced Hypotension in mice was prevented by pre-treatment with the kynurenine monooxigenase (KMO) inhibitor, Ro-618048, which lowered serum levels of xanthurenic acid but enhanced serum levels of L-kynurenine. UPF 648, another KMO inhibitor, could also abrogate LPS-Induced Hypotension. Our data identify xanthurenic acid as a novel vasoactive compound and suggest that formation of xanthurenic acid is a key event in the pathophysiology of inflammation-Induced Hypotension.

Erik L Owens - One of the best experts on this subject based on the ideXlab platform.

  • spinal cord ischemia occurring in association with Induced Hypotension for colonic surgery
    Anesthesia & Analgesia, 2012
    Co-Authors: John C Drummond, Roland R Lee, Erik L Owens
    Abstract:

    A 19-year-old woman underwent an ileoanal pull-through. Intraoperatively, deepening of anesthesia was associated with reduced bleeding. Therefore, Induced Hypotension, mean arterial blood pressure 50 to 55 mm Hg, was maintained for 2.5 hours. Postoperatively, the patient was paraplegic with spinal cord infarction on magnetic resonance imaging from T9 to the tip of the conus medullaris. The collateralization of the anterior spinal artery is very variable and it seems likely that in this individual Induced Hypotension was associated with inadequate blood flow in the distribution of the artery of Adamkiewicz.