The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Gunnar Nilsson - One of the best experts on this subject based on the ideXlab platform.
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Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4
Biochemical and Biophysical Research Communications, 2002Co-Authors: Mikael Juremalm, Niclas Olsson, Gunnar NilssonAbstract:Mast cells (MCs) accumulate at sites of allergic mucosal Inflammation where they act as central effector and regulatory cells. Because chemokines are of vital importance in directing inflammatory leukocytes to the sites of Inflammations, we have investigated the expression and function of CC-chemokine receptor (CCR) on human MCs. Two previously unrecognized MC-chemokine receptors, CCR1 and CCR4, could be identified on cord blood-derived MCs (CBMCs). CCR1 and CCR4 expressed on CBMCs exhibited a unique response profile. Of seven CCR1 and CCR4 agonists tested, only CCL5/RANTES act as an agonist inducing chemotaxis. The migration could be partially blocked by specific antibodies against CCR1 or CCR4, while a complete inhibition was achieved when both CCR1 and CCR4 were blocked. These results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5.
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selective ccl5 rantes induced mast cell migration through interactions with chemokine receptors ccr1 and ccr4
Biochemical and Biophysical Research Communications, 2002Co-Authors: Mikael Juremalm, Niclas Olsson, Gunnar NilssonAbstract:Mast cells (MCs) accumulate at sites of allergic mucosal Inflammation where they act as central effector and regulatory cells. Because chemokines are of vital importance in directing inflammatory leukocytes to the sites of Inflammations, we have investigated the expression and function of CC-chemokine receptor (CCR) on human MCs. Two previously unrecognized MC-chemokine receptors, CCR1 and CCR4, could be identified on cord blood-derived MCs (CBMCs). CCR1 and CCR4 expressed on CBMCs exhibited a unique response profile. Of seven CCR1 and CCR4 agonists tested, only CCL5/RANTES act as an agonist inducing chemotaxis. The migration could be partially blocked by specific antibodies against CCR1 or CCR4, while a complete inhibition was achieved when both CCR1 and CCR4 were blocked. These results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5.
Mikael Juremalm - One of the best experts on this subject based on the ideXlab platform.
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Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4
Biochemical and Biophysical Research Communications, 2002Co-Authors: Mikael Juremalm, Niclas Olsson, Gunnar NilssonAbstract:Mast cells (MCs) accumulate at sites of allergic mucosal Inflammation where they act as central effector and regulatory cells. Because chemokines are of vital importance in directing inflammatory leukocytes to the sites of Inflammations, we have investigated the expression and function of CC-chemokine receptor (CCR) on human MCs. Two previously unrecognized MC-chemokine receptors, CCR1 and CCR4, could be identified on cord blood-derived MCs (CBMCs). CCR1 and CCR4 expressed on CBMCs exhibited a unique response profile. Of seven CCR1 and CCR4 agonists tested, only CCL5/RANTES act as an agonist inducing chemotaxis. The migration could be partially blocked by specific antibodies against CCR1 or CCR4, while a complete inhibition was achieved when both CCR1 and CCR4 were blocked. These results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5.
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selective ccl5 rantes induced mast cell migration through interactions with chemokine receptors ccr1 and ccr4
Biochemical and Biophysical Research Communications, 2002Co-Authors: Mikael Juremalm, Niclas Olsson, Gunnar NilssonAbstract:Mast cells (MCs) accumulate at sites of allergic mucosal Inflammation where they act as central effector and regulatory cells. Because chemokines are of vital importance in directing inflammatory leukocytes to the sites of Inflammations, we have investigated the expression and function of CC-chemokine receptor (CCR) on human MCs. Two previously unrecognized MC-chemokine receptors, CCR1 and CCR4, could be identified on cord blood-derived MCs (CBMCs). CCR1 and CCR4 expressed on CBMCs exhibited a unique response profile. Of seven CCR1 and CCR4 agonists tested, only CCL5/RANTES act as an agonist inducing chemotaxis. The migration could be partially blocked by specific antibodies against CCR1 or CCR4, while a complete inhibition was achieved when both CCR1 and CCR4 were blocked. These results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5.
Niclas Olsson - One of the best experts on this subject based on the ideXlab platform.
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Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4
Biochemical and Biophysical Research Communications, 2002Co-Authors: Mikael Juremalm, Niclas Olsson, Gunnar NilssonAbstract:Mast cells (MCs) accumulate at sites of allergic mucosal Inflammation where they act as central effector and regulatory cells. Because chemokines are of vital importance in directing inflammatory leukocytes to the sites of Inflammations, we have investigated the expression and function of CC-chemokine receptor (CCR) on human MCs. Two previously unrecognized MC-chemokine receptors, CCR1 and CCR4, could be identified on cord blood-derived MCs (CBMCs). CCR1 and CCR4 expressed on CBMCs exhibited a unique response profile. Of seven CCR1 and CCR4 agonists tested, only CCL5/RANTES act as an agonist inducing chemotaxis. The migration could be partially blocked by specific antibodies against CCR1 or CCR4, while a complete inhibition was achieved when both CCR1 and CCR4 were blocked. These results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5.
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selective ccl5 rantes induced mast cell migration through interactions with chemokine receptors ccr1 and ccr4
Biochemical and Biophysical Research Communications, 2002Co-Authors: Mikael Juremalm, Niclas Olsson, Gunnar NilssonAbstract:Mast cells (MCs) accumulate at sites of allergic mucosal Inflammation where they act as central effector and regulatory cells. Because chemokines are of vital importance in directing inflammatory leukocytes to the sites of Inflammations, we have investigated the expression and function of CC-chemokine receptor (CCR) on human MCs. Two previously unrecognized MC-chemokine receptors, CCR1 and CCR4, could be identified on cord blood-derived MCs (CBMCs). CCR1 and CCR4 expressed on CBMCs exhibited a unique response profile. Of seven CCR1 and CCR4 agonists tested, only CCL5/RANTES act as an agonist inducing chemotaxis. The migration could be partially blocked by specific antibodies against CCR1 or CCR4, while a complete inhibition was achieved when both CCR1 and CCR4 were blocked. These results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5.
Pierre-antoine Bonnet - One of the best experts on this subject based on the ideXlab platform.
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IKK inhibitory activities of imidazo[1,2-a]pyrazine, imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline and pyrazolo[1,5-a]quinoxaline derivatives.
2017Co-Authors: Nour Karroum, Cindy Patinote, Adrien Chouchou, Georges Moarbess, Mona Diab-assaf, Carine Deleuze-masquéfa, Issam Kassab, Pierre-antoine BonnetAbstract:The transcription factor NF-κB plays a key role in multiple cellular processes, including immune signaling, Inflammation, development, proliferation and survival. Dysregulated NF-κB activation is associated with autoimmunitya, chronic Inflammationb and cancerc. Activation of NF-κB requires IκB kinases IKKα and IKK β, therefore, targeting the activation of NF-κB-dependent pathway by IKK inibitors is becoming an increasingly popular avenue for the development of novel therapeutic interventions for Inflammation and cancer and many pharmaceutical companies are developing inhibitors that target IKK. BMS-345541 (4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline) was identified as a selective inhibitor of the catalytic subunits of IKK (IKK2: IC50= 0.3 μM, IKK1: IC50 = 4 μM)d. The aim of this study is to obtain new IKK inhibitors, analogues of BMS-345541. For this purpose, we have synthesized a variety of compounds diversely substituted belonging to four chemical series: imidazo[1,2-a]pyrazine, imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline and pyrazolo[1,5-a]quinoxaline. Their biological activities as potential IKK1 and IKK2 inhibitors are describede. Four strategies of synthesis are developed to obtain a variety of compounds with short reaction times by using micro-wave assistance. The preparation of these compounds is particularly simple and is carried out in good yields.
Thomas A Aloia - One of the best experts on this subject based on the ideXlab platform.
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Inflammation and pro resolution Inflammation after hepatobiliary surgery
World Journal of Surgical Oncology, 2017Co-Authors: Juan P Cata, Jose F Velasquez, Maria F Ramirez, Jean-nicolas Vauthey, Vijaya Gottumukkala, Claudius Conrad, Thomas A AloiaAbstract:The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of Inflammation in the context of surgery. Here, we described the temporal kinetics of interleukin-6, cortisol, lipoxin A4, and resolvin D in patients who underwent oncologic liver resections. All patients gave written informed consent. Demographic and perioperative surgical data were collected, along with blood samples, before surgery and on the mornings of postoperative days 1, 3, and 5. Interleukin-6, cortisol, lipoxin-A4, and resolvin D were measured in plasma. A P value < 0.05 was considered statistically significant. Forty-one patients were included in the study. Liver resection for colorectal metastatic disease was the most commonly performed surgery. The plasma concentrations of interleukin-6 were highest on day 1 after surgery and remained higher than the baseline up to postoperative day 1. Postoperative complications occurred in 14 (24%) patients. Cortisol concentrations spiked on postoperative day 1. The concentrations of lipoxin A4 and resolvin D were lowest on day 1 after surgery. The inflammatory response associated with hepatobiliary surgery is associated with low circulating concentrations of lipoxin A4 and resolvin D that mirror, in an opposite manner, the kinetics of interleukin 6 and cortisol. NCT01438476
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Inflammation and pro-resolution Inflammation after hepatobiliary surgery
World Journal of Surgical Oncology, 2017Co-Authors: Juan P Cata, Jose F Velasquez, Maria F Ramirez, Jean-nicolas Vauthey, Vijaya Gottumukkala, Claudius Conrad, Thomas A AloiaAbstract:The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of Inflammation in the context of surgery. Here, we described the temporal kinetics of interleukin-6, cortisol, lipoxin A4, and resolvin D in patients who underwent oncologic liver resections. All patients gave written informed consent. Demographic and perioperative surgical data were collected, along with blood samples, before surgery and on the mornings of postoperative days 1, 3, and 5. Interleukin-6, cortisol, lipoxin-A4, and resolvin D were measured in plasma. A P value
