The Experts below are selected from a list of 110544 Experts worldwide ranked by ideXlab platform
Leif H Skibsted - One of the best experts on this subject based on the ideXlab platform.
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electron spin resonance spin trapping for analysis of lipid oxidation in oils Inhibiting Effect of the spin trap alpha phenyl n tert butylnitrone on lipid oxidation
Journal of Agricultural and Food Chemistry, 2005Co-Authors: Joaquin Velasco, Mogens L Andersen, Leif H SkibstedAbstract:The electron spin resonance (ESR) spin trapping technique was investigated as an analytical approach to follow lipid oxidation of rapeseed oil, sunflower oil, and fish oil during storage at 40 degrees C. Unlike previous investigations, alpha-phenyl-N-tert-butylnitrone (PBN), used as spin trap, was added to the fresh oils and formation of radicals was monitored during storage. Results were compared with the development in peroxide value (PV) and the thiobarbituric acid index (TBA). Increasing radical development was detected during the initial stages of oxidation, during which no significant changes in PV and TBA were observed. Evidence of spin adduct depletion was found during prolonged storage, suggesting that although spin trapping of radicals may be used to follow early events in lipid oxidation, it is not a suitable parameter for long periods of time. Addition of the spin trap after sequential samplings is recommended for getting an insight of oxidative changes during storage. Further, the influence of the spin trap (PBN) on lipid oxidation was studied in detail by application of PV and TBA and by following the depletion of naturally occurring tocopherol. PBN was found to possess a profound Inhibiting Effect on lipid oxidation. Such an Effect was found to be dependent on the nature of the oil, and it was observed that the lower the oxidative stability, the larger the Effect of PBN on lipid oxidation. This Effect was interpreted in terms of the capability of PBN to react with peroxyl radicals, which in turn depends on the initial tocopherol content of the oils.
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electron spin resonance spin trapping for analysis of lipid oxidation in oils Inhibiting Effect of the spin trap alpha phenyl n tert butylnitrone on lipid oxidation
Journal of Agricultural and Food Chemistry, 2005Co-Authors: Joaquin Velasco, Mogens L Andersen, Leif H SkibstedAbstract:The electron spin resonance (ESR) spin trapping technique was investigated as an analytical approach to follow lipid oxidation of rapeseed oil, sunflower oil, and fish oil during storage at 40 degrees C. Unlike previous investigations, alpha-phenyl-N-tert-butylnitrone (PBN), used as spin trap, was added to the fresh oils and formation of radicals was monitored during storage. Results were compared with the development in peroxide value (PV) and the thiobarbituric acid index (TBA). Increasing radical development was detected during the initial stages of oxidation, during which no significant changes in PV and TBA were observed. Evidence of spin adduct depletion was found during prolonged storage, suggesting that although spin trapping of radicals may be used to follow early events in lipid oxidation, it is not a suitable parameter for long periods of time. Addition of the spin trap after sequential samplings is recommended for getting an insight of oxidative changes during storage. Further, the influence of the spin trap (PBN) on lipid oxidation was studied in detail by application of PV and TBA and by following the depletion of naturally occurring tocopherol. PBN was found to possess a profound Inhibiting Effect on lipid oxidation. Such an Effect was found to be dependent on the nature of the oil, and it was observed that the lower the oxidative stability, the larger the Effect of PBN on lipid oxidation. This Effect was interpreted in terms of the capability of PBN to react with peroxyl radicals, which in turn depends on the initial tocopherol content of the oils.
Denis Grancher - One of the best experts on this subject based on the ideXlab platform.
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comparative inhibitory Effect of prenylated coumarins ferulenol and ferprenin contained in the poisonous chemotype of ferula communis on mammal liver microsomal vkorc1 activity
Phytochemistry, 2015Co-Authors: Mariesophie Louvet, Gilbert Gault, Manon Boulven, Florence Popowycz, Sébastien Lefebvre, Virginie Lattard, Stéphane Besse, Etienne Benoit, Denis GrancherAbstract:Two distinguishable chemotypes of Ferula communis have been described: the 'nonpoisonous' chemotype, containing as main constituents the daucane esters; and the 'poisonous' chemotype containing prenylated coumarins, such as ferulenol and ferprenin. Ferulenol and ferprenin are 4-oxygenated molecules such as dicoumarol and warfarin, the first developed antivitamin K molecules. Antivitamin K molecules specifically inhibit VKORC1, an enzyme essential for recycling vitamin K. This latest is involved in the activation of clotting factors II, VII, IX, X. The Inhibiting Effect of ferulenol on VKORC1 was shown in rat, but not for species exposed to F. communis while in vivo studies suggest differences between animal susceptibility to ferulenol. The Inhibiting Effect of ferprenin on VKORC1 was never demonstrated. The aim of this study was to compare the Inhibiting Effect of both compounds on VKORC1 of different species exposed to F. communis. Vitamin K epoxide activity was evaluated for each species from liver microsomes and Inhibiting Effect of ferulenol and ferprenin was characterized. Ferulenol and ferprenin were shown to be able to inhibit VKORC1 from all analyzed species. Nevertheless, susceptibility to ferulenol and ferprenin presented differences between species, suggesting a different susceptibility to 'poisonous' chemotypes of F. communis.
Joaquin Velasco - One of the best experts on this subject based on the ideXlab platform.
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electron spin resonance spin trapping for analysis of lipid oxidation in oils Inhibiting Effect of the spin trap alpha phenyl n tert butylnitrone on lipid oxidation
Journal of Agricultural and Food Chemistry, 2005Co-Authors: Joaquin Velasco, Mogens L Andersen, Leif H SkibstedAbstract:The electron spin resonance (ESR) spin trapping technique was investigated as an analytical approach to follow lipid oxidation of rapeseed oil, sunflower oil, and fish oil during storage at 40 degrees C. Unlike previous investigations, alpha-phenyl-N-tert-butylnitrone (PBN), used as spin trap, was added to the fresh oils and formation of radicals was monitored during storage. Results were compared with the development in peroxide value (PV) and the thiobarbituric acid index (TBA). Increasing radical development was detected during the initial stages of oxidation, during which no significant changes in PV and TBA were observed. Evidence of spin adduct depletion was found during prolonged storage, suggesting that although spin trapping of radicals may be used to follow early events in lipid oxidation, it is not a suitable parameter for long periods of time. Addition of the spin trap after sequential samplings is recommended for getting an insight of oxidative changes during storage. Further, the influence of the spin trap (PBN) on lipid oxidation was studied in detail by application of PV and TBA and by following the depletion of naturally occurring tocopherol. PBN was found to possess a profound Inhibiting Effect on lipid oxidation. Such an Effect was found to be dependent on the nature of the oil, and it was observed that the lower the oxidative stability, the larger the Effect of PBN on lipid oxidation. This Effect was interpreted in terms of the capability of PBN to react with peroxyl radicals, which in turn depends on the initial tocopherol content of the oils.
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electron spin resonance spin trapping for analysis of lipid oxidation in oils Inhibiting Effect of the spin trap alpha phenyl n tert butylnitrone on lipid oxidation
Journal of Agricultural and Food Chemistry, 2005Co-Authors: Joaquin Velasco, Mogens L Andersen, Leif H SkibstedAbstract:The electron spin resonance (ESR) spin trapping technique was investigated as an analytical approach to follow lipid oxidation of rapeseed oil, sunflower oil, and fish oil during storage at 40 degrees C. Unlike previous investigations, alpha-phenyl-N-tert-butylnitrone (PBN), used as spin trap, was added to the fresh oils and formation of radicals was monitored during storage. Results were compared with the development in peroxide value (PV) and the thiobarbituric acid index (TBA). Increasing radical development was detected during the initial stages of oxidation, during which no significant changes in PV and TBA were observed. Evidence of spin adduct depletion was found during prolonged storage, suggesting that although spin trapping of radicals may be used to follow early events in lipid oxidation, it is not a suitable parameter for long periods of time. Addition of the spin trap after sequential samplings is recommended for getting an insight of oxidative changes during storage. Further, the influence of the spin trap (PBN) on lipid oxidation was studied in detail by application of PV and TBA and by following the depletion of naturally occurring tocopherol. PBN was found to possess a profound Inhibiting Effect on lipid oxidation. Such an Effect was found to be dependent on the nature of the oil, and it was observed that the lower the oxidative stability, the larger the Effect of PBN on lipid oxidation. This Effect was interpreted in terms of the capability of PBN to react with peroxyl radicals, which in turn depends on the initial tocopherol content of the oils.
Mogens L Andersen - One of the best experts on this subject based on the ideXlab platform.
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electron spin resonance spin trapping for analysis of lipid oxidation in oils Inhibiting Effect of the spin trap alpha phenyl n tert butylnitrone on lipid oxidation
Journal of Agricultural and Food Chemistry, 2005Co-Authors: Joaquin Velasco, Mogens L Andersen, Leif H SkibstedAbstract:The electron spin resonance (ESR) spin trapping technique was investigated as an analytical approach to follow lipid oxidation of rapeseed oil, sunflower oil, and fish oil during storage at 40 degrees C. Unlike previous investigations, alpha-phenyl-N-tert-butylnitrone (PBN), used as spin trap, was added to the fresh oils and formation of radicals was monitored during storage. Results were compared with the development in peroxide value (PV) and the thiobarbituric acid index (TBA). Increasing radical development was detected during the initial stages of oxidation, during which no significant changes in PV and TBA were observed. Evidence of spin adduct depletion was found during prolonged storage, suggesting that although spin trapping of radicals may be used to follow early events in lipid oxidation, it is not a suitable parameter for long periods of time. Addition of the spin trap after sequential samplings is recommended for getting an insight of oxidative changes during storage. Further, the influence of the spin trap (PBN) on lipid oxidation was studied in detail by application of PV and TBA and by following the depletion of naturally occurring tocopherol. PBN was found to possess a profound Inhibiting Effect on lipid oxidation. Such an Effect was found to be dependent on the nature of the oil, and it was observed that the lower the oxidative stability, the larger the Effect of PBN on lipid oxidation. This Effect was interpreted in terms of the capability of PBN to react with peroxyl radicals, which in turn depends on the initial tocopherol content of the oils.
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electron spin resonance spin trapping for analysis of lipid oxidation in oils Inhibiting Effect of the spin trap alpha phenyl n tert butylnitrone on lipid oxidation
Journal of Agricultural and Food Chemistry, 2005Co-Authors: Joaquin Velasco, Mogens L Andersen, Leif H SkibstedAbstract:The electron spin resonance (ESR) spin trapping technique was investigated as an analytical approach to follow lipid oxidation of rapeseed oil, sunflower oil, and fish oil during storage at 40 degrees C. Unlike previous investigations, alpha-phenyl-N-tert-butylnitrone (PBN), used as spin trap, was added to the fresh oils and formation of radicals was monitored during storage. Results were compared with the development in peroxide value (PV) and the thiobarbituric acid index (TBA). Increasing radical development was detected during the initial stages of oxidation, during which no significant changes in PV and TBA were observed. Evidence of spin adduct depletion was found during prolonged storage, suggesting that although spin trapping of radicals may be used to follow early events in lipid oxidation, it is not a suitable parameter for long periods of time. Addition of the spin trap after sequential samplings is recommended for getting an insight of oxidative changes during storage. Further, the influence of the spin trap (PBN) on lipid oxidation was studied in detail by application of PV and TBA and by following the depletion of naturally occurring tocopherol. PBN was found to possess a profound Inhibiting Effect on lipid oxidation. Such an Effect was found to be dependent on the nature of the oil, and it was observed that the lower the oxidative stability, the larger the Effect of PBN on lipid oxidation. This Effect was interpreted in terms of the capability of PBN to react with peroxyl radicals, which in turn depends on the initial tocopherol content of the oils.
Mariesophie Louvet - One of the best experts on this subject based on the ideXlab platform.
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comparative inhibitory Effect of prenylated coumarins ferulenol and ferprenin contained in the poisonous chemotype of ferula communis on mammal liver microsomal vkorc1 activity
Phytochemistry, 2015Co-Authors: Mariesophie Louvet, Gilbert Gault, Manon Boulven, Florence Popowycz, Sébastien Lefebvre, Virginie Lattard, Stéphane Besse, Etienne Benoit, Denis GrancherAbstract:Two distinguishable chemotypes of Ferula communis have been described: the 'nonpoisonous' chemotype, containing as main constituents the daucane esters; and the 'poisonous' chemotype containing prenylated coumarins, such as ferulenol and ferprenin. Ferulenol and ferprenin are 4-oxygenated molecules such as dicoumarol and warfarin, the first developed antivitamin K molecules. Antivitamin K molecules specifically inhibit VKORC1, an enzyme essential for recycling vitamin K. This latest is involved in the activation of clotting factors II, VII, IX, X. The Inhibiting Effect of ferulenol on VKORC1 was shown in rat, but not for species exposed to F. communis while in vivo studies suggest differences between animal susceptibility to ferulenol. The Inhibiting Effect of ferprenin on VKORC1 was never demonstrated. The aim of this study was to compare the Inhibiting Effect of both compounds on VKORC1 of different species exposed to F. communis. Vitamin K epoxide activity was evaluated for each species from liver microsomes and Inhibiting Effect of ferulenol and ferprenin was characterized. Ferulenol and ferprenin were shown to be able to inhibit VKORC1 from all analyzed species. Nevertheless, susceptibility to ferulenol and ferprenin presented differences between species, suggesting a different susceptibility to 'poisonous' chemotypes of F. communis.
