The Experts below are selected from a list of 9846 Experts worldwide ranked by ideXlab platform

Takashi Miura - One of the best experts on this subject based on the ideXlab platform.

  • Noise-induced scaling in skull suture Interdigitation.
    PloS one, 2020
    Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi Miura
    Abstract:

    Sutures, the thin, soft tissue between skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn skull, the sutures are straight; however, as the skull develops, the sutures wind dynamically to form an Interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the Interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal suture and formulated a new mathematical model with time-space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the suture tissue and included a time-space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing skull, and found that actual suture patterns followed a scaling law similar to that of the theoretical prediction.

  • Noise-induced scaling in skull suture Interdigitation
    2020
    Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi Miura
    Abstract:

    Abstract Sutures, the thin, soft tissue between skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn skull, the sutures are straight; however, as the skull develops, the sutures wind dynamically to form an Interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the Interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal suture and formulated a new mathematical model with time–space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the suture tissue and included a time–space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing skull, and found that actual suture patterns followed a scaling law similar to that of the theoretical prediction. Author summary Skull sutures (thin, undifferentiated tissue between bones) act as the growth centers for the skull. Sutures are straight at birth but later develop an interdigitated pattern that ultimately becomes a fractal structure. While our previous mathematical model of sutures generated a periodic pattern, the mechanism underlying the fractal structure formation remained to be elucidated. Here, we focused only on the anterior part of the sagittal suture and formulated a reduced model representing the initial linear phase of pattern formation with the addition of a time–space-dependent noise term. We showed analytically that the model generates patterns with a scaling law. This result was confirmed numerically and experimentally.

  • A new mathematical model for pattern formation by cranial sutures.
    Journal of Theoretical Biology, 2016
    Co-Authors: Kenji Yoshimura, Ryo Kobayashi, Tomohisa Ohmura, Yoshinaga Kajimoto, Takashi Miura
    Abstract:

    Cranial sutures are narrow mesenchymal tissues that connect skull bones to each other. Given that they serve as growth centers in the skull, these undifferentiated tissues play crucial roles in skull development. Cranial sutures are also of clinical importance, because the premature fusion of skull bones results in a pathological condition called craniosynostosis. In newborns, skull sutures are wide and straight; during adolescence, they become thinner and start winding to form an interdigitating pattern. From a functional aspect, as the degree of Interdigitation becomes larger, the strength of the connection between bones increases. However, the mechanisms underlying the maintenance of mesenchymal narrow bands or formation of Interdigitation remain poorly understood. In the present study, we presented a new mathematical model that can reproduce the suture width maintenance and Interdigitation formation. We can predict the width of the mesenchyme bands and wavelengths of suture Interdigitations from the model.

  • Mechanism of skull suture maintenance and Interdigitation.
    Journal of anatomy, 2009
    Co-Authors: Takashi Miura, Chad A. Perlyn, Masato Kinboshi, Naomichi Ogihara, Mikiko Kobayashi-miura, Gillian M. Morriss-kay, Kohei Shiota
    Abstract:

    Skull sutures serve as growth centers whose function involves multiple molecular pathways. During periods of brain growth the sutures remain thin and straight, later developing complex fractal Interdigitations that provide interlocking strength. The nature of the relationship between the molecular interactions and suture pattern formation is not understood. Here we show that by classifying the molecules involved into two groups, stabilizing factors and substrate molecules, complex molecular networks can be modeled by a simple two-species reaction–diffusion model that recapitulates all the known behavior of suture pattern formation. This model reproduces the maintenance of thin sutural tissue at early stages, the later modification of the straight suture to form osseous Interdigitations, and the formation of fractal structures. Predictions from the model are in good agreement with experimental observations, indicating that the model captures the essential nature of the Interdigitation process.

Lei Shao - One of the best experts on this subject based on the ideXlab platform.

  • using spectral domain optical coherence tomography to evaluate the type and thickness of Interdigitation zone band in adult chinese
    Scientific Reports, 2018
    Co-Authors: Lei Shao, Qing Lin Zhang, Ling Xiao Zhou, Qi Sheng You, Wen Bin Wei
    Abstract:

    To study types and thickness of Interdigitation zone band in adult Chinese subjects, we conducted a cross-sectional study. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years. 263 people (263eyes) with a mean age of 64.8 years were randomly selected cases without macular diseases included in the study. A detailed ophthalmic examination was performed including SD-OCT for measurement of the thickness of Interdigitation zone band. There are two types of Interdigitation zone band; the type1 which can distinguish RPE–BM complex in 170 eyes; and the Type 2 which the two layers merged involved 93 eyes. In type1, the mean thickness of the Interdigitation zone band was significantly thicker in the foveal center (16.46 ± 2.92 μm), then nasal macular region (16.19 ± 2.69 μm), temporal macular region (15.73 ± 2.68 . μm), superior region (15.72 ± 2.70 μm), and inferior macular region (14.84 ± 2.63 μm) (P all < 0.05). And the mean thickness of the Interdigitation zone band in the foveal center associated with the subfoveal choroidal thickness (P = 0.025) and level of education (P = 0.033). The increase in the thickness of the Interdigitation zone band may play a role in the pathophysiologic features of various age-related ocular conditions.

  • Using spectral-domain optical coherence tomography to evaluate the type and thickness of Interdigitation zone band in adult Chinese.
    Scientific reports, 2018
    Co-Authors: Lei Shao, Qing Lin Zhang, Ling Xiao Zhou, Qi Sheng You, Wen Bin Wei
    Abstract:

    To study types and thickness of Interdigitation zone band in adult Chinese subjects, we conducted a cross-sectional study. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years. 263 people (263eyes) with a mean age of 64.8 years were randomly selected cases without macular diseases included in the study. A detailed ophthalmic examination was performed including SD-OCT for measurement of the thickness of Interdigitation zone band. There are two types of Interdigitation zone band; the type1 which can distinguish RPE–BM complex in 170 eyes; and the Type 2 which the two layers merged involved 93 eyes. In type1, the mean thickness of the Interdigitation zone band was significantly thicker in the foveal center (16.46 ± 2.92 μm), then nasal macular region (16.19 ± 2.69 μm), temporal macular region (15.73 ± 2.68 . μm), superior region (15.72 ± 2.70 μm), and inferior macular region (14.84 ± 2.63 μm) (P all 

Kenji Yoshimura - One of the best experts on this subject based on the ideXlab platform.

  • Noise-induced scaling in skull suture Interdigitation.
    PloS one, 2020
    Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi Miura
    Abstract:

    Sutures, the thin, soft tissue between skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn skull, the sutures are straight; however, as the skull develops, the sutures wind dynamically to form an Interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the Interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal suture and formulated a new mathematical model with time-space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the suture tissue and included a time-space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing skull, and found that actual suture patterns followed a scaling law similar to that of the theoretical prediction.

  • Noise-induced scaling in skull suture Interdigitation
    2020
    Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi Miura
    Abstract:

    Abstract Sutures, the thin, soft tissue between skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn skull, the sutures are straight; however, as the skull develops, the sutures wind dynamically to form an Interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the Interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal suture and formulated a new mathematical model with time–space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the suture tissue and included a time–space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing skull, and found that actual suture patterns followed a scaling law similar to that of the theoretical prediction. Author summary Skull sutures (thin, undifferentiated tissue between bones) act as the growth centers for the skull. Sutures are straight at birth but later develop an interdigitated pattern that ultimately becomes a fractal structure. While our previous mathematical model of sutures generated a periodic pattern, the mechanism underlying the fractal structure formation remained to be elucidated. Here, we focused only on the anterior part of the sagittal suture and formulated a reduced model representing the initial linear phase of pattern formation with the addition of a time–space-dependent noise term. We showed analytically that the model generates patterns with a scaling law. This result was confirmed numerically and experimentally.

  • A new mathematical model for pattern formation by cranial sutures.
    Journal of Theoretical Biology, 2016
    Co-Authors: Kenji Yoshimura, Ryo Kobayashi, Tomohisa Ohmura, Yoshinaga Kajimoto, Takashi Miura
    Abstract:

    Cranial sutures are narrow mesenchymal tissues that connect skull bones to each other. Given that they serve as growth centers in the skull, these undifferentiated tissues play crucial roles in skull development. Cranial sutures are also of clinical importance, because the premature fusion of skull bones results in a pathological condition called craniosynostosis. In newborns, skull sutures are wide and straight; during adolescence, they become thinner and start winding to form an interdigitating pattern. From a functional aspect, as the degree of Interdigitation becomes larger, the strength of the connection between bones increases. However, the mechanisms underlying the maintenance of mesenchymal narrow bands or formation of Interdigitation remain poorly understood. In the present study, we presented a new mathematical model that can reproduce the suture width maintenance and Interdigitation formation. We can predict the width of the mesenchyme bands and wavelengths of suture Interdigitations from the model.

Wen Bin Wei - One of the best experts on this subject based on the ideXlab platform.

  • using spectral domain optical coherence tomography to evaluate the type and thickness of Interdigitation zone band in adult chinese
    Scientific Reports, 2018
    Co-Authors: Lei Shao, Qing Lin Zhang, Ling Xiao Zhou, Qi Sheng You, Wen Bin Wei
    Abstract:

    To study types and thickness of Interdigitation zone band in adult Chinese subjects, we conducted a cross-sectional study. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years. 263 people (263eyes) with a mean age of 64.8 years were randomly selected cases without macular diseases included in the study. A detailed ophthalmic examination was performed including SD-OCT for measurement of the thickness of Interdigitation zone band. There are two types of Interdigitation zone band; the type1 which can distinguish RPE–BM complex in 170 eyes; and the Type 2 which the two layers merged involved 93 eyes. In type1, the mean thickness of the Interdigitation zone band was significantly thicker in the foveal center (16.46 ± 2.92 μm), then nasal macular region (16.19 ± 2.69 μm), temporal macular region (15.73 ± 2.68 . μm), superior region (15.72 ± 2.70 μm), and inferior macular region (14.84 ± 2.63 μm) (P all < 0.05). And the mean thickness of the Interdigitation zone band in the foveal center associated with the subfoveal choroidal thickness (P = 0.025) and level of education (P = 0.033). The increase in the thickness of the Interdigitation zone band may play a role in the pathophysiologic features of various age-related ocular conditions.

Qing Lin Zhang - One of the best experts on this subject based on the ideXlab platform.

  • using spectral domain optical coherence tomography to evaluate the type and thickness of Interdigitation zone band in adult chinese
    Scientific Reports, 2018
    Co-Authors: Lei Shao, Qing Lin Zhang, Ling Xiao Zhou, Qi Sheng You, Wen Bin Wei
    Abstract:

    To study types and thickness of Interdigitation zone band in adult Chinese subjects, we conducted a cross-sectional study. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years. 263 people (263eyes) with a mean age of 64.8 years were randomly selected cases without macular diseases included in the study. A detailed ophthalmic examination was performed including SD-OCT for measurement of the thickness of Interdigitation zone band. There are two types of Interdigitation zone band; the type1 which can distinguish RPE–BM complex in 170 eyes; and the Type 2 which the two layers merged involved 93 eyes. In type1, the mean thickness of the Interdigitation zone band was significantly thicker in the foveal center (16.46 ± 2.92 μm), then nasal macular region (16.19 ± 2.69 μm), temporal macular region (15.73 ± 2.68 . μm), superior region (15.72 ± 2.70 μm), and inferior macular region (14.84 ± 2.63 μm) (P all < 0.05). And the mean thickness of the Interdigitation zone band in the foveal center associated with the subfoveal choroidal thickness (P = 0.025) and level of education (P = 0.033). The increase in the thickness of the Interdigitation zone band may play a role in the pathophysiologic features of various age-related ocular conditions.

  • Using spectral-domain optical coherence tomography to evaluate the type and thickness of Interdigitation zone band in adult Chinese.
    Scientific reports, 2018
    Co-Authors: Lei Shao, Qing Lin Zhang, Ling Xiao Zhou, Qi Sheng You, Wen Bin Wei
    Abstract:

    To study types and thickness of Interdigitation zone band in adult Chinese subjects, we conducted a cross-sectional study. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years. 263 people (263eyes) with a mean age of 64.8 years were randomly selected cases without macular diseases included in the study. A detailed ophthalmic examination was performed including SD-OCT for measurement of the thickness of Interdigitation zone band. There are two types of Interdigitation zone band; the type1 which can distinguish RPE–BM complex in 170 eyes; and the Type 2 which the two layers merged involved 93 eyes. In type1, the mean thickness of the Interdigitation zone band was significantly thicker in the foveal center (16.46 ± 2.92 μm), then nasal macular region (16.19 ± 2.69 μm), temporal macular region (15.73 ± 2.68 . μm), superior region (15.72 ± 2.70 μm), and inferior macular region (14.84 ± 2.63 μm) (P all