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B Rath - One of the best experts on this subject based on the ideXlab platform.

  • pediatric acute leukemia presenting as bilateral renal enlargement report of a case with fine needle aspiration cytologic features suggestive of megakaryocytic differentiation
    Acta Cytologica, 2000
    Co-Authors: Dilip K Das, Durjoy K Shome, Anju Garg, Naveen C Bhatt, B Rath
    Abstract:

    BACKGROUND Fine needle aspiration (FNA) cytologic diagnosis of acute myeloid leukemia involving the kidney has rarely been reported, but acute leukemia with cytologic features suggestive of megakaryocytic differentiation has not been described before. CASE: An 8-month-old male presented with an abdominal swelling, bilateral cervical and Inguinal Lymphadenopathy and enlarged left epididymis. Ultrasonography of the abdomen revealed a space-occupying lesion in the liver and bilateral enlargement of the kidneys. FNA smears from the right kidney and right submandibular lymph node showed numerous blast cells. Since rare blast cells were positive for myeloperoxidase, a cytodiagnosis of involvement by acute myeloid leukemia (AML) was made. However, following the hematologic diagnosis of acute megakaryoblastic leukemia (M7) from peripheral blood and bone marrow smear examination, FNA smears were reviewed. There were cytoplasmic blebs or protrusions in the blast cells and cytologic features suggestive of their differentiation toward micromegakaryocytes and megakaryocytes. There was also evidence of shedding of platelets, including numerous giant platelets. The reviewed FNA cytodiagnosis was suggestive of AML (M7). CONCLUSION: Extramedullary involvement by acute megakaryoblastic leukemia (M7) can be suspected based on cytomorphologic features in FNA smears.

N Macdonald - One of the best experts on this subject based on the ideXlab platform.

  • diagnosis of lymphogranuloma venereum from biopsy samples
    Gut, 2006
    Co-Authors: Iona M C Martin, N Macdonald, Catherine A Ison, S A Alexander, K Mccarthy, Helen Ward
    Abstract:

    The Health Protection Agency Centre for Infections launched an alert in October 2004 to improve the awareness, diagnosis, and control of lymphogranuloma venereum (LGV), a sexually transmitted chlamydial infection, following a series of outbreaks in Western Europe.1 To date (9/3/2006), 334 cases of LGV have been diagnosed in 334 men. The case definition for a confirmed case of LGV is the presence of C trachomatis specific DNA, using two nucleic acid amplification tests (NAATs) with different primers, of serovars L1, L2, or L3, determined by genotyping (http://www.hpa.org.uk/infections/topics\_az/hiv\_and_sti/LGV/lgv.htm). All cases of LGV to date in the UK have been in men who have sex with men and typically present with proctitis and/or Inguinal Lymphadenopathy. Some of the men in the UK diagnosed with LGV reported long duration of symptoms presenting to gastroenterologists and having been wrongly diagnosed with inflammatory …

  • lymphogranuloma venereum in the united kingdom
    Sexually Transmitted Infections, 2005
    Co-Authors: Patrick French, Cathy Ison, N Macdonald
    Abstract:

    First cases reported from enhanced surveillance Until 2003 lymphogranuloma venereum (LGV), a disease caused by the more invasive L serovars of Chlamydia trachomatis , was considered a rare disease outside resource poor countries. Since then it has emerged as a significant problem among men who have sex with men (MSM) in Europe. In 2003 an outbreak of LGV was recognised in Rotterdam in the Netherlands.1 More than 100 men have been reported in this outbreak, most of whom were HIV positive and many had concomitant sexually transmitted infections including hepatitis C infection. Although many reported unprotected anal sex as a risk factor for acquisition of LGV, fisting and the sharing of sex toys also appeared as possible routes of transmission. Almost all presented with proctitis and symptoms included rectal pain, discharge, tenesmus, and other signs of lower gastrointestinal inflammation including constipation and abdominal pain. Some reported systemic symptoms such as fever and malaise. Genital and Inguinal symptoms were rare with only one patient presenting with Inguinal Lymphadenopathy. Since that report similar outbreaks have been …

Kimberly A Workowski - One of the best experts on this subject based on the ideXlab platform.

  • treatment of lymphogranuloma venereum
    Clinical Infectious Diseases, 2007
    Co-Authors: Catherine Mclean, Bradley P Stoner, Kimberly A Workowski
    Abstract:

    Background Lymphogranuloma venereum (LGV) classically presents with 1 or more genital ulcers or papules, as well as Inguinal Lymphadenopathy (buboes). Recently reported cases of LGV proctitis in men who have sex with men, many of whom are coinfected with human immunodeficiency virus (HIV), have highlighted the importance of optimal clinical treatment of LGV. Methods A review was conducted of the literature on LGV published between 1998 and 2004, as part of the development of the 2006 sexually transmitted disease treatment guidelines of the Centers for Disease Control and Prevention (CDC). Results Doxycycline (100 mg orally twice daily for 21 days) remains the treatment of choice for LGV. No controlled trials support the use of azithromycin or the use of alternative treatment regimens for persons with HIV infection. Conclusions On the basis of the present literature review, the CDC's treatment recommendations for LGV remain unchanged. LGV clinical care, surveillance, and research are severely hindered by the lack of widely available, rapid, standardized tests for the diagnosis of LGV; therefore, patients with symptoms suggestive of LGV, including LGV proctitis, should be presumptively treated with antibacterial therapy for 3 weeks.

M Sunati D Sahoo - One of the best experts on this subject based on the ideXlab platform.

  • fine needle aspiration biopsy diagnosis of metastatic prostate carcinoma to Inguinal lymph node
    Diagnostic Cytopathology, 2007
    Co-Authors: Marilin Rosa, K Harpreet M D Chopra, M Sunati D Sahoo
    Abstract:

    Carcinoma of the prostate is predominantly a disease of older men. Men younger than 50 years of age account for approximately 1% of all patients diagnosed with prostate cancer. Patients generally present with urinary symptoms and rarely with metastatic disease. Lymphatic spread typically occurs to the obturator and internal iliac nodes. We report a case of an aggressive prostate adenocarcinoma in a 47-year-old white male who presented with nausea, vomiting, and enlarged Inguinal lymph nodes for 1 month. A fine needle aspiration biopsy (FNAB) and immunohistochemical stains performed on the FNAB revealed metastatic prostatic adenocarcinoma. The initial clinical presentation of Inguinal Lymphadenopathy, the age of the patient and the cytologic features made this an unusual case. Diagn. Cytopathol. 2007;35:565-567. © 2007 Wiley-Liss, Inc.

John G. Strickler - One of the best experts on this subject based on the ideXlab platform.

  • Unusual Initial Presentation of Herpes Simplex Virus as Inguinal Lymphadenopathy
    Hindawi Limited, 2015
    Co-Authors: Sarah A. Fleming, John G. Strickler
    Abstract:

    Genital herpes simplex virus (HSV) infections are a common cause of Inguinal Lymphadenopathy. However, surgical excision of enlarged Inguinal nodes is almost never performed to initially diagnose genital herpes simplex virus, due to the distinct external presentation of genital herpetic vesicles that usually occur with the first symptoms of infection. Therefore, the histologic and immunophenotypic features of HSV-associated Inguinal Lymphadenopathy are unfamiliar to most pathologists. The current report describes the lymph node pathology of two immunocompetent patients, whose initial HSV diagnosis was established through surgical excision of enlarged Inguinal lymph nodes. Histologic examination showed features consistent with viral Lymphadenopathy, including florid follicular hyperplasia, monocytoid B-cell hyperplasia, and paracortical hyperplasia without extensive necrosis. Immunohistochemical stains for HSV antigens, using polyclonal anti-HSV I and II antibodies, demonstrate strong immunoreactivity for HSV in a small number of cells in the subcapsular sinuses, especially in areas with monocytoid B-cell hyperplasia. Rare scattered HSV-positive cells also are identified in paracortical areas and germinal centers. We conclude that an initial diagnosis of genital HSV infection may be established by Inguinal lymph node biopsy

  • Case Report Unusual Initial Presentation of Herpes Simplex Virus as
    2015
    Co-Authors: Inguinal Lymphadenopathy, Sarah A. Fleming, John G. Strickler
    Abstract:

    Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Genital herpes simplex virus (HSV) infections are a common cause of Inguinal Lymphadenopathy. However, surgical excision of enlarged Inguinal nodes is almost never performed to initially diagnose genital herpes simplex virus, due to the distinct external presentation of genital herpetic vesicles that usually occur with the first symptoms of infection. Therefore, the histologic and immunophenotypic features of HSV-associated Inguinal Lymphadenopathy are unfamiliar to most pathologists. The current report describes the lymph node pathology of two immunocompetent patients, whose initial HSV diagnosis was established through surgical excision of enlarged Inguinal lymph nodes. Histologic examination showed features consistent with viral Lymphadenopathy, including florid follicular hyperplasia, monocytoid B-cell hyperplasia, and paracortical hyperplasia without extensive necrosis. Immunohistochemical stains for HSV antigens, using polyclonal anti-HSV I and II antibodies, demonstrate strong immunoreactivity for HSV in a small number of cells in the subcapsular sinuses, especially in areas with monocytoid B-cell hyperplasia. Rare scattered HSV-positive cells also are identified in paracortical areas and germinal centers. We conclude that an initial diagnosis of genital HSV infection may be established by Inguinal lymph node biopsy. 1