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C G Moran - One of the best experts on this subject based on the ideXlab platform.

  • a modified posterior approach to the knee for postero medial tibial plateau fracture fixation
    Orthopaedic Proceedings, 2018
    Co-Authors: R Berber, C P Lewis, D P Forward, C G Moran
    Abstract:

    HypothesisThis study demonstrates the utility of a modified postero-medial surgical approach to the knee in treating a series of patients with complex tibial plateau injuries with associated postero-medial shear fractures.Postero-medial shear fractures are under-appreciated and their clinical relevance have recently been characterised. Less invasive surgery and indirect reduction techniques are inadequate for treating these postero-medial coronal plane fractures.MethodsThe approach includes an inverted ‘L’ shaped incision and reflection of the medial head of gastrocnemius, while protecting the neurovascular structures. This is a more extensile exposure than described by Trickey (1968). Our case series includes 8 females and 8 males. The average age is 53.1 years. The mechanism of injury included 7 RTAs, 5 fall from height, 1 Industrial Accident and 3 valgus injuries. All patients' schatzker grade 4, or above, fractures with a posteromedial split depression. Two were open, two had vascular compromise and o...

  • a modified posterior approach to the knee for postero medial tibial plateau fracture fixation
    Journal of Bone and Joint Surgery-british Volume, 2013
    Co-Authors: R Berber, C P Lewis, D P Forward, C G Moran
    Abstract:

    Hypothesis This study demonstrates the utility of a modified postero-medial surgical approach to the knee in treating a series of patients with complex tibial plateau injuries with associated postero-medial shear fractures. Postero-medial shear fractures are under-appreciated and their clinical relevance have recently been characterised. Less invasive surgery and indirect reduction techniques are inadequate for treating these postero-medial coronal plane fractures. Methods The approach includes an inverted ‘L’ shaped incision and reflection of the medial head of gastrocnemius, while protecting the neurovascular structures. This is a more extensile exposure than described by Trickey (1968). Our case series includes 8 females and 8 males. The average age is 53.1 years. The mechanism of injury included 7 RTAs, 5 fall from height, 1 Industrial Accident and 3 valgus injuries. All patients' schatzker grade 4, or above, fractures with a posteromedial split depression. Two were open, two had vascular compromise and one had neurological injury. Results Average time to surgery was 6.4 days (range 0–12), operative time 142 mins (range 76–300), and length of stay 17.3 days (range 7–46). 11 patients were treated using the posrtero-medial approach alone and 5 were combined with an anterior approach. 2 patients suffered reduced range of movement requiring manipulation and physiotherapy, and 3 patients had a 5 degree fixed flexion deformity. 2 patients developed superficial wound infections treated with antibiotics alone. Anatomical reduction and fracture union was achieved in 13 patients; of the remaining 3 patients, 2 had unavoidable articular surface comminution, and 1 suffered antero-medial collapse and varus deformity. Conclusions These are complex fractures to treat and this posterior surgical approach allows direct reduction and optimal positioning of plates to act as buttress devices. It can be extended across the midline to the postero-lateral corner and also allows excellent exposure of the popliteal vessels should concurrent vascular repair be required.

Seongkyu Kang - One of the best experts on this subject based on the ideXlab platform.

  • asbestos related occupational cancers compensated under the Industrial Accident compensation insurance in korea
    Industrial Health, 2009
    Co-Authors: Seongkyu Kang
    Abstract:

    Compensation for asbestos-related cancers occurring in occupationally-exposed workers is a global issue; this is also an issue in Korea. To provide basic information regarding compensation for workers exposed to asbestos, 60 cases of asbestos-related occupational lung cancer and mesothelioma that were compensated during 15 yr; from 1993 (the year the first case was compensated) to 2007 by the Korea Labor Welfare Corporation (KLWC) are described. The characteristics of the cases were analyzed using the KLWC electronic data and the epidemiologic investigation data conducted by the Occupational Safety and Health Research Institute (OSHRI) of the Korea Occupational Safety and Health Agency (KOSHA). The KLWC approved compensation for 41 cases of lung cancer and 19 cases of mesothelioma. Males accounted for 91.7% (55 cases) of the approved cases. The most common age group was 50-59 yr (45.0%). The mean duration of asbestos exposure for lung cancer and mesothelioma cases was 19.2 and 16.0 yr, respectively. The mean latency period for lung cancer and mesothelioma cases was 22.1 and 22.6 yr, respectively. The major industries associated with mesothelioma cases were shipbuilding and maintenance (4 cases) and manufacture of asbestos textiles (3 cases). The major industries associated with lung cancer cases were shipbuilding and maintenance (7 cases), construction (6 cases), and manufacture of basic metals (4 cases). The statistics pertaining to asbestos-related occupational cancers in Korea differ from other developed countries in that more cases of mesothelioma were compensated than lung cancer cases. Also, the mean latency period for disease onset was shorter than reported by existing epidemiologic studies; this discrepancy may be related to the short history of occupational asbestos use in Korea. Considering the current Korean use of asbestos, the number of compensated cases in Korea is expected to increase in the future but not as much as developed countries.

  • analysis of occupational diseases compensated with the Industrial Accident compensation insurance from 2001 to 2003
    Annals of occupational and environmental medicine, 2004
    Co-Authors: Seongkyu Kang
    Abstract:

    목적: 이 연구는 2001년부터 2003년까지 최근 3년 동안 근로복지공단에서 업무상질병으로 인정한 사례를 정밀분석하여 직업병의 종류와 특성을 밝힘으로써 직업병 예방사업이나 산업보건연구의 우선순위를 결정하는데 기초자료로 제공하기 위하여 실시하였다. 방법: 근로복지공단 주전산망을 통하여 요양 승인일자가 2001...

Jangwoen Lee - One of the best experts on this subject based on the ideXlab platform.

  • Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection
    Journal of Medicinal Chemistry, 2015
    Co-Authors: Adriano Chan, Jingjing Jiang, Alla Fridman, Ling T. Guo, G. Diane Shelton, Ming-tao Liu, Carol E. Green, Kristofer J. Haushalter, Hemal H. Patel, Jangwoen Lee
    Abstract:

    Currently available cyanide antidotes must be given by intravenous injection over 5-10 min, making them ill-suited for treating many people in the field, as could occur in a major fire, an Industrial Accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g., by intramuscular injection. We have shown that aquohydroxocobinamide is a potent cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly absorbed after intramuscular injection. Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection. We also show that the efficacy of nitrocobinamide is markedly enhanced by coadministering sodium thiosulfate (reducing the total injected volume), and we calculate that ∼1.4 mL each of nitrocobinamide and sodium thiosulfate should rescue a human from a lethal cyanide exposure.

  • Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection
    2015
    Co-Authors: Adriano Chan, Jingjing Jiang, Alla Fridman, Ling T. Guo, Ming-tao Liu, Kristofer J. Haushalter, Hemal H. Patel, Diane G. Shelton, Carol Green, Jangwoen Lee
    Abstract:

    Currently available cyanide antidotes must be given by intravenous injection over 5–10 min, making them ill-suited for treating many people in the field, as could occur in a major fire, an Industrial Accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g., by intramuscular injection. We have shown that aquohydroxocobinamide is a potent cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly absorbed after intramuscular injection. Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection. We also show that the efficacy of nitrocobinamide is markedly enhanced by coadministering sodium thiosulfate (reducing the total injected volume), and we calculate that ∼1.4 mL each of nitrocobinamide and sodium thiosulfate should rescue a human from a lethal cyanide exposure

R Berber - One of the best experts on this subject based on the ideXlab platform.

  • a modified posterior approach to the knee for postero medial tibial plateau fracture fixation
    Orthopaedic Proceedings, 2018
    Co-Authors: R Berber, C P Lewis, D P Forward, C G Moran
    Abstract:

    HypothesisThis study demonstrates the utility of a modified postero-medial surgical approach to the knee in treating a series of patients with complex tibial plateau injuries with associated postero-medial shear fractures.Postero-medial shear fractures are under-appreciated and their clinical relevance have recently been characterised. Less invasive surgery and indirect reduction techniques are inadequate for treating these postero-medial coronal plane fractures.MethodsThe approach includes an inverted ‘L’ shaped incision and reflection of the medial head of gastrocnemius, while protecting the neurovascular structures. This is a more extensile exposure than described by Trickey (1968). Our case series includes 8 females and 8 males. The average age is 53.1 years. The mechanism of injury included 7 RTAs, 5 fall from height, 1 Industrial Accident and 3 valgus injuries. All patients' schatzker grade 4, or above, fractures with a posteromedial split depression. Two were open, two had vascular compromise and o...

  • a modified posterior approach to the knee for postero medial tibial plateau fracture fixation
    Journal of Bone and Joint Surgery-british Volume, 2013
    Co-Authors: R Berber, C P Lewis, D P Forward, C G Moran
    Abstract:

    Hypothesis This study demonstrates the utility of a modified postero-medial surgical approach to the knee in treating a series of patients with complex tibial plateau injuries with associated postero-medial shear fractures. Postero-medial shear fractures are under-appreciated and their clinical relevance have recently been characterised. Less invasive surgery and indirect reduction techniques are inadequate for treating these postero-medial coronal plane fractures. Methods The approach includes an inverted ‘L’ shaped incision and reflection of the medial head of gastrocnemius, while protecting the neurovascular structures. This is a more extensile exposure than described by Trickey (1968). Our case series includes 8 females and 8 males. The average age is 53.1 years. The mechanism of injury included 7 RTAs, 5 fall from height, 1 Industrial Accident and 3 valgus injuries. All patients' schatzker grade 4, or above, fractures with a posteromedial split depression. Two were open, two had vascular compromise and one had neurological injury. Results Average time to surgery was 6.4 days (range 0–12), operative time 142 mins (range 76–300), and length of stay 17.3 days (range 7–46). 11 patients were treated using the posrtero-medial approach alone and 5 were combined with an anterior approach. 2 patients suffered reduced range of movement requiring manipulation and physiotherapy, and 3 patients had a 5 degree fixed flexion deformity. 2 patients developed superficial wound infections treated with antibiotics alone. Anatomical reduction and fracture union was achieved in 13 patients; of the remaining 3 patients, 2 had unavoidable articular surface comminution, and 1 suffered antero-medial collapse and varus deformity. Conclusions These are complex fractures to treat and this posterior surgical approach allows direct reduction and optimal positioning of plates to act as buttress devices. It can be extended across the midline to the postero-lateral corner and also allows excellent exposure of the popliteal vessels should concurrent vascular repair be required.

Adriano Chan - One of the best experts on this subject based on the ideXlab platform.

  • Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection
    Journal of Medicinal Chemistry, 2015
    Co-Authors: Adriano Chan, Jingjing Jiang, Alla Fridman, Ling T. Guo, G. Diane Shelton, Ming-tao Liu, Carol E. Green, Kristofer J. Haushalter, Hemal H. Patel, Jangwoen Lee
    Abstract:

    Currently available cyanide antidotes must be given by intravenous injection over 5-10 min, making them ill-suited for treating many people in the field, as could occur in a major fire, an Industrial Accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g., by intramuscular injection. We have shown that aquohydroxocobinamide is a potent cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly absorbed after intramuscular injection. Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection. We also show that the efficacy of nitrocobinamide is markedly enhanced by coadministering sodium thiosulfate (reducing the total injected volume), and we calculate that ∼1.4 mL each of nitrocobinamide and sodium thiosulfate should rescue a human from a lethal cyanide exposure.

  • Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection
    2015
    Co-Authors: Adriano Chan, Jingjing Jiang, Alla Fridman, Ling T. Guo, Ming-tao Liu, Kristofer J. Haushalter, Hemal H. Patel, Diane G. Shelton, Carol Green, Jangwoen Lee
    Abstract:

    Currently available cyanide antidotes must be given by intravenous injection over 5–10 min, making them ill-suited for treating many people in the field, as could occur in a major fire, an Industrial Accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g., by intramuscular injection. We have shown that aquohydroxocobinamide is a potent cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly absorbed after intramuscular injection. Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection. We also show that the efficacy of nitrocobinamide is markedly enhanced by coadministering sodium thiosulfate (reducing the total injected volume), and we calculate that ∼1.4 mL each of nitrocobinamide and sodium thiosulfate should rescue a human from a lethal cyanide exposure