The Experts below are selected from a list of 144 Experts worldwide ranked by ideXlab platform

Qiang Liu - One of the best experts on this subject based on the ideXlab platform.

  • embedded architecture description language
    Computer Software and Applications Conference, 2008
    Co-Authors: Nicholas T Pilkington, Fei Xie, Qiang Liu
    Abstract:

    In the state-of-the-art hardware/software (HW/SW) co- design of embedded systems, there is a lack of sufficient support for architectural specifications across HW/SW boundaries. Such an architectural specification ought to capture both hardware and software Components and their interactions, and facilitate effective design exploitation of HW/SW trade-offs and scalable HW/SW co-verification. In this paper, we present the embedded architecture description language (EADL). It is based on a Component model for embedded systems that unifies hardware and software Components. EADL does not dictate execution and interface semantics of hardware and software Components while supporting flexible platform-oriented semantics instantiation. EADL supports concise representation of embedded system architectures and also formulation of architectural patterns of embedded systems. Besides facilitating design reuse, architectural patterns also facilitate verification reuse via association of properly templates with these patterns. Effectiveness of EADL has been demonstrated by its successful application in Integrating Component-based co-design, co- simulation, co-verification, and system synthesis.

  • COMPSAC - Embedded Architecture Description Language
    2008 32nd Annual IEEE International Computer Software and Applications Conference, 2008
    Co-Authors: Nicholas T Pilkington, Fei Xie, Qiang Liu
    Abstract:

    In the state-of-the-art hardware/software (HW/SW) co- design of embedded systems, there is a lack of sufficient support for architectural specifications across HW/SW boundaries. Such an architectural specification ought to capture both hardware and software Components and their interactions, and facilitate effective design exploitation of HW/SW trade-offs and scalable HW/SW co-verification. In this paper, we present the embedded architecture description language (EADL). It is based on a Component model for embedded systems that unifies hardware and software Components. EADL does not dictate execution and interface semantics of hardware and software Components while supporting flexible platform-oriented semantics instantiation. EADL supports concise representation of embedded system architectures and also formulation of architectural patterns of embedded systems. Besides facilitating design reuse, architectural patterns also facilitate verification reuse via association of properly templates with these patterns. Effectiveness of EADL has been demonstrated by its successful application in Integrating Component-based co-design, co- simulation, co-verification, and system synthesis.

Dermot Kelleher - One of the best experts on this subject based on the ideXlab platform.

  • the scaffolding protein cg nap akap450 is a critical Integrating Component of the lfa 1 induced signaling complex in migratory t cells
    Journal of Immunology, 2005
    Co-Authors: Basma Salah El Din El Homasany, Yuri Volkov, Mikiko Takahashi, Yoshitaka Ono, Guy Keryer, Annie Delouvée, Eileen Looby, Aideen Long, Dermot Kelleher
    Abstract:

    T cell migration represents a complex highly coordinated process involving participation of surface receptor/ligand interactions, cytoskeletal rearrangements, and phosphorylation-dependent signaling cascades. Members of the A-kinase anchoring protein (AKAP) family of giant scaffolding proteins can assemble and compartmentalize multiple signaling and structural molecules thereby providing a platform for their targeted positioning and efficient interactions. We characterize here the expression, intracellular distribution, and functional role of the scaffolding protein CG-NAP (centrosome and Golgi localized protein kinase N-associated protein)/AKAP450 in the process of active T cell motility induced via LFA-1 integrins. This protein is predominantly localized at the centrosome and Golgi complex. T cell locomotion triggered by LFA-1 ligation induces redistribution of CG-NAP/AKAP450 along microtubules in trailing cell extensions. Using an original in situ immunoprecipitation approach, we show that CG-NAP/AKAP450 is physically associated with LFA-1 in the multimolecular signaling complex also including tubulin and the protein kinase C beta and delta isoenzymes. CG-NAP/AKAP450 recruitment to this complex was specific for the T cells migrating on LFA-1 ligands, but not on the beta(1) integrin ligand fibronectin. Using the GFP-tagged C-terminal CG-NAP/AKAP450 construct, we demonstrate that expression of the intact CG-NAP/AKAP450 and its recruitment to the LFA-1-associated multimolecular complex is critically important for polarization and migration of T cells induced by this integrin.

  • The scaffolding protein CG-NAP/AKAP450 is a critical Integrating Component of the LFA-1-induced signaling complex in migratory T cells.
    Journal of immunology (Baltimore Md. : 1950), 2005
    Co-Authors: Basma Salah El Din El Homasany, Yuri Volkov, Mikiko Takahashi, Yoshitaka Ono, Guy Keryer, Annie Delouvée, Eileen Looby, Aideen Long, Dermot Kelleher
    Abstract:

    T cell migration represents a complex highly coordinated process involving participation of surface receptor/ligand interactions, cytoskeletal rearrangements, and phosphorylation-dependent signaling cascades. Members of the A-kinase anchoring protein (AKAP) family of giant scaffolding proteins can assemble and compartmentalize multiple signaling and structural molecules thereby providing a platform for their targeted positioning and efficient interactions. We characterize here the expression, intracellular distribution, and functional role of the scaffolding protein CG-NAP (centrosome and Golgi localized protein kinase N-associated protein)/AKAP450 in the process of active T cell motility induced via LFA-1 integrins. This protein is predominantly localized at the centrosome and Golgi complex. T cell locomotion triggered by LFA-1 ligation induces redistribution of CG-NAP/AKAP450 along microtubules in trailing cell extensions. Using an original in situ immunoprecipitation approach, we show that CG-NAP/AKAP450 is physically associated with LFA-1 in the multimolecular signaling complex also including tubulin and the protein kinase C beta and delta isoenzymes. CG-NAP/AKAP450 recruitment to this complex was specific for the T cells migrating on LFA-1 ligands, but not on the beta(1) integrin ligand fibronectin. Using the GFP-tagged C-terminal CG-NAP/AKAP450 construct, we demonstrate that expression of the intact CG-NAP/AKAP450 and its recruitment to the LFA-1-associated multimolecular complex is critically important for polarization and migration of T cells induced by this integrin.

Nicholas T Pilkington - One of the best experts on this subject based on the ideXlab platform.

  • embedded architecture description language
    Computer Software and Applications Conference, 2008
    Co-Authors: Nicholas T Pilkington, Fei Xie, Qiang Liu
    Abstract:

    In the state-of-the-art hardware/software (HW/SW) co- design of embedded systems, there is a lack of sufficient support for architectural specifications across HW/SW boundaries. Such an architectural specification ought to capture both hardware and software Components and their interactions, and facilitate effective design exploitation of HW/SW trade-offs and scalable HW/SW co-verification. In this paper, we present the embedded architecture description language (EADL). It is based on a Component model for embedded systems that unifies hardware and software Components. EADL does not dictate execution and interface semantics of hardware and software Components while supporting flexible platform-oriented semantics instantiation. EADL supports concise representation of embedded system architectures and also formulation of architectural patterns of embedded systems. Besides facilitating design reuse, architectural patterns also facilitate verification reuse via association of properly templates with these patterns. Effectiveness of EADL has been demonstrated by its successful application in Integrating Component-based co-design, co- simulation, co-verification, and system synthesis.

  • COMPSAC - Embedded Architecture Description Language
    2008 32nd Annual IEEE International Computer Software and Applications Conference, 2008
    Co-Authors: Nicholas T Pilkington, Fei Xie, Qiang Liu
    Abstract:

    In the state-of-the-art hardware/software (HW/SW) co- design of embedded systems, there is a lack of sufficient support for architectural specifications across HW/SW boundaries. Such an architectural specification ought to capture both hardware and software Components and their interactions, and facilitate effective design exploitation of HW/SW trade-offs and scalable HW/SW co-verification. In this paper, we present the embedded architecture description language (EADL). It is based on a Component model for embedded systems that unifies hardware and software Components. EADL does not dictate execution and interface semantics of hardware and software Components while supporting flexible platform-oriented semantics instantiation. EADL supports concise representation of embedded system architectures and also formulation of architectural patterns of embedded systems. Besides facilitating design reuse, architectural patterns also facilitate verification reuse via association of properly templates with these patterns. Effectiveness of EADL has been demonstrated by its successful application in Integrating Component-based co-design, co- simulation, co-verification, and system synthesis.

Basma Salah El Din El Homasany - One of the best experts on this subject based on the ideXlab platform.

  • the scaffolding protein cg nap akap450 is a critical Integrating Component of the lfa 1 induced signaling complex in migratory t cells
    Journal of Immunology, 2005
    Co-Authors: Basma Salah El Din El Homasany, Yuri Volkov, Mikiko Takahashi, Yoshitaka Ono, Guy Keryer, Annie Delouvée, Eileen Looby, Aideen Long, Dermot Kelleher
    Abstract:

    T cell migration represents a complex highly coordinated process involving participation of surface receptor/ligand interactions, cytoskeletal rearrangements, and phosphorylation-dependent signaling cascades. Members of the A-kinase anchoring protein (AKAP) family of giant scaffolding proteins can assemble and compartmentalize multiple signaling and structural molecules thereby providing a platform for their targeted positioning and efficient interactions. We characterize here the expression, intracellular distribution, and functional role of the scaffolding protein CG-NAP (centrosome and Golgi localized protein kinase N-associated protein)/AKAP450 in the process of active T cell motility induced via LFA-1 integrins. This protein is predominantly localized at the centrosome and Golgi complex. T cell locomotion triggered by LFA-1 ligation induces redistribution of CG-NAP/AKAP450 along microtubules in trailing cell extensions. Using an original in situ immunoprecipitation approach, we show that CG-NAP/AKAP450 is physically associated with LFA-1 in the multimolecular signaling complex also including tubulin and the protein kinase C beta and delta isoenzymes. CG-NAP/AKAP450 recruitment to this complex was specific for the T cells migrating on LFA-1 ligands, but not on the beta(1) integrin ligand fibronectin. Using the GFP-tagged C-terminal CG-NAP/AKAP450 construct, we demonstrate that expression of the intact CG-NAP/AKAP450 and its recruitment to the LFA-1-associated multimolecular complex is critically important for polarization and migration of T cells induced by this integrin.

  • The scaffolding protein CG-NAP/AKAP450 is a critical Integrating Component of the LFA-1-induced signaling complex in migratory T cells.
    Journal of immunology (Baltimore Md. : 1950), 2005
    Co-Authors: Basma Salah El Din El Homasany, Yuri Volkov, Mikiko Takahashi, Yoshitaka Ono, Guy Keryer, Annie Delouvée, Eileen Looby, Aideen Long, Dermot Kelleher
    Abstract:

    T cell migration represents a complex highly coordinated process involving participation of surface receptor/ligand interactions, cytoskeletal rearrangements, and phosphorylation-dependent signaling cascades. Members of the A-kinase anchoring protein (AKAP) family of giant scaffolding proteins can assemble and compartmentalize multiple signaling and structural molecules thereby providing a platform for their targeted positioning and efficient interactions. We characterize here the expression, intracellular distribution, and functional role of the scaffolding protein CG-NAP (centrosome and Golgi localized protein kinase N-associated protein)/AKAP450 in the process of active T cell motility induced via LFA-1 integrins. This protein is predominantly localized at the centrosome and Golgi complex. T cell locomotion triggered by LFA-1 ligation induces redistribution of CG-NAP/AKAP450 along microtubules in trailing cell extensions. Using an original in situ immunoprecipitation approach, we show that CG-NAP/AKAP450 is physically associated with LFA-1 in the multimolecular signaling complex also including tubulin and the protein kinase C beta and delta isoenzymes. CG-NAP/AKAP450 recruitment to this complex was specific for the T cells migrating on LFA-1 ligands, but not on the beta(1) integrin ligand fibronectin. Using the GFP-tagged C-terminal CG-NAP/AKAP450 construct, we demonstrate that expression of the intact CG-NAP/AKAP450 and its recruitment to the LFA-1-associated multimolecular complex is critically important for polarization and migration of T cells induced by this integrin.

Arndt Von Staa - One of the best experts on this subject based on the ideXlab platform.

  • Integrating Component and product lines technologies
    International Conference on Software Reuse, 2008
    Co-Authors: Elder Cirilo, Uira Kulesza, Roberta Coelho, Carlos Jose Pereira De Lucena, Arndt Von Staa
    Abstract:

    In this paper, we explore the integration of product line and Component technologies in the context of the product derivation process. In particular, we propose new extensions to our existing model-based product derivation tool, called GenArch, in order to address the new abstractions and mechanisms provided by the Spring and OSGi Component models. The GenArch extensions enable the automatic instantiation of product lines and applications - implemented using these Component technologies. Moreover, it also enables different levels of customization, from fine-grained configuration of Component properties to the automatic selection of Components that will compose the final product.

  • ICSR - Integrating Component and Product Lines Technologies
    Lecture Notes in Computer Science, 2008
    Co-Authors: Cirilo, Uira Kulesza, Roberta Coelho, Carlos Jose Pereira De Lucena, Arndt Von Staa
    Abstract:

    In this paper, we explore the integration of product line and Component technologies in the context of the product derivation process. In particular, we propose new extensions to our existing model-based product derivation tool, called GenArch, in order to address the new abstractions and mechanisms provided by the Spring and OSGi Component models. The GenArch extensions enable the automatic instantiation of product lines and applications - implemented using these Component technologies. Moreover, it also enables different levels of customization, from fine-grained configuration of Component properties to the automatic selection of Components that will compose the final product.