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Nicola Sverzellati - One of the best experts on this subject based on the ideXlab platform.

  • diagnostic imaging of diffuse Infiltrative Disease of the lung
    Respiration, 2004
    Co-Authors: Maurizio Zompatori, Claudio Bna, Venerino Poletti, Enrica Spaggiari, Francesca Ormitti, Elisa Calabro, G Tognini, Nicola Sverzellati
    Abstract:

    Plain chest radiography remains the first diagnostic approach to diffuse Infiltrative lung Disease but has limited diagnostic sensitivity and specificity. Many Diseases remain occult or are not correctly assessed using chest X-ray, appearing as a nonspecific 'reticulonodular pattern'. High-resolution CT (HRCT) is actually the recommended imaging technique in the diagnosis, assessment, and follow-up of these Diseases, allowing also the evaluation of the effectiveness of the medical therapy and the selection of the type and the location of the biopsy when required. Appropriate techniques must be used to acquire high-quality HRCT scans, with the thin collimation and high spatial reconstruction algorithm being the most important factors. A nodular pattern, linear and reticular opacities, cystic lesions, ground-glass opacities and consolidations are the most common HRCT patterns of diffuse Infiltrative lung Disease. This article reviews the role of chest radiography and HRCT in the diagnosis and assessment of these Diseases, the technical aspects of HRCT, its clinical indications and the radiological pattern of the most common types of chronic diffuse Infiltrative lung Disease.

Gilbert H Daniels - One of the best experts on this subject based on the ideXlab platform.

  • follicular variant of papillary thyroid carcinoma hybrid or mixture
    Thyroid, 2016
    Co-Authors: Gilbert H Daniels
    Abstract:

    The prognosis of the follicular variant of papillary thyroid carcinoma (FVPTC) falls between that of classical papillary thyroid carcinoma (cPTC) and follicular thyroid carcinoma (FTC) (1). FVPTC has lower mortality and less frequent distant metastases than FTC, but higher mortality and more frequent distant metastases than cPTC. FVPTC has fewer lymph node metastases and less frequent Infiltrative Disease and extrathyroidal extension than cPTC, but more than FTC. But is it a hybrid Disease or a mixture of Diseases? The pathological appearance of a follicular-patterned tumor with the nuclear features of cPTC suggests that FVPTC is a hybrid. However, the heterogeneous nature of the Disease and the mutational profile of FVPTC strongly suggest that it is a mixture of Diseases (2). It is the intersection of classical descriptive pathology and modern molecular biology that permits an understanding of this group of Diseases.

Francoise Camus - One of the best experts on this subject based on the ideXlab platform.

  • normal pulmonary capillary blood volume in patients with chronic Infiltrative lung Disease and high pulmonary artery pressure
    Chest, 2004
    Co-Authors: Marcel Bonay, Catherine Bancal, Dominique De Zuttere, Florence Arnoult, Georges Saumon, Francoise Camus
    Abstract:

    Study objectives: Pulmonary capillary blood volume (Qc), a component of diffusing capacity of the lung for carbon monoxide (DLCO), is increased in postcapillary pulmonary hypertension due to valve Disease, but is decreased in primitive and thromboembolic pulmonary hypertension. This study was performed to evaluate which way pulmonary Qc is affected in patients with chronic Infiltrative lung Disease according to the value of systolic pulmonary artery pressure (SPAP). Patients and methods: Twenty-four patients who were nonsmokers and had chronic Infiltrative lung Disease secondary to connective tissue Disease (12 patients), asbestosis (1 patient), sarcoidosis (5 patients), or of unknown origin (6 patients), and 8 control subjects underwent pulmonary function tests and Doppler echocardiography. Measurements and results: Total lung capacity, alveolar-arterial oxygen pressure difference, DLCO, and conductance of the alveolar-capillary membrane (Dm) did not differ between patients with low SPAP (LPAP) [ie, < 30 mm Hg] or high SPAP (HPAP). Patients with LPAP, but not HPAP, experienced significant decreases in pulmonary Qc, whatever the cause of the Disease. There was a strong positive correlation between SPAP and Qc scaled by Dm to account for Infiltrative Disease severity (r 0.68; p < 0.001). Conclusions: We thus conclude that pulmonary Qc is not decreased as expected in patients with chronic Infiltrative lung Disease and high pulmonary artery pressure. A high Qc/Dm ratio should encourage the physician to look for HPAP compatible with pulmonary hypertension, whatever the etiology of lung Infiltrative Disease. (CHEST 2004; 126:1460–1466)

Wolfgang Dichtl - One of the best experts on this subject based on the ideXlab platform.

Irina Bancos - One of the best experts on this subject based on the ideXlab platform.

  • primary adrenal insufficiency due to bilateral Infiltrative Disease
    Endocrine, 2018
    Co-Authors: Justine Herndon, Ashley Nadeau, Caroline J Davidgepitts, William F Young, Irina Bancos
    Abstract:

    Evidence on clinical presentation, evaluation, and management of patients with primary adrenal insufficiency (PAI) due to bilateral adrenal Infiltrative Disease is scarce. Our objective was to review the clinical presentation, biochemical work-up, imaging findings, and management of patients with PAI due to Infiltrative adrenal Disease in order to determine the best diagnostic and management approach. Retrospective study of patients with PAI due to bilateral Infiltrative adrenal Disease referred for adrenal biopsy during 2000–2014 at Mayo Clinic, Rochester, Minnesota. Two additional patients evaluated after 2014 were included. Seven patients (six males and one female) were diagnosed with PAI caused by bilateral adrenal Infiltrative Disease at a median age of 54 (range 36–80) years. Duration of symptoms prior to the diagnosis of PAI and initiating treatment was 6 months (range 3 months–4 years). All patients demonstrated bilateral adrenal masses on adrenal imaging. The underlying diagnosis was confirmed by histopathology and included: bilateral adrenal metastases (lung and breast adenocarcinoma), diffuse large B-cell lymphoma, tuberculosis, cryptococcus, histoplasmosis, and, Erdheim-Chester Disease. In patients with newly diagnosed PAI, the differential diagnosis should include bilateral Infiltrative adrenal Disease, especially when testing for autoimmune adrenalitis is negative, or if there is clinical history suggesting another etiology. Patients who present with known bilateral adrenal Infiltrative Disease should be counseled and tested for PAI periodically, particularly if presenting with suggestive signs or symptoms.