The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Monte S. Buchsbaum - One of the best experts on this subject based on the ideXlab platform.
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Cortical Intercorrelations of frontal area volumes in schizophrenia.
NeuroImage, 2005Co-Authors: Serge A Mitelman, Monte S. Buchsbaum, Adam M Brickman, Lina ShihabuddinAbstract:Abstract Background: Abnormal regional volume Intercorrelations between selected cortical areas in schizophrenia patients were previously reported in several MRI studies. Methods: A detailed analysis of frontal gray and white matter volume correlations with Brodmann's area volumes in the rest of the cortex was undertaken in normal subjects (n = 42) and patients with schizophrenia (n = 106), divided into good-outcome (n = 52) and poor-outcome (Kraepelinian; n = 54) subtypes. Results: Frontal gray matter volumes were correlated with temporal lobe volumes in schizophrenics but not in normal subjects. Some frontal–parietal and frontal–occipital correlations showed a similar pattern. In comparison to normal subjects, schizophrenia patients showed weaker or absent Intercorrelations intrafrontally, specifically between left motor–premotor and eye-movement areas (4, 6, 8) and dorsolateral area 44, as well as between left areas 9 and 46 vs. area 24 (cingulate gyrus). Poor outcome among patients with schizophrenia was associated with weaker correlations between left frontal area 9 and both medial and lateral temporal cortices, as compared to normal subjects or good-outcome patients. Conclusions: There appears to be a structural component in the task or symptom-related dysfunctional interactions between the frontal and more posterior cortical regions with preferential pathological involvement of frontotemporal and more limited involvement of frontoparietal and fronto-occipital systems in schizophrenia. Impaired regional associations within the frontal lobe, between left motor–premotor and Broca's areas, may play a role in language processing deficits in schizophrenia, while frontocingulate disconnection may result in working memory disturbances. Poor outcome may be associated with more widespread disconnections between prefrontal vs. cingulate and temporal regions in the left hemisphere, consistent with a disruption along the course of the left cingulum or uncinate bundles.
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Correlations between volumes of the pulvinar, centromedian, and mediodorsal nuclei and cortical Brodmann's areas in schizophrenia.
Neuroscience letters, 2005Co-Authors: Serge A Mitelman, Erin A. Hazlett, William Byne, Eileen M Kemether, Monte S. BuchsbaumAbstract:Correlations between the MRI-assessed volumes of the pulvinar, centromedian, and mediodorsal nuclei of the thalamus and 39 cortical Brodmann's areas were evaluated and compared in 41 unmedicated schizophrenia patients and 59 healthy comparison subjects. For the right pulvinar, positive Intercorrelations with ipsilateral orbitofrontal and occipital cortices were significantly weaker while negative Intercorrelations with dorsolateral prefrontal and temporopolar/entorhinal cortices were stronger in schizophrenia patients compared to healthy subjects. For the centromedian nucleus, positive correlation with the dorsolateral prefrontal area 46 in the right hemisphere was significantly weaker in patients than in healthy subjects. Higher cortical/pulvinar volume ratios for the right frontotemporal regions with stronger negative correlations in patients were associated with better performance on recall and semantic memory tasks. Right pulvinocortical disconnections in patients with schizophrenia may be related to visual attentional deficits whereas stronger-than-normal inverse pulvinar associations with the heteromodal cortical regions may reflect compensatory reliance on alternative information-processing strategies.
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Cortical Intercorrelations of temporal area volumes in schizophrenia.
Schizophrenia research, 2005Co-Authors: Serge A Mitelman, Lina Shihabuddin, Adam M Brickman, Monte S. BuchsbaumAbstract:Abnormal temporal connections with other cortical areas may underlie some of the most prominent cognitive deficits described in schizophrenia. In order to evaluate the relationship between temporal and other cortical regions in schizophrenia, we examined the Intercorrelations of volumetric measures of gray and white matter for each Brodmann's area of the temporal lobe with volumes in the rest of the cortex in patients with schizophrenia and normal comparison subjects. MR images were acquired in normal subjects (n=46) and patients with schizophrenia (n=106), divided into good-outcome (n=52) and poor-outcome (Kraepelinian; n=54) subtypes; and correlational patterns between the volumes of individual Brodmann's areas were compared and examined in relation to outcome. Positive frontotemporal Intercorrelations were significantly stronger while negative frontotemporal Intercorrelations were weaker in schizophrenia patients as compared to normal subjects. Correlations between the right temporal pole and other temporal regions were significantly weaker in schizophrenia patients than in controls. When compared to normal controls and good-outcome patients, schizophrenia patients with poor outcomes showed a selective pattern of stronger gray matter correlations between the medial temporal vs. primary visual and between primary auditory vs. dorsolateral prefrontal cortices, all in the left hemisphere. Strengthening of positive associations among the temporal and extratemporal (mainly frontal and occipital) regions as well as weakening of regional Intercorrelations within the temporal lobe in patients appear to constitute the major differences of correlational patterns in schizophrenia patients and normal subjects. Present findings may be implicated in object recognition deficits seen in patients with schizophrenia, as well as in purportedly deficient spatial and semantic processing of both auditory and visual information that may be associated with poor outcome.
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Cortical Intercorrelations of temporal area volumes in schizophrenia.
Schizophrenia Research, 2005Co-Authors: Serge A Mitelman, Lina Shihabuddin, Adam M Brickman, Monte S. BuchsbaumAbstract:Abstract Background Abnormal temporal connections with other cortical areas may underlie some of the most prominent cognitive deficits described in schizophrenia. In order to evaluate the relationship between temporal and other cortical regions in schizophrenia, we examined the Intercorrelations of volumetric measures of gray and white matter for each Brodmann's area of the temporal lobe with volumes in the rest of the cortex in patients with schizophrenia and normal comparison subjects. Methods MR images were acquired in normal subjects ( n =46) and patients with schizophrenia ( n =106), divided into good-outcome ( n =52) and poor-outcome (Kraepelinian; n =54) subtypes; and correlational patterns between the volumes of individual Brodmann's areas were compared and examined in relation to outcome. Results Positive frontotemporal Intercorrelations were significantly stronger while negative frontotemporal Intercorrelations were weaker in schizophrenia patients as compared to normal subjects. Correlations between the right temporal pole and other temporal regions were significantly weaker in schizophrenia patients than in controls. When compared to normal controls and good-outcome patients, schizophrenia patients with poor outcomes showed a selective pattern of stronger gray matter correlations between the medial temporal vs. primary visual and between primary auditory vs. dorsolateral prefrontal cortices, all in the left hemisphere. Conclusions Strengthening of positive associations among the temporal and extratemporal (mainly frontal and occipital) regions as well as weakening of regional Intercorrelations within the temporal lobe in patients appear to constitute the major differences of correlational patterns in schizophrenia patients and normal subjects. Present findings may be implicated in object recognition deficits seen in patients with schizophrenia, as well as in purportedly deficient spatial and semantic processing of both auditory and visual information that may be associated with poor outcome.
Todd D Little - One of the best experts on this subject based on the ideXlab platform.
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direct and indirect aggression during childhood and adolescence a meta analytic review of gender differences Intercorrelations and relations to maladjustment
Child Development, 2008Co-Authors: Noel A Card, Brian D Stucky, Gita M Sawalani, Todd D LittleAbstract:This meta-analytic review of 148 studies on child and adolescent direct and indirect aggression examined the magnitude of gender differences, Intercorrelations between forms, and associations with maladjustment. Results confirmed prior findings of gender differences (favoring boys) in direct aggression and trivial gender differences in indirect aggression. Results also indicated a substantial intercorrelation (= .76) between these forms. Despite this high intercorrelation, the 2 forms showed unique associations with maladjustment: Direct aggression is more strongly related to externalizing problems, poor peer relations, and low prosocial behavior, and indirect aggression is related to internalizing problems and higher prosocial behavior. Moderation of these effect sizes by method of assessment, age, gender, and several additional variables were systematically investigated.
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Direct and Indirect Aggression During Childhood and Adolescence: A Meta‐Analytic Review of Gender Differences, Intercorrelations, and Relations to Maladjustment
Child development, 2008Co-Authors: Noel A Card, Brian D Stucky, Gita M Sawalani, Todd D LittleAbstract:This meta-analytic review of 148 studies on child and adolescent direct and indirect aggression examined the magnitude of gender differences, Intercorrelations between forms, and associations with maladjustment. Results confirmed prior findings of gender differences (favoring boys) in direct aggression and trivial gender differences in indirect aggression. Results also indicated a substantial intercorrelation (= .76) between these forms. Despite this high intercorrelation, the 2 forms showed unique associations with maladjustment: Direct aggression is more strongly related to externalizing problems, poor peer relations, and low prosocial behavior, and indirect aggression is related to internalizing problems and higher prosocial behavior. Moderation of these effect sizes by method of assessment, age, gender, and several additional variables were systematically investigated.
Lina Shihabuddin - One of the best experts on this subject based on the ideXlab platform.
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Cortical Intercorrelations of frontal area volumes in schizophrenia.
NeuroImage, 2005Co-Authors: Serge A Mitelman, Monte S. Buchsbaum, Adam M Brickman, Lina ShihabuddinAbstract:Abstract Background: Abnormal regional volume Intercorrelations between selected cortical areas in schizophrenia patients were previously reported in several MRI studies. Methods: A detailed analysis of frontal gray and white matter volume correlations with Brodmann's area volumes in the rest of the cortex was undertaken in normal subjects (n = 42) and patients with schizophrenia (n = 106), divided into good-outcome (n = 52) and poor-outcome (Kraepelinian; n = 54) subtypes. Results: Frontal gray matter volumes were correlated with temporal lobe volumes in schizophrenics but not in normal subjects. Some frontal–parietal and frontal–occipital correlations showed a similar pattern. In comparison to normal subjects, schizophrenia patients showed weaker or absent Intercorrelations intrafrontally, specifically between left motor–premotor and eye-movement areas (4, 6, 8) and dorsolateral area 44, as well as between left areas 9 and 46 vs. area 24 (cingulate gyrus). Poor outcome among patients with schizophrenia was associated with weaker correlations between left frontal area 9 and both medial and lateral temporal cortices, as compared to normal subjects or good-outcome patients. Conclusions: There appears to be a structural component in the task or symptom-related dysfunctional interactions between the frontal and more posterior cortical regions with preferential pathological involvement of frontotemporal and more limited involvement of frontoparietal and fronto-occipital systems in schizophrenia. Impaired regional associations within the frontal lobe, between left motor–premotor and Broca's areas, may play a role in language processing deficits in schizophrenia, while frontocingulate disconnection may result in working memory disturbances. Poor outcome may be associated with more widespread disconnections between prefrontal vs. cingulate and temporal regions in the left hemisphere, consistent with a disruption along the course of the left cingulum or uncinate bundles.
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Cortical Intercorrelations of temporal area volumes in schizophrenia.
Schizophrenia research, 2005Co-Authors: Serge A Mitelman, Lina Shihabuddin, Adam M Brickman, Monte S. BuchsbaumAbstract:Abnormal temporal connections with other cortical areas may underlie some of the most prominent cognitive deficits described in schizophrenia. In order to evaluate the relationship between temporal and other cortical regions in schizophrenia, we examined the Intercorrelations of volumetric measures of gray and white matter for each Brodmann's area of the temporal lobe with volumes in the rest of the cortex in patients with schizophrenia and normal comparison subjects. MR images were acquired in normal subjects (n=46) and patients with schizophrenia (n=106), divided into good-outcome (n=52) and poor-outcome (Kraepelinian; n=54) subtypes; and correlational patterns between the volumes of individual Brodmann's areas were compared and examined in relation to outcome. Positive frontotemporal Intercorrelations were significantly stronger while negative frontotemporal Intercorrelations were weaker in schizophrenia patients as compared to normal subjects. Correlations between the right temporal pole and other temporal regions were significantly weaker in schizophrenia patients than in controls. When compared to normal controls and good-outcome patients, schizophrenia patients with poor outcomes showed a selective pattern of stronger gray matter correlations between the medial temporal vs. primary visual and between primary auditory vs. dorsolateral prefrontal cortices, all in the left hemisphere. Strengthening of positive associations among the temporal and extratemporal (mainly frontal and occipital) regions as well as weakening of regional Intercorrelations within the temporal lobe in patients appear to constitute the major differences of correlational patterns in schizophrenia patients and normal subjects. Present findings may be implicated in object recognition deficits seen in patients with schizophrenia, as well as in purportedly deficient spatial and semantic processing of both auditory and visual information that may be associated with poor outcome.
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Cortical Intercorrelations of temporal area volumes in schizophrenia.
Schizophrenia Research, 2005Co-Authors: Serge A Mitelman, Lina Shihabuddin, Adam M Brickman, Monte S. BuchsbaumAbstract:Abstract Background Abnormal temporal connections with other cortical areas may underlie some of the most prominent cognitive deficits described in schizophrenia. In order to evaluate the relationship between temporal and other cortical regions in schizophrenia, we examined the Intercorrelations of volumetric measures of gray and white matter for each Brodmann's area of the temporal lobe with volumes in the rest of the cortex in patients with schizophrenia and normal comparison subjects. Methods MR images were acquired in normal subjects ( n =46) and patients with schizophrenia ( n =106), divided into good-outcome ( n =52) and poor-outcome (Kraepelinian; n =54) subtypes; and correlational patterns between the volumes of individual Brodmann's areas were compared and examined in relation to outcome. Results Positive frontotemporal Intercorrelations were significantly stronger while negative frontotemporal Intercorrelations were weaker in schizophrenia patients as compared to normal subjects. Correlations between the right temporal pole and other temporal regions were significantly weaker in schizophrenia patients than in controls. When compared to normal controls and good-outcome patients, schizophrenia patients with poor outcomes showed a selective pattern of stronger gray matter correlations between the medial temporal vs. primary visual and between primary auditory vs. dorsolateral prefrontal cortices, all in the left hemisphere. Conclusions Strengthening of positive associations among the temporal and extratemporal (mainly frontal and occipital) regions as well as weakening of regional Intercorrelations within the temporal lobe in patients appear to constitute the major differences of correlational patterns in schizophrenia patients and normal subjects. Present findings may be implicated in object recognition deficits seen in patients with schizophrenia, as well as in purportedly deficient spatial and semantic processing of both auditory and visual information that may be associated with poor outcome.
Serge A Mitelman - One of the best experts on this subject based on the ideXlab platform.
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Cortical Intercorrelations of frontal area volumes in schizophrenia.
NeuroImage, 2005Co-Authors: Serge A Mitelman, Monte S. Buchsbaum, Adam M Brickman, Lina ShihabuddinAbstract:Abstract Background: Abnormal regional volume Intercorrelations between selected cortical areas in schizophrenia patients were previously reported in several MRI studies. Methods: A detailed analysis of frontal gray and white matter volume correlations with Brodmann's area volumes in the rest of the cortex was undertaken in normal subjects (n = 42) and patients with schizophrenia (n = 106), divided into good-outcome (n = 52) and poor-outcome (Kraepelinian; n = 54) subtypes. Results: Frontal gray matter volumes were correlated with temporal lobe volumes in schizophrenics but not in normal subjects. Some frontal–parietal and frontal–occipital correlations showed a similar pattern. In comparison to normal subjects, schizophrenia patients showed weaker or absent Intercorrelations intrafrontally, specifically between left motor–premotor and eye-movement areas (4, 6, 8) and dorsolateral area 44, as well as between left areas 9 and 46 vs. area 24 (cingulate gyrus). Poor outcome among patients with schizophrenia was associated with weaker correlations between left frontal area 9 and both medial and lateral temporal cortices, as compared to normal subjects or good-outcome patients. Conclusions: There appears to be a structural component in the task or symptom-related dysfunctional interactions between the frontal and more posterior cortical regions with preferential pathological involvement of frontotemporal and more limited involvement of frontoparietal and fronto-occipital systems in schizophrenia. Impaired regional associations within the frontal lobe, between left motor–premotor and Broca's areas, may play a role in language processing deficits in schizophrenia, while frontocingulate disconnection may result in working memory disturbances. Poor outcome may be associated with more widespread disconnections between prefrontal vs. cingulate and temporal regions in the left hemisphere, consistent with a disruption along the course of the left cingulum or uncinate bundles.
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Correlations between volumes of the pulvinar, centromedian, and mediodorsal nuclei and cortical Brodmann's areas in schizophrenia.
Neuroscience letters, 2005Co-Authors: Serge A Mitelman, Erin A. Hazlett, William Byne, Eileen M Kemether, Monte S. BuchsbaumAbstract:Correlations between the MRI-assessed volumes of the pulvinar, centromedian, and mediodorsal nuclei of the thalamus and 39 cortical Brodmann's areas were evaluated and compared in 41 unmedicated schizophrenia patients and 59 healthy comparison subjects. For the right pulvinar, positive Intercorrelations with ipsilateral orbitofrontal and occipital cortices were significantly weaker while negative Intercorrelations with dorsolateral prefrontal and temporopolar/entorhinal cortices were stronger in schizophrenia patients compared to healthy subjects. For the centromedian nucleus, positive correlation with the dorsolateral prefrontal area 46 in the right hemisphere was significantly weaker in patients than in healthy subjects. Higher cortical/pulvinar volume ratios for the right frontotemporal regions with stronger negative correlations in patients were associated with better performance on recall and semantic memory tasks. Right pulvinocortical disconnections in patients with schizophrenia may be related to visual attentional deficits whereas stronger-than-normal inverse pulvinar associations with the heteromodal cortical regions may reflect compensatory reliance on alternative information-processing strategies.
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Cortical Intercorrelations of temporal area volumes in schizophrenia.
Schizophrenia research, 2005Co-Authors: Serge A Mitelman, Lina Shihabuddin, Adam M Brickman, Monte S. BuchsbaumAbstract:Abnormal temporal connections with other cortical areas may underlie some of the most prominent cognitive deficits described in schizophrenia. In order to evaluate the relationship between temporal and other cortical regions in schizophrenia, we examined the Intercorrelations of volumetric measures of gray and white matter for each Brodmann's area of the temporal lobe with volumes in the rest of the cortex in patients with schizophrenia and normal comparison subjects. MR images were acquired in normal subjects (n=46) and patients with schizophrenia (n=106), divided into good-outcome (n=52) and poor-outcome (Kraepelinian; n=54) subtypes; and correlational patterns between the volumes of individual Brodmann's areas were compared and examined in relation to outcome. Positive frontotemporal Intercorrelations were significantly stronger while negative frontotemporal Intercorrelations were weaker in schizophrenia patients as compared to normal subjects. Correlations between the right temporal pole and other temporal regions were significantly weaker in schizophrenia patients than in controls. When compared to normal controls and good-outcome patients, schizophrenia patients with poor outcomes showed a selective pattern of stronger gray matter correlations between the medial temporal vs. primary visual and between primary auditory vs. dorsolateral prefrontal cortices, all in the left hemisphere. Strengthening of positive associations among the temporal and extratemporal (mainly frontal and occipital) regions as well as weakening of regional Intercorrelations within the temporal lobe in patients appear to constitute the major differences of correlational patterns in schizophrenia patients and normal subjects. Present findings may be implicated in object recognition deficits seen in patients with schizophrenia, as well as in purportedly deficient spatial and semantic processing of both auditory and visual information that may be associated with poor outcome.
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Cortical Intercorrelations of temporal area volumes in schizophrenia.
Schizophrenia Research, 2005Co-Authors: Serge A Mitelman, Lina Shihabuddin, Adam M Brickman, Monte S. BuchsbaumAbstract:Abstract Background Abnormal temporal connections with other cortical areas may underlie some of the most prominent cognitive deficits described in schizophrenia. In order to evaluate the relationship between temporal and other cortical regions in schizophrenia, we examined the Intercorrelations of volumetric measures of gray and white matter for each Brodmann's area of the temporal lobe with volumes in the rest of the cortex in patients with schizophrenia and normal comparison subjects. Methods MR images were acquired in normal subjects ( n =46) and patients with schizophrenia ( n =106), divided into good-outcome ( n =52) and poor-outcome (Kraepelinian; n =54) subtypes; and correlational patterns between the volumes of individual Brodmann's areas were compared and examined in relation to outcome. Results Positive frontotemporal Intercorrelations were significantly stronger while negative frontotemporal Intercorrelations were weaker in schizophrenia patients as compared to normal subjects. Correlations between the right temporal pole and other temporal regions were significantly weaker in schizophrenia patients than in controls. When compared to normal controls and good-outcome patients, schizophrenia patients with poor outcomes showed a selective pattern of stronger gray matter correlations between the medial temporal vs. primary visual and between primary auditory vs. dorsolateral prefrontal cortices, all in the left hemisphere. Conclusions Strengthening of positive associations among the temporal and extratemporal (mainly frontal and occipital) regions as well as weakening of regional Intercorrelations within the temporal lobe in patients appear to constitute the major differences of correlational patterns in schizophrenia patients and normal subjects. Present findings may be implicated in object recognition deficits seen in patients with schizophrenia, as well as in purportedly deficient spatial and semantic processing of both auditory and visual information that may be associated with poor outcome.
Noel A Card - One of the best experts on this subject based on the ideXlab platform.
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direct and indirect aggression during childhood and adolescence a meta analytic review of gender differences Intercorrelations and relations to maladjustment
Child Development, 2008Co-Authors: Noel A Card, Brian D Stucky, Gita M Sawalani, Todd D LittleAbstract:This meta-analytic review of 148 studies on child and adolescent direct and indirect aggression examined the magnitude of gender differences, Intercorrelations between forms, and associations with maladjustment. Results confirmed prior findings of gender differences (favoring boys) in direct aggression and trivial gender differences in indirect aggression. Results also indicated a substantial intercorrelation (= .76) between these forms. Despite this high intercorrelation, the 2 forms showed unique associations with maladjustment: Direct aggression is more strongly related to externalizing problems, poor peer relations, and low prosocial behavior, and indirect aggression is related to internalizing problems and higher prosocial behavior. Moderation of these effect sizes by method of assessment, age, gender, and several additional variables were systematically investigated.
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Direct and Indirect Aggression During Childhood and Adolescence: A Meta‐Analytic Review of Gender Differences, Intercorrelations, and Relations to Maladjustment
Child development, 2008Co-Authors: Noel A Card, Brian D Stucky, Gita M Sawalani, Todd D LittleAbstract:This meta-analytic review of 148 studies on child and adolescent direct and indirect aggression examined the magnitude of gender differences, Intercorrelations between forms, and associations with maladjustment. Results confirmed prior findings of gender differences (favoring boys) in direct aggression and trivial gender differences in indirect aggression. Results also indicated a substantial intercorrelation (= .76) between these forms. Despite this high intercorrelation, the 2 forms showed unique associations with maladjustment: Direct aggression is more strongly related to externalizing problems, poor peer relations, and low prosocial behavior, and indirect aggression is related to internalizing problems and higher prosocial behavior. Moderation of these effect sizes by method of assessment, age, gender, and several additional variables were systematically investigated.
